Christian A. Merlo
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View article: Metabolomic and machine learning enhances patient diagnosis and stratification in systemic autoimmune diseases
Metabolomic and machine learning enhances patient diagnosis and stratification in systemic autoimmune diseases Open
Systemic Autoimmune Diseases (SADs) present clinical challenges due to their heterogeneity, which complicates patient classification, and delays diagnosis. We characterized their metabolomic fingerprints aiming to uncover novel molecular i…
View article: Outcomes of lung transplants utilizing donors from outside the continental United States
Outcomes of lung transplants utilizing donors from outside the continental United States Open
Transplants utilizing nonmainland donors had lower-risk donor and recipient characteristics. Despite greater distances and ischemic times, these transplants had similar post-transplant survival compared to transplants using mainland donors…
View article: OP0259 METABOLOMIC AND MACHINE LEARNING ENHANCES PATIENT DIAGNOSIS AND STRATIFICATION IN SYSTEMIC AUTOIMMUNE DISEASES
OP0259 METABOLOMIC AND MACHINE LEARNING ENHANCES PATIENT DIAGNOSIS AND STRATIFICATION IN SYSTEMIC AUTOIMMUNE DISEASES Open
View article: POS1143 The NAD+ Metabolome Pathway is Profoundly Altered in Chronic Inflammatory Rheumatic Diseases, Modulated by anti-TNF, and Modified by NAD+ Boosters
POS1143 The NAD+ Metabolome Pathway is Profoundly Altered in Chronic Inflammatory Rheumatic Diseases, Modulated by anti-TNF, and Modified by NAD+ Boosters Open
View article: POS0065 AN IMMUNE-MOLECULAR SIGNATURE MODULATED BY JAK INHIBITORS EX VIVO PREDICTS IN VIVO THERAPY RESPONSE AND EXHIBITS SPECIFICITY COMPARED TO ANTI-TNF TREATMENTS IN RHEUMATOID ARTHRITIS
POS0065 AN IMMUNE-MOLECULAR SIGNATURE MODULATED BY JAK INHIBITORS EX VIVO PREDICTS IN VIVO THERAPY RESPONSE AND EXHIBITS SPECIFICITY COMPARED TO ANTI-TNF TREATMENTS IN RHEUMATOID ARTHRITIS Open
View article: POS1139 Unravelling transcriptomic landscapes in rheumatoid arthritis and systemic lupus erythematosus: shared and unique molecular signatures related to relevant clinical features
POS1139 Unravelling transcriptomic landscapes in rheumatoid arthritis and systemic lupus erythematosus: shared and unique molecular signatures related to relevant clinical features Open
View article: ABS0033 SYNOVIAL PROTEIN SIGNATURES AS PREDICTIVE SERUM BIOMARKERS OF INFLAMMATION, DISEASE ACTIVITY, AND TREATMENT RESPONSE IN EARLY RHEUMATOID ARTHRITIS
ABS0033 SYNOVIAL PROTEIN SIGNATURES AS PREDICTIVE SERUM BIOMARKERS OF INFLAMMATION, DISEASE ACTIVITY, AND TREATMENT RESPONSE IN EARLY RHEUMATOID ARTHRITIS Open
View article: ABS0045 SEX AND AGE-RELATED INFLAMMATORY PROFILES IN RHEUMATOID ARTHRITIS: IMPACT ON DISEASE ACTIVITY AND TREATMENT RESPONSE.
ABS0045 SEX AND AGE-RELATED INFLAMMATORY PROFILES IN RHEUMATOID ARTHRITIS: IMPACT ON DISEASE ACTIVITY AND TREATMENT RESPONSE. Open
View article: Outcomes of SOT Recipients With COVID-19 in Different Eras of COVID-19 Therapeutics
Outcomes of SOT Recipients With COVID-19 in Different Eras of COVID-19 Therapeutics Open
BACKGROUND: Few reports have focused on newer coronavirus disease 2019 (COVID-19) therapies (remdesivir, dexamethasone, and convalescent plasma) in solid organ transplant recipients; concerns had been raised regarding possible adverse impa…
View article: Lung transplant outcomes by surgeon practice and volume
Lung transplant outcomes by surgeon practice and volume Open
View article: Artificial Intelligence-Driven Wireless Sensing for Health Management
Artificial Intelligence-Driven Wireless Sensing for Health Management Open
(1) Background: With technological advancements, the integration of wireless sensing and artificial intelligence (AI) has significant potential for real-time monitoring and intervention. Wireless sensing devices have been applied to variou…
View article: Increasing risk of postlung transplant hospitalizations for infection: An analysis of recent trends
Increasing risk of postlung transplant hospitalizations for infection: An analysis of recent trends Open
IRB00352819.
View article: Lung transplant outcomes for recipients with alpha-1 antitrypsin deficiency, by use of alpha-1 antitrypsin augmentation therapy
Lung transplant outcomes for recipients with alpha-1 antitrypsin deficiency, by use of alpha-1 antitrypsin augmentation therapy Open
In our study, the use of augmentation therapy post-LT was associated with improved survival. Confirmatory prospective studies should be considered to inform post-LT AAT therapy guidelines.
View article: The Contralateral Lung: An Opportunity for Lung Transplant at a Lower Lung Allocation Score?
The Contralateral Lung: An Opportunity for Lung Transplant at a Lower Lung Allocation Score? Open
In this nationwide analysis, we found that contralateral SLT recipients received SLTs at a lower median LAS without compromising outcomes, suggesting that contralateral single-lung transplantation may provide a valuable approach to help ex…
View article: Impact of variable titer COVID-19 convalescent plasma and recipient SARS-CoV2-specific humoral immunity on survival in hospitalized patients
Impact of variable titer COVID-19 convalescent plasma and recipient SARS-CoV2-specific humoral immunity on survival in hospitalized patients Open
COVID-19 convalescent plasma (CCP) was one of the first therapies to receive emergency use authorization for management of COVID-19. We assessed the effectiveness of CCP in a propensity-matched analysis, and whether the presence of antibod…
View article: Association of Pre–Lung Transplant Opioid Use With Posttransplant Opioid Use and Outcomes
Association of Pre–Lung Transplant Opioid Use With Posttransplant Opioid Use and Outcomes Open
View article: A Retrospective, Longitudinal Registry Study on the Long-Term Durability of Ivacaftor Treatment in People with Cystic Fibrosis
A Retrospective, Longitudinal Registry Study on the Long-Term Durability of Ivacaftor Treatment in People with Cystic Fibrosis Open
View article: Lung Transplantation Outcomes and Peritransplant Sirolimus Use in Lymphangioleiomyomatosis
Lung Transplantation Outcomes and Peritransplant Sirolimus Use in Lymphangioleiomyomatosis Open
View article: Long-term impact of ivacaftor on mortality rate and health outcomes in people with cystic fibrosis
Long-term impact of ivacaftor on mortality rate and health outcomes in people with cystic fibrosis Open
Background Ivacaftor (IVA) has been shown to improve lung function and other clinical outcomes in people with cystic fibrosis (CF). A decade of real-world IVA availability has enabled the examination of long-term outcomes with this treatme…
View article: Impact of age at ivacaftor initiation on pulmonary outcomes among people with cystic fibrosis
Impact of age at ivacaftor initiation on pulmonary outcomes among people with cystic fibrosis Open
Background Ivacaftor (IVA) improves lung function and other extrapulmonary outcomes in people with cystic fibrosis (CF). However, the effect of initiating IVA at earlier versus later ages has not been studied. Methods We conducted an obser…
View article: Assessing the Relationship Between Pre-Operative Opioid Use and Outcomes of Patients with Cystic Fibrosis Undergoing Lung Transplantation
Assessing the Relationship Between Pre-Operative Opioid Use and Outcomes of Patients with Cystic Fibrosis Undergoing Lung Transplantation Open
View article: Personalized cardiovascular risk assessment in Rheumatoid Arthritis patients using circulating molecular profiles and their modulation by TNFi, IL6Ri, and JAKinibs
Personalized cardiovascular risk assessment in Rheumatoid Arthritis patients using circulating molecular profiles and their modulation by TNFi, IL6Ri, and JAKinibs Open
View article: Debunking the July Effect in lung transplantation recipients
Debunking the July Effect in lung transplantation recipients Open
The "July Effect" is not evident in US lung transplantation recipient outcomes during the transplant hospitalization. This suggests that current institutional monitoring systems for trainees across multiple specialties, including surgery, …
View article: Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates
Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates Open
View article: Outcomes of Recipients Aged 65 Years and Older Bridged to Lung Transplant With Extracorporeal Membrane Oxygenation
Outcomes of Recipients Aged 65 Years and Older Bridged to Lung Transplant With Extracorporeal Membrane Oxygenation Open
Extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplant (BTT) has been used for critically ill candidates with excellent outcomes, but data on this strategy in older recipients remain limited. We compared outcomes of no B…
View article: 627 Prevalence and predictors of high cardiovascular risk in adults with cystic fibrosis
627 Prevalence and predictors of high cardiovascular risk in adults with cystic fibrosis Open
View article: 310 Primary nasal epithelial cultures present extensive clinical versatility in an era of personalized medicine
310 Primary nasal epithelial cultures present extensive clinical versatility in an era of personalized medicine Open
View article: 582 Cholesterol levels increase on elexacaftor-tezacaftor-ivacaftor therapy but remain within acceptable ranges
582 Cholesterol levels increase on elexacaftor-tezacaftor-ivacaftor therapy but remain within acceptable ranges Open
View article: 681 Collecting and addressing social determinants of health information in an adult cystic fibrosis clinic through quality improvement
681 Collecting and addressing social determinants of health information in an adult cystic fibrosis clinic through quality improvement Open
View article: 253 Functional and RNA-level recovery of CFTR nonsense variants with nonsense-mediated mRNA decay inhibition, readthrough, and elexacaftor-tezacaftor-ivacaftor
253 Functional and RNA-level recovery of CFTR nonsense variants with nonsense-mediated mRNA decay inhibition, readthrough, and elexacaftor-tezacaftor-ivacaftor Open