Christian Fetzer
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View article: <i>Listeria monocytogenes</i> utilizes the ClpP1/2 proteolytic machinery for fine-tuned substrate degradation at elevated temperatures
<i>Listeria monocytogenes</i> utilizes the ClpP1/2 proteolytic machinery for fine-tuned substrate degradation at elevated temperatures Open
Unlike most bacteria, L. monocytogenes encodes 2 isoforms of Caseinolytic Protease P. Balogh et al. show that both proteins form a heterocomplex temperature-dependently and find protein substrate candidates with an integrated proteomic app…
View article: <i>Listeria monocytogenes</i> utilizes the ClpP1/2 proteolytic machinery for fine-tuned substrate degradation under heat stress
<i>Listeria monocytogenes</i> utilizes the ClpP1/2 proteolytic machinery for fine-tuned substrate degradation under heat stress Open
Listeria monocytogenes exhibits two ClpP isoforms (ClpP1/ClpP2) which assemble into a heterooligomeric complex with enhanced proteolytic activity. Herein, we demonstrate that the formation of this complex depends on temperature and reaches…
View article: Comparative Target Analysis of Chlorinated Biphenyl Antimicrobials Highlights MenG as a Molecular Target of Triclocarban
Comparative Target Analysis of Chlorinated Biphenyl Antimicrobials Highlights MenG as a Molecular Target of Triclocarban Open
TCC’s widespread use as an antimicrobial agent has made it a ubiquitous environmental pollutant despite its withdrawal due to ecological and toxicological concerns. With its antibacterial mechanism of action still being unknown, we underto…
View article: Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms
Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms Open
View article: Hydantoin analogs inhibit the fully assembled ClpXP protease without affecting the individual peptidase and chaperone domains
Hydantoin analogs inhibit the fully assembled ClpXP protease without affecting the individual peptidase and chaperone domains Open
A new class of non-covalent inhibitors attenuates ClpXP turnover, neither impairing chaperone nor peptidase activity.
View article: Promysalin Elicits Species-Selective Inhibition of <i>Pseudomonas aeruginosa</i> by Targeting Succinate Dehydrogenase
Promysalin Elicits Species-Selective Inhibition of <i>Pseudomonas aeruginosa</i> by Targeting Succinate Dehydrogenase Open
Natural products have served as an inspiration to scientists both for their complex three-dimensional architecture and exquisite biological activity. Promysalin is one such Pseudomonad secondary metabolite that exhibits narrow-spectrum ant…
View article: Quantitative Mapof β-Lactone-Induced VirulenceRegulation
Quantitative Mapof β-Lactone-Induced VirulenceRegulation Open
β-Lactones\nhave recently been introduced as the first selective\nClpP inhibitors that attenuate virulence of both sensitive Staphylococcus aureus and multiresistant strains\n(MRSA). Although previous knockout studies showed that ClpP is e…
View article: Natural‐Product‐Inspired Aminoepoxybenzoquinones Kill Members of the Gram‐Negative Pathogen <i>Salmonella</i> by Attenuating Cellular Stress Response
Natural‐Product‐Inspired Aminoepoxybenzoquinones Kill Members of the Gram‐Negative Pathogen <i>Salmonella</i> by Attenuating Cellular Stress Response Open
Gram‐negative bacteria represent a challenging task for antibacterial drug discovery owing to their impermeable cell membrane and restricted uptake of small molecules. We herein describe the synthesis of natural‐product‐derived epoxycycloh…