Christian Kleist
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View article: Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance (Adv. Therap. 5/2025)
Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance (Adv. Therap. 5/2025) Open
View article: Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance
Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance Open
The benefit that antibiotics confer to the welfare of mankind is threatened by bacterial resistance. Resistance to daptomycin, a cyclic lipopeptide frequently used for the treatment of complicated bacteremia, is a prime example of this ala…
View article: Conjugation of Polycationic Peptides Extends the Efficacy Spectrum of β‐Lactam Antibiotics
Conjugation of Polycationic Peptides Extends the Efficacy Spectrum of β‐Lactam Antibiotics Open
Antibiotic‐resistant enterococci represent a significant global health challenge. Unfortunately, most β‐lactam antibiotics are not applicable for enterococcal infections due to intrinsic resistance. To extend their antimicrobial spectrum, …
View article: Feasibility, Tolerability, and Preliminary Clinical Response of Fractionated Radiopharmaceutical Therapy with<sup>213</sup>Bi-FAPI-46: Pilot Experience in Patients with End-Stage, Progressive Metastatic Tumors
Feasibility, Tolerability, and Preliminary Clinical Response of Fractionated Radiopharmaceutical Therapy with<sup>213</sup>Bi-FAPI-46: Pilot Experience in Patients with End-Stage, Progressive Metastatic Tumors Open
Radiopharmaceutical therapies (RPTs) based on fibroblast activation protein (FAP) and FAP inhibitors (FAPIs) are a new option for progressive metastatic cancer in patients pretreated multiple times. To date, published in-human data refer t…
View article: Improved pharmacokinetics and enhanced efficacy of the vancomycin derivative FU002 using a liposomal nanocarrier
Improved pharmacokinetics and enhanced efficacy of the vancomycin derivative FU002 using a liposomal nanocarrier Open
Antibiotic resistance still represents a global health concern which diminishes the pool of effective antibiotics. With the vancomycin derivative FU002, we recently reported a highly potent substance active against Gram-positive bacteria w…
View article: Five-year follow-up of a phase I trial of donor-derived modified immune cell infusion in kidney transplantation
Five-year follow-up of a phase I trial of donor-derived modified immune cell infusion in kidney transplantation Open
Background The administration of modified immune cells (MIC) before kidney transplantation led to specific immunosuppression against the allogeneic donor and a significant increase in regulatory B lymphocytes. We wondered how this approach…
View article: Modified Immune Cell (MIC) Therapy disrupts Tertiary Lymphoid Structures in Murine Lupus Nephritis
Modified Immune Cell (MIC) Therapy disrupts Tertiary Lymphoid Structures in Murine Lupus Nephritis Open
Induction of tolerance can be achieved with Modified Immune Cells (MIC) by infusion of mononuclear cells challenged with mitomycin C (MMC). Although MIC treatment has been successful in several animal models for autoimmunity and in clinica…
View article: Personen- und Werkregister
Personen- und Werkregister Open
View article: Individualised immunosuppression with intravenously administered donor-derived modified immune cells compared with standard of care in living donor kidney transplantation (TOL-2 Study): protocol for a multicentre, open-label, phase II, randomised controlled trial
Individualised immunosuppression with intravenously administered donor-derived modified immune cells compared with standard of care in living donor kidney transplantation (TOL-2 Study): protocol for a multicentre, open-label, phase II, randomised controlled trial Open
Introduction Donor-derived modified immune cells (MIC) induced long-term specific immunosuppression against the allogeneic donor in preclinical models of transplantation. In a phase I clinical trial (TOL-1 Study), MIC treatment resulted in…
View article: Induction of Long-Lasting Regulatory B Lymphocytes by Modified Immune Cells in Kidney Transplant Recipients
Induction of Long-Lasting Regulatory B Lymphocytes by Modified Immune Cells in Kidney Transplant Recipients Open
Significance Statement In previous work, the authors demonstrated that kidney transplant recipients developed donor-specific unresponsiveness when they were given a pretransplant infusion of modified donor-derived PBMCs. In this study, the…
View article: Refined Chelator Spacer Moieties Ameliorate the Pharmacokinetics of PSMA-617
Refined Chelator Spacer Moieties Ameliorate the Pharmacokinetics of PSMA-617 Open
Prostate-specific membrane antigen (PSMA) binding tracers are promising agents for the targeting of prostate tumors. To further optimize the clinically established radiopharmaceutical PSMA-617, novel PSMA ligands for prostate cancer endora…
View article: HDAC Inhibition for Optimized Cellular Immunotherapy of NY-ESO-1-Positive Soft Tissue Sarcoma
HDAC Inhibition for Optimized Cellular Immunotherapy of NY-ESO-1-Positive Soft Tissue Sarcoma Open
Adoptive cell therapy with NY-ESO-1-specific T cells is a promising option for the treatment of soft tissue sarcoma (STS) but achieves only transient tumor control in the majority of cases. A strategy to optimize this cell therapeutic appr…
View article: Impact of Linker Modification and PEGylation of Vancomycin Conjugates on Structure-Activity Relationships and Pharmacokinetics
Impact of Linker Modification and PEGylation of Vancomycin Conjugates on Structure-Activity Relationships and Pharmacokinetics Open
As multidrug-resistant bacteria represent a concerning burden, experts insist on the need for a dramatic rethinking on antibiotic use and development in order to avoid a post-antibiotic era. New and rapidly developable strategies for antim…
View article: <scp>CD33</scp>‐directed immunotherapy with third‐generation chimeric antigen receptor T cells and gemtuzumab ozogamicin in intact and <scp>CD33</scp>‐edited acute myeloid leukemia and hematopoietic stem and progenitor cells
<span>CD33</span>‐directed immunotherapy with third‐generation chimeric antigen receptor T cells and gemtuzumab ozogamicin in intact and <span>CD33</span>‐edited acute myeloid leukemia and hematopoietic stem and progenitor cells Open
Immunotherapies, such as chimeric antigen receptor (CAR) modified T cells and antibody‐drug conjugates (ADCs), have revolutionized the treatment of cancer, especially of lymphoid malignancies. The application of targeted immunotherapy to p…
View article: 18F-labeled tracers targeting fibroblast activation protein
18F-labeled tracers targeting fibroblast activation protein Open
Background Cancer-associated fibroblasts are found in the stroma of epithelial tumors. They are characterized by overexpression of the fibroblast activation protein (FAP), a serine protease which was already proven as attractive target for…
View article: Combining selective inhibitors of nuclear export (SINEs) with chimeric antigen receptor (CAR) T cells for CD19‑positive malignancies
Combining selective inhibitors of nuclear export (SINEs) with chimeric antigen receptor (CAR) T cells for CD19‑positive malignancies Open
Chimeric antigen receptor (CAR) T cells directed against CD19 (CD19.CAR T cells) have yielded impressive clinical responses in the treatment of patients with lymphoid malignancies. However, resistance and/or relapse can limit treatment out…
View article: Dual Effects of Cyclooxygenase Inhibitors in Combination With CD19.CAR-T Cell Immunotherapy
Dual Effects of Cyclooxygenase Inhibitors in Combination With CD19.CAR-T Cell Immunotherapy Open
Chimeric antigen receptor T (CAR-T) cells targeting CD19 came into clinical practice for the treatment of B cell lymphoma in 2018. However, patients being treated for B cell lymphoma often suffer from comorbidities such as chronic pain, ca…
View article: Evaluation of Production Protocols for the Generation of NY-ESO-1-Specific T Cells
Evaluation of Production Protocols for the Generation of NY-ESO-1-Specific T Cells Open
NY-ESO-1-specific T cells have shown promising activity in the treatment of soft tissue sarcoma (STS). However, standardized protocols for their generation are limited. Particularly, cost-effectiveness considerations of cell production pro…
View article: Pre-sensitization of Malignant B Cells Through Venetoclax Significantly Improves the Cytotoxic Efficacy of CD19.CAR-T Cells
Pre-sensitization of Malignant B Cells Through Venetoclax Significantly Improves the Cytotoxic Efficacy of CD19.CAR-T Cells Open
Chimeric antigen receptor (CAR) T cell therapy has shown promising responses in patients with refractory or relapsed aggressive B-cell malignancies that are resistant to conventional chemotherapy or stem cell transplantation. A potentially…
View article: Fatty Acid Conjugation Leads to Length-Dependent Antimicrobial Activity of a Synthetic Antibacterial Peptide (Pep19-4LF)
Fatty Acid Conjugation Leads to Length-Dependent Antimicrobial Activity of a Synthetic Antibacterial Peptide (Pep19-4LF) Open
The increasing number of infections caused by multidrug-resistant bacteria requires an intensified search for new antibiotics. Pep19-4LF is a synthetic antimicrobial peptide (GKKYRRFRWKFKGKLFLFG) that was previously designed with the main …
View article: Corrigendum: Vancomycin Resistance is Overcome by Conjugation of Polycationic Peptides
Corrigendum: Vancomycin Resistance is Overcome by Conjugation of Polycationic Peptides Open
A vancomycin-arginine conjugate that is effective against Gram-negative bacteria, [1] and a D-octaarginine conjugate of vancomycin that eliminates biofilm-associated MRSA in a murine wound infection model, MRSA persister cells, and vancomy…
View article: Berichtigung: Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden
Berichtigung: Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden Open
View article: Vancomycin-Lipopeptide Conjugates with High Antimicrobial Activity on Vancomycin-Resistant Enterococci
Vancomycin-Lipopeptide Conjugates with High Antimicrobial Activity on Vancomycin-Resistant Enterococci Open
Multidrug-resistant bacteria represent one of the most important health care problems worldwide. While there are numerous drugs available for standard therapy, there are only a few compounds capable of serving as a last resort for severe i…
View article: Graphisches Inhaltsverzeichnis: Angew. Chem. 23/2020
Graphisches Inhaltsverzeichnis: Angew. Chem. 23/2020 Open
The interpretation of the chemical bond in NaBH 3À as a dative bond Na À !BH 3 proposed by Liu et al. is questioned.The dissociation products are Na À and BH 3 but the nature of the bond changes during the bond formation from dative intera…
View article: Innenrücktitelbild: Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden (Angew. Chem. 23/2020)
Innenrücktitelbild: Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden (Angew. Chem. 23/2020) Open
Bakterielle Resistenzen drohen, die Errungenschaften der Antibiotikatherapie zunichte zu machen. Wie P. Uhl et al. in ihrer Zuschrift auf S. 8908 erläutern, konnte am Klinikum Heidelberg mit Peptid-Konjugaten eine tausendfache Aktivitätsst…
View article: Inside Back Cover: Vancomycin Resistance Is Overcome by Conjugation of Polycationic Peptides (Angew. Chem. Int. Ed. 23/2020)
Inside Back Cover: Vancomycin Resistance Is Overcome by Conjugation of Polycationic Peptides (Angew. Chem. Int. Ed. 23/2020) Open
Bacterial resistance threatens to destroy the achievements of antibiotic therapy. As P. Uhl and co-workers report in their Communication on page 8823, a 1000-fold increase in the activity of the reserve antibiotic vancomycin was achieved b…
View article: Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden
Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden Open
Die zunehmende Prävalenz von Resistenzen bei Bakterien gegen Glykopeptid‐Antibiotika macht auch vor Vancomycin nicht halt. Um die ursprünglich hohe Effektivität gegen diese resistenten Bakterien wieder zu erzielen, wurden hier polykationis…
View article: Vancomycin Resistance Is Overcome by Conjugation of Polycationic Peptides
Vancomycin Resistance Is Overcome by Conjugation of Polycationic Peptides Open
Multidrug‐resistant bacteria represent one of the biggest challenges facing modern medicine. The increasing prevalence of glycopeptide resistance compromises the efficacy of vancomycin, for a long time considered as the last resort for the…
View article: Design and Development of <sup>99m</sup>Tc-Labeled FAPI Tracers for SPECT Imaging and <sup>188</sup>Re Therapy
Design and Development of <sup>99m</sup>Tc-Labeled FAPI Tracers for SPECT Imaging and <sup>188</sup>Re Therapy Open
Most epithelial tumors recruit fibroblasts and other nonmalignant cells and activate them into cancer-associated fibroblasts. This often leads to overexpression of the membrane serine protease fibroblast-activating protein (FAP). It has al…
View article: Phase I trial of donor-derived modified immune cell infusion in kidney transplantation
Phase I trial of donor-derived modified immune cell infusion in kidney transplantation Open
BACKGROUNDPreclinical experiments have shown that donor blood cells, modified in vitro by an alkylating agent (modified immune cells [MICs]), induced long-term specific immunosuppression against the allogeneic donor.METHODSIn this phase I …