Christian Scheller
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View article: Loss of Schwann cell’s normal rhythmic core clock gene expression and gain of rhythmic expression of oncogenic driver genes in malignant NF1-associated peripheral nerve sheath tumor
Loss of Schwann cell’s normal rhythmic core clock gene expression and gain of rhythmic expression of oncogenic driver genes in malignant NF1-associated peripheral nerve sheath tumor Open
Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor syndrome caused by pathogenic variants in the NF1 gene. Beside tumor formation, patients often have sleep disturbances, suggesting circadian involvement. Previous NF1 studies ha…
View article: Intranodal palisaded myofibroblastoma shows a unique epigenetic profile—first molecular study of their epigenetic and copy number variation profile
Intranodal palisaded myofibroblastoma shows a unique epigenetic profile—first molecular study of their epigenetic and copy number variation profile Open
Intranodal palisaded myofibroblastomas with amianthoid fibers (IPM) are rare mesenchymal neoplasms showing a myofibroblastic differentiation. Histopathologically, they might be difficult to distinguish from schwannoma or other neoplasia wi…
View article: The Protective Effect of Nimodipine in Schwann Cells Is Related to the Upregulation of LMO4 and SERCA3 Accompanied by the Fine-Tuning of Intracellular Calcium Levels
The Protective Effect of Nimodipine in Schwann Cells Is Related to the Upregulation of LMO4 and SERCA3 Accompanied by the Fine-Tuning of Intracellular Calcium Levels Open
Nimodipine is the current gold standard in the treatment of subarachnoid hemorrhage, as it is the only known calcium channel blocker that has been proven to improve neurological outcomes. In addition, nimodipine exhibits neuroprotective pr…
View article: Nimodipine Used with Vincristine: Protects Schwann Cells and Neuronal Cells from Vincristine-Induced Cell Death but Increases Tumor Cell Susceptibility
Nimodipine Used with Vincristine: Protects Schwann Cells and Neuronal Cells from Vincristine-Induced Cell Death but Increases Tumor Cell Susceptibility Open
The chemotherapeutic agent vincristine is commonly used for a variety of hematologic cancers, as well as solid tumors of the head and neck, bronchial carcinoma, as part of the procarbazine, lomustine and vincristine (PCV) regimen, for glio…
View article: Correlation of Immunomodulatory Cytokines with Tumor Volume and Cerebrospinal Fluid in Vestibular Schwannoma Patients
Correlation of Immunomodulatory Cytokines with Tumor Volume and Cerebrospinal Fluid in Vestibular Schwannoma Patients Open
Sporadic vestibular schwannomas (VSs) often exhibit slow or negligible growth. Nevertheless, some VSs increase significantly in volume within a few months or grow continuously. Recent evidence indicates a role of inflammation in promoting …
View article: Glycation Interferes with the Expression of Sialyltransferases and Leads to Increased Polysialylation in Glioblastoma Cells
Glycation Interferes with the Expression of Sialyltransferases and Leads to Increased Polysialylation in Glioblastoma Cells Open
Glioblastoma (GBM) is a highly aggressive brain tumor that often utilizes aerobic glycolysis for energy production (Warburg effect), resulting in increased methylglyoxal (MGO) production. MGO, a reactive dicarbonyl compound, causes protein…
View article: STT4SG-350: A Speech Corpus for All Swiss German Dialect Regions
STT4SG-350: A Speech Corpus for All Swiss German Dialect Regions Open
We present STT4SG-350 (Speech-to-Text for Swiss German), a corpus of Swiss German speech, annotated with Standard German text at the sentence level. The data is collected using a web app in which the speakers are shown Standard German sent…
View article: STT4SG-350: A Speech Corpus for All Swiss German Dialect Regions
STT4SG-350: A Speech Corpus for All Swiss German Dialect Regions Open
We present STT4SG-350 (Speech-to-Text for Swiss German), a corpus of Swiss German speech, annotated with Standard German text at the sentence level. The data is collected using a web app in which the speakers are shown Standard German sent…
View article: Establishment of vestibular schwannoma primary cell cultures obtained from cavitron ultrasonic surgical aspirator tissue material
Establishment of vestibular schwannoma primary cell cultures obtained from cavitron ultrasonic surgical aspirator tissue material Open
This approach could be particularly useful for testing substances that represent candidates for drug therapy of vestibular schwannoma.
View article: Massive obstruction of the spinal canal and progressive cervical myelopathy due to osseous hypertrophy of a facet joint: A case report
Massive obstruction of the spinal canal and progressive cervical myelopathy due to osseous hypertrophy of a facet joint: A case report Open
Cervical spondylotic myelopathy is one of the most common causes of cervical spinal cord dysfunction. A 65-year-old patient was admitted with slowly-progressing myelopathic symptoms. Imaging studies indicated a massive lesion, which was th…
View article: Recurrences and progression following microsurgery of vestibular schwannoma
Recurrences and progression following microsurgery of vestibular schwannoma Open
Background The treatment approach of vestibular schwannoma (VS) has seen a change in recent years, with a trend away from radical surgery towards preservation of cranial nerve function. A recent study reported recurrences as long as 20 yea…
View article: STT4SG-350: A Speech Corpus for All Swiss German Dialect Regions
STT4SG-350: A Speech Corpus for All Swiss German Dialect Regions Open
We present STT4SG-350 (Speech-to-Text for Swiss German), a corpus of Swiss German speech, annotated with Standard German text at the sentence level. The data is collected using a web app in which the speakers are shown Standard German sent…
View article: Impact of cancer stem cell marker expression in vestibular schwannoma progression
Impact of cancer stem cell marker expression in vestibular schwannoma progression Open
Background: Vestibular schwannoma (VS), a benign tumor originating from the Schwann cells surrounding the 8th cranial nerve, is one of the most common intracranial tumors. Affected patients suffer from symptoms such as impaired hearing, di…
View article: Impact of cancer stem cell marker expression in vestibular schwannoma progression
Impact of cancer stem cell marker expression in vestibular schwannoma progression Open
Background: Vestibular schwannoma (VS), a benign tumor originating from the Schwann cells surrounding the 8th cranial nerve, is one of the most common intracranial tumors. Affected patients suffer from symptoms such as impaired hearing, di…
View article: Glycation Leads to Increased Invasion of Glioblastoma Cells
Glycation Leads to Increased Invasion of Glioblastoma Cells Open
Glioblastoma (GBM) is a highly aggressive and invasive brain tumor with a poor prognosis despite extensive treatment. The switch to aerobic glycolysis, known as the Warburg effect, in cancer cells leads to an increased production of methyl…
View article: 2nd Swiss German Speech to Standard German Text Shared Task at SwissText 2022
2nd Swiss German Speech to Standard German Text Shared Task at SwissText 2022 Open
We present the results and findings of the 2nd Swiss German speech to Standard German text shared task at SwissText 2022. Participants were asked to build a sentence-level Swiss German speech to Standard German text system specialized on t…
View article: STT4SG-350: A Speech Corpus for All Swiss German Dialect Regions
STT4SG-350: A Speech Corpus for All Swiss German Dialect Regions Open
We present STT4SG-350, a corpus of Swiss German speech, annotated with Standard German text at the sentence level. The data is collected using a web app in which the speakers are shown Standard German sentences, which they translate to Swi…
View article: Correction to: Neural networks for estimation of facial palsy after vestibular schwannoma surgery
Correction to: Neural networks for estimation of facial palsy after vestibular schwannoma surgery Open
facial palsy after vestibular schwannoma surgery'.
View article: Neural networks for estimation of facial palsy after vestibular schwannoma surgery
Neural networks for estimation of facial palsy after vestibular schwannoma surgery Open
Purpose Facial nerve damage in vestibular schwannoma surgery is associated with A-train patterns in free-running EMG, correlating with the degree of postoperative facial palsy. However, anatomy, preoperative functional status, tumor size a…
View article: Rationale and design of the peripheral nerve tumor registry: an observational cohort study
Rationale and design of the peripheral nerve tumor registry: an observational cohort study Open
To date, the PNT registry has grown into an international study group with regular scientific and clinical exchange awaiting the first results of the retrospective study arm.
View article: Massive Obstruction of the Spinal Canal and Progressive Cervical Myelopathy due to Osseous Hypertrophy of a Facet Joint: A Case Report
Massive Obstruction of the Spinal Canal and Progressive Cervical Myelopathy due to Osseous Hypertrophy of a Facet Joint: A Case Report Open
Introduction: Cervical spondylotic myelopathy is one of the most common causes of cervical spinal cord dysfunction. Case Report: A 65-year-old patient was admitted with slowly-progressing myelopathic symptoms. Imaging studies indicated a m…
View article: Vestibular Schwannoma Volume and Tumor Growth Correlates with Macrophage Marker Expression
Vestibular Schwannoma Volume and Tumor Growth Correlates with Macrophage Marker Expression Open
Vestibular schwannoma is the most common benign tumor of the cerebellopontine angle and originates from Schwann cells surrounding the vestibulocochlear nerve. Since the size of the VS varies widely, affected patients suffer from symptoms o…
View article: Swiss German Speech to Text system evaluation
Swiss German Speech to Text system evaluation Open
We present an in-depth evaluation of four commercially available Speech-to-Text (STT) systems for Swiss German. The systems are anonymized and referred to as system a-d in this report. We compare the four systems to our STT model, referred…
View article: Nimodipine Treatment Protects Auditory Hair Cells from Cisplatin-Induced Cell Death Accompanied by Upregulation of LMO4
Nimodipine Treatment Protects Auditory Hair Cells from Cisplatin-Induced Cell Death Accompanied by Upregulation of LMO4 Open
Ototoxicity is one of the main dose-limiting side effects of cisplatin chemotherapy and impairs the quality of life of tumor patients dramatically. Since there is currently no established standard therapy targeting hearing loss in cisplati…