Christian Göbl
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View article: Gestational Diabetes Mellitus Subtypes Derived by Clustering Analysis Show Heterogeneity in Glucometabolic Parameters Already at Early Pregnancy
Gestational Diabetes Mellitus Subtypes Derived by Clustering Analysis Show Heterogeneity in Glucometabolic Parameters Already at Early Pregnancy Open
Background/Objectives: The classification of patients with diabetes into phenotypes with distinct risks and therapeutic needs is crucial for individualized care. We recently introduced a clustering model for gestational diabetes mellitus (…
View article: Is It Worth Assessing the Prevalence of Sarcopenia in Pregnant Women? Should Any Impact on Pregnancy Outcomes Be Expected?
Is It Worth Assessing the Prevalence of Sarcopenia in Pregnant Women? Should Any Impact on Pregnancy Outcomes Be Expected? Open
The present article is an opinion piece mainly based on selected articles in the field of sarcopenia, with possible relevance for pregnancy. Sarcopenia has gained increasing interest in recent years, since it has emerged that sarcopenia ma…
View article: The utility of early gestational OGTT and biomarkers for the development of gestational diabetes mellitus: an international prospective multicentre cohort study
The utility of early gestational OGTT and biomarkers for the development of gestational diabetes mellitus: an international prospective multicentre cohort study Open
View article: The impact of prenatal ultrasound screening on termination of pregnancy with and without feticide: a retrospective analysis
The impact of prenatal ultrasound screening on termination of pregnancy with and without feticide: a retrospective analysis Open
First trimester screening is critical in early fetal assessment and preventing unnecessary late terminations and feticide. Mid-trimester anomaly scan further increases the early detection of fetal malformations, especially those that becom…
View article: The Impact of Overweight and Obesity on Pregnancy: A Narrative Review of Physiological Consequences, Risks and Challenges in Prenatal Care, and Early Intervention Strategies
The Impact of Overweight and Obesity on Pregnancy: A Narrative Review of Physiological Consequences, Risks and Challenges in Prenatal Care, and Early Intervention Strategies Open
View article: Availability of Open Dynamic Glycemic Data in the Field of Diabetes Research: A Scoping Review
Availability of Open Dynamic Glycemic Data in the Field of Diabetes Research: A Scoping Review Open
Background: Poor data availability and accessibility characterizing some research areas in biomedicine are still limiting potentialities for increasing knowledge and boosting technological advancement. This phenomenon also characterizes th…
View article: Sensors and Devices Based on Electrochemical Skin Conductance and Bioimpedance Measurements for the Screening of Diabetic Foot Syndrome: Review and Meta-Analysis
Sensors and Devices Based on Electrochemical Skin Conductance and Bioimpedance Measurements for the Screening of Diabetic Foot Syndrome: Review and Meta-Analysis Open
Diabetic foot syndrome is a multifactorial disease involving different etiological factors. This syndrome is also insidious, due to frequent lack of early symptoms, and its prevalence has increased in recent years. This justifies the remar…
View article: Unconventional structure and function of PHD domains from Additional Sex Combs-like proteins
Unconventional structure and function of PHD domains from Additional Sex Combs-like proteins Open
The Polycomb Repressive-Deubiquitinase (PR-DUB) complex removes ubiquitin from Lysine residue 119 on histone H2A (H2AK119Ub) in humans. The PR-DUB is composed of two central protein factors, the catalytic Breast Cancer type 1 susceptibilit…
View article: In-silico modelling of insulin secretion and pancreatic beta-cell function for clinical applications: is it worth the effort?
In-silico modelling of insulin secretion and pancreatic beta-cell function for clinical applications: is it worth the effort? Open
View article: Identification and validation of gestational diabetes subgroups by data-driven cluster analysis
Identification and validation of gestational diabetes subgroups by data-driven cluster analysis Open
View article: Glucagon kinetics assessed by mathematical modelling during oral glucose administration in people spanning from normal glucose tolerance to type 2 diabetes
Glucagon kinetics assessed by mathematical modelling during oral glucose administration in people spanning from normal glucose tolerance to type 2 diabetes Open
Background/Objectives Glucagon is important in the maintenance of glucose homeostasis, with also effects on lipids. In this study, we aimed to apply a recently developed model of glucagon kinetics to determine the sensitivity of glucagon v…
View article: Glucometabolism in Kidney Transplant Recipients with and without Posttransplant Diabetes: Focus on Beta-Cell Function
Glucometabolism in Kidney Transplant Recipients with and without Posttransplant Diabetes: Focus on Beta-Cell Function Open
Posttransplant diabetes mellitus (PTDM) is a common complication after kidney transplantation. Pathophysiologically, whether beta-cell dysfunction rather than insulin resistance may be the predominant defect in PTDM has been a matter of de…
View article: The impact of regional origin on the incidence of gestational diabetes mellitus in a multiethnic European cohort
The impact of regional origin on the incidence of gestational diabetes mellitus in a multiethnic European cohort Open
Introduction Women with migration background present specific challenges related to risk stratification and care of gestational diabetes mellitus (GDM). Therefore, this study aims to investigate the role of ethnic origin on the risk of dev…
View article: Risk Stratification in Twin Pregnancies Complicated by GDM
Risk Stratification in Twin Pregnancies Complicated by GDM Open
Aims: This study was aimed at assessing the association of oral glucose tolerance test (OGTT) glucose threshold levels and the requirement of insulin therapy in twin pregnancies with gestational diabetes mellitus (GDM). Methods: In this po…
View article: Factors Affecting Mode of Birth in Women With Preexisting Diabetes and Gestational Diabetes: A Retrospective Cohort at a Tertiary Referral Center
Factors Affecting Mode of Birth in Women With Preexisting Diabetes and Gestational Diabetes: A Retrospective Cohort at a Tertiary Referral Center Open
Women with preexisting diabetes and gestational diabetes mellitus (GDM) are at higher risk for adverse maternal and neonatal outcomes. However, there is no consensus on a uniform approach regarding mode of birth (MOB) for all forms of diab…
View article: Maternal overweight and obesity and its association with metabolic changes and fetal overgrowth in the absence of gestational diabetes mellitus: A prospective cohort study
Maternal overweight and obesity and its association with metabolic changes and fetal overgrowth in the absence of gestational diabetes mellitus: A prospective cohort study Open
Introduction Previous studies indicated an association between fetal overgrowth and maternal obesity independent of gestational diabetes mellitus (GDM). However, the underlying mechanisms beyond this possible association are not completely…
View article: Glucometabolic Alterations in Pregnant Women with Overweight or Obesity but without Gestational Diabetes Mellitus: An Observational Study
Glucometabolic Alterations in Pregnant Women with Overweight or Obesity but without Gestational Diabetes Mellitus: An Observational Study Open
Introduction: Maternal overweight is a risk factor for gestational diabetes mellitus (GDM). However, emerging evidence suggests that an increased maternal body mass index (BMI) promotes the development of perinatal complicati…
View article: Clinical Factors for Predicting Pharmacotherapy in Twin Pregnancies Complicated by Gestational Diabetes Mellitus
Clinical Factors for Predicting Pharmacotherapy in Twin Pregnancies Complicated by Gestational Diabetes Mellitus Open
Controlling blood glucose levels is the main target in pregnant women with gestational diabetes mellitus (GDM). Twin pregnancies are offered the same screening selection and have the same diagnostic criteria as well as treatment of gestati…
View article: EP15.13: Glucose levels of the oral glucose tolerance test can predict fetal overgrowth at delivery
EP15.13: Glucose levels of the oral glucose tolerance test can predict fetal overgrowth at delivery Open
Gestational diabetes is a common complication during pregnancy, associated with adverse fetal and maternal outcome. There is a strong association of maternal blood glucose levels and increased birthweight and subsequent fetal and maternal …
View article: Prevalence of gestational diabetes mellitus in women with a family history of type 2 diabetes in first- and second-degree relatives
Prevalence of gestational diabetes mellitus in women with a family history of type 2 diabetes in first- and second-degree relatives Open
Aims A family history of type 2 diabetes mellitus (T2DM) markedly increases an individual's lifetime risk of developing the disease. For gestational diabetes (GDM), this risk factor is less well characterized. This study aimed to investiga…
View article: New Developments, Challenges and Open Questions in Diagnosis and Treatment of Gestational Diabetes Mellitus
New Developments, Challenges and Open Questions in Diagnosis and Treatment of Gestational Diabetes Mellitus Open
The prevalence of gestational diabetes mellitus (GDM) is increasing alongside a rising maternal age at conception, an increasing number of people making unhealthy lifestyle choices and, especially, an increasing pregestational body weight …
View article: TyGIS: improved triglyceride-glucose index for the assessment of insulin sensitivity during pregnancy
TyGIS: improved triglyceride-glucose index for the assessment of insulin sensitivity during pregnancy Open
Background The triglyceride-glucose index (TyG) has been proposed as a surrogate marker of insulin resistance, which is a typical trait of pregnancy. However, very few studies analyzed TyG performance as marker of insulin resistance in pre…
View article: Software Packages and Tools for the Analysis of Continuous Glucose Monitoring Data
Software Packages and Tools for the Analysis of Continuous Glucose Monitoring Data Open
The advancement of technology in the field of glycemic control has led to the widespread use of continuous glucose monitoring (CGM), which can be nowadays obtained from wearable devices equipped with a minimally invasive sensor, that is, t…
View article: Assessment of glucose levels in pregnant women with history of COVID-19 in a case-control study
Assessment of glucose levels in pregnant women with history of COVID-19 in a case-control study Open
Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection may negatively affect glucose metabolism. This study aims to assess glucose levels, prevalence of gestational diabetes mellitus (GDM) and perinatal outcome in women wit…
View article: Letter to the Editor From Göbl and Tura: “Oral Glucose Tolerance Test-based Measures of Insulin Secretory Response in Pregnancy”
Letter to the Editor From Göbl and Tura: “Oral Glucose Tolerance Test-based Measures of Insulin Secretory Response in Pregnancy” Open
Journal Article Letter to the Editor From Göbl and Tura: “Oral Glucose Tolerance Test-based Measures of Insulin Secretory Response in Pregnancy” Get access Christian Göbl, Christian Göbl Department of Obstetrics and Gynaecology, Medical Un…
View article: Impact Of Prepregnancy Overweight And Obesity On Treatment Modality And Pregnancy Outcome In Women With Gestational Diabetes Mellitus
Impact Of Prepregnancy Overweight And Obesity On Treatment Modality And Pregnancy Outcome In Women With Gestational Diabetes Mellitus Open
Background We aim to evaluate the impact of prepregnancy overweight on treatment modalities of Gestational Diabetes Mellitus (GDM). We assessed the association of increased pregravid Body Mass Index (BMI) with dosing of basal and rapid act…
View article: Assessing the Effect of Incretin Hormones and Other Insulin Secretagogues on Pancreatic Beta-Cell Function: Review on Mathematical Modelling Approaches
Assessing the Effect of Incretin Hormones and Other Insulin Secretagogues on Pancreatic Beta-Cell Function: Review on Mathematical Modelling Approaches Open
Mathematical modelling in glucose metabolism has proven very useful for different reasons. Several models have allowed deeper understanding of the relevant physiological and pathophysiological aspects and promoted new experimental activity…
View article: Bioelectrical Impedance Analysis for the Assessment of Body Composition in Sarcopenia and Type 2 Diabetes
Bioelectrical Impedance Analysis for the Assessment of Body Composition in Sarcopenia and Type 2 Diabetes Open
Sarcopenia is emerging as a severe complication in type 2 diabetes (T2DM). On the other hand, it has been documented that nutritional aspects, such as insufficient protein or total energy intake, increase sarcopenia risk. The analysis of b…
View article: Unraveling the Factors Determining Development of Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus Through Machine-Learning Techniques
Unraveling the Factors Determining Development of Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus Through Machine-Learning Techniques Open
Gestational diabetes mellitus (GDM) is a type of diabetes that usually resolves at the end of the pregnancy but exposes to a higher risk of developing type 2 diabetes mellitus (T2DM). This study aimed to unravel the factors, among those th…
View article: Insulin clearance and incretin hormones following oral and “isoglycemic” intravenous glucose in type 2 diabetes patients under different antidiabetic treatments
Insulin clearance and incretin hormones following oral and “isoglycemic” intravenous glucose in type 2 diabetes patients under different antidiabetic treatments Open