Christian Candrian
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View article: Effect of different factors on predicting patient mortality beyond the NACA classification: a multivariate analysis of more than 2,000 polytrauma patients
Effect of different factors on predicting patient mortality beyond the NACA classification: a multivariate analysis of more than 2,000 polytrauma patients Open
Background The National Advisory Committee for Aeronautics (NACA) score is widely used to assess polytrauma patients. NACA scores of 4 and 5 indicate severe and potentially life-threatening injuries. However, these two categories are rathe…
View article: Tuning the physico-chemical properties of 3D-printed pectin-constructs for regulating mesenchymal stem cell differentiation in an endochondral ossification in vitro
Tuning the physico-chemical properties of 3D-printed pectin-constructs for regulating mesenchymal stem cell differentiation in an endochondral ossification in vitro Open
View article: A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration
A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration Open
Endochondral ossification (ECO) is the process at the basis of long bone development, occurring in children and involving vascularization and subsequent mineralization of a cartilage template. Deregulated bone developmental pathways could …
View article: A High-Throughput Bone Marrow 3D Co-Culture System to Develop Resistance to B Cell Receptor Signaling Targeted Agents in B Cell Non-Hodgkin Lymphoma
A High-Throughput Bone Marrow 3D Co-Culture System to Develop Resistance to B Cell Receptor Signaling Targeted Agents in B Cell Non-Hodgkin Lymphoma Open
B cell receptor (BCR) signaling plays a central role in the pathogenesis of B cell lymphomas, making it a crucial therapeutic target. The advent of BCR-targeted inhibitors, particularly those directed at PI3K and BTK, has revolutionized tr…
View article: Surgical Fixation Reduces Scapular Dyskinesis and Mal-Union Rates in Midshaft Clavicle Fractures: A Retrospective Comparative Analysis
Surgical Fixation Reduces Scapular Dyskinesis and Mal-Union Rates in Midshaft Clavicle Fractures: A Retrospective Comparative Analysis Open
View article: The NACA score predicts mortality in polytrauma patients before hospital admission: a registry-based study
The NACA score predicts mortality in polytrauma patients before hospital admission: a registry-based study Open
Background The early assessment of the severity of polytrauma patients is key for their optimal management. The aim of this study was to investigate the discriminative performance of the NACA score in a large dataset by stratifying the sev…
View article: The NACA score predicts mortality in polytrauma patients before hospital admission: A registry-based study.
The NACA score predicts mortality in polytrauma patients before hospital admission: A registry-based study. Open
Background: The early assessment of the severity of polytrauma patients is key for their optimal management. The aim of this study was to investigate the discriminative performance of the NACA score in a large dataset by stratifying the se…
View article: Rotator cuff repair: Sleep disturbance significantly improves after arthroscopic tendon repair
Rotator cuff repair: Sleep disturbance significantly improves after arthroscopic tendon repair Open
Purpose The aim of this study was to quantify sleep quality and define its evolution in patients treated for rotator cuff tears (RCTs) with arthroscopic rotator cuff repair (ARCR) and to understand its correlation with patients' depression…
View article: Complications after volar plate synthesis for distal radius fractures
Complications after volar plate synthesis for distal radius fractures Open
Purpose Distal radius fractures (DRFs) represent up to 18% of all fractures in the elderly population, yet studies on the rate of complications following surgery are lacking in the literature. This systematic review aimed to quantify the r…
View article: A personalized osteoarthritic joint-on-a-chip as a screening platform for biological treatments
A personalized osteoarthritic joint-on-a-chip as a screening platform for biological treatments Open
Osteoarthritis (OA) is a highly disabling pathology, characterized by synovial inflammation and cartilage degeneration. Orthobiologics have shown promising results in OA treatment thanks to their ability to influence articular cells and mo…
View article: The influence of sex is a neglected focus in rotator cuff repair: A systematic review and meta‐analysis
The influence of sex is a neglected focus in rotator cuff repair: A systematic review and meta‐analysis Open
Purpose Rotator cuff (RC) disorders are the most common cause of shoulder disability. The aim of this study was to quantify the evidence on the sex‐related differences in RC repair. Methods A systematic review of the literature was perform…
View article: Complex or not too complex? One size does not fit all in next generation microphysiological systems
Complex or not too complex? One size does not fit all in next generation microphysiological systems Open
In the attempt to overcome the increasingly recognized shortcomings of existing in vitro and in vivo models, researchers have started to implement alternative models, including microphysiological systems. First examples were …
View article: Proximal humerus fractures: deltopectoral open reduction and internal fixation vs deltosplit minimally invasive plate osteosynthesis: which surgical approach provides superior results?
Proximal humerus fractures: deltopectoral open reduction and internal fixation vs deltosplit minimally invasive plate osteosynthesis: which surgical approach provides superior results? Open
Purpose To compare the two main surgical approaches to address proximal humerus fractures (PHFs) stratified for Neer fracture types, to demonstrate which approach gives the best result for each fracture type. Methods A literature search wa…
View article: Quality of Life from Return to Work and Sport Activities to Sexual Dysfunction after Surgical Treatment of Pelvic Ring Fractures
Quality of Life from Return to Work and Sport Activities to Sexual Dysfunction after Surgical Treatment of Pelvic Ring Fractures Open
Background: Pelvic ring fractures are life-threatening injuries that have a severe impact on patients’ lives. The aim of this clinical study was to evaluate the outcome of surgical treatment in terms of Quality of Life (QoL), return to wor…
View article: The modified Lapidus fusion: a systematic review of biomechanical studies
The modified Lapidus fusion: a systematic review of biomechanical studies Open
Purpose The biomechanical characteristics of different techniques to perform the modified Lapidus procedure are controversial, discussing the issue of stability, rigidity, and compression forces from a biomechanical point of view. The aim …
View article: Differential angiogenesis of bone and muscle endothelium in aging and inflammatory processes
Differential angiogenesis of bone and muscle endothelium in aging and inflammatory processes Open
View article: Effects of negative pressure wound therapy with instillation and dwell time (<scp>NPWTi</scp>‐d) versus <scp>NPWT</scp> or standard of care in orthoplastic surgery: A systematic review and m<scp>eta‐analysis</scp>
Effects of negative pressure wound therapy with instillation and dwell time (<span>NPWTi</span>‐d) versus <span>NPWT</span> or standard of care in orthoplastic surgery: A systematic review and m<span>eta‐analysis</span> Open
Negative pressure wound therapy (NPWT) is a wound‐dressing system that applies sub‐atmospheric pressure on the surface of a wound to promote healing. An evolution of this technology, NPWT with solution instillation and dwell time (NPWTi‐d)…
View article: Clinical performance of the Femoral Neck System within 1 year in 125 patients with acute femoral neck fractures, a prospective observational case series
Clinical performance of the Femoral Neck System within 1 year in 125 patients with acute femoral neck fractures, a prospective observational case series Open
Introduction Osteosynthesis of femoral neck fractures (FNFs) is an important treatment option, especially for younger patients. We aimed to assess the rate of early implant-related complications in FNF osteosynthesis using the Femoral Neck…
View article: Volar locking plate vs cast immobilization for distal radius fractures: a systematic review and meta-analysis
Volar locking plate vs cast immobilization for distal radius fractures: a systematic review and meta-analysis Open
Introduction The aim of this systematic review and meta-analysis was to evaluate whether volar locking plate (VLP) fixation leads to better clinical and radiological outcomes than those of closed reduction and cast immobilization for the t…
View article: Reply to Sidiropoulos, K.; Tsikopoulos, K. Comment on “Oldrini et al. PHILOS Synthesis for Proximal Humerus Fractures Has High Complications and Reintervention Rates: A Systematic Review and Meta-Analysis. Life 2022, 12, 311”
Reply to Sidiropoulos, K.; Tsikopoulos, K. Comment on “Oldrini et al. PHILOS Synthesis for Proximal Humerus Fractures Has High Complications and Reintervention Rates: A Systematic Review and Meta-Analysis. Life 2022, 12, 311” Open
Thank you for the opportunity to respond to the commentary [...]
View article: Tendinopathies and Pain Sensitisation: A Meta-Analysis with Meta-Regression
Tendinopathies and Pain Sensitisation: A Meta-Analysis with Meta-Regression Open
The presence of pain sensitisation has been documented and reported as being a possible cause of treatment failure and pain chronicity in several musculoskeletal conditions, such as tendinopathies. The aim of the present study is to analys…
View article: Union, complication, reintervention and failure rates of surgical techniques for large diaphyseal defects: a systematic review and meta-analysis
Union, complication, reintervention and failure rates of surgical techniques for large diaphyseal defects: a systematic review and meta-analysis Open
To understand the potential and limitations of the different available surgical techniques used to treat large, long-bone diaphyseal defects by focusing on union, complication, re-intervention, and failure rates, summarizing the pros and c…
View article: Balance Remains Impaired after Hip Arthroplasty: A Systematic Review and Best Evidence Synthesis
Balance Remains Impaired after Hip Arthroplasty: A Systematic Review and Best Evidence Synthesis Open
Background: Hip arthroplasty (HA) is the most common intervention for joint replacement, but there is no consensus in the literature on the real influence of this procedure on balance, or on what factors in the pre-operative, surgical, and…
View article: PHILOS Synthesis for Proximal Humerus Fractures Has High Complications and Reintervention Rates: A Systematic Review and Meta-Analysis
PHILOS Synthesis for Proximal Humerus Fractures Has High Complications and Reintervention Rates: A Systematic Review and Meta-Analysis Open
Purpose: The aim of this study was to quantify the rate of complications and reinterventions in patients treated with PHILOS plate for proximal humerus fractures (PHFs) synthesis. Methods: A comprehensive literature search was performed on…
View article: High Prevalence of Pain Sensitization in Knee Osteoarthritis: A Meta-Analysis with Meta-Regression
High Prevalence of Pain Sensitization in Knee Osteoarthritis: A Meta-Analysis with Meta-Regression Open
Objective The aim of this meta-analysis was to study the evidence on pain sensitization in knee osteoarthritis (OA), providing a quantitative synthesis of its prevalence and impact. Factors associated with pain sensitization were also inve…
View article: Infrared Thermography for the Evaluation of Inflammatory and Degenerative Joint Diseases: A Systematic Review
Infrared Thermography for the Evaluation of Inflammatory and Degenerative Joint Diseases: A Systematic Review Open
Objective Inflammation plays a central role in the pathophysiology of rheumatic diseases as well as in osteoarthritis. Temperature, which can be quantified using infrared thermography, provides information about the inflammatory component …
View article: Anterior Cruciate Ligament Reconstruction versus Nonoperative Treatment: Better Function and Less Secondary Meniscectomies But No Difference in Knee Osteoarthritis—A Meta-Analysis
Anterior Cruciate Ligament Reconstruction versus Nonoperative Treatment: Better Function and Less Secondary Meniscectomies But No Difference in Knee Osteoarthritis—A Meta-Analysis Open
Objectives The impact of anterior cruciate ligament (ACL) reconstruction on knee osteoarthritis (OA) is still unclear. The aim of the current meta-analysis was to compare surgical treatment versus nonoperative management of ACL tears to as…
View article: One-stage bilateral unicompartmental knee arthroplasty is a suitable option vs. the two-stage approach: a meta-analysis
One-stage bilateral unicompartmental knee arthroplasty is a suitable option vs. the two-stage approach: a meta-analysis Open
To compare one-stage vs. two-stage bilateral unicondylar knee arthroplasty (UKA) in terms of complications, mortality, reinterventions, transfusion rate, days to discharge, and outcomes for the treatment of bilateral mono-compartmental kne…
View article: Operative Versus Nonoperative Management for Distal Biceps Brachii Tendon Lesions: A Systematic Review and Meta-analysis
Operative Versus Nonoperative Management for Distal Biceps Brachii Tendon Lesions: A Systematic Review and Meta-analysis Open
Background: Both nonoperative and operative treatments have been proposed to manage distal biceps brachii tendon avulsions. However, the advantages and disadvantages of these approaches have not been properly quantified. Purpose: To summar…
View article: Independent Versus Transtibial Drilling in Anterior Cruciate Ligament Reconstruction: A Meta-analysis With Meta-regression
Independent Versus Transtibial Drilling in Anterior Cruciate Ligament Reconstruction: A Meta-analysis With Meta-regression Open
Background: Anterior cruciate ligament (ACL) reconstruction can be performed with different techniques for independent and transtibial (TT) drilling of femoral tunnels, but there is still no consensus on which approach leads to the best ou…