Christelle Breillat
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View article: Paralog-specific intrabodies for PSD-93 and SAP102 expand the molecular toolkit to resolve excitatory synapse organization
Paralog-specific intrabodies for PSD-93 and SAP102 expand the molecular toolkit to resolve excitatory synapse organization Open
A scarcity of live, paralog-specific tools has limited analysis of PSD-MAGUKs at excitatory synapses. To address this gap, we engineered small, 10 FN3-derived binders that selectively recognize PSD-93 and SAP102 -alongside an enhanced PSD-…
View article: Synapse specific and plasticity-regulated AMPAR mobility tunes synaptic integration
Synapse specific and plasticity-regulated AMPAR mobility tunes synaptic integration Open
Synaptic responses adapt to fast repetitive inputs during bursts of neuronal network activity over timescales of milliseconds to seconds, either transiently facilitating or depressing. This high-frequency stimulus-dependent short-term syna…
View article: Engineering paralog-specific PSD-95 recombinant binders as minimally interfering multimodal probes for advanced imaging techniques
Engineering paralog-specific PSD-95 recombinant binders as minimally interfering multimodal probes for advanced imaging techniques Open
Despite the constant advances in fluorescence imaging techniques, monitoring endogenous proteins still constitutes a major challenge in particular when considering dynamics studies or super-resolution imaging. We have recently evolved spec…
View article: Author response: Engineering paralog-specific PSD-95 recombinant binders as minimally interfering multimodal probes for advanced imaging techniques
Author response: Engineering paralog-specific PSD-95 recombinant binders as minimally interfering multimodal probes for advanced imaging techniques Open
View article: High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning
High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning Open
Regulation of synaptic neurotransmitter receptor content is a fundamental mechanism for tuning synaptic efficacy during experience-dependent plasticity and behavioral adaptation. However, experimental approaches to track and modify recepto…
View article: High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning
High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning Open
Data set for the MS
View article: High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning
High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning Open
Data set for the MS
View article: High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning
High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning Open
SUMMARY Regulation of synaptic neurotransmitter receptor content is a fundamental mechanism for tuning synaptic efficacy during experience-dependent plasticity and behavioral adaptation. However, experimental approaches to track and modify…
View article: The vSNAREs VAMP2 and VAMP4 control recycling and intracellular sorting of post-synaptic receptors in neuronal dendrites
The vSNAREs VAMP2 and VAMP4 control recycling and intracellular sorting of post-synaptic receptors in neuronal dendrites Open
The endosomal recycling system dynamically tunes synaptic strength, which underlies synaptic plasticity. Exocytosis is involved in the expression of long-term potentiation (LTP), as postsynaptic cleavage of the SNARE (soluble NSF-attachmen…
View article: Engineering paralog-specific PSD-95 synthetic binders as potent and minimally invasive imaging probes
Engineering paralog-specific PSD-95 synthetic binders as potent and minimally invasive imaging probes Open
Despite the constant advances in fluorescence imaging techniques, monitoring endogenous proteins still constitutes a major challenge in particular when considering dynamics studies or super-resolution imaging. We have recently evolved spec…
View article: VAMP4 Controls Constitutive Recycling and Sorting of Post-Synaptic Receptors in Neuronal Dendrites
VAMP4 Controls Constitutive Recycling and Sorting of Post-Synaptic Receptors in Neuronal Dendrites Open
View article: Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules Open
Designing highly specific modulators of protein-protein interactions (PPIs) is especially challenging in the context of multiple paralogs and conserved interaction surfaces. In this case, direct generation of selective and competitive inhi…
View article: CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity
CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity Open
View article: Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors
Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors Open