Christian Chicherio
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View article: International consensus for the assessment of social cognition in neurocognitive disorders: framework definition and clinical recommendations of the SIGNATURE initiative
International consensus for the assessment of social cognition in neurocognitive disorders: framework definition and clinical recommendations of the SIGNATURE initiative Open
BACKGROUND: Socio-cognitive assessment in neurocognitive disorders (NCDs) is rare in clinical practice and no consensus exists as to a uniform operationalization of socio-cognitive measures for neurocognitive disorders in memory clinics. T…
View article: Understanding barriers and optimizing socio‐cognitive assessment in the diagnosis of neurocognitive disorders
Understanding barriers and optimizing socio‐cognitive assessment in the diagnosis of neurocognitive disorders Open
Harmonized neuropsychological assessment for neurocognitive disorders (NCDs) is an urgent priority in clinics. Neuropsychology assessments in NCDs seldom include tests exploring social cognitive skills. In 2022, we launched the SIGNATURE i…
View article: Resilience in Alzheimer's disease: Impact of operationalization and methodological choices
Resilience in Alzheimer's disease: Impact of operationalization and methodological choices Open
INTRODUCTION Resilience, the ability to maintain cognition or brain integrity despite Alzheimer's disease (AD) pathology, is often quantified using the residual approach. However, the variability in methodology and correction methods for t…
View article: Three‐Objects‐Three‐Places Episodic Memory Test to Screen Mild Cognitive Impairment and Mild Dementia: Validation in a Memory Clinic Population
Three‐Objects‐Three‐Places Episodic Memory Test to Screen Mild Cognitive Impairment and Mild Dementia: Validation in a Memory Clinic Population Open
Background The Three‐Objects‐Three‐Places (3O3P) test is a 5‐min screen for episodic memory impairment due to Alzheimer's disease, known for its briefness and easy administration, culture‐ and language‐free nature, and the absence of speci…
View article: Is the residual approach reliable to estimate resilience to Alzheimer’s disease pathology? Comparison among different methods
Is the residual approach reliable to estimate resilience to Alzheimer’s disease pathology? Comparison among different methods Open
Background Resilience, the ability to maintain normal cognition (cognitive resilience, CR) or brain integrity (brain resilience, BR) despite neuropathological burden, is often quantified using the residual approach. This method calculates …
View article: Metacognition as a tool to differentiate cognitively unimpaired from impaired subjects: judgments of learning in prospective memory task
Metacognition as a tool to differentiate cognitively unimpaired from impaired subjects: judgments of learning in prospective memory task Open
Background Metacognition may give useful insight in early stages of Alzheimer’s disease (AD) continuum. Recent studies suggest differences in the ability of judging their own cognitive performance along clinical stages. For instance, subje…
View article: Resting-state functional connectivity abnormalities in subjective cognitive decline: A 7T MRI study
Resting-state functional connectivity abnormalities in subjective cognitive decline: A 7T MRI study Open
View article: Subjective cognitive decline: Memory complaints, cognitive awareness, and metacognition
Subjective cognitive decline: Memory complaints, cognitive awareness, and metacognition Open
Cognitive complaints are common in elderly subjects and are a frequent reason for referral to memory clinics. If the complaints are not associated with objective cognitive impairment, the condition is labelled subjective cognitive decline …
View article: The Taxonomy of Subjective Cognitive Decline: Proposal and First Clinical Evidence from the Geneva Memory Clinic Cohort
The Taxonomy of Subjective Cognitive Decline: Proposal and First Clinical Evidence from the Geneva Memory Clinic Cohort Open
Introduction: Subjective cognitive decline (SCD) is characterized by subjective cognitive concerns without objective cognitive impairment and is considered a risk factor for cognitive decline and dementia. However, most SCD p…
View article: Three‐objects‐three‐places test as a screening test for prodromal and mild dementia: validation in a memory clinic population
Three‐objects‐three‐places test as a screening test for prodromal and mild dementia: validation in a memory clinic population Open
Background The Three‐Objects‐Three‐Places (3O3P) test has been developed as a quick screen for episodic memory impairment due to Alzheimer’s Disease (AD). The examiner shows the patient three objects and hides them in three separate places…
View article: The natural history of subjective complaints, awareness and metacognition in AD
The natural history of subjective complaints, awareness and metacognition in AD Open
Background Subjective cognitive decline (SCD) is the self‐reported experience of decrease in cognitive function in absence of cognitive impairment. This condition is common in elderly subjects and is a frequent reason for referral to memor…
View article: Prognostic value of imaging-based ATN profiles in a memory clinic cohort
Prognostic value of imaging-based ATN profiles in a memory clinic cohort Open
View article: The taxonomy of subjective cognitive decline: proposal and first clinical evidence from the Geneva memory clinic cohort
The taxonomy of subjective cognitive decline: proposal and first clinical evidence from the Geneva memory clinic cohort Open
Background: Subjective Cognitive Decline (SCD) is characterized by subjective cognitive complaints without objective cognitive impairment and is considered a risk factor for cognitive decline and dementia. However, most SCD patients will n…
View article: Resistance, brain and cognitive resilience to ATN in a memory clinic population
Resistance, brain and cognitive resilience to ATN in a memory clinic population Open
Background Brain resistance (R) has been defined as the capacity of the brain to preserve its integrity and to sustain normal cognition despite aging. Resilience has been defined as the capacity to sustain a better‐than‐expected brain inte…
View article: Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design
Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design Open
View article: Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe
Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe Open
Introduction Harmonized neuropsychological assessment for neurocognitive disorders, an international priority for valid and reliable diagnostic procedures, has been achieved only in specific countries or research contexts. Methods To harmo…
View article: Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): Rationale and study design
Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): Rationale and study design Open
BACKGROUND. Subjective cognitive decline (SCD) is the subjective perception of a decline in memory and/or other cognitive functions in the absence of objective evidence. Some SCD individuals however may suffer from very early stages of neu…
View article: Diagnostic value of amyloid-PET and tau-PET: a head-to-head comparison
Diagnostic value of amyloid-PET and tau-PET: a head-to-head comparison Open
View article: Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): Retrospective analyses on the Geneva Memory Clinic cohort
Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): Retrospective analyses on the Geneva Memory Clinic cohort Open
Background Advances in the Alzheimer’s disease (AD) field have enhanced awareness on brain health and prevention. This brings an increasing number of adults to ask for help in memory clinics for mild forgetfulness, leading to the increased…
View article: O4‐04‐03: THE BIOLOGICAL BASIS OF COGNITIVE IMPAIRMENT DUE TO SUSPECTED NON‐ALZHEIMER'S PATHOLOGY (SNAP): STUDY DESIGN AND BASELINE COHORT FEATURES
O4‐04‐03: THE BIOLOGICAL BASIS OF COGNITIVE IMPAIRMENT DUE TO SUSPECTED NON‐ALZHEIMER'S PATHOLOGY (SNAP): STUDY DESIGN AND BASELINE COHORT FEATURES Open
Accumulation of amyloid-beta and hyper-phosphorilated tau, as well as neurodegeneration, are the core pathological processes of Alzheimer's disease (AD) but their interplay is still unclear. Clarifying the different pathways leading to neu…
View article: Interaction between BDNF Polymorphism and Physical Activity on Inhibitory Performance in the Elderly without Cognitive Impairment
Interaction between BDNF Polymorphism and Physical Activity on Inhibitory Performance in the Elderly without Cognitive Impairment Open
Background: In the elderly, physical activity (PA) enhances cognitive performances, increases brain plasticity and improves brain health. The neurotrophic hypothesis is that the release of brain-derived neurotrophic factor (BDNF), w…
View article: COGNITIVE RESERVE AND COGNITION IN OLD AGE: THE MEDIATING ROLE OF CHRONIC DISEASES
COGNITIVE RESERVE AND COGNITION IN OLD AGE: THE MEDIATING ROLE OF CHRONIC DISEASES Open
The present study is the first so far in empirically testing the recent conceptual view that the number of chronic diseases may mediate between the build-up of cognitive reserve (e.g., by educational attainment and cognitive level of job) …
View article: Call for uniform neuropsychological assessment after aneurysmal subarachnoid hemorrhage: Swiss recommendations
Call for uniform neuropsychological assessment after aneurysmal subarachnoid hemorrhage: Swiss recommendations Open