Christian Lüscher
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View article: Roadmap for direct and indirect translation of optogenetics into discoveries and therapies for humans
Roadmap for direct and indirect translation of optogenetics into discoveries and therapies for humans Open
View article: Striatal Crosstalk Between Dopamine and Serotonin Systems
Striatal Crosstalk Between Dopamine and Serotonin Systems Open
Dopamine (DA) and serotonin (5-HT) are neuromodulators in reward processing, decision- making, and motivated behavior. While often viewed as opposing or complementary systems, how DA and 5-HT release integrate in the striatum remains elusi…
View article: Striatal Crosstalk Between Dopamine and Serotonin Systems
Striatal Crosstalk Between Dopamine and Serotonin Systems Open
Dopamine (DA) and serotonin (5-HT) are neuromodulators in reward processing, decision- making, and motivated behavior. While often viewed as opposing or complementary systems, how DA and 5-HT release integrate in the striatum remains elusi…
View article: The neurobiology of overeating
The neurobiology of overeating Open
Food intake serves to maintain energy homeostasis; however, overeating can result in obesity, which is associated with serious health complications. In this review, we explore the intricate relationship between overeating, obesity, and the…
View article: Striatal Crosstalk Between Dopamine and Serotonin Systems
Striatal Crosstalk Between Dopamine and Serotonin Systems Open
Dopamine (DA) and serotonin (5-HT) are neuromodulators in reward processing, decision- making, and motivated behavior. While often viewed as opposing or complementary systems, how DA and 5-HT release integrate in the striatum remains elusi…
View article: Remission of alcohol use disorder following traumatic brain injury with focal orbitofrontal cortex hemorrhage: case report and network mapping
Remission of alcohol use disorder following traumatic brain injury with focal orbitofrontal cortex hemorrhage: case report and network mapping Open
View article: Distinct µ-opioid ensembles trigger positive and negative fentanyl reinforcement
Distinct µ-opioid ensembles trigger positive and negative fentanyl reinforcement Open
View article: µ-opioid receptors of distinct neuronal populations trigger positive and negative fentanyl reinforcement
µ-opioid receptors of distinct neuronal populations trigger positive and negative fentanyl reinforcement Open
Fentanyl is a powerful painkiller that elicits euphoria and positive reinforcement1. Fentanyl also leads to dependence, defined by the aversive withdrawal syndrome, which fuels negative reinforcement (i.e., individuals take the …
View article: Supplementary Material for: Successful MRI-guided focused ultrasound thalamotomy after ipsilateral Gamma Knife radiosurgery for essential tremor: a case report with video
Supplementary Material for: Successful MRI-guided focused ultrasound thalamotomy after ipsilateral Gamma Knife radiosurgery for essential tremor: a case report with video Open
We report the case of a 67-year-old left-handed female patient with disabling medically-refractory essential tremor who underwent successful right-sided Magnetic Resonance-guided focused ultrasound (MRgFUS) of the ventral intermediate (VIM…
View article: Successful MRI-Guided Focused Ultrasound Thalamotomy after Ipsilateral Gamma Knife Radiosurgery for Essential Tremor: A Case Report with Video
Successful MRI-Guided Focused Ultrasound Thalamotomy after Ipsilateral Gamma Knife Radiosurgery for Essential Tremor: A Case Report with Video Open
We report the case of a 67-year-old left-handed female patient with disabling medically refractory essential tremor who underwent successful right-sided magnetic resonance-guided focused ultrasound (MRgFUS) of the ventral intermediate nucl…
View article: Cell-type specific synaptic plasticity in dorsal striatum is associated with punishment-resistance compulsive-like cocaine self-administration in mice
Cell-type specific synaptic plasticity in dorsal striatum is associated with punishment-resistance compulsive-like cocaine self-administration in mice Open
Addiction-related compulsion-like behavior can be modeled in rodents with drug self-administration (SA) despite harmful consequences. Recent studies suggest that the potentiation of glutamatergic transmission at the orbitofrontal cortex (O…
View article: Optogenetics for light control of biological systems
Optogenetics for light control of biological systems Open
View article: Understanding the biological basis of psychiatric disease: What’s next?
Understanding the biological basis of psychiatric disease: What’s next? Open
View article: Dual action of ketamine confines addiction liability
Dual action of ketamine confines addiction liability Open
Ketamine is clinically used as an anesthetic, a fast-acting antidepressant, and recreationally used for its dissociative properties. Addictive drugs, such as cocaine, increase dopamine (DA) levels in the nucleus accumbens (NAc). This facil…
View article: Author response: Dynamic dichotomy of accumbal population activity underlies cocaine sensitization
Author response: Dynamic dichotomy of accumbal population activity underlies cocaine sensitization Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Locomotor sensitization (LS) is an early b…
View article: Dynamic dichotomy of accumbal population activity underlies cocaine sensitization
Dynamic dichotomy of accumbal population activity underlies cocaine sensitization Open
Locomotor sensitization (LS) is an early behavioral adaptation to addictive drugs, driven by the increase of dopamine in the Nucleus Accumbens (NAc). However, the effect on accumbal population activity remains elusive. Here we used single …
View article: Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction
Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction Open
Prevention of compulsive cocaine taking Over time, about 20% of chronic cocaine users lose control and become addicted. There are indications that the differential efficacy of the brain serotonin (5-HT) system may be involved in the vulner…
View article: Corticostriatal Activity Driving Compulsive Reward Seeking
Corticostriatal Activity Driving Compulsive Reward Seeking Open
Our results suggest that compulsive individuals display stronger neuronal activity in the DS during the cue predicting reward availability even when at the risk of punishment, nurturing further compulsive reward seeking.
View article: Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction
Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction Open
Compulsive drug use despite adverse consequences defines addiction. While mesolimbic dopamine signaling is sufficient to drive compulsion, psychostimulants such as cocaine also boost extracellular serotonin (5-HT) by inhibiting reuptake. W…
View article: Bugs R Us: Restoring sociability with microbiota in autism
Bugs R Us: Restoring sociability with microbiota in autism Open
View article: Consolidating the Circuit Model for Addiction
Consolidating the Circuit Model for Addiction Open
Addiction is a disease characterized by compulsive drug seeking and consumption observed in 20–30% of users. An addicted individual will favor drug reward over natural rewards, despite major negative consequences. Mechanistic research on r…
View article: Dynamic dichotomy of accumbal population activity underlies cocaine sensitization
Dynamic dichotomy of accumbal population activity underlies cocaine sensitization Open
Locomotor sensitization (LS) is an early behavioral adaptation to addictive drugs, driven by the increase of dopamine in the Nucleus Accumbens (NAc). However, the effect on accumbal population activity remains elusive. Here we used single …
View article: Context-Dependent Multiplexing by Individual VTA Dopamine Neurons
Context-Dependent Multiplexing by Individual VTA Dopamine Neurons Open
Dopamine (DA) neurons of the VTA track cues and rewards to generate a reward prediction error signal during Pavlovian conditioning. Here we explored how these neurons respond to a self-paced, operant task in freely moving mice. The animal …
View article: Regulation of GluA1 Phosphorylation by D-amphetamine and Methylphenidate in the Cerebellum
Regulation of GluA1 Phosphorylation by D-amphetamine and Methylphenidate in the Cerebellum Open
Prescription stimulants, such as d-amphetamine or methylphenidate, are potent dopamine (DA) and norepinephrine (NE) releasers used to treat children and adults diagnosed for attention-deficit/hyperactivity disorder (ADHD). Although increas…
View article: Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice
Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice Open
View article: Drug-Evoked Synaptic Plasticity of Excitatory Transmission in the Ventral Tegmental Area
Drug-Evoked Synaptic Plasticity of Excitatory Transmission in the Ventral Tegmental Area Open
Camilla Bellone1,2, Michael Loureiro1,2 and Christian Lüscher1,2 1Department of Basic Neurosciences, University of Geneva, 1211 Geneva 14, Switzerland 2Department of Clinical Neurosciences, Geneva University Hospital, 1211 Geneva 14, Switz…
View article: Depression of Accumbal to Lateral Hypothalamic Synapses Gates Overeating
Depression of Accumbal to Lateral Hypothalamic Synapses Gates Overeating Open
View article: The transition to compulsion in addiction
The transition to compulsion in addiction Open
View article: The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue
The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue Open
View article: Aberrant habit formation in the Sapap3-knockout mouse model of obsessive-compulsive disorder
Aberrant habit formation in the Sapap3-knockout mouse model of obsessive-compulsive disorder Open