Christian Berthomier
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View article: Disorder of consciousness rather than complete Locked-In Syndrome for end stage Amyotrophic Lateral Sclerosis: a case series
Disorder of consciousness rather than complete Locked-In Syndrome for end stage Amyotrophic Lateral Sclerosis: a case series Open
Background The end-stage of amyotrophic lateral sclerosis (ALS) is commonly regarded as a complete Locked-In Syndrome (cLIS). Shifting the perspective from cLIS (assumed consciousness) to Cognitive Motor Dissociation (potentially demonstra…
View article: EEG–Metabolic Coupling and Time Limit at V˙O2max During Constant-Load Exercise
EEG–Metabolic Coupling and Time Limit at V˙O2max During Constant-Load Exercise Open
Background: Exercise duration at maximum oxygen uptake (V˙O2max) appears to be influenced not only by metabolic factors but also by the interplay between brain dynamics and ventilatory regulation. This study examined how cortical activity,…
View article: Study protocol for evaluating EEG-based predictive model for drowsiness measurement to reduce accident risk in active individuals
Study protocol for evaluating EEG-based predictive model for drowsiness measurement to reduce accident risk in active individuals Open
Voluntary behaviors and socio-economic factors, such as social jetlag and shift work, can lead to insufficient or disrupted sleep, resulting in drowsiness in active individuals. In occupational and driving contexts, drowsiness poses a seri…
View article: Threshold Values of Sleep Spindles Features in Healthy Adults Using Scalp‐<scp>EEG</scp> and Associations With Sleep Parameters
Threshold Values of Sleep Spindles Features in Healthy Adults Using Scalp‐<span>EEG</span> and Associations With Sleep Parameters Open
Objective Sleep spindles are an electrophysiological fingerprint of the sleeping human brain. They can be described in terms of duration, frequency, amplitude, and density, and vary widely according to age and sex. Spindles play a role in …
View article: REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness
REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness Open
View article: Age-related differences in the association between REM sleep and the polygenic risk for Parkinson’s disease
Age-related differences in the association between REM sleep and the polygenic risk for Parkinson’s disease Open
Objective Parkinson’s disease (PD) is one of the rare diseases for which sleep alteration is a true marker of disease outcome. Yet, how the association between sleep and PD emerges over the healthy lifetime is not established. We examined …
View article: Impact of Varying Sleep Pressure on Daytime Sleep Propensity in Healthy Young and Older Adults
Impact of Varying Sleep Pressure on Daytime Sleep Propensity in Healthy Young and Older Adults Open
Fixed sleep schedules with an 8 h time in bed (TIB) are used to ensure participants are well-rested before laboratory studies. However, such schedules may lead to cumulative excess wakefulness in young individuals. Effects on older individ…
View article: Brain, Metabolic, and RPE Responses during a Free-Pace Marathon: A Preliminary Study
Brain, Metabolic, and RPE Responses during a Free-Pace Marathon: A Preliminary Study Open
The concept of the “central governor” in exercise physiology suggests the brain plays a key role in regulating exercise performance by continuously monitoring physiological and psychological factors. In this case report, we monitored, for …
View article: Circadian rapid eye movement sleep expression is associated with brain microstructural integrity in older adults
Circadian rapid eye movement sleep expression is associated with brain microstructural integrity in older adults Open
Rapid eye movement sleep (REMS) is increasingly suggested as a discriminant sleep state for subtle signs of age-related neurodegeneration. While REMS expression is under strong circadian control and circadian dysregulation increases with a…
View article: Electroencephalography Response during an Incremental Test According to the VO2max Plateau Incidence
Electroencephalography Response during an Incremental Test According to the VO2max Plateau Incidence Open
V̇O2max is recognized as a key measure in exercise physiology and sports medicine. However, only 20–50% of maximal incremental exercise tests (IET) result in a plateau of V̇O2 (V̇O2pl). To our knowledge, no study has yet examined the possible…
View article: Author Correction: In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men
Author Correction: In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men Open
View article: Twenty-four-hour rhythmicities in disorders of consciousness are associated with a favourable outcome
Twenty-four-hour rhythmicities in disorders of consciousness are associated with a favourable outcome Open
View article: In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men
In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men Open
View article: Napping and circadian sleep–wake regulation during healthy aging
Napping and circadian sleep–wake regulation during healthy aging Open
Study Objectives Daytime napping is frequently reported among the older population and has attracted increasing attention due to its association with multiple health conditions. Here, we tested whether napping in the aged is associated wit…
View article: Wake and non-rapid eye movement sleep dysfunction is associated with colonic neuropathology in Parkinson’s disease
Wake and non-rapid eye movement sleep dysfunction is associated with colonic neuropathology in Parkinson’s disease Open
Study Objectives The body-first Parkinson’s disease (PD) hypothesis suggests initial gut Lewy body pathology that propagates to the pons before reaching the substantia nigra, and subsequently progresses to the diencephalic and cortical lev…
View article: Locus coeruleus activity while awake is associated with REM sleep quality in older individuals
Locus coeruleus activity while awake is associated with REM sleep quality in older individuals Open
BACKGROUNDThe locus coeruleus (LC) is the primary source of norepinephrine in the brain and regulates arousal and sleep. Animal research shows that it plays important roles in the transition between sleep and wakefulness, and between slow …
View article: Looking for a balance between visual and automatic sleep scoring
Looking for a balance between visual and automatic sleep scoring Open
Sleep recordings are visually classified in stages by experts in the field, based on consensus international criteria. This procedure is expensive and time-consuming. Automatic sleep scoring systems have, progressively over the years, demo…
View article: Napping and circadian sleep-wake regulation during healthy aging
Napping and circadian sleep-wake regulation during healthy aging Open
Study objectives Daytime napping is frequently reported among the older population and has attracted increasing attention due to its association with multiple health conditions. Here, we tested whether napping in the aged is associated wit…
View article: <i>In vivo</i>marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men
<i>In vivo</i>marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men Open
Brain structural integrity has been suggested to contribute to the variability in human sleep quality and composition. The associations between sleep parameters and the regional integrity of subcortical structures implicated in sleep-wake …
View article: Revisiting the maintenance of wakefulness test: from intra‐/inter‐scorer agreement to normative values in patients treated for obstructive sleep apnea
Revisiting the maintenance of wakefulness test: from intra‐/inter‐scorer agreement to normative values in patients treated for obstructive sleep apnea Open
Summary The Maintenance of Wakefulness Test is widely used to objectively assess sleepiness and make safety‐related decisions, but its interpretation is subjective and normative values remain debated. Our work aimed to determine normative …
View article: Association between circadian sleep regulation and cortical gyrification in young and older adults
Association between circadian sleep regulation and cortical gyrification in young and older adults Open
The circadian system orchestrates sleep timing and structure and is altered with increasing age. Sleep propensity, and particularly REM sleep is under strong circadian control and has been suggested to play an important role in brain plast…
View article: Association between sleep slow-wave activity and in-vivo estimates of myelin in healthy young men
Association between sleep slow-wave activity and in-vivo estimates of myelin in healthy young men Open
View article: <i>In vivo</i>Locus Coeruleus activity while awake is associated with REM sleep quality in healthy older individuals
<i>In vivo</i>Locus Coeruleus activity while awake is associated with REM sleep quality in healthy older individuals Open
The locus coeruleus (LC) is the primary source of norepinephrine (NE) in the brain, and the LC-NE system is involved in regulating arousal and sleep. It plays key roles in the transition between sleep and wakefulness, and between slow wave…
View article: Genetic risk for insomnia is associated with objective sleep measures in young and healthy good sleepers
Genetic risk for insomnia is associated with objective sleep measures in young and healthy good sleepers Open
Insomnia disorder (ID) is the second most common neuropsychiatric disorder. Its socioeconomic burden is enormous while diagnosis and treatment are difficult. A novel approach that reveals associations between insomnia genetic propensity an…
View article: Sleep-dependent memory consolidation in breast cancer: Use of a virtual reality prospective memory task
Sleep-dependent memory consolidation in breast cancer: Use of a virtual reality prospective memory task Open
Background Previous studies have revealed both sleep alterations and prospective memory (PM) impairments in breast cancer (BC) patients. PM refers to memory of intended actions and is crucial for daily living tasks and treatment compliance…
View article: Frontal grey matter microstructure is associated with sleep slow waves characteristics in late midlife
Frontal grey matter microstructure is associated with sleep slow waves characteristics in late midlife Open
Study Objectives The ability to generate slow waves (SW) during non-rapid eye movement (NREM) sleep decreases as early as the 5th decade of life, predominantly over frontal regions. This decrease may concern prominently SW characterized by…
View article: Timely coupling of sleep spindles and slow waves linked to early amyloid-β burden and predicts memory decline
Timely coupling of sleep spindles and slow waves linked to early amyloid-β burden and predicts memory decline Open
Sleep alteration is a hallmark of ageing and emerges as a risk factor for Alzheimer’s disease (AD). While the fine-tuned coalescence of sleep microstructure elements may influence age-related cognitive trajectories, its association with AD…
View article: Author response: Timely coupling of sleep spindles and slow waves linked to early amyloid-β burden and predicts memory decline
Author response: Timely coupling of sleep spindles and slow waves linked to early amyloid-β burden and predicts memory decline Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Sleep alteration is a …
View article: Timely sleep coupling: spindle-slow wave synchrony is linked to early amyloid-β burden and predicts memory decline
Timely sleep coupling: spindle-slow wave synchrony is linked to early amyloid-β burden and predicts memory decline Open
Sleep alteration is a hallmark of ageing and emerges as a risk factor for Alzheimer’s disease (AD). While the fine-tuned coalescence of sleep microstructure elements may influence age-related cognitive trajectories, its association with AD…
View article: Heterogeneity in the links between sleep arousals, amyloid-β, and cognition
Heterogeneity in the links between sleep arousals, amyloid-β, and cognition Open
BACKGROUNDTight relationships between sleep quality, cognition, and amyloid-β (Aβ) accumulation, a hallmark of Alzheimer's disease (AD) neuropathology, have been shown. Sleep arousals become more prevalent with aging and are considered to …