Christian M. Page
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View article: The Overlooked Legacy: Genetic Contributions of the Childless – ERRATUM
The Overlooked Legacy: Genetic Contributions of the Childless – ERRATUM Open
View article: Sex-Specific Cord Blood DNA Methylation Signatures for Childhood ADHD Symptoms
Sex-Specific Cord Blood DNA Methylation Signatures for Childhood ADHD Symptoms Open
The underdiagnosis of Attention-Deficit/Hyperactivity Disorder (ADHD) in females, particularly those with the inattentive presentation, highlights a critical gap in clinical care. While DNA methylation may be tissue-specific, accessible pe…
View article: Methylation differences between assisted reproductive technology-conceived and naturally conceived children near <i>BRCA1</i> and <i>NBR2</i>
Methylation differences between assisted reproductive technology-conceived and naturally conceived children near <i>BRCA1</i> and <i>NBR2</i> Open
Recent studies have shown that newborns conceived using assisted reproductive technology (ART) exhibited significantly different DNA methylation (DNAm) profiles at birth compared to those conceived naturally. Of note was the observation of…
View article: Genetic Susceptibility to Neurodevelopmental Conditions Is Associated With Neonatal DNA Methylation Patterns in the General Population: An Individual Participant Data Meta-Analysis
Genetic Susceptibility to Neurodevelopmental Conditions Is Associated With Neonatal DNA Methylation Patterns in the General Population: An Individual Participant Data Meta-Analysis Open
Genetic susceptibility to NDCs, particularly SCZ, is detectable in cord blood DNAm in the general population.
View article: Cohort Profile Update: The Norwegian Mother, Father and Child Cohort (MoBa)
Cohort Profile Update: The Norwegian Mother, Father and Child Cohort (MoBa) Open
View article: Prenatal Smoking Exposures and Epigenome-wide Methylation in Newborn Blood
Prenatal Smoking Exposures and Epigenome-wide Methylation in Newborn Blood Open
Maternal sustained smoking has the largest impact on newborn DNA methylation, suggesting a strong influence of the intrauterine environment. We observed minimal impacts for less studied exposures including SHS, maternal former smoking and …
View article: The development of childhood internalising problems: A meta-analysis of epigenome-wide-association-studies
The development of childhood internalising problems: A meta-analysis of epigenome-wide-association-studies Open
Background Pre- and postpartum environments and genetic effects influence childhood internalising problems, which increase depression risk. DNA methylation (DNAm) may capture some of these effects. We therefore investigated associations be…
View article: Polygenic scores for dizygotic twinning: insights into the genetic architecture of female fertility
Polygenic scores for dizygotic twinning: insights into the genetic architecture of female fertility Open
Purpose Natural dizygotic twinning (DZT) results from hyper-ovulation and is an indicator of female fertility. However, some traits linked to DZ twinning are also associated with infertility. We examined the relationship between DZT and fe…
View article: Genetic and Epigenetic Foundations of Childhood Internalizing and Externalizing Problems and their Co-occurrence
Genetic and Epigenetic Foundations of Childhood Internalizing and Externalizing Problems and their Co-occurrence Open
Childhood behavioural problems pose long-term mental health risks, yet the biological basis of co-occurring internalizing and externalizing symptoms remains unclear. In a cohort of 40,212 children, we integrated genome-wide association stu…
View article: The Overlooked Legacy: Genetic Contributions of the Childless
The Overlooked Legacy: Genetic Contributions of the Childless Open
Childless individuals have historically faced stigma with assumptions that they lack an interest in future generations because they do not directly contribute to genetic lineage. Individuals share approximately half of their genes with sib…
View article: Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium
Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium Open
Background DNA methylation (DNAm) is a developmentally dynamic epigenetic process; yet, most epigenome-wide association studies (EWAS) have examined DNAm at only one timepoint or without systematic comparisons between timepoints. Thus, it …
View article: Prenatal stress, epigenetically-assessed glucocorticoid exposure at birth, and child psychiatric symptoms: A prospective, multi-cohort study
Prenatal stress, epigenetically-assessed glucocorticoid exposure at birth, and child psychiatric symptoms: A prospective, multi-cohort study Open
We did not find support that the MPS-GC in cord blood reliably proxies prenatal stress, associates with child psychiatric risk, or partially mediates the associations between prenatal stress and psychiatric risk.
View article: Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium
Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium Open
View article: Associations between lifetime history of depression, OXTR DNA methylation and breastfeeding outcomes
Associations between lifetime history of depression, OXTR DNA methylation and breastfeeding outcomes Open
Importance: Women with a history of depression are less likely to breastfeed and experience more breastfeeding challenges. Potential biological mechanisms that link maternal depression with poor breastfeeding outcomes have not been investi…
View article: Polygenic Scores for Dizygotic Twinning: Insights into the Genetic Architecture of Female Fertility
Polygenic Scores for Dizygotic Twinning: Insights into the Genetic Architecture of Female Fertility Open
Natural dizygotic twinning (DZT) results from hyper-ovulation and is considered an indicator of female fertility. DZT has low polygenicity, with only 0.20% of SNPs estimated to have a nonzero effect. A polygenic score (PGS) for DZT explain…
View article: Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium
Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium Open
Children born via cesarean delivery have a higher risk of metabolic, immunological, and neurodevelopmental disorders compared to those born via vaginal delivery, although mechanisms remain unclear. We conducted a meta-analysis of epigenome…
View article: The association between alcohol consumption and colorectal carcinogenesis is partially mediated by the gut microbiome
The association between alcohol consumption and colorectal carcinogenesis is partially mediated by the gut microbiome Open
Background Alcohol consumption is one of the major risk factors of colorectal cancer (CRC). However, the mechanisms underlying this relationship are not fully understood, particularly the potential role of gut microbes. Objective To study …
View article: Epigenome-wide meta-analysis of prenatal vitamin D insufficiency and cord blood DNA methylation
Epigenome-wide meta-analysis of prenatal vitamin D insufficiency and cord blood DNA methylation Open
Low maternal vitamin D concentrations during pregnancy have been associated with a range of offspring health outcomes. DNA methylation is one mechanism by which the maternal vitamin D status during pregnancy could impact offspring's health…
View article: Sex differences in DNA methylation variations according to ART conception-evidence from the Norwegian mother, father, and child cohort study
Sex differences in DNA methylation variations according to ART conception-evidence from the Norwegian mother, father, and child cohort study Open
Previous studies have shown cord-blood DNA methylation differences in newborns conceived using assisted reproductive technologies (ART) compared to those conceived naturally. However, whether these ART-related DNA methylation differences v…
View article: Individual heterogeneity, educational attainment and cardiovascular mortality: a pooled analysis of Norwegian health surveys
Individual heterogeneity, educational attainment and cardiovascular mortality: a pooled analysis of Norwegian health surveys Open
Background Smoking, physical inactivity, cholesterol level and systolic blood pressure are well-established risk factors for cardiovascular diseases (CVD). However, even among individuals with similar levels of these factors, a substantial…
View article: Prenatal stress and gestational epigenetic age: No evidence of associations based on a large prospective multi-cohort study
Prenatal stress and gestational epigenetic age: No evidence of associations based on a large prospective multi-cohort study Open
View article: Genetic susceptibility to neurodevelopmental conditions associates with neonatal DNA methylation patterns in the general population: an individual participant data meta-analysis
Genetic susceptibility to neurodevelopmental conditions associates with neonatal DNA methylation patterns in the general population: an individual participant data meta-analysis Open
Background Autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and schizophrenia (SCZ) are highly heritable and linked to disruptions in foetal (neuro)development. While epigenetic processes are considered an i…
View article: Maternal Characteristics in Natural and Medically Assisted Reproduction Dizygotic Twin Pregnancies
Maternal Characteristics in Natural and Medically Assisted Reproduction Dizygotic Twin Pregnancies Open
Previous studies have shown that mothers of naturally conceived dizygotic (DZ) twins tend to be taller, older, and smoke more than mothers of naturally conceived monozygotic (MZ) twin and mothers of singletons. Here, we investigate whether…
View article: Maternal age is related to offspring <scp>DNA</scp> methylation: A meta‐analysis of results from the <scp>PACE</scp> consortium
Maternal age is related to offspring <span>DNA</span> methylation: A meta‐analysis of results from the <span>PACE</span> consortium Open
Worldwide trends to delay childbearing have increased parental ages at birth. Older parental age may harm offspring health, but mechanisms remain unclear. Alterations in offspring DNA methylation (DNAm) patterns could play a role as aging …
View article: Longitudinal associations of DNA methylation and sleep in children: a meta-analysis
Longitudinal associations of DNA methylation and sleep in children: a meta-analysis Open
Background: Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to unde…
View article: Prenatal stress, epigenetically-assessed glucocorticoid exposure at birth, and child psychiatric symptoms: A prospective, multi-cohort study
Prenatal stress, epigenetically-assessed glucocorticoid exposure at birth, and child psychiatric symptoms: A prospective, multi-cohort study Open
Background. Recent work suggests that a DNA methylation can be used as a proxy of fetal glucocorticoid exposure (MPS-GC),showing associations with maternal psychopathology during pregnancy and length of child psychiatric treatment. However…
View article: Epigenetic timing effects on child developmental outcomes: A longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium
Epigenetic timing effects on child developmental outcomes: A longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium Open
DNA methylation (DNAm) is a developmentally dynamic epigenetic process, yet we still know little about how epigenetic effects on health outcomes vary over time; whether DNAm alterations during certain periods of development are more inform…
View article: Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study
Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study Open
View article: Comprehensive evaluation of smoking exposures and their interactions on DNA methylation
Comprehensive evaluation of smoking exposures and their interactions on DNA methylation Open
View article: A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation
A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation Open