Christian Ringler
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View article: Fibroblast orchestration of inflammaging via NF-kB activation
Fibroblast orchestration of inflammaging via NF-kB activation Open
Summary Aged tissue is characterized by chronic inflammation known as “inflammaging”. While this aging immune phenotype supposedly drives some of the most common diseases affecting the elderly, little is known about the structural drivers …
View article: An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis
An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis Open
The appearance of senescent cells in age-related diseases has spurred the search for compounds that can target senescent cells in tissues, termed senolytics. However, a major caveat with current senolytic screens is the use of cell lines a…