Christian Kraef
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View article: Prevalence of current substance and hazardous alcohol use among people with <scp>HIV</scp> and tuberculosis disease and its impact on tuberculosis treatment outcomes: A systematic review
Prevalence of current substance and hazardous alcohol use among people with <span>HIV</span> and tuberculosis disease and its impact on tuberculosis treatment outcomes: A systematic review Open
Objective To examine the prevalence of current substance and hazardous alcohol use in people with HIV and tuberculosis (TB) disease and its impact on TB treatment outcomes. Methods A systematic review following the Preferred Reporting Item…
View article: Multisite infection with Austrian syndrome caused by non-vaccine pneumococcal serotype—case report
Multisite infection with Austrian syndrome caused by non-vaccine pneumococcal serotype—case report Open
Background Although rare, Austrian syndrome remains a life-threatening triad consisting of pneumonia, endocarditis, and meningitis caused by Streptococcus pneumoniae . Case Summary We present a case of Austrian syndrome, further complicate…
View article: DNA methylation patterns associated with prior tuberculosis infection in people with HIV
DNA methylation patterns associated with prior tuberculosis infection in people with HIV Open
View article: Association of prior tuberculosis with altered cardiometabolic profiles of people with HIV: A comparative cross-sectional study in Uganda
Association of prior tuberculosis with altered cardiometabolic profiles of people with HIV: A comparative cross-sectional study in Uganda Open
View article: Association of prior tuberculosis with altered cardiometabolic profiles of people with HIV: A comparative cross-sectional study in Uganda
Association of prior tuberculosis with altered cardiometabolic profiles of people with HIV: A comparative cross-sectional study in Uganda Open
Background Cardiovascular disease (CVD) is the leading cause of mortality among people with HIV (PWH), but the influence of co-infections like tuberculosis (TB) on CVD risk remains underexplored. We aimed to compare cardiometabolic profile…
View article: DNA methylation patterns associated with prior tuberculosis infection in people with HIV: a pilot cross-sectional study
DNA methylation patterns associated with prior tuberculosis infection in people with HIV: a pilot cross-sectional study Open
Background Mechanisms by which prior tuberculosis (TB) increases long-term risk for cancer, cardiovascular, and neurological disorders remain unclear, particularly in people with HIV (PWH). This study investigated DNA methylation (DNAm) pa…
View article: ESCMID's World Antimicrobial Resistance Awareness Week 2024: Key takeaways and path forward
ESCMID's World Antimicrobial Resistance Awareness Week 2024: Key takeaways and path forward Open
View article: Specialist training in infectious diseases in Europe
Specialist training in infectious diseases in Europe Open
View article: Risk of tuberculosis after initiation of antiretroviral therapy among persons with HIV in Europe
Risk of tuberculosis after initiation of antiretroviral therapy among persons with HIV in Europe Open
View article: All-cause and AIDS-related mortality among people with HIV across Europe from 2001 to 2020: impact of antiretroviral therapy, tuberculosis and regional differences in a multicentre cohort study
All-cause and AIDS-related mortality among people with HIV across Europe from 2001 to 2020: impact of antiretroviral therapy, tuberculosis and regional differences in a multicentre cohort study Open
View article: Prevalence of Mental Health Disorders and Their Associated Risk Factors Among People Living with HIV in Rwanda: A Cross-Sectional Study
Prevalence of Mental Health Disorders and Their Associated Risk Factors Among People Living with HIV in Rwanda: A Cross-Sectional Study Open
View article: Differences in integrated assessment and management of non‐communicable diseases (<scp>NCDs</scp>) for people with <scp>HIV</scp> across the <scp>WHO</scp> European region
Differences in integrated assessment and management of non‐communicable diseases (<span>NCDs</span>) for people with <span>HIV</span> across the <span>WHO</span> European region Open
Objectives We aimed to assess the extent of integration of non‐communicable disease (NCD) assessment and management in HIV clinics across Europe. Methods A structured electronic questionnaire with 41 multiple‐choice and rating‐scale questi…
View article: Hospital-based antimicrobial stewardship in Denmark, Greenland and the Faroe Islands – current landscape and barriers
Hospital-based antimicrobial stewardship in Denmark, Greenland and the Faroe Islands – current landscape and barriers Open
Core elements important for multi-disciplinary hospital-based AMS can be strengthened in Danish hospitals. Funding, clear mandates, prioritization from the hospital management and the implementation of multi-disciplinary AMS structures may…
View article: Fighting cervical cancer in Africa: a cross-sectional study on prevalence and risk factors for precancerous lesions in rural Uganda
Fighting cervical cancer in Africa: a cross-sectional study on prevalence and risk factors for precancerous lesions in rural Uganda Open
The results underline an unmet need for broad-scale cervical cancer screening focusing on all women in the reproductive age. Abnormal bleeding was the only substantial risk factor for precancerous lesions, indicating that specific algorith…
View article: Climate change and health risks in Mukuru informal settlement in Nairobi, Kenya – knowledge, attitudes and practices among residents
Climate change and health risks in Mukuru informal settlement in Nairobi, Kenya – knowledge, attitudes and practices among residents Open
View article: Uptake of the lateral flow urine LAM test in Europe and Central Asia
Uptake of the lateral flow urine LAM test in Europe and Central Asia Open
INTRODUCTION: Since 2015 (updated in 2019), the WHO has recommended to include the commercial lateral flow urine lipoarabinomannan TB test (LF-LAM), AlereLAM, in the diagnostic toolkit for severely ill people living with HIV. METHODS: To a…
View article: Healthcare Provider Advocacy for Primary Health Care Strengthening: A Call for Action
Healthcare Provider Advocacy for Primary Health Care Strengthening: A Call for Action Open
Primary Health Care (PHC) is the backbone of health systems and a cornerstone of Universal Health Coverage. In 2018, political commitment to PHC, including a comprehensive approach based on essential care throughout the lifespan, integrate…
View article: TIPS and splenorenal shunt for complications of portal hypertension in chronic hepatosplenic schistosomiasis–A case series and review of the literature
TIPS and splenorenal shunt for complications of portal hypertension in chronic hepatosplenic schistosomiasis–A case series and review of the literature Open
Background Transjugular intrahepatic portosystemic shunt (TIPS) and shunt surgery are established treatment options for portal hypertension, but have not been systematically evaluated in patients with portal hypertension due to hepatosplen…
View article: Perspectives of Local Community Leaders, Health Care Workers, Volunteers, Policy Makers and Academia on Climate Change Related Health Risks in Mukuru Informal Settlement in Nairobi, Kenya—A Qualitative Study
Perspectives of Local Community Leaders, Health Care Workers, Volunteers, Policy Makers and Academia on Climate Change Related Health Risks in Mukuru Informal Settlement in Nairobi, Kenya—A Qualitative Study Open
Sub-Saharan Africa has been identified as one of the most vulnerable regions to climate change. The objective of this study was to explore knowledge and perspectives on climate change and health-related issues, with a particular focus on n…
View article: Patient perspectives on integrated healthcare for HIV, hypertension and type 2 diabetes: a scoping review
Patient perspectives on integrated healthcare for HIV, hypertension and type 2 diabetes: a scoping review Open
Introduction Antiretroviral therapy has reduced mortality and led to longer life expectancy in people living with HIV. These patients are now at an increased risk of non-communicable diseases (NCDs). Integration of care for HIV and NCDs ha…
View article: Delayed diagnosis of tuberculosis in persons living with HIV in Eastern Europe: associated factors and effect on mortality—a multicentre prospective cohort study
Delayed diagnosis of tuberculosis in persons living with HIV in Eastern Europe: associated factors and effect on mortality—a multicentre prospective cohort study Open
View article: Improving healthcare for patients with HIV, tuberculosis and hepatitis C in eastern Europe: a review of current challenges and important next steps
Improving healthcare for patients with HIV, tuberculosis and hepatitis C in eastern Europe: a review of current challenges and important next steps Open
Objectives In some eastern European countries, serious challenges exist to meet the HIV‐, tuberculosis (TB)‐ and hepatitis‐related target of the United Nations Sustainable Development Goals. Some of the highest incidence rates for HIV and …
View article: Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza
Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza Open
View article: Climate change and health in urban informal settlements in low- and middle-income countries – a scoping review of health impacts and adaptation strategies
Climate change and health in urban informal settlements in low- and middle-income countries – a scoping review of health impacts and adaptation strategies Open
Background: Climate change affects human health with those with the least resources being most vulnerable. However, little is known about the impact of climate change on human health and effective adaptation methods in informal sett…
View article: Fighting non-communicable diseases in East Africa: assessing progress and identifying the next steps
Fighting non-communicable diseases in East Africa: assessing progress and identifying the next steps Open
Sub-Saharan Africa has seen a rapid increase in non-communicable disease (NCD) burden over the last decades. The East African Community (EAC) comprises Burundi, Rwanda, Kenya, Tanzania, South Sudan and Uganda, with a population of 177 mill…
View article: Digital telemedicine interventions for patients with multimorbidity: a systematic review and meta-analysis
Digital telemedicine interventions for patients with multimorbidity: a systematic review and meta-analysis Open
Objective To determine the effectiveness of digital telemedicine interventions designed to improve outcomes in patients with multimorbidity. Design Systematic review and meta-analysis of available literature. Data sources MEDLINE, EMBASE, …
View article: Primary health care and nutrition
Primary health care and nutrition Open
Globally, dietary factors are responsible for about one in five deaths. In many low- and middle-income countries different forms of malnutrition (including obesity and undernutrition) can co-exist within the same population. This double bu…
View article: The COVID-19 Pandemic and Non-communicable Diseases—A Wake-up Call for Primary Health Care System Strengthening in Sub-Saharan Africa
The COVID-19 Pandemic and Non-communicable Diseases—A Wake-up Call for Primary Health Care System Strengthening in Sub-Saharan Africa Open
Strengthening Primary Health Care Systems is the most effective policy response in low-and middle-income countries to protect against health emergencies, achieve universal health coverage, and promote health and wellbeing. Despite the Asta…
View article: After the Astana declaration: is comprehensive primary health care set for success this time?
After the Astana declaration: is comprehensive primary health care set for success this time? Open
Primary health care (PHC) strengthening in order to achieve the Sustainable Development Goal has again, 40 years after the Alma-Ata declaration, been declared a priority by the global health community. Despite initial progress the Alma-Ata…
View article: Management der saisonalen Influenza 2017/2018: Erfahrungen an einem deutschen Universitätsklinikum
Management der saisonalen Influenza 2017/2018: Erfahrungen an einem deutschen Universitätsklinikum Open