Christian F. Poets
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View article: Prevalence of sleep-related breathing disorders in children with myelomeningocele and other spinal dysraphisms and risk factors
Prevalence of sleep-related breathing disorders in children with myelomeningocele and other spinal dysraphisms and risk factors Open
The prevalence of SRBD is high in children with MMC and clinical signs of SRBD are often missing. Therefore, routine screening of all children with MMC is recommended.
View article: Associations between parental shift work and children's sleep behavior in a sample of health care workers
Associations between parental shift work and children's sleep behavior in a sample of health care workers Open
In this cross-sectional study, most aspects of children's sleep parameters did not differ between families with or without shift work, based on parent-reported measures. While a weak statistical association was observed between parasomnia …
View article: Complete Protocol and Guidelines for the Implementation and Manufacturing of the Tübingen Palatal Plate—An Interdisciplinary Technical Note on the Tübingen Approach for Infants with Robin Sequence
Complete Protocol and Guidelines for the Implementation and Manufacturing of the Tübingen Palatal Plate—An Interdisciplinary Technical Note on the Tübingen Approach for Infants with Robin Sequence Open
Robin sequence (RS) is a rare congenital anomaly characterized by micrognathia, glossoptosis, and upper airway obstruction (UAO), often accompanied by a cleft palate. The Tübingen Palatal Plate (TPP), also referred to as the pre-epiglottic…
View article: Extracellular Vesicles Derived From the Feces of Pregnant Women Modulate T Cells Toward a Pregnancy‐Supportive Phenotype In Vitro
Extracellular Vesicles Derived From the Feces of Pregnant Women Modulate T Cells Toward a Pregnancy‐Supportive Phenotype In Vitro Open
Pregnancy requires immune tolerance to a semi‐allogeneic fetus, involving profound adaptations, particularly in the T helper (Th) cell response. The intestinal microbiome plays a crucial role in health, but its influence on immune adaptati…
View article: Imposed work of breathing of 16 neonatal CPAP-devices using different mechanisms of CPAP generation
Imposed work of breathing of 16 neonatal CPAP-devices using different mechanisms of CPAP generation Open
Background and Objectives Failure of continuous positive airway pressure (CPAP) in preterm infants may result from respiratory exhaustion, potentially also evoked by the CPAP device’s imposed work of breathing (iWOB). This study investigat…
View article: Choline in Pediatric Nutrition: Assessing Formula, Fortifiers and Supplements Across Age Groups and Clinical Indications
Choline in Pediatric Nutrition: Assessing Formula, Fortifiers and Supplements Across Age Groups and Clinical Indications Open
Background: Sufficient choline supply is essential for tissue functions via phosphatidylcholine and sphingomyelin within membranes and secretions like bile, lipoproteins and surfactant, and in one-carbon metabolism via betaine. Choline req…
View article: The impact of sleep in high-risk infants
The impact of sleep in high-risk infants Open
Most of an infant’s day is devoted to sleep – and normal sleep is vital to normal brain development. Sleep disruptions may impair overall health, well-being, and neurodevelopment. Disruptors of sleep and circadian health, such as noise, li…
View article: Effects of liberal versus restrictive transfusion strategies on intermittent hypoxaemia in extremely low birthweight infants: secondary analyses of the ETTNO randomised controlled trial
Effects of liberal versus restrictive transfusion strategies on intermittent hypoxaemia in extremely low birthweight infants: secondary analyses of the ETTNO randomised controlled trial Open
Objectives To compare the effect of liberal versus restrictive transfusion strategies on the proportion of time (%time) spent with intermittent hypoxaemia (IH, ie, arterial haemoglobin oxygen saturation measured by pulse oximetry (SpO 2 ) …
View article: A Randomized Crossover Trial to Evaluate the Effect of Positioning on Obstructive Sleep Apnea in Infants with Robin Sequence
A Randomized Crossover Trial to Evaluate the Effect of Positioning on Obstructive Sleep Apnea in Infants with Robin Sequence Open
Background: The prone position is one of the most frequently used treatment options for infants with Robin sequence (RS), but its effect and its safety regarding the increased risk of sudden infant death syndrome are controversial. Methods…
View article: Bundle‐Of‐Care vs. Single‐Intervention <scp>RCTs</scp> in Neonatology: Clinical Research in Neonatology—Quo Vadis?
Bundle‐Of‐Care vs. Single‐Intervention <span>RCTs</span> in Neonatology: Clinical Research in Neonatology—Quo Vadis? Open
Extreme prematurity is a multi‐organ medical emergency. Most high‐profile studies in this field are done as single‐intervention randomised controlled trials (RCTs), often yielding negative or inconclusive results. Given the complexity of e…
View article: Towards standardized and clinically relevant definitions of hypoxemia and hyperoxemia in preterm infants: A systematic review
Towards standardized and clinically relevant definitions of hypoxemia and hyperoxemia in preterm infants: A systematic review Open
In neonatal care, maintaining oxygen levels in the target range is essential to minimize adverse outcomes. Both episodes of hyperoxemia and hypoxemia are associated with adverse neonatal outcomes. Criteria to determine the hypoxemic and hy…
View article: Effects of malocclusion and orthodontic treatment on quality of life among orthodontic patients with craniofacial disorder compared to healthy controls
Effects of malocclusion and orthodontic treatment on quality of life among orthodontic patients with craniofacial disorder compared to healthy controls Open
Purpose Craniofacial disorders (CD) affect the Oral Health Impact Profile (OHIP). Therefore, this study evaluates the OHIP in orthodontic patients with cleft lip and/or palate or Robin sequence compared to healthy controls (C). Methods A p…
View article: Randomised In Vitro Study Investigating <scp>PEEP</scp>‐Stability During Application of <scp>CPAP</scp> With Binasal Prongs and Face Masks
Randomised In Vitro Study Investigating <span>PEEP</span>‐Stability During Application of <span>CPAP</span> With Binasal Prongs and Face Masks Open
Aim Face masks and binasal prongs are commonly used interfaces for applying continuous positive airway pressure (CPAP) in neonatology. We aimed to assess CPAP stability in a randomised controlled in vitro study. Methods In a simulated resu…
View article: Neonatal apnea and hypopnea prediction in infants with Robin sequence with neural additive models for time series
Neonatal apnea and hypopnea prediction in infants with Robin sequence with neural additive models for time series Open
Neonatal apneas and hypopneas present a serious risk for healthy infant development. Treating these adverse events requires frequent manual stimulation by skilled personnel, which can lead to alarm fatigue. This study aims to develop and v…
View article: Comparative Effectiveness of Preepiglottic Baton Plates and Mandibular Distraction in Infants with Robin Sequence
Comparative Effectiveness of Preepiglottic Baton Plates and Mandibular Distraction in Infants with Robin Sequence Open
Background: Mandibular distraction osteogenesis (MDO) and preepiglottic baton plates (PEBP) are both effective for early management of upper-airway obstruction (UAO) in infants with Robin sequence (RS), but have not been directly compared.…
View article: Impact of the adenosine receptor A2BR expressed on myeloid cells on immune regulation during pregnancy
Impact of the adenosine receptor A2BR expressed on myeloid cells on immune regulation during pregnancy Open
During pregnancy, the maternal immune system must carefully balance protection against pathogens with tolerance toward the semiallogeneic fetus. Dysfunctions of the immune system can lead to severe complications such as preeclampsia, fetal…
View article: Complete Digital Workflow for Manufacturing Presurgical Orthodontic Palatal Plates in Newborns and Infants with Cleft Lip and/or Palate
Complete Digital Workflow for Manufacturing Presurgical Orthodontic Palatal Plates in Newborns and Infants with Cleft Lip and/or Palate Open
Deciding on the implementation or modification of steps in daily clinical care is a nuanced process that demands careful evaluation. This is crucial not only for selecting the most appropriate solution but also for achieving the best treat…
View article: Facial growth dynamics dictate optimal facemask fitting during the first year of life
Facial growth dynamics dictate optimal facemask fitting during the first year of life Open
Aim The aim of this study is to prevent mask leak during ventilation in infant emergencies, appropriate facemask fitting is essential. Therefore, we investigated facial profiles during the first year of life and their correlation with the …
View article: Lung ultrasound to predict the duration of respiratory support in newborn infants with respiratory distress
Lung ultrasound to predict the duration of respiratory support in newborn infants with respiratory distress Open
Aim Lung ultrasound (LU) and clinical parameters evaluated during the first postnatal hour potentially predict the length of CPAP therapy in newborns with respiratory distress. Methods In a single‐centre, prospective observational pilot st…
View article: Averaging Times for Pulse Oximeter Measurements – A Review of Manuscripts Published in the Top Five Sleep Medicine Journals
Averaging Times for Pulse Oximeter Measurements – A Review of Manuscripts Published in the Top Five Sleep Medicine Journals Open
The AVT is only rarely mentioned in sleep medicine papers, despite its influence on sleep study results. Reported AVTs were heterogenous. Further research is warranted to set up guidelines for using or reporting the AVT.
View article: Evidence and Perspectives for Choline Supplementation during Parenteral Nutrition—A Narrative Review
Evidence and Perspectives for Choline Supplementation during Parenteral Nutrition—A Narrative Review Open
Choline is an essential nutrient, with high requirements during fetal and postnatal growth. Tissue concentrations of total choline are tightly regulated, requiring an increase in its pool size proportional to growth. Phosphatidylcholine an…
View article: Failure of an electric rocking device to improve neonatal sleep
Failure of an electric rocking device to improve neonatal sleep Open
Aim We wanted to investigate whether an electric rocking device (Swing2Sleep, Neumünster, Germany), sold with the claim to promote infant sleep, would increase total sleep time or reduce sleep latency once infants are put therein. Methods …
View article: Simulated model revealed significant continuous positive airway pressure fluctuations with facemasks
Simulated model revealed significant continuous positive airway pressure fluctuations with facemasks Open
There is an ongoing debate about whether facemasks or binasal prongs provide the optimal respiratory interface.1 It has been suggested that prongs provide more stable target continuous positive airway pressure (CPAP). Explanations for the …
View article: Delineating morbidity patterns in preterm infants at near-term age using a data-driven approach
Delineating morbidity patterns in preterm infants at near-term age using a data-driven approach Open
Background Long-term survival after premature birth is significantly determined by development of morbidities, primarily affecting the cardio-respiratory or central nervous system. Existing studies are limited to pairwise morbidity associa…