Explanipedia

Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks Open

S Liebe, Johannes Niediek, Matthijs Pals, Thomas P. Reber, Jennifer Faber , et al. · 2025

The temporal order of a sequence of events has been thought to be reflected in the ordered firing of neurons at different phases of theta oscillations. Here we assess this by measuring single neuron activity (1,420 neurons) and local field…

Zum 100. Geburtstag von Professor Dr. med. Heinz Penin Open

W. Fröscher, H. Stefan, Christian E. Elger, Rainer Surges · 2024

Concept and location neurons in the human brain provide the ‘what’ and ‘where’ in memory formation Open

Sina Mackay, Thomas P. Reber, Marcel Bausch, Jan Boström, Christian E. Elger , et al. · 2024

Our brains create new memories by capturing the ‘who/what’, ‘where’ and ‘when’ of everyday experiences. On a neuronal level, mechanisms facilitating a successful transfer into episodic memory are still unclear. We investigated this by meas…

Anwendung von Valproat, Topiramat oder Lamotrigin in der Schwangerschaft Open

Christian E. Elger · 2024

Long-term seizure outcome after epilepsy surgery of neuroglial tumors Open

Áttila Rácz, Philipp Müller, Albert J. Becker, Nico Hoffmann, Theodor Rüber , et al. · 2024

Purpose Neuroglial tumors are frequently associated with pharmacorefractory epilepsies. However, comprehensive knowledge about long-term outcomes after epilepsy surgery and the main prognostic factors for outcome is still limited. We sough…

[18F]DPA-714-PET-MRI reveals pronounced innate immunity in human anti-LGI1 and anti-CASPR2 limbic encephalitis Open

Wolfgang Roll, Jan Bauer, Andre Dik, Christoph Mueller, Philipp Backhaus , et al. · 2024

The importance of routine genetic testing in pediatric epilepsy surgery Open

Lena‐Luise Becker, Konstantin L. Makridis, Angela Teresa Abad‐Perez, Ulrich‐Wilhelm Thomale, Anna Tietze , et al. · 2024

Genetic variants in relevant genes coexisting with MRI lesions in children with drug‐resistant epilepsy (DRE) can negatively influence epilepsy surgery outcomes. Still, presurgical evaluation does not include genetic diagnostics routinely.…

Bridging the Gap between Human and Artificial Intelligence - An Evaluation Framework for Computer-Aided Detection of Brain Lesions Open

Lennart Walger, Tobias Bauer, David Kügler, Matthias Schmitz, Fabiane Schuch , et al. · 2024

GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture Open

Remi Stevelink, Ciarán Campbell, Siwei Chen, Bassel Abou‐Khalil, Oluyomi M. Adesoji , et al. · 2023

Epilepsy is a highly heritable disorder affecting over 50 million people worldwide, of which about one-third are resistant to current treatments. Here we report a multi-ancestry genome-wide association study including 29,944 cases, stratif…

Epilepsy surgery in early infancy: A retrospective, multicenter study Open

Konstantin L. Makridis, Kerstin Alexandra Klotz, Georgia Ramantani, Lena‐Luise Becker, Victoria San Antonio‐Arce , et al. · 2023

Although epilepsy surgery is the only curative therapeutic approach for lesional drug‐resistant epilepsy (DRE), there is reluctance to operate on infants due to a fear of complications. A recent meta‐analysis showed that epilepsy surgery i…

Treatment of pediatric convulsive status epilepticus Open

Lena‐Luise Becker, Alexander Gratopp, Christine Prager, Christian E. Elger, Angela M. Kaindl · 2023

Status epilepticus is one of the most common life-threatening neurological emergencies in childhood with the highest incidence in the first 5 years of life and high mortality and morbidity rates. Although it is known that a delayed treatme…

Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug-Resistant Epilepsy in the MORE Multicenter Patient Registry Open

Jukka Peltola, Albert Colon, José Pimentel, Volker A. Coenen, António Gil‐Nagel , et al. · 2023

MORE ClinicalTrials.gov Identifier: NCT01521754, first posted on January 31, 2012.

Artificial intelligence for the detection of focal cortical dysplasia: Challenges in translating algorithms into clinical practice Open

Lennart Walger, Sophie Adler, Konrad Wagstyl, Leonie Henschel, Bastian David , et al. · 2023

Focal cortical dysplasias (FCDs) are malformations of cortical development and one of the most common pathologies causing pharmacoresistant focal epilepsy. Resective neurosurgery yields high success rates, especially if the full extent of …

Neuropathological Insights into Unexpected Cognitive Decline in Epilepsy Open

Annika Reimers, Christoph Helmstaedter, Christian E. Elger, Julika Pitsch, Motaz Hamed , et al. · 2022

Objective Some patients unexpectedly display an unfavorable cognitive course after epilepsy surgery subsequent to any direct cognitive sequelae of the surgical treatment. Therefore, we conducted in‐depth neuropathological examinations of r…

Evaluation of a Rapid Topiramate Titration Scheme for the Early Detection of Cognitive Side Effects Open

Juri‐Alexander Witt, Guido Widman, Niels Hansen, Randi von Wrede, Christian E. Elger , et al. · 2022

Physicians might be able to detect adverse cognitive side effects sooner in epilepsy patients if TPM is administered using a faster titration rate while applying repeated cognitive assessments within days. This approach might help prevent …

Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks Open

S Liebe, Johannes Niediek, Matthijs Pals, Thomas P. Reber, Jenny Faber , et al. · 2022

A prominent theory proposes that the temporal order of a sequence of items held in memory is reflected in ordered firing of neurons at different phases of theta oscillations 1 . We probe this theory by directly measuring single neuron acti…

‘Hippocampal innate inflammatory gliosis only’ in pharmacoresistant temporal lobe epilepsy Open

Alexander Grote, Dieter-Henrik Heiland, Julia Taube, Christoph Helmstaedter, Vidhya M. Ravi , et al. · 2022

Drug-resistant mesial-temporal lobe epilepsy is a devastating disease with seizure onset in the hippocampal formation. A fraction of hippocampi samples from epilepsy-surgical procedures reveals a peculiar histological pattern referred to a…

Complement activation contributes to GAD antibody-associated encephalitis Open

Omar Chuquisana, Christine Strippel, Anna R. Tröscher, Tobias Baumgartner, Áttila Rácz , et al. · 2022

Histopathologic Characterization and Neurodegenerative Markers in Patients With Limbic Encephalitis Undergoing Epilepsy Surgery Open

Áttila Rácz, Chiara A. Hummel, Albert J. Becker, Christoph Helmstaedter, Fabiane Schuch , et al. · 2022

Purpose Limbic encephalitis is an increasingly recognized cause of medial temporal lobe epilepsy (mTLE) and associated cognitive deficits, potentially resulting in hippocampal sclerosis (HS). For several reasons, these patients usually do …

A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies Open

Christine Strippel, Marisol Herrera-Rivero, Mareike Wendorff, Anja Tietz, Frauke Degenhardt , et al. · 2022

Autoimmune neurological syndromes (AINS) with autoantibodies against the 65 kDa isoform of the glutamic acid decarboxylase (GAD65) present with limbic encephalitis, including temporal lobe seizures or epilepsy, cerebellitis with ataxia, an…

Neuronal codes for arithmetic rule processing in the human brain Open

Esther F. Kutter, Jan Boström, Christian E. Elger, Andreas Nieder, Florian Mormann · 2022

Arithmetic is a cornerstone of scientifically and technologically advanced human culture, but its neuronal mechanisms are poorly understood. Calculating with numbers requires temporary maintenance and manipulation of numerical information …

Is There Cognitive Improvement after Epilepsy Surgery in Children and Adolescents? Open

Konstantin L. Makridis, Sebastian Triller, Christian E. Elger, Angela M. Kaindl · 2022

Increased T- and B-cells associated with the phenotype of autoimmune limbic encephalitis with mainly memory dysfunction Open

Niels Hansen, Guido Widman, Demet Önder, Kerstin Schwing, Pitshaporn Leelaarporn , et al. · 2022

Taken together, the phenotypes in combination with CSF antibody-positivity are biomarkers for stratifying patients. Furthermore, our results confirm the role of CD4⁺ T-cells, CD8+T-cells and CD19+B-cells in AE patients with a me…

Case Report: Hemispherotomy in the First Days of Life to Treat Drug-Resistant Lesional Epilepsy Open

Konstantin L. Makridis, Christine Prager, Anna Tietze, Deniz A. Atalay, Sebastian Triller , et al. · 2021

Background: Neonatal drug-resistant epilepsy is often caused by perinatal epileptogenic insults such as stroke, ischemia, hemorrhage, and/or genetic defects. Rapid seizure control is particularly important for cognitive development. Since …

Case Report: Behavioral Disorder Following Hemispherotomy: A Valproate Effect? Open

Konstantin L. Makridis, Sebastian Triller, Deniz A. Atalay, Christine Prager, Christian E. Elger , et al. · 2021

Background: Hemispherotomy is an epilepsy surgery procedure applied to cure particularly pharmacorefractory lesional epilepsy due to unihemispheric pathologies. Such a disconnection of an entire hemisphere is followed by reorganizational p…

Impact of T cells on neurodegeneration in anti‐GAD65 limbic encephalitis Open

Andre Dik, Guido Widman, Andreas Schulte‐Mecklenbeck, Juri‐Alexander Witt, Julika Pitsch , et al. · 2021

Objective Direct pathogenic effects of autoantibodies to the 65 kDa isoform of glutamic acid decarboxylase (GAD65) in autoimmune limbic encephalitis (LE) have been questioned due to its intracellular localization. We therefore hypothesized…

Rasmussen encephalitis: Predisposing factors and their potential role in unilaterality Open

Susanne Fauser, Christian E. Elger, Friedrich G. Woermann, Christian G. Bien · 2021

Objective Rasmussen encephalitis (RE) is a progressive and destructive inflammatory disease of one hemisphere. Its cause is unknown. We investigated comorbidity and laterality factors that might predispose to RE. Methods We retrospectively…

Face Processing in Developmental Prosopagnosia: Altered Neural Representations in the Fusiform Face Area Open

Alexa Haeger, Christophe Pouzat, Volker Luecken, K. N’Diaye, Christian E. Elger , et al. · 2021

Rationale: Face expertise is a pivotal social skill. Developmental prosopagnosia (DP), i.e., the inability to recognize faces without a history of brain damage, affects about 2% of the general population, and is a renowned model system of …

Concept neurons in the human medial temporal lobe flexibly represent abstract relations between concepts Open

Marcel Bausch, Johannes Niediek, Thomas P. Reber, Sina Mackay, Jan Boström , et al. · 2021

Concept neurons in the medial temporal lobe respond to semantic features of presented stimuli. Analyzing 61 concept neurons recorded from twelve patients who underwent surgery to treat epilepsy, we show that firing patterns of concept neur…

Outcome after resective epilepsy surgery in the elderly Open

Áttila Rácz, Kathryn Menne, Valeri Borger, Kevin G. Hampel, Hartmut Vatter , et al. · 2021

OBJECTIVE The objective of this study was to compare complications, seizures, and neuropsychological outcomes after resective epilepsy surgery in patients ≥ 60 years of age who underwent operations to younger and matched controls. METHODS …

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