Christian M. Constantz
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View article: Cellular immune signatures associated with fast versus slow clearance of infectious SARS-CoV-2 4227
Cellular immune signatures associated with fast versus slow clearance of infectious SARS-CoV-2 4227 Open
Description The reasons for varied SARS-CoV-2 transmission risk among infected individuals remain unclear. In this study, we identify cellular immune signatures associated with the speed of viral clearance in individuals with acute SARS-Co…
View article: Young children have limited mucosal immunity when stimulated with an influenza vaccine in tonsil organoids
Young children have limited mucosal immunity when stimulated with an influenza vaccine in tonsil organoids Open
While it has been known for many years that children under five years old are much more vulnerable to most infectious diseases than older children or adults, we know very little about the specific immunological reasons. Thus, we leveraged …
View article: A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2 Open
View article: A universal TLR7-nanoparticle adjuvant promotes broad immune responses against heterologous strains of Influenza and SARS-CoV-2
A universal TLR7-nanoparticle adjuvant promotes broad immune responses against heterologous strains of Influenza and SARS-CoV-2 Open
Fully effective vaccines for viruses such as Influenza and SARS-CoV-2 must elicit a diverse repertoire of antibodies against multiple drifted virus strains. However, how to achieve a diverse response has no general solution except to combi…
View article: HIV-specific CD8 T cells from elite controllers have an epigenetic imprint that preserves effector functions
HIV-specific CD8 T cells from elite controllers have an epigenetic imprint that preserves effector functions Open
Several lines of evidence support a central role for CD8 T cells as key determinants in the control of HIV, particularly in rare “elite controllers” who control the virus to undetectable levels in the blood in the absence of antiretroviral…
View article: Modeling human adaptive immune responses with tonsil organoids
Modeling human adaptive immune responses with tonsil organoids Open
View article: Tracking Five Millennia of Horse Management with Extensive Ancient Genome Time Series
Tracking Five Millennia of Horse Management with Extensive Ancient Genome Time Series Open