Christian Reh
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View article: Effect of Daridorexant on the Pharmacokinetics of Midazolam, and on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Male Subjects
Effect of Daridorexant on the Pharmacokinetics of Midazolam, and on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Male Subjects Open
View article: Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll‐like receptors 7 and 8
Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll‐like receptors 7 and 8 Open
This study evaluated the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple oral doses of enpatoran (formerly named M5049), a new toll‐like receptor (TLR) 7 and 8 dual antagonist, and the effect o…
View article: P135 A phase I, first-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of single and multiple ascending doses of M5049, a dual antagonist of TLR7/8, in healthy subjects
P135 A phase I, first-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of single and multiple ascending doses of M5049, a dual antagonist of TLR7/8, in healthy subjects Open
Background Toll-like receptors 7 and 8 (TLR7/8) are widely expressed in a variety of immune cells and detect single-stranded RNAs, activating signalling cascades which trigger an immune response. Aberrant TLR7/8 activation by RNA-containin…
View article: Imaging Biomarkers for Adult Medulloblastomas: Genetic Entities May Be Identified by Their MR Imaging Radiophenotype
Imaging Biomarkers for Adult Medulloblastomas: Genetic Entities May Be Identified by Their MR Imaging Radiophenotype Open
MR imaging biomarkers can help distinguish histologic and genetic medulloblastoma entities in adults and appear to be different from those identified in children.
View article: Medulloblastoma in adults: identifying imaging biomarkers of genetic status in a prospective multi-centre study
Medulloblastoma in adults: identifying imaging biomarkers of genetic status in a prospective multi-centre study Open
Poster: ECR 2017 / B-0608 / Medulloblastoma in adults: identifying imaging biomarkers of genetic status in a prospective multi-centre study by: V. C. Keil 1, M. Warmutz-Metz2, C. Reh1, J. Enkirch1, H. Schild1, T. Pietsch1, E. Ha…