Explanipedia

Adverse outcomes in patients with atrial fibrillation and a pacemaker: a cohort study Open

Veronika Meier, Stefanie Aeschbacher, Michael Coslovsky, Andreas Gasser, Rebecca E. Paladini , et al. · 2025

Aims Patients with atrial fibrillation (AF) are at a high risk of adverse cardiovascular outcomes. Little is known about the specific population of AF patients with implanted pacemaker (PM) and their prognosis. Therefore, we aimed to compa…

Swiss national cardiac device registry: Changing trends in implantation procedures over the last two decades Open

Nadine Molitor, Angelo Auricchio, Etienne Delacrétaz, Giulia Dominichini, Michael Kühne , et al. · 2025

There was a pronounced increase in the number of pacemaker procedures in Switzerland in the last two decades and a marked increase in ICD procedures, which have plateaued recently. Overall, there is a constant increase in mean age of patie…

Anterior mitral isthmus line using pulsed-field ablation with the pentaspline catheter or radiofrequency ablation: procedural characteristics, safety, and mid-term outcomes Open

Jonas Brügger, Corinne Isenegger, Fabian Jordan, Behnam Subin, Reto Stump , et al. · 2025

Aims Pulsed-field ablation (PFA) is a non-thermal energy source for pulmonary vein isolation (PVI), offering advantages in safety and procedural efficiency. However, data comparing anterior mitral isthmus line (MIL) ablation using PFA vs. …

Risk Stratification in Left Bundle Branch Block After Transcatheter Aortic Valve Implantation Open

Patrick Badertscher, Teodor Serban, Grégoire Massoullié, Romain Eschalier, Léna Rivard , et al. · 2025

The novel, simplified ECG algorithm showed a superior performance for the rule-out and rule-in of infranodal conduction delay compared with current ESC ECG criteria.

Influence of proton pump inhibitors on the incidence and clinical course of oesophageal fistula following catheter ablation for atrial fibrillation: a subanalysis of the POTTER-AF study Open

Thomas Beiert, Vincent Knappe, Andreas Zietzer, V Schmidt, Helmut Pürerfellner , et al. · 2025

Feasibility and accuracy of wearable electrocardiogram monitoring in adult congenital heart disease Open

Florine Runge, Jonas Brügger, Francisco Javier Ruperti‐Repilado, Behnam Subin, Fabian Jordan , et al. · 2025

Sex differences in procedural characteristics, safety, and clinical outcomes of pulsed field ablation for atrial fibrillation Open

Fabian Jordan, Behnam Subin, Corinne Isenegger, Jonas Brügger, Jeanne du Fay de Lavallaz , et al. · 2025

Comparison of Two Different Pulsed Field Ablation Systems: The Dual Pulse System Study Open

Behnam Subin, Corinne Isenegger, David Spreen, Philipp Krisai, Sven Knecht , et al. · 2025

Background Recently, multiple pulsed field ablation (PFA)‐system were introduced for catheter ablation (CA) of atrial fibrillation (AF). However, data comparing procedural performance, the extent of low‐voltage areas (LVA), and myocardial …

Impact of alternative efficacy end point definitions on reported outcomes after ablation of paroxysmal atrial fibrillation – Insights from the COMPARE-CRYO study using continuous rhythm monitoring Open

Salik ur Rehman Iqbal, Thomas Kueffer, Sven Knecht, Patrick Badertscher, Jens Maurhofer , et al. · 2025

Alternative efficacy end point definitions have a significant impact on reported outcomes and health care utilization metrics after AF ablation. These findings are important when considering end point definitions other than the traditional…

External Validation of the REACT‐HF Score for Predicting Heart Failure in Patients With Atrial Fibrillation Open

Giorgio Moschovitis, Elia Rigamonti, Andrea Wiencierz, Michael Coslovsky, Steffen Blum , et al. · 2025

Background Validated risk prediction scores for incident heart failure (HF) in patients with atrial fibrillation are lacking. We aimed to externally validate the the HF prediction risk score derived from three large control randomized tria…

Cost-effectiveness of apixaban vs. aspirin for the reduction of thrombo-embolism in high-risk patients with device-detected atrial fibrillation: insights from the ARTESiA trial Open

André Lamy, Roopinder K. Sandhu, Wesley Tong, William F. McIntyre, Renato D. Lópes , et al. · 2025

Aims Apixaban was superior to aspirin for the prevention of stroke or systemic embolism in participants with subclinical atrial fibrillation (SCAF) in the Apixaban for the Reduction of Thromboembolism in Patients With Device-Detected Subcl…

Pacing beyond rhythm – improving myocardial function by tickling the heart electrically? Open

Christian Sticherling, Gerd Hasenfuß, Felix Mahfoud · 2025

Comparative analysis of newest-generation variable-diameter cryoballoon with pulsed-field ablation for the treatment of atrial fibrillation: the CRYO-PULSE Study Open

Behnam Subin, Corinne Isenegger, Felix Mahfoud, Michael Kühne, Sven Knecht , et al. · 2025

Pulsed-field ablation vs. thermal ablation for paroxysmal atrial fibrillation: a systematic review and meta-analysis of randomized controlled trials Open

Patrick Badertscher, Jeanne du Fay de Lavallaz, Tobias Reichlin, Laurent Roten, Thomas Kueffer , et al. · 2025

Impact of left atrial anatomy on pulmonary vein isolation with cryoballoon ablation: Insights from the randomized controlled COMPARE CRYO study Open

David Spreen, Thomas Kueffer, Salik ur Rehman Iqbal, Patrick Badertscher, Jens Maurhofer , et al. · 2025

Pulsed-field ablation versus radiofrequency ablation in patients undergoing repeat catheter ablation for atrial fibrillation Open

Corinne Isenegger, Gábor Bari, Rebecca Arnet, Fabian Jordan, David Spreen , et al. · 2025

In patients undergoing repeat CA after thermal PVI, PFA resulted in similar procedural characteristics, safety, and arrythmia-free survival compared with RFA.

Use of guideline-directed medical heart failure therapy in patients with suspected arrhythmia-induced cardiomyopathy Open

Rebecca Arnet, Corinne Isenegger, Sven Knecht, Jonas Brügger, Philipp Krisai , et al. · 2025

Life-threatening arrhythmia in patients with suspected acute myocarditis Open

Melina Krempke, Jasmin Büchel, K Bulatova, G Balestra, Philip Haaf , et al. · 2025

In patients with suspected AM, life-threatening arrhythmias were rare but associated with a 40% mortality rate. A combined model including 3 clinical variables ruled-out life-threatening arrhythmia with a high sensitivity and may help to g…

Inconclusive Single-Lead ECGs From Smart-Devices Open

Corinne Isenegger, Diego Mannhart, S Weidlich, Jonas Brügger, Teodor Serban , et al. · 2025

Automated rhythm classification is highly susceptible to baseline ECG anomalies. This study provides insights into the most appropriate patient population for smart device-based arrhythmia monitoring and offers guidance for selecting the o…

Catheter ablation for atrial fibrillation in patients with tricuspid regurgitation Open

Corinne Isenegger, Jonas Brügger, G Balestra, Beat A. Kaufmann, Fabian Jordan , et al. · 2025

Long-term follow up of single-chamber atrial pacing—system upgrade and Wenckebach block point behavior: potential implications for leadless AAI pacing? Open

Patrick Badertscher, Rebecca Arnet, Corinne Isenegger, Behnam Subin, Sven Knecht , et al. · 2025

Background Single chamber atrial pacing (AAI) provides a disease-specific treatment for sick sinus syndrome (SSS) but has largely been replaced by DDD pacing. With the advent of leadless atrial pacemakers (PM), there is growing interest in…

Catheter ablation for atrial fibrillation in patients with tricuspid regurgitation Open

Corinne Isenegger, Jan Bruegger, Faron Jordan, Sven Knecht, Philipp Krisai , et al. · 2025

Introduction Contemporary guidelines recommend early rhythm control strategies including catheter ablation (CA) for patients with symptomatic atrial fibrillation. The impact of coexisting tricuspid regurgitation (TR) on procedural characte…

Sex differences in electrophysiological characteristics of left bundle branch area pacing Open

Julia Pouly, Melina Krempke, David Spreen, K Bulatova, Sven Knecht , et al. · 2025

Background Conduction system pacing (CSP) with left bundle branch area pacing (LBBAP) is a novel and promising technique for pacemaker implantation. However, sex differences in the electrophysiological characteristics of LBBAP and its pote…

Discrimination of atrial fibrillation burden using clinical and cardiac imaging data Open

Andreas Gasser, Michael Coslovsky, M Liskij, Tobias Reichlin, L Roten , et al. · 2025

Background Current literature suggests that atrial fibrillation (AF) burden has prognostic implications in AF patients. However, it is not feasible to assess AF burden in all AF patients. Therefore, we aim to investigate whether clinical a…

Early postoperative electrocardiographic changes after left bundle branch area pacing Open

Edgardo Moretti, Samuel Stempfel, Julia Pouly, Beat Schaer, David Spreen , et al. · 2025

Background During left bundle area pacing (LBBAP), careful attention is given to lead positioning and the electrocardiographic features of the stimulated QRS complexes. Little is known about the early perioperative electrocardiographic cha…

Pulsed-field ablation versus radiofrequency ablation in patients undergoing repeat catheter ablation for atrial fibrillation Open

Gábor Bari, Corinne Isenegger, A R Arnet, F. Jordan, David Spreen , et al. · 2025

Background Pulsed-field ablation (PFA) is non-inferior compared to thermal energy sources such as radiofrequency ablation (RFA) or cryoballoon ablation for de novo pulmonary vein isolation (PVI). However, its potential value for repeat cat…

Predictors of pacing-induced cardiomyopathy in patients undergoing AV nodal ablation: insights from a Delphi process and retrospective cohort study Open

Nikola Kozhuharov, Peter Calvert, Ioanna Koniari, Aurélie Najm, A M Gstoehl , et al. · 2025

Background Pacing-induced cardiomyopathy (PICM) is a recognised complication in patients undergoing ablate and pace therapy. Identifying patients at high risk for PICM can enable tailored therapy, such as upfront CRT (biventricular pacing …

Temporal patterns of atrial fibrillation recurrence after catheter ablation using pulsed-field ablation Open

Faron Jordan, Corinne Isenegger, Rebecca Arnet, Sven Knecht, Philipp Krisai , et al. · 2025

Background The prognostic implications of temporal patterns of atrial fibrillation (AF) recurrence after catheter ablation might differ between thermal and non-thermal energy sources such as pulsed-field ablation (PFA). While recurrence of…

Pulsed-field ablation versus cryoballoon ablation in patients with persistent atrial fibrillation undergoing first catheter ablation Open

Corinne Isenegger, Jan Bruegger, Faron Jordan, Sven Knecht, Philipp Krisai , et al. · 2025

Background Catheter ablation (CA) for persistent atrial fibrillation (AF) is more challenging and associated with less favorable outcomes. While early studies showed similar outcomes for pulsed-field ablation (PFA) and cryoballoon ablation…

Adverse outcomes in patients with atrial fibrillation and a pacemaker: a cohort study Open

Valeria Meier, Michael Coslovsky, R. Kerler, Tobias Reichlin, Nicolas Rodondi , et al. · 2025

Background Patients with atrial fibrillation (AF) have a higher rate of pacemaker (PM) implantations compared to the general population. Little is known if a present PM in AF patients is associated with adverse cardiovascular outcomes. We …

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