Christian Frezza
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View article: Figure 5 from Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma
Figure 5 from Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma Open
Intracellular pH shift of FRCs contributes to mitochondrial changes and the observed signature. A, Metabolic analysis of mitochondrial function in the computational model. Shown is OCR for mitochondria exposed to LA versus control. …
View article: Figure 4 from Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma
Figure 4 from Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma Open
Deregulated metabolism in response to tumor factors and LA. A, Using the RNA-seq data from Fig. 3, depicted here are the top 10 most significant GO terms for ”biological process” using all significantly upregulated genes in in vi…
View article: Figure 3 from Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma
Figure 3 from Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma Open
Tumor factors and LA induce FRC remodeling. A, PCA plot of RNA-seq data calculated for the 500 genes showing the highest variance in a variance stabilizing transformed matrix with log2-transformed data from in vitro
View article: Figure 2 from Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma
Figure 2 from Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma Open
Tumor-derived lactate is responsible for the observed changes in FRC activation and mitochondria. A, Metabolomic analysis of amino acids and glycolysis- and TCA cycle–intermediates in CCM or B16.F10 TCM using LC–MS. Metabolites with…
View article: Figure 1 from Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma
Figure 1 from Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma Open
Soluble factors mediate FRC activation and mitochondrial imbalance. A, Experimental scheme used to investigate tumor-draining factors in vivo. B, Draining lymph nodes were harvested from female C57BL/6 mice that had re…
View article: FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer
FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer Open
Mutations in KRAS, particularly at codon 12, are frequent in adenocarcinomas of the colon, lungs and pancreas, driving carcinogenesis by altering cell signalling and reprogramming metabolism. However, the specific mechanisms by which diffe…
View article: Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma
Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma Open
Human isotopic tracer studies are key for in vivo studies of cancer metabolism. Yet, the effects of sampling conditions on the tissue metabolome remain understudied. Here, we perform a 13 C-glucose study coupled with metabolomic, transcrip…
View article: Metformin induces ferroptosis associated with lipidomic remodeling in AML
Metformin induces ferroptosis associated with lipidomic remodeling in AML Open
Metabolic reprogramming is a hallmark of cancer, essential for sustaining leukemogenesis. In acute myeloid leukemia (AML), high dependency on oxidative phosphorylation (OXPHOS) is often linked to poor outcomes and inhibiting this pathway h…
View article: Publisher Correction: Functional synapses between neurons and small cell lung cancer
Publisher Correction: Functional synapses between neurons and small cell lung cancer Open
View article: Functional synapses between neurons and small cell lung cancer
Functional synapses between neurons and small cell lung cancer Open
View article: Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma
Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma Open
Squamous cell lung carcinoma (SqCC) is the second most common histological subtype of lung cancer. Besides tumor‐initiating and promoting DNA, RNA, and epigenetic alterations, aberrant cell metabolism is a hallmark of carcinogenesis. This …
View article: ADSL deficiency is a secondary mitochondrial disease affecting organelle homeostasis and ERK2/AKT signaling in a linear genotype-phenotype relation
ADSL deficiency is a secondary mitochondrial disease affecting organelle homeostasis and ERK2/AKT signaling in a linear genotype-phenotype relation Open
Adenylosuccinate lyase deficiency (ADSLd) is a rare autosomal recessive purine metabolism disorder with several clinical manifestations. While toxic substrate accumulation is a known hallmark, no additional molecular mechanisms have been e…
View article: Chemotherapy modulation by a cancer-associated microbiota metabolite
Chemotherapy modulation by a cancer-associated microbiota metabolite Open
Understanding how the microbiota produces regulatory metabolites is of significance for cancer and cancer therapy. Using a host-microbe-drug-nutrient 4-way screening approach, we evaluated the role of nutrition at the molecular level in th…
View article: Integrated metabolomics data analysis to generate mechanistic hypotheses with MetaProViz
Integrated metabolomics data analysis to generate mechanistic hypotheses with MetaProViz Open
With the growing number of metabolomics and lipidomics studies, robust strategies for bioinformatic analyses are increasingly important. However, the absence of standardized and reproducible workflows, coupled with ambiguous metabolite ann…
View article: 2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction
2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction Open
View article: Macrophage respiratory complex III governs immune evasion
Macrophage respiratory complex III governs immune evasion Open
The intricate interplay between cellular metabolism and immune function has emerged as a pivotal area of research in immunology. Macrophages, as central players in the innate immune system, exhibit remarkable metabolic flexibility that inf…
View article: Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal-like cancers
Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal-like cancers Open
View article: Impact of mtG3PDH inhibitors on proliferation and metabolism of androgen receptor-negative prostate cancer cells: Role of extracellular pyruvate
Impact of mtG3PDH inhibitors on proliferation and metabolism of androgen receptor-negative prostate cancer cells: Role of extracellular pyruvate Open
Mitochondrial glycerol 3-P dehydrogenase (mtG3PDH) plays a significant role in cellular bioenergetics by serving as a rate-limiting element in the glycerophosphate shuttle, which connects cytosolic glycolysis to mitochondrial oxidative met…
View article: ABS0042 HIGHER BASAL ACTIVATION OF THE PROXIMAL KYNURENINE PATHWAY IN RHEUMATOID ARTHRITIS MONOCYTES BUT IMPAIRED INFLAMMATORY RESPONSE
ABS0042 HIGHER BASAL ACTIVATION OF THE PROXIMAL KYNURENINE PATHWAY IN RHEUMATOID ARTHRITIS MONOCYTES BUT IMPAIRED INFLAMMATORY RESPONSE Open
View article: An atlas of ferroptosis-induced secretomes
An atlas of ferroptosis-induced secretomes Open
Cells undergoing regulated necrosis systemically communicate with the immune system via the release of protein and non-protein secretomes. Ferroptosis is a recently described iron-dependent type of regulated necrosis driven by massive lipi…
View article: Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis Open
Somatic DNMT3A -R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk 1,2 . Preventing expansion of DNMT3A -R882-mutant haematopoietic stem/progen…
View article: The impact of the new WHO classification of renal cell carcinoma on the diagnosis of hereditary leiomyomatosis and renal cell carcinoma
The impact of the new WHO classification of renal cell carcinoma on the diagnosis of hereditary leiomyomatosis and renal cell carcinoma Open
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is caused by heterozygous germline variants in the fumarate hydratase (FH) gene. Inheritance follows an autosomal dominant pattern. Loss of FH confers a predisposition for…
View article: Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation
Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation Open
Macrophages stimulated by lipopolysaccharide (LPS) generate mitochondria-derived reactive oxygen species (mtROS) that act as antimicrobial agents and redox signals; however, the mechanism of LPS-induced mitochondrial superoxide generation …
View article: Fumarate
Fumarate Open
View article: Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity
Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity Open
View article: SiRCle (Signature Regulatory Clustering) model integration reveals mechanisms of phenotype regulation in renal cancer
SiRCle (Signature Regulatory Clustering) model integration reveals mechanisms of phenotype regulation in renal cancer Open
Background Clear cell renal cell carcinoma (ccRCC) tumours develop and progress via complex remodelling of the kidney epigenome, transcriptome, proteome and metabolome. Given the subsequent tumour and inter-patient heterogeneity, drug-base…
View article: Tissue-specific adaptations to cytochrome c oxidase deficiency shape physiological outcomes
Tissue-specific adaptations to cytochrome c oxidase deficiency shape physiological outcomes Open
It becomes increasingly clear that the tissue specificity of mitochondrial diseases might in part rely on their ability to compensate for mitochondrial defects, contributing to the heterogeneous nature of mitochondrial diseases. Here, we i…
View article: Exploration of the mutational landscape of cutaneous leiomyoma confirms <i>FH</i> as a driver gene and identifies targeting purine metabolism as a potential therapeutic strategy
Exploration of the mutational landscape of cutaneous leiomyoma confirms <i>FH</i> as a driver gene and identifies targeting purine metabolism as a potential therapeutic strategy Open
To comprehensively explore the mutational landscape of cutaneous leiomyoma (cLM) and identify candidate driver events, we performed a retrospective, multi-institutional, whole-exome sequencing and RNA sequencing study. We confirmed that a …
View article: KRAS G12 mutant alleles differentially control glutamine metabolism via FOXO1
KRAS G12 mutant alleles differentially control glutamine metabolism via FOXO1 Open
SUMMARY Mutations in KRAS, particularly at codon 12, are frequent in adenocarcinomas of the colon, lungs and pancreas, driving carcinogenesis by altering cell signalling and reprogramming metabolism. However, the specific mechanisms by whi…
View article: Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis Open
Senescent neural progenitor cells have been identified in brain lesions of people with progressive multiple sclerosis (PMS). However, their role in disease pathobiology and contribution to the lesion environment remains unclear. By establi…