Christian P. Speer
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View article: Oxygenation of Immature Infants in the Delivery Room and Beyond: A Quest for Future Research
Oxygenation of Immature Infants in the Delivery Room and Beyond: A Quest for Future Research Open
View article: Neonatal central nervous system infection by Ureaplasma species is rare, but relevant: results from a multicenter nationwide surveillance study
Neonatal central nervous system infection by Ureaplasma species is rare, but relevant: results from a multicenter nationwide surveillance study Open
Purpose Ureaplasma species (spp.) are relevant contributors to preterm birth but may also cause invasive infections particularly in very immature preterm infants. This study aimed to assess the incidence of neonatal Ureaplasma infections o…
View article: Neonatal Sepsis Episodes and Retinopathy of Prematurity in Very Preterm Infants
Neonatal Sepsis Episodes and Retinopathy of Prematurity in Very Preterm Infants Open
Importance Retinopathy of prematurity (ROP) is a major morbidity of preterm infants causing visual impairment, including blindness, for which timely treatment is vital and prevention is key. Increasing evidence suggests that exposure to ne…
View article: The Journal <i>Neonatology</i>: Up to New Frontiers
The Journal <i>Neonatology</i>: Up to New Frontiers Open
View article: Erythrocyte transfusions are associated with retinopathy of prematurity in extremely low gestational age newborns
Erythrocyte transfusions are associated with retinopathy of prematurity in extremely low gestational age newborns Open
Aim Retinopathy of prematurity (ROP) is a major morbidity in preterm infants causing visual impairment including blindness. Prevention and timely treatment are critical. We investigated the potential role of red blood cell (RBC) transfusio…
View article: Ontogenesis of functional platelet subpopulations from preterm and term neonates to adulthood: The PLINIUS study
Ontogenesis of functional platelet subpopulations from preterm and term neonates to adulthood: The PLINIUS study Open
Erythrocytes undergo a well-defined switch from fetal to postnatal circulation, which is mainly reflected by the stage-specific expression of hemoglobin chains. Perinatal alterations in thrombopoiesis are poorly understood. We assessed the…
View article: Imbalanced Inflammatory Responses in Preterm and Term Cord Blood Monocytes and Expansion of the CD14+CD16+ Subset upon Toll-like Receptor Stimulation
Imbalanced Inflammatory Responses in Preterm and Term Cord Blood Monocytes and Expansion of the CD14+CD16+ Subset upon Toll-like Receptor Stimulation Open
Developmentally regulated features of innate immunity are thought to place preterm and term infants at risk of infection and inflammation-related morbidity. Underlying mechanisms are incompletely understood. Differences in monocyte functio…
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View article: Corrigendum to Non-Invasive Ventilation and Exogenous Surfactant in Times of Ever Decreasing Gestational Age: How Do We Make the Most of These Tools? The Journal of Pediatrics 247(2022):138-146
Corrigendum to Non-Invasive Ventilation and Exogenous Surfactant in Times of Ever Decreasing Gestational Age: How Do We Make the Most of These Tools? The Journal of Pediatrics 247(2022):138-146 Open
View article: The Delicate Skin of Preterm Infants: Barrier Function, Immune-Microbiome Interaction, and Clinical Implications
The Delicate Skin of Preterm Infants: Barrier Function, Immune-Microbiome Interaction, and Clinical Implications Open
The skin of preterm infants is a delicate organ with critical structural and functional differences as compared to term born infants. Unique features contribute to an increased susceptibility to injury, infection, thermal instability, and …
View article: European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2022 Update
European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2022 Update Open
Respiratory distress syndrome (RDS) care pathways evolve slowly as new evidence emerges. We report the sixth version of “European Guidelines for the Management of RDS” by a panel of experienced European neonatologists and an expert perinat…
View article: Ureaplasma-Driven Neonatal Neuroinflammation: Novel Insights from an Ovine Model
Ureaplasma-Driven Neonatal Neuroinflammation: Novel Insights from an Ovine Model Open
View article: A case report of Sanfilippo syndrome – the long way to diagnosis
A case report of Sanfilippo syndrome – the long way to diagnosis Open
Background Mucopolysaccharidosis type III (Sanfilippo syndrome) is a lysosomal storage disorder, caused by a deficiency in the heparan-N-sulfatase enzyme involved in the catabolism of the glycosaminoglycan heparan sulfate. It is characteri…
View article: Report of two siblings with spondylodysplastic Ehlers-Danlos syndrome and B4GALT7 deficiency
Report of two siblings with spondylodysplastic Ehlers-Danlos syndrome and B4GALT7 deficiency Open
View article: The Miracles of Surfactant: Less Invasive Surfactant Administration, Nebulization, and Carrier of Topical Drugs
The Miracles of Surfactant: Less Invasive Surfactant Administration, Nebulization, and Carrier of Topical Drugs Open
Surfactant replacement therapy (SRT) has long become the standard of care in the treatment of neonatal respiratory distress syndrome (RDS), significantly decreasing acute pulmonary morbidity and mortality in preterm infants. For decades, t…
View article: Global Neonatal Research
Global Neonatal Research Open
In this issue of Neonatology, we have introduced a new section of the journal, Global Neonatal Research and published the first article from Tibet on near infrared spectroscopy monitoring of cerebral oxygen at high altitude [1].Why have we…
View article: A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome: two-year outcomes
A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome: two-year outcomes Open
This assessment offers reassurance that treatment with CHF5633 surfactant was not associated with adverse neurodevelopmental, respiratory, or health outcomes by two years corrected age.
View article: Fine Tuning Non-invasive Respiratory Support to Prevent Lung Injury in the Extremely Premature Infant
Fine Tuning Non-invasive Respiratory Support to Prevent Lung Injury in the Extremely Premature Infant Open
Within the last decades, therapeutic advances, such as antenatal corticosteroids, surfactant replacement, monitored administration of supplemental oxygen, and sophisticated ventilatory support have significantly improved the survival of ex…
View article: <b><i>Ureaplasma</i></b>-Driven Neuroinflammation in Neonates: Assembling the Puzzle Pieces
<b><i>Ureaplasma</i></b>-Driven Neuroinflammation in Neonates: Assembling the Puzzle Pieces Open
Ureaplasma species (spp.) are commonly regarded as low-virulence colonizers of the genitourinary tract. Intrauterine Ureaplasma infection, however, has been associated with chorioamnionitis and preterm birth. The overall impa…
View article: COVID-19 and Neonatal Resuscitation
COVID-19 and Neonatal Resuscitation Open
In this issue of Neonatology, we publish two papers with suggestions for neonatal resuscitation when the mother is suspected of having COVID-19 infection [1,2].These papers come from Italy [1] where the COVID-19 pandemic has resulted in ma…
View article: Richard B. Johnston Jr.: Unravelling the Secrets of Neonatal Host Defense
Richard B. Johnston Jr.: Unravelling the Secrets of Neonatal Host Defense Open
View article: Diverging effects of premature birth and bronchopulmonary dysplasia on exercise capacity and physical activity – a case control study
Diverging effects of premature birth and bronchopulmonary dysplasia on exercise capacity and physical activity – a case control study Open
View article: Ureaplasma Species Modulate Cytokine and Chemokine Responses in Human Brain Microvascular Endothelial Cells
Ureaplasma Species Modulate Cytokine and Chemokine Responses in Human Brain Microvascular Endothelial Cells Open
Ureaplasma species are common colonizers of the adult genitourinary tract and often considered as low-virulence commensals. Intraamniotic Ureaplasma infections, however, facilitate chorioamnionitis and preterm birth, and cases of Ureaplasm…
View article: Hereditary spherocytosis is associated with decreased pyruvate kinase activity due to impaired structural integrity of the red blood cell membrane
Hereditary spherocytosis is associated with decreased pyruvate kinase activity due to impaired structural integrity of the red blood cell membrane Open
Summary Hereditary spherocytosis (HS) is characterised by increased osmotic fragility and enhanced membrane loss of red blood cells (RBC) due to defective membrane protein complexes. In our diagnostic laboratory, we observed that pyruvate …
View article: Differential modulation of pulmonary caspases: Is this the key to Ureaplasma-driven chronic inflammation?
Differential modulation of pulmonary caspases: Is this the key to Ureaplasma-driven chronic inflammation? Open
Although accepted agents in chorioamnionitis and preterm birth, the role of Ureaplasma species (spp.) in inflammation-driven morbidities of prematurity, including the development of bronchopulmonary dysplasia, remains controversial. To add…
View article: Perinatal Ureaplasma Exposure Is Associated With Increased Risk of Late Onset Sepsis and Imbalanced Inflammation in Preterm Infants and May Add to Lung Injury
Perinatal Ureaplasma Exposure Is Associated With Increased Risk of Late Onset Sepsis and Imbalanced Inflammation in Preterm Infants and May Add to Lung Injury Open
Background: Controversy remains concerning the impact of Ureaplasma on preterm neonatal morbidity. Methods: Prospective single-center study in very low birth weight infants Ureaplasma parvum and U. urealyticum
View article: More than just inflammation: Ureaplasma species induce apoptosis in human brain microvascular endothelial cells
More than just inflammation: Ureaplasma species induce apoptosis in human brain microvascular endothelial cells Open
View article: 60 Years of Publishing Fetal and Neonatal Research
60 Years of Publishing Fetal and Neonatal Research Open
View article: Sharing Progress in Neonatology (SPIN): A Critical Appraisal of Our Current Knowledge
Sharing Progress in Neonatology (SPIN): A Critical Appraisal of Our Current Knowledge Open
View article: European Consensus Guidelines on the Management of Respiratory Distress Syndrome – 2019 Update
European Consensus Guidelines on the Management of Respiratory Distress Syndrome – 2019 Update Open
As management of respiratory distress syndrome (RDS) advances, clinicians must continually revise their current practice. We report the fourth update of “European Guidelines for the Management of RDS” by a European panel of experienced neo…