Christian Schachtrup
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View article: Fibrinogen triggers perivascular fibroblast activation in a mouse model of cortical ischemic stroke
Fibrinogen triggers perivascular fibroblast activation in a mouse model of cortical ischemic stroke Open
Fibrotic scar formation caused by stromal cells is often associated with chronic, non-healing pathology impeding repair of the central nervous system (CNS). Perivascular fibroblasts (PVFs) in the perivascular space are activated, express a…
View article: ID3-depleted human induced pluripotent stem cell–derived neural stem/progenitor cells promote neurorepair
ID3-depleted human induced pluripotent stem cell–derived neural stem/progenitor cells promote neurorepair Open
Human induced pluripotent stem cell–derived neural stem/progenitor cells are used in cell-replacement and regenerative therapeutic strategies after traumatic central nervous system injury. Traumatic injury alters the host microenvironment,…
View article: Interaction between subventricular zone microglia and neural stem cells impacts the neurogenic response in a mouse model of cortical ischemic stroke
Interaction between subventricular zone microglia and neural stem cells impacts the neurogenic response in a mouse model of cortical ischemic stroke Open
View article: Fibrinogen: connecting the blood circulatory system with CNS scar formation
Fibrinogen: connecting the blood circulatory system with CNS scar formation Open
Wound healing of the central nervous system (CNS) is characterized by the classical phases of ‘hemostasis’, ‘inflammation’, ‘proliferation’, and ‘remodeling’. Uncontrolled wound healing results in pathological scar formation hindering tiss…
View article: Tpr Misregulation in Hippocampal Neural Stem Cells in Mouse Models of Alzheimer’s Disease
Tpr Misregulation in Hippocampal Neural Stem Cells in Mouse Models of Alzheimer’s Disease Open
Nuclear pore complexes (NPCs) are highly dynamic macromolecular protein structures that facilitate molecular exchange across the nuclear envelope. Aberrant NPC functioning has been implicated in neurodegeneration. The translocated promoter…
View article: Dense dopaminergic innervation of the peri‐infarct cortex despite dopaminergic cell loss after a pure motor‐cortical stroke in rats
Dense dopaminergic innervation of the peri‐infarct cortex despite dopaminergic cell loss after a pure motor‐cortical stroke in rats Open
After ischemic stroke, the cortex directly adjacent to the ischemic core (i.e., the peri‐infarct cortex, PIC) undergoes plastic changes that facilitate motor recovery. Dopaminergic signaling is thought to support this process. However, isc…
View article: Pointing fingers at blood contact: mechanisms of subventricular zone neural stem cell differentiation
Pointing fingers at blood contact: mechanisms of subventricular zone neural stem cell differentiation Open
The limited ability of the central nervous system (CNS) to regenerate in adult mammals after injury or disease is a significant problem. Intriguingly, neural stem/progenitor cells (NSPCs) offer great promise for regenerating the CNS. Endog…
View article: Fibrinogen regulates lesion border‐forming reactive astrocyte properties after vascular damage
Fibrinogen regulates lesion border‐forming reactive astrocyte properties after vascular damage Open
Reactive astrocytes at the border of damaged neuronal tissue organize into a barrier surrounding the fibrotic lesion core, separating this central region of inflammation and fibrosis from healthy tissue. Astrocytes are essential to form th…
View article: Modulating scar formation for improving brain repair: from coagulation and inflammation to cell therapy
Modulating scar formation for improving brain repair: from coagulation and inflammation to cell therapy Open
View article: P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke
P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke Open
View article: In vivo functions of p75NTR: challenges and opportunities for an emerging therapeutic target
In vivo functions of p75NTR: challenges and opportunities for an emerging therapeutic target Open
View article: Id proteins: emerging roles in CNS disease and targets for modifying neural stemcell behavior
Id proteins: emerging roles in CNS disease and targets for modifying neural stemcell behavior Open
View article: Fibrinogen triggered signaling pathways modify stem cell behavior in central nervous system disease
Fibrinogen triggered signaling pathways modify stem cell behavior in central nervous system disease Open
View article: Fibrin hydrogels promote scar formation and prevent therapeutic angiogenesis in the heart
Fibrin hydrogels promote scar formation and prevent therapeutic angiogenesis in the heart Open
Therapeutic angiogenesis is the delivery of factors to promote vascular growth and holds promise for the treatment of ischemic heart conditions. Recombinant protein delivery to the myocardium by factor-decorated fibrin matrices is an attra…
View article: Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling
Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling Open
View article: Single-cell RNA-sequencing identifies the developmental trajectory of C-Myc-dependent NK1.1− T-bet+ intraepithelial lymphocyte precursors
Single-cell RNA-sequencing identifies the developmental trajectory of C-Myc-dependent NK1.1− T-bet+ intraepithelial lymphocyte precursors Open
Natural intraepithelial lymphocytes (IELs) are thymus-derived adaptive immune cells, which are important contributors to intestinal immune homeostasis. Similar to other innate-like T cells, they are induced in the thymus through high-avidi…
View article: The Concerted Action of E2-2 and HEB Is Critical for Early Lymphoid Specification
The Concerted Action of E2-2 and HEB Is Critical for Early Lymphoid Specification Open
The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted …
View article: TGFβ-Signaling and FOXG1-Expression Are a Hallmark of Astrocyte Lineage Diversity in the Murine Ventral and Dorsal Forebrain
TGFβ-Signaling and FOXG1-Expression Are a Hallmark of Astrocyte Lineage Diversity in the Murine Ventral and Dorsal Forebrain Open
Heterogeneous astrocyte populations are defined by diversity in cellular environment, progenitor identity or function. Yet, little is known about the extent of the heterogeneity and how this diversity is acquired during development. To inv…
View article: The concerted action of E2-2 and HEB is critical for early lymphoid specification
The concerted action of E2-2 and HEB is critical for early lymphoid specification Open
The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action i…
View article: Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage
Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage Open
View article: The E2A splice variant E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical development
The E2A splice variant E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical development Open
During corticogenesis, distinct classes of neurons are born from progenitor cells located in the ventricular and subventricular zones, from where they migrate towards the pial surface to assemble into highly organized layer-specific circui…
View article: Id3 Maintains Foxp3 Expression in Regulatory T Cells by Controlling a Transcriptional Network of E47, Spi-B, and SOCS3
Id3 Maintains Foxp3 Expression in Regulatory T Cells by Controlling a Transcriptional Network of E47, Spi-B, and SOCS3 Open
View article: ID(ealizing) control of adult subventricular zone neural stem/precursor cell differentiation for CNS regeneration
ID(ealizing) control of adult subventricular zone neural stem/precursor cell differentiation for CNS regeneration Open
The adult central nervous system (CNS) was considered a comparatively static tissue with little cell turnover. It is now well established that there is more plasticity than previously thought and that astrocytes act as neural stem/precurso…
View article: The balance of Id3 and E47 determines neural stem/precursor cell differentiation into astrocytes
The balance of Id3 and E47 determines neural stem/precursor cell differentiation into astrocytes Open
View article: Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions
Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions Open