Christian Pradier
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View article: The Effects of High-Dose Probiotic Supplementation on Immune Activation and Neurocognitive Disorders in People Living with HIV Undergoing Successful Antiretroviral Treatment: The Procog Study
The Effects of High-Dose Probiotic Supplementation on Immune Activation and Neurocognitive Disorders in People Living with HIV Undergoing Successful Antiretroviral Treatment: The Procog Study Open
Background: The prevalence of HIV-associated neurocognitive disorders (HAND) remains high despite antiretroviral treatment (ART). Changes in gut microbiota and persistent immune activation have been suggested as possible causes, while the …
View article: Mental health of airline pilots in France: insights from an anonymous online survey
Mental health of airline pilots in France: insights from an anonymous online survey Open
Background The German wings crash highlighted the need to better understand the mental health of airline pilots. Airline pilots are exposed to psychosocial risks, and they may constitute a population at risk of developing anxiety and depre…
View article: Risk of Cancer in People With Human Immunodeficiency Virus Experiencing Varying Degrees of Immune Recovery With Sustained Virological Suppression on Antiretroviral Treatment for More Than 2 Years: An International, Multicenter, Observational Cohort
Risk of Cancer in People With Human Immunodeficiency Virus Experiencing Varying Degrees of Immune Recovery With Sustained Virological Suppression on Antiretroviral Treatment for More Than 2 Years: An International, Multicenter, Observational Cohort Open
Background The impact of long-term virological suppression (VS) and CD4 count recovery on non–AIDS-defining cancers (NADCs) is unclear. We determined whether poor immune recovery was associated with incident cancer risk in people with huma…
View article: Immunosenescence markers in T- and NK-cells according to the CD4/CD8 ratio in successfully treated people living with HIV
Immunosenescence markers in T- and NK-cells according to the CD4/CD8 ratio in successfully treated people living with HIV Open
Introduction The CD4/CD8 ratio has emerged as a useful indicator of immune dysfunction and comorbid conditions in people living with HIV (PLWH). However, its optimal cut-off value is unclear. We explored the correlation between the CD4/CD8…
View article: Spatial distribution of SARS-CoV-2 incidence, social inequality, housing conditions, and density in South-Eastern France: keys for future epidemics
Spatial distribution of SARS-CoV-2 incidence, social inequality, housing conditions, and density in South-Eastern France: keys for future epidemics Open
Introduction Early in 2021, the SARS-CoV-2 incidence rate was higher in the East than in the West of the Alpes-Maritimes district in France. What was the impact of social deprivation, household overcrowding and population density per km 2 …
View article: A Nationwide Analysis in France on Sex Difference and Outcomes Following Carotid Intervention in Asymptomatic Patients
A Nationwide Analysis in France on Sex Difference and Outcomes Following Carotid Intervention in Asymptomatic Patients Open
Objective: The impact of sex on outcomes following carotid endarterectomy (CEA) and carotid artery stenting (CAS) is not fully elucidated. The aim of this study was to analyze the association between sex and outcomes of asymptomatic patien…
View article: Wild-Type AmpC Beta-Lactamase-Producing Enterobacterales Are a Risk Factor for Empirical Treatment Failure in Patients with Bloodstream Infection
Wild-Type AmpC Beta-Lactamase-Producing Enterobacterales Are a Risk Factor for Empirical Treatment Failure in Patients with Bloodstream Infection Open
Introduction: Beta-lactamases are frequently prescribed for Gram-negative bloodstream infections (BSIs). However, chromosomally encoded AmpC-producing Enterobacterales (AE) could overproduce beta-lactamases when exposed to third-generation…
View article: COVID-19 patient experiences in prehospital pathways: a processual approach using life-events calendar method and state sequence analysis shows detrimental delays
COVID-19 patient experiences in prehospital pathways: a processual approach using life-events calendar method and state sequence analysis shows detrimental delays Open
Objectives To our best knowledge, no study in France has comprehensively investigated the prehospital history of patients admitted for severe cases of COVID-19. ‘Patients’ voice is an excellent means to capture data on primary care pathway…
View article: Measures of Longitudinal Immune Dysfunction and Risk of AIDS and Non-AIDS Defining Malignancies in Antiretroviral-Treated People With Human Immunodeficiency Virus
Measures of Longitudinal Immune Dysfunction and Risk of AIDS and Non-AIDS Defining Malignancies in Antiretroviral-Treated People With Human Immunodeficiency Virus Open
Background Human immunodeficiency virus (HIV) infection leads to chronic immune activation/inflammation that can persist in virally suppressed persons on fully active antiretroviral therapy (ART) and increase risk of malignancies. The prog…
View article: Nationwide Study in France To Predict One Year Major Bleeding and Validate the OAC3-PAD Score in Patients Undergoing Revascularisation for Lower Extremity Arterial Disease
Nationwide Study in France To Predict One Year Major Bleeding and Validate the OAC3-PAD Score in Patients Undergoing Revascularisation for Lower Extremity Arterial Disease Open
View article: Enhancing multi-sectoral collaboration in health: the open arena for public health as a model for bridging the knowledge-translation gap
Enhancing multi-sectoral collaboration in health: the open arena for public health as a model for bridging the knowledge-translation gap Open
Effective public health interventions at local level must involve communities and stakeholders beyond the health services spectrum. A dedicated venue for structured discussion will ensure ongoing multi-sectoral collaboration more effective…
View article: Both Humoral and Cellular Immune Responses to SARS-CoV-2 Are Essential to Prevent Infection: a Prospective Study in a Working Vaccinated Population from Southern France
Both Humoral and Cellular Immune Responses to SARS-CoV-2 Are Essential to Prevent Infection: a Prospective Study in a Working Vaccinated Population from Southern France Open
View article: Trends in Cancer Incidence in Different Antiretroviral Treatment-Eras amongst People with HIV
Trends in Cancer Incidence in Different Antiretroviral Treatment-Eras amongst People with HIV Open
Despite cancer being a leading comorbidity amongst individuals with HIV, there are limited data assessing cancer trends across different antiretroviral therapy (ART)-eras. We calculated age-standardised cancer incidence rates (IRs) from 20…
View article: COVID-19 patient experiences in pre-hospital pathways: a processual qualitative approach using the life-events calendar method highlights diagnostic delays and healthcare renunciation.
COVID-19 patient experiences in pre-hospital pathways: a processual qualitative approach using the life-events calendar method highlights diagnostic delays and healthcare renunciation. Open
Background During the height of the COVID-19 pandemic in 2020, 11% of patients who were hospitalized in France were immediately admitted to intensive care. We aimed to identify and characterize the different types of primary care pathways …
View article: Impact of social and demographic factors on the spread of the SARS-CoV-2 epidemic in the town of Nice
Impact of social and demographic factors on the spread of the SARS-CoV-2 epidemic in the town of Nice Open
Introduction Socio-demographic factors are known to influence epidemic dynamics. The town of Nice, France, displays major socio-economic inequalities, according to the National Institute of Statistics and Economic Studies (INSEE), 10% of t…
View article: Prevalence of osteoporosis in people living with <scp>HIV</scp> and risk factors associated in the <scp>cART</scp> era
Prevalence of osteoporosis in people living with <span>HIV</span> and risk factors associated in the <span>cART</span> era Open
Despite successful combination antiretroviral therapies (cART), patients living with HIV (PLWH) continue experiencing long-term complications [1]. Lower bone mineral density (BMD) has been described as a consequence of chronic HIV infectio…
View article: Immune response to BNT162b2 SARS-CoV-2 vaccine in patients living with HIV: The COVIH-DAPT study
Immune response to BNT162b2 SARS-CoV-2 vaccine in patients living with HIV: The COVIH-DAPT study Open
Introduction Data on immune response to SARS-CoV-2 vaccine in patients living with HIV (PLWH) over a period longer than 3 months are currently limited. We measured the immune response after BNT162b2 vaccination against SARS-CoV-2 in this p…
View article: Editor's Choice – Impact of Sex on the Outcomes of Patients Undergoing Repair for Lower Extremity Peripheral Arterial Disease in France
Editor's Choice – Impact of Sex on the Outcomes of Patients Undergoing Repair for Lower Extremity Peripheral Arterial Disease in France Open
View article: Both humoral and cellular immune responses to SARS-CoV-2 are essential to prevent infection: a prospective study in a working vaccinated population from southern France
Both humoral and cellular immune responses to SARS-CoV-2 are essential to prevent infection: a prospective study in a working vaccinated population from southern France Open
COVID-19 vaccines have significantly decreased the number severe cases of the disease but the virus circulation remains important and questions about the need of new vaccination campaigns remain unanswered. The individual’s protection agai…
View article: COVID-19 patient experiences in pre-hospital pathways (article 1): a processual approach using the life-events calendar method highlights diagnostic delays and healthcare renunciation
COVID-19 patient experiences in pre-hospital pathways (article 1): a processual approach using the life-events calendar method highlights diagnostic delays and healthcare renunciation Open
Objectives To our best knowledge, no study in France has comprehensively investigated the prehospital history of patients admitted for severe cases of COVID-19. ‘Patients’ voice is an excellent means to capture data on primary care pathway…
View article: Factors influencing participation in breast cancer screening in an urban setting. A study of organized and individual opportunistic screening among potentially active and retired women in the city of Nice
Factors influencing participation in breast cancer screening in an urban setting. A study of organized and individual opportunistic screening among potentially active and retired women in the city of Nice Open
View article: Facteurs déterminant la participation au dépistage du cancer du seinEtude du dépistage organisé et du dépistage individuel chez les femmes potentiellement actives et retraitées de la Ville de Nice
Facteurs déterminant la participation au dépistage du cancer du seinEtude du dépistage organisé et du dépistage individuel chez les femmes potentiellement actives et retraitées de la Ville de Nice Open
Cette étude s’inscrit dans le projet Syndémie portée par la Métropole Nice Côte d’Azur et a bénéficié d’une subvention de la ville de Nice. Nous remercions le professeur Pierre Dellamonica qui a initié ce projet. Thierry Blayac (Université…
View article: Impact of social and demographic factors on the spread of the SARS-CoV-2 epidemic in the town of Nice
Impact of social and demographic factors on the spread of the SARS-CoV-2 epidemic in the town of Nice Open
Introduction: Socio-demographic factors are known to influence epidemic dynamics. The town of Nice displays major socio-economic inequalities, with over 50% of the population living below the poverty threshold in some districts. Objective:…
View article: Air pollution exposure induces a decrease in type II interferon response: A paired cohort study
Air pollution exposure induces a decrease in type II interferon response: A paired cohort study Open
View article: Correlation between <scp>CD4</scp>/<scp>CD8</scp> ratio and neurocognitive performance during early <scp>HIV</scp> infection
Correlation between <span>CD4</span>/<span>CD8</span> ratio and neurocognitive performance during early <span>HIV</span> infection Open
Introduction CD4/CD8 ratio is a marker of immune activation in HIV infection and has been associated with neurocognitive performance during chronic infection, but little is known about the early phases. The aim of this study was to examine…
View article: Recent abacavir use and incident cardiovascular disease in contemporary-treated people with HIV
Recent abacavir use and incident cardiovascular disease in contemporary-treated people with HIV Open
Objective: Assessing whether the previously reported association between abacavir (ABC) and cardiovascular disease (CVD) remained amongst contemporarily treated people with HIV. Design: Multinational cohort collaboration. Methods: RESPOND …
View article: Observational cohort study of rilpivirine (RPV) utilization in Europe
Observational cohort study of rilpivirine (RPV) utilization in Europe Open
View article: Evaluation of an Antibiotic Susceptibility Testing Method on Enterobacterales-Positive Blood Cultures in Less Than 8 h Using the Rapid Mueller-Hinton Diffusion Method in Conjunction with the SIRscan 2000 Automatic Reading Device
Evaluation of an Antibiotic Susceptibility Testing Method on Enterobacterales-Positive Blood Cultures in Less Than 8 h Using the Rapid Mueller-Hinton Diffusion Method in Conjunction with the SIRscan 2000 Automatic Reading Device Open
Enterobacterales bloodstream infections are life-threatening and require rapid, targeted antibiotherapy based on antibiotic susceptibility testing (AST). A new method using Muller-Hinton Rapid-SIR (MHR-SIR) agar (i2a, Montpellier, France) …
View article: Associations between integrase strand-transfer inhibitors and cardiovascular disease in people living with HIV: a multicentre prospective study from the RESPOND cohort consortium
Associations between integrase strand-transfer inhibitors and cardiovascular disease in people living with HIV: a multicentre prospective study from the RESPOND cohort consortium Open
View article: Who Were Hospitalized Deceased Patients from COVID-19 During the First Year of Pandemic? Retrospective Analysis of 1104 Deceased Patients in South of France
Who Were Hospitalized Deceased Patients from COVID-19 During the First Year of Pandemic? Retrospective Analysis of 1104 Deceased Patients in South of France Open