Explanipedia

Obesity Impairs Skin Barrier Function and Facilitates Allergic Sensitization in Mice Open

Arnošt Martínek, Andrea Deinzer, Roman G. Gerlach, Jana Petzold, Lea Semmler , et al. · 2025

Atopic dermatitis is a chronic inflammatory skin condition marked by intense itching and a weakened skin barrier. The compromised skin barrier often leads to exaggerated immune responses and greater sensitivity to allergens. Previous studi…

Epidémiologie des eaux usées : Identifier les pathogènes présents dans les eaux usées grâce au séquençage métagénomique à haut-débit. Open

Clémentine Wallet, Valerio Massimo Sora, Léo Di Jorio, Ghina El Soufi, Solène Fenninger , et al. · 2025

International audience

BCL11b interacts with RNA and proteins involved in RNA processing and developmental diseases Open

Haitham Sobhy, Marco De Rovere, Amina Aït-Ammar, Muhammad Kashif, Clémentine Wallet , et al. · 2024

La fin du VIH peut-elle devenir une réalité ? Open

Thomas Loustau, Muhammad Kashif, Théo Bernhardt, Clémentine Wallet, Christian Schwartz , et al. · 2024

International audience

Highly efficient and sensitive membrane-based concentration process allows quantification, surveillance, and sequencing of viruses in large volumes of wastewater Open

Ghina El Soufi, Léo Di Jorio, Zuzana Gerber, Nicolas Cluzel, J Van Assche , et al. · 2023

Wastewater-based epidemiology is experiencing exponential development. Despite undeniable advantages compared to patient-centered approaches (cost, anonymity, survey of large populations without bias, detection of asymptomatic infected peo…

Highly efficient and sensitive membrane-based concentration process allows quantification, surveillance, and sequencing of viruses in large volumes of wastewater Open

Ghina El Soufi, Léo Di Jorio, Zuzana Gerber, Nicolas Cluzel, Jeanne Van Assche , et al. · 2023

Wastewater-based epidemiology is experiencing exponential development. Despite undeniable advantages compared to patient-centered approaches (cost, anonymity, survey of large populations without bias, detection of asymptomatic infected peo…

Retinoic Acid–Related Orphan Receptor α Is Required for Generation of Th2 Cells in Type 2 Pulmonary Inflammation Open

Joseph Roberts, Anne Chevalier, Heike C. Hawerkamp, Aoife Yeow, Laura Matarazzo , et al. · 2023

The transcription factor retinoic acid–related orphan receptor α (RORα) is important in regulating several physiological functions, such as cellular development, circadian rhythm, metabolism, and immunity. In two in vivo animal models of t…

La mémoire de l'eau usée, ou l'importance d'une aquathèque dans le suivi épidémique via les eaux usées Open

Clémentine Wallet, Ghina El Soufi, Jeanne Van Assche, Thomas Loustau, Christian Schwartz , et al. · 2023

International audience

Développement d'un nouvel outil de concentration et de quantification de SARS-CoV-2 dans les eaux usées Open

Ghina El Soufi, Jeanne Van Assche, Thomas Loustau, Christian Schwartz, Dominique Trébouet , et al. · 2023

International audience

Obesity-Mediated Immune Modulation: One Step Forward, (Th)2 Steps Back Open

Viviane Schmidt, Andrew E. Hogan, Padraic G. Fallon, Christian Schwartz · 2022

Over the past decades, the relationship between the immune system and metabolism has become a major research focus. In this arena of immunometabolism the capacity of adipose tissue to secrete immunomodulatory molecules, including adipokine…

Novel role of UHRF1 in the epigenetic repression of the latent HIV-1 Open

Roxane Verdikt, Maryam Bendoumou, Sophie Bouchat, Lorena Nestola, Alexander Pasternak , et al. · 2022

Novel role of UHRF1 in the epigenetic repression of the latent HIV-1 Open

Roxane Verdikt, Maryam Bendoumou, Sophie Bouchat, Lorena Nestola, Alexander Pasternak , et al. · 2022

Funding was provided by the Belgian National Fund for Scientific Research (F.R.S.-FNRS, Belgium), the « Fondation Roi Baudouin », the NEAT (European AIDS Treatment Network) program, the Internationale Brachet Stiftung, ViiV Healthcare, the…

Break on Through: The Role of Innate Immunity and Barrier Defence in Atopic Dermatitis and Psoriasis Open

Heike C. Hawerkamp, Caoimhe Fahy, Padraic G. Fallon, Christian Schwartz · 2022

The human skin can be affected by a multitude of diseases including inflammatory conditions such as atopic dermatitis and psoriasis. Here, we describe how skin barrier integrity and immunity become dysregulated during these two most common…

Suicide gene therapy in cancer and HIV-1 infection: An alternative to conventional treatments Open

Sepideh Saeb, Jeanne Van Assche, Thomas Loustau, Olivier Rohr, Clémentine Wallet , et al. · 2021

Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo Open

Steven A. Saenz, Andrea Local, Tiffany Carr, Arvind Shakya, Shivsmriti Koul , et al. · 2021

Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expres…

Brain HIV-1 latently-infected reservoirs targeted by the suicide gene strategy Open

Sepideh Saeb, Mehrdad Ravanshad, Mahmoud Reza Pourkarim, Fadoua Daouad, Kazem Baesi , et al. · 2021

Are BET Inhibitors yet Promising Latency-Reversing Agents for HIV-1 Reactivation in AIDS Therapy? Open

Thanarat Salahong, Christian Schwartz, Rungroch Sungthong · 2021

AIDS first emerged decades ago; however, its cure, i.e., eliminating all virus sources, is still unachievable. A critical burden of AIDS therapy is the evasive nature of HIV-1 in face of host immune responses, the so-called “latency.” Rece…

Resveratrol Inhibits HCoV-229E and SARS-CoV-2 Coronavirus Replication In Vitro Open

Sébastien Pasquereau, Zeina Nehme, Sandy Haidar Ahmad, Fadoua Daouad, Jeanne Van Assche , et al. · 2021

A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China at the end of 2019 causing a large global outbreak. As treatments are of the utmost importance, drug repurposing embodies a rich and rapid …

Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage Open

Amina Aït-Ammar, Maxime Bellefroid, Fadoua Daouad, Valérie Martinelli, Jeanne Van Assche , et al. · 2021

Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo Open

Steven A. Saenz, Andrea Local, Tiffany Carr, Arvind Shakya, Shivsmriti Koul , et al. · 2021

Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expres…

BCL11b interacts with RNA and proteins involved in RNA processing and developmental diseases Open

Haitham Sobhy, Marco De Rovere, Amina Aït-Ammar, Muhammad Kashif, Clémentine Wallet , et al. · 2020

BCL11b (B-cell lymphoma/leukemia 11B, CTIP2) is a C2H2 zinc-finger transcription regulator and tumor suppressor. BCL11b is involved in lymphomagenesis and in fetal, central nervous system (CNS) and immune system developments. Therefore, it…

Dysregulated skin barrier function in Tmem79 mutant mice promotes IL‐17A‐dependent spontaneous skin and lung inflammation Open

Sean P. Saunders, Achilleas Floudas, Tara Moran, Ciara Byrne, Michael Rooney , et al. · 2020

Background Atopic dermatitis (AD) is associated with a dysregulation of the skin barrier and may predispose to the development of secondary allergic conditions, such as asthma. Tmem79 ma/ma mice harbor a mutation in the gene encoding Trans…

Brain HIV-1 latently-infected reservoirs targeted by the suicide gene strategy Open

Sepideh Saeb, Mehrdad Ravanshad, Mahmoud Reza Pourkarim, Fadoua Daouad, Kazem Baesi , et al. · 2020

Several strategies are currently investigated to reduce the pool of all HIV-1 reservoirs in infected patients in order to achieve functional cure. The most prominent HIV-1 cell reservoirs in the brain are microglial cells. Virus infection …

Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage Open

Amina Aït-Ammar, Maxime Bellefroid, Fadoua Daouad, Valérie Martinelli, Jeanne Van Assche , et al. · 2020

HIV-1 latency generates reservoirs that prevent viral eradication by the current therapies. To find strategies toward an HIV cure, detailed understandings of the molecular mechanisms underlying establishment and persistence of the reservoi…

The high and lows of type 2 asthma and mouse models Open

Padraic G. Fallon, Christian Schwartz · 2019

Futebol em tradução Open

Christian Schwartz · 2019

Este artigo faz uso do diário argentino Crítica para uma análise de relatos de imprensa sobre futebol como narrativas da consolidação de uma língua nacional e de um suposto estilo de jogo que é traduzido, por assim dizer, naquela mesma lín…

Microglial Cells: The Main HIV-1 Reservoir in the Brain Open

Clémentine Wallet, Marco De Rovere, Jeanne Van Assche, Fadoua Daouad, Christoph Stephan , et al. · 2019

Despite efficient combination of the antiretroviral therapy (cART), which significantly decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been achieved. Hidden HIV-1 in cellular and anatomic reservoirs is …

HIV-1 Vpr mediates the depletion of the cellular repressor CTIP2 to counteract viral gene silencing Open

Faezeh Forouzanfar, Sultan Ali, Clémentine Wallet, Marco De Rovere, Camille Ducloy , et al. · 2019

Mammals have evolved many antiviral factors impacting different steps of the viral life cycle. Associated with chromatin-modifying enzymes, the cellular cofactor CTIP2 contributes to HIV-1 gene silencing in latently infected reservoirs tha…

Schistosoma mansoni Worm Infection Regulates the Intestinal Microbiota and Susceptibility to Colitis Open

Achilleas Floudas, Gabriella Aviello, Christian Schwartz, Ian B. Jeffery, Paul W. O’Toole , et al. · 2019

Infection with parasite helminths induces potent modulation of the immune system of the host. Epidemiological and animal studies have shown that helminth infections can suppress or exacerbate unrelated autoimmune, allergic, and other infla…

Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL‐1β Open

Christian Schwartz, Tara Moran, Sean P. Saunders, Agnieszka Kaszlikowska, Achilleas Floudas , et al. · 2019

Background Atopic dermatitis (AD) is one of the most common skin diseases with a multifactorial etiology. Mutations leading to loss of skin barrier function are associated with the development of AD with group 2 innate lymphoid cells (ILC2…

Christian Schwartz YOU? Author Swipe