Christian B. Bergmann
YOU?
Author Swipe
View article: Diagnostic utility of IL-18 plasma levels in distinguishing abdominal from non-abdominal sepsis
Diagnostic utility of IL-18 plasma levels in distinguishing abdominal from non-abdominal sepsis Open
Background Abdominal sepsis is a critical and high-risk condition in intensive care, characterized by diagnostic challenges, complex treatment, and high mortality. Non-specific symptoms and the difficulty of discriminating harmful bacteria…
View article: Absolute lymphocyte count trajectory predicts clinical outcome in severely injured patients
Absolute lymphocyte count trajectory predicts clinical outcome in severely injured patients Open
Purpose Lymphopenia is associated with adverse clinical outcome in trauma, but no immunomonitoring method is established to identify patients at risk. Absolute lymphocyte count (ALC) represents a promising biomarker and may support clinica…
View article: Dynamic functional assessment of T cells reveals an early suppression correlating with adverse outcome in polytraumatized patients
Dynamic functional assessment of T cells reveals an early suppression correlating with adverse outcome in polytraumatized patients Open
Introduction Most trauma patients require intensive care treatment and are susceptible to developing persistent inflammation and immunosuppression, potentially leading to multi organ dysfunction syndrome (MODS) and dependence on long term …
View article: Alcohol drinking leads to sex-dependent differentiation of T cells
Alcohol drinking leads to sex-dependent differentiation of T cells Open
Objective Global per capita alcohol consumption is increasing, posing significant socioeconomic and medical challenges also due to alcohol-related traumatic injuries but also its biological effects. Trauma as a leading cause of death in yo…
View article: Surviving septic patients endotyped with a functional assay demonstrate active immune responses
Surviving septic patients endotyped with a functional assay demonstrate active immune responses Open
Introduction Sepsis is a complex clinical syndrome characterized by a heterogenous host immune response. Historically, static protein and transcriptomic metrics have been employed to describe the underlying biology. Here, we tested the hyp…
View article: Development and optimization of a diluted whole blood ELISpot assay to test immune function
Development and optimization of a diluted whole blood ELISpot assay to test immune function Open
Sepsis remains a leading cause of death worldwide with no proven immunomodulatory therapies. Stratifying Patient Immune Endotypes in Sepsis ('SPIES') is a prospective, multicenter observational study testing the utility of ELISpot as a fun…
View article: Adverse outcomes and an immunosuppressed endotype in septic patients with reduced IFN-γ ELISpot
Adverse outcomes and an immunosuppressed endotype in septic patients with reduced IFN-γ ELISpot Open
BACKGROUNDSepsis remains a major clinical challenge for which successful treatment requires greater precision in identifying patients at increased risk of adverse outcomes requiring different therapeutic approaches. Predicting clinical out…
View article: Utilizing predictive machine-learning modelling unveils feature-based risk assessment system for hyperinflammatory patterns and infectious outcomes in polytrauma
Utilizing predictive machine-learning modelling unveils feature-based risk assessment system for hyperinflammatory patterns and infectious outcomes in polytrauma Open
Purpose Earlier research has identified several potentially predictive features including biomarkers associated with trauma, which can be used to assess the risk for harmful outcomes of polytraumatized patients. These features encompass va…
View article: Adverse Long-Term Outcomes and an Immune Suppressed Endotype in Sepsis Patients with Reduced Interferon-γ ELISpot: A Multicenter, Prospective Observational Study
Adverse Long-Term Outcomes and an Immune Suppressed Endotype in Sepsis Patients with Reduced Interferon-γ ELISpot: A Multicenter, Prospective Observational Study Open
Background Sepsis remains a major clinical challenge for which successful treatment requires greater precision in identifying patients at increased risk of adverse outcomes requiring different therapeutic approaches. Predicting clinical ou…
View article: sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury
sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury Open
Significance Oxylipins alter immune cell function and potentially drive pathophysiology in burn and sepsis patients. Past and recent data reveal a correlation between increased systemic EpOME levels and reduced survival in human burn traum…
View article: Functional Characterization of Neutrophils Allows Source Control Evaluation in a Murine Sepsis Model
Functional Characterization of Neutrophils Allows Source Control Evaluation in a Murine Sepsis Model Open
View article: Platelets differentially modulate CD4+ Treg activation via GPIIa/IIIb-, fibrinogen-, and PAR4-dependent pathways
Platelets differentially modulate CD4+ Treg activation via GPIIa/IIIb-, fibrinogen-, and PAR4-dependent pathways Open
View article: TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function
TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function Open
View article: Potential Targets to Mitigate Trauma- or Sepsis-Induced Immune Suppression
Potential Targets to Mitigate Trauma- or Sepsis-Induced Immune Suppression Open
In sepsis and trauma, pathogens and injured tissue provoke a systemic inflammatory reaction which can lead to overwhelming inflammation. Concurrent with the innate hyperinflammatory response is adaptive immune suppression that can become c…
View article: The posttraumatic response of CD4+ regulatory T cells is modulated by direct cell-cell contact via CD40L- and P-selectin-dependent pathways
The posttraumatic response of CD4+ regulatory T cells is modulated by direct cell-cell contact via CD40L- and P-selectin-dependent pathways Open
CD4+ FoxP3+ regulatory T cells (CD4+ Tregs) are important for the posttraumatic anti-inflammatory host response. As described previously, platelets are able to modulate CD4+ Treg activity in a reciprocally activating interaction following …
View article: Lymphocyte Immunosuppression and Dysfunction Contributing to Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS)
Lymphocyte Immunosuppression and Dysfunction Contributing to Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) Open
Persistent Inflammation, Immune Suppression, and Catabolism Syndrome (PICS) is a disease state affecting patients who have a prolonged recovery after the acute phase of a large inflammatory insult. Trauma and sepsis are two pathologies aft…
View article: Intraperitoneal Neutrophil IL-10 production is promoted by interferon γ in a murine model of sepsis model in the acute phase of sepsis
Intraperitoneal Neutrophil IL-10 production is promoted by interferon γ in a murine model of sepsis model in the acute phase of sepsis Open
View article: Novel Therapeutics for the Treatment of Burn Infection
Novel Therapeutics for the Treatment of Burn Infection Open
Background: Burn injury continues to be a significant cause of morbidity and death, with infectious complications being the primary cause of death. Patients are susceptible to overwhelming infection secondary to both the phys…
View article: Thrombozyten modulieren die Immunantwort nach Trauma durch die Interaktion mit CD4+ regulatorischen T-Zellen (CD4+ Tregs) in einem Mausmodell
Thrombozyten modulieren die Immunantwort nach Trauma durch die Interaktion mit CD4+ regulatorischen T-Zellen (CD4+ Tregs) in einem Mausmodell Open
In dieser Arbeit wurde anhand eines murinen Verbrennungsmodells untersucht ob Thrombozyten die posttraumatische Immunantwort der CD4+Tregs modulieren. Thrombozyten sind in der Lage die korpereigene Immunantwort nach Trauma durch die Versta…