Christian Thoben
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View article: Synchronizing droplet microfluidics and ion mobility spectrometry via the electrospray current recorded with a tailored low-noise, high-gain current amplifier
Synchronizing droplet microfluidics and ion mobility spectrometry via the electrospray current recorded with a tailored low-noise, high-gain current amplifier Open
In the process of coupling ion mobility spectrometry (IMS) and droplet microfluidics, the sample to be analyzed is ionized by electrospray ionization (ESI), thereby transferring the liquid samples into the gas phase with concurrent ionizat…
View article: Fast Chemical Analysis of Droplets Unlocked by Ultra-Fast Ion Mobility Spectrometry
Fast Chemical Analysis of Droplets Unlocked by Ultra-Fast Ion Mobility Spectrometry Open
This study presents the first coupling of high-throughput droplet microfluidics to an ultra-fast ion mobility spectrometer (IMS), providing a method for the label-free and comprehensive analysis of droplet contents at very high speeds. Bui…
View article: An observational laboratory study to evaluate an anesthetic gas adsorber without anesthetic gas scavenging system
An observational laboratory study to evaluate an anesthetic gas adsorber without anesthetic gas scavenging system Open
View article: Coupling Capillary Electrophoresis With a Shifted Inlet Potential High‐Resolution Ion Mobility Spectrometer
Coupling Capillary Electrophoresis With a Shifted Inlet Potential High‐Resolution Ion Mobility Spectrometer Open
We present the coupling of capillary electrophoresis to a custom‐built high‐resolution ion mobility spectrometer (IMS). This system integrates a shifted inlet potential IMS configuration with a customised nanoflow ESI sheath interface. It …
View article: Miniaturized Supercritical Fluid Chromatography Coupled with Ion Mobility Spectrometry: A Chip-Based Platform for Rapid Chiral and Complex Mixture Analysis
Miniaturized Supercritical Fluid Chromatography Coupled with Ion Mobility Spectrometry: A Chip-Based Platform for Rapid Chiral and Complex Mixture Analysis Open
This study presents the first coupling of miniaturized chip-based supercritical fluid chromatography (SFC) with ion mobility spectrometry (IMS) enabling rapid two-dimensional analysis of moderately polar compounds. For the first time, ioni…
View article: A dual-polarity ion mobility spectrometer for capturing hyper-fast chromatographic peaks
A dual-polarity ion mobility spectrometer for capturing hyper-fast chromatographic peaks Open
For higher analytical performance, ion mobility spectrometers (IMS), especially when analyzing complex mixtures, are often coupled with gas chromatographs (GC). However, analysis time remains a critical parameter in gas chromatography. The…
View article: Rapid Stereochemical Analysis of Glycosylations in Flow by Ion Mobility Spectrometry
Rapid Stereochemical Analysis of Glycosylations in Flow by Ion Mobility Spectrometry Open
Glycans are biologically important molecules that are difficult to synthesize and analyze due to their structural diversity and conformational flexibility. Stereoselective glycosylation reactions are key to achieving high‐yielding glycan s…
View article: P05 - Self-built low-cost pyrolyzer using Curie-Point temperature coupled to a gas chromatograph-ion mobility spectrometer
P05 - Self-built low-cost pyrolyzer using Curie-Point temperature coupled to a gas chromatograph-ion mobility spectrometer Open
View article: A hyper-fast gas chromatograph coupled to an ion mobility spectrometer with high repetition rate and flow-optimized ion source to resolve the short chromatographic peaks
A hyper-fast gas chromatograph coupled to an ion mobility spectrometer with high repetition rate and flow-optimized ion source to resolve the short chromatographic peaks Open
By combining the high selectivity of a gas chromatograph (GC) with the high sensitivity and decent selectivity of an ion mobility spectrometer (IMS), GC-IMS have become increasingly popular in many applications. However, most GC suffer fro…
View article: Ultra-fast polarity switching GC-IMS for the analysis of volatiles in biogas
Ultra-fast polarity switching GC-IMS for the analysis of volatiles in biogas Open
The Renewable Energy Act 2023 (§39i) requires reducing corn silage in biogas plants from 40 % to 30 % in 2026. Since corn silage yields the highest biogas per weight unit of all biogas feedstocks, this poses new challenges for biogas plant…
View article: Coated Blade Spray Ion Mobility Spectrometry
Coated Blade Spray Ion Mobility Spectrometry Open
Coated blade spray (CBS) is a microextraction technology with blades that serve as both the extraction device and the electrospray ionization (ESI) emitter. CBS is designed for easy and rapid extraction of analytes in complex matrices as w…
View article: Ultra-Fast Ion Mobility Spectrometer for High-Throughput Chromatography
Ultra-Fast Ion Mobility Spectrometer for High-Throughput Chromatography Open
Fast chromatography systems especially developed for high sample throughput applications require sensitive detectors with a high repetition rate. These high throughput techniques, including various chip-based microfluidic designs, often be…
View article: Rebounds of sevoflurane concentration during simulated trigger-free pediatric and adult anesthesia
Rebounds of sevoflurane concentration during simulated trigger-free pediatric and adult anesthesia Open
Background In trigger-free anesthesia a volatile anesthetic concentration of 5 parts per million (ppm) should not be exceeded. According to European Malignant Hyperthermia Group (EMHG) guideline, this may be achieved by removing the vapor,…
View article: How to Improve the Resolving Power of Compact Electrospray Ionization Ion Mobility Spectrometers
How to Improve the Resolving Power of Compact Electrospray Ionization Ion Mobility Spectrometers Open
Every drift tube ion mobility spectrometer (IMS) has an optimum drift voltage to reach maximum resolving power. This optimum depends, among other things, on the temporal and spatial width of the injected ion packet and the pressure within …
View article: Regarding the Influence of Additives and Additional Plasma-Induced Chemical Ionization on Adduct Formation in ESI/IMS/MS
Regarding the Influence of Additives and Additional Plasma-Induced Chemical Ionization on Adduct Formation in ESI/IMS/MS Open
Ion mobility spectrometers (IMS) separate ions based on their ion mobility, which depends mainly on collision cross-section, mass, and charge of the ions. However, the performance is often hampered in electrospray ionization (ESI) by the a…
View article: Towards a miniaturized on-site nano-high performance liquid chromatography electrospray ionization ion mobility spectrometer with online enrichment
Towards a miniaturized on-site nano-high performance liquid chromatography electrospray ionization ion mobility spectrometer with online enrichment Open
Safeguarding water quality is resource-intensive and costly. Especially in cases of accidents or disasters, compact devices that allow quick assessment of the current situation are lacking. The objective of this work is the development of …
View article: Preparation of Dräger Atlan A350 and General Electric Healthcare Carestation 650 anesthesia workstations for malignant hyperthermia susceptible patients
Preparation of Dräger Atlan A350 and General Electric Healthcare Carestation 650 anesthesia workstations for malignant hyperthermia susceptible patients Open
View article: 4.2 - Compact Electrospray Ionization Ion Mobility Spectrometer
4.2 - Compact Electrospray Ionization Ion Mobility Spectrometer Open
View article: Echtzeitüberwachung der Position eines Cochlea-Implantats während der Insertion in ein Innenohrphantom
Echtzeitüberwachung der Position eines Cochlea-Implantats während der Insertion in ein Innenohrphantom Open
Zusammenfassung Während der Implantation von Cochlea-Implantaten muss eine Verletzung bzw. Reizung des Gehörganggewebes vermieden werden. Ziel der vorliegenden Arbeit ist eine Echtzeitüberwachung der Position eines Cochlea-Implantats basie…