Christian W. Hamm
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View article: Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension govern right ventricle remodeling and recovery
Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension govern right ventricle remodeling and recovery Open
View article: Absorb® bioresorbable scaffold in “established” versus “off-label” coronary lesions: 5-year data from the GABI-R® registry
Absorb® bioresorbable scaffold in “established” versus “off-label” coronary lesions: 5-year data from the GABI-R® registry Open
View article: A Word of Caution—Potential Limitations of Pulmonary Artery Pressure Monitoring in Detecting Congestion Caused by Right-Sided Heart Failure
A Word of Caution—Potential Limitations of Pulmonary Artery Pressure Monitoring in Detecting Congestion Caused by Right-Sided Heart Failure Open
Background/Objectives: Patients with New York Heart Association (NYHA) class III heart failure (HF) suffer from frequent hospitalizations. Non-invasive pulmonary artery pressure (PAP) sensor-guided HF care has been shown to reduce hospital…
View article: Pregnancy-Associated Spontaneous Coronary Dissection in a 32-Year-Old During the Third Trimester
Pregnancy-Associated Spontaneous Coronary Dissection in a 32-Year-Old During the Third Trimester Open
We report a case of spontaneous coronary dissection (SCAD) in a 32-year-old pregnant patient during the seventh month of her second pregnancy. A 32-year-old pregnant woman in the 28th week of gestation was referred to our intensive care un…
View article: Antagonizing CCR2 With Propagermanium Leads to Altered Distribution of Macrophage Subsets and Favorable Tissue Remodeling After Myocardial Infarction in Mice
Antagonizing CCR2 With Propagermanium Leads to Altered Distribution of Macrophage Subsets and Favorable Tissue Remodeling After Myocardial Infarction in Mice Open
Aims: The aim of the present study was to investigate the inhibition of classically activated macrophages in myocardial infarction (MI) under the influence of the chemokine (C‐C motif) receptor 2 (CCR2) antagonist propagermanium (PPG). Met…
View article: A Flow Cytometric Approach to Identifying the Relative Abundance and Functional Capacities of Hemocyte Subsets in the American Cockroach, Periplaneta Americana (L.)
A Flow Cytometric Approach to Identifying the Relative Abundance and Functional Capacities of Hemocyte Subsets in the American Cockroach, Periplaneta Americana (L.) Open
View article: Association of aortic root diameter and vascular function with an exaggerated blood pressure response to exercise among elite athletes
Association of aortic root diameter and vascular function with an exaggerated blood pressure response to exercise among elite athletes Open
Background The systolic blood pressure/workload (SBP/MET) slope was recently reported to reliably identify an exaggerated blood pressure response (eBPR) in the normal population and in athletes. We investigated whether the aortic root diam…
View article: SPARCL1 and NT‐proBNP as biomarkers of right ventricular‐to‐pulmonary artery uncoupling in pulmonary hypertension
SPARCL1 and NT‐proBNP as biomarkers of right ventricular‐to‐pulmonary artery uncoupling in pulmonary hypertension Open
Aims SPARCL1 was recently identified as a biomarker of right ventricular (RV) maladaptation in patients with pulmonary hypertension (PH), and N‐terminal pro‐brain natriuretic protein (NT‐proBNP) is an established biomarker of RV failure in…
View article: Femoral or Radial Secondary Access in TAVR
Femoral or Radial Secondary Access in TAVR Open
During transfemoral TAVR, TR-SA was associated with lower rates of access site complications and severe bleeding compared to TF-SA. In fact, secondary access-related complications were 10× higher for TF-SA and frequently required invasive …
View article: Prognostic utility of mid-regional pro-adrenomedullin and growth differentiation factor 15 in patients undergoing transfemoral transcatheter aortic valve implantation
Prognostic utility of mid-regional pro-adrenomedullin and growth differentiation factor 15 in patients undergoing transfemoral transcatheter aortic valve implantation Open
Background Risk prediction in patients with severe, symptomatic aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) remains an unsolved issue. In addition to classical risk scoring systems, novel circulating biom…
View article: Prehospital tirofiban increases the rate of disrupted myocardial infarction in patients with ST-segment elevation myocardial infarction: insights from the On-TIME 2 trial
Prehospital tirofiban increases the rate of disrupted myocardial infarction in patients with ST-segment elevation myocardial infarction: insights from the On-TIME 2 trial Open
Aims In patients with ST-segment elevation myocardial infarction (STEMI), prehospital tirofiban significantly improved myocardial reperfusion. However, its impact on the rate of disrupted myocardial infarction (MI), particularly in the con…
View article: Comparison of interventional treatment options for coronary calcified nodules: A sub-analysis of the ROTA.shock trial
Comparison of interventional treatment options for coronary calcified nodules: A sub-analysis of the ROTA.shock trial Open
RA or IVL are unable to reduce the volume of the calcified plaque. CN modulation seems to be mainly induced by the stent implantation and not by RA or IVL.
View article: Epicardial fat volume is associated with primary coronary slow-flow phenomenon in patients with severe aortic stenosis undergoing transcatheter valve implantation
Epicardial fat volume is associated with primary coronary slow-flow phenomenon in patients with severe aortic stenosis undergoing transcatheter valve implantation Open
View article: Insights of Inflammatory Heart Involvement in Cardiac Sarcoidosis – A Systemic Review
Insights of Inflammatory Heart Involvement in Cardiac Sarcoidosis – A Systemic Review Open
Purpose of the Review The purpose of this paper is to review the current knowledge regarding imaging inflammation in cardiac sarcoidosis (CS). Recent Findings Noninvasive imaging methods like cardiac magnetic resonance (CMR) and 18-fluorod…
View article: The role of Matrix Metalloproteinase-2 and Galectin-3 as predictive biomarkers for all-cause mortality in patients undergoing transfemoral transcatheter aortic valve implantation
The role of Matrix Metalloproteinase-2 and Galectin-3 as predictive biomarkers for all-cause mortality in patients undergoing transfemoral transcatheter aortic valve implantation Open
In patients with severe aortic stenosis undergoing transfemoral TAVI, MMP-2 and to a lesser extent Gal-3, seem to have additive value in optimizing risk prediction and streamlining decision-making.
View article: Pulmonary Vein Isolation Followed by Biatrial Ablation of Rotational Activity in Patients with Persistent Atrial Fibrillation: Results of the Cryo-Vest Study
Pulmonary Vein Isolation Followed by Biatrial Ablation of Rotational Activity in Patients with Persistent Atrial Fibrillation: Results of the Cryo-Vest Study Open
Background and Aims: Noninvasive mapping allows the identification of patient-specific atrial rotational activity (RA) that might play a key role in the perpetuation of persistent atrial fibrillation (PsAF). So far, the impact of pulmonary…
View article: T2 Mapping Predicts Clinical Outcome over a Wide Range of Clinical Indications but Not Independent of Native T1
T2 Mapping Predicts Clinical Outcome over a Wide Range of Clinical Indications but Not Independent of Native T1 Open
View article: Native t1-mapping and Global Longitudinal Strain Are Modestly Correlated but Have Different Prognostic Implications
Native t1-mapping and Global Longitudinal Strain Are Modestly Correlated but Have Different Prognostic Implications Open
View article: t2-mapping Is a Valuable Tool in Monitoring Inflammation in Cardiac Sarcoidosis Under Immunosuppressive Therapy
t2-mapping Is a Valuable Tool in Monitoring Inflammation in Cardiac Sarcoidosis Under Immunosuppressive Therapy Open
View article: Association of cardiorespiratory fitness level with vascular function and subclinical atherosclerosis in the elderly
Association of cardiorespiratory fitness level with vascular function and subclinical atherosclerosis in the elderly Open
Purpose Physical exercise is crucial for healthy aging and plays a decisive role in the prevention of atherosclerotic cardiovascular disease (ASCVD). A higher level of cardiorespiratory fitness (CRF) in the elderly is associated with lower…
View article: Association of central blood pressure with an exaggerated blood pressure response to exercise among elite athletes
Association of central blood pressure with an exaggerated blood pressure response to exercise among elite athletes Open
Purpose The systolic blood pressure/workload (SBP/MET) slope was recently reported to be a reliable parameter to identify an exaggerated blood pressure response (eBPR) in the normal population and in athletes. However, it is unclear whethe…
View article: Challenges in developing and validating machine learning models for TAVI mortality risk prediction: reply
Challenges in developing and validating machine learning models for TAVI mortality risk prediction: reply Open
View article: Correlation of the novel biomarker cellular communication network factor 1 (CCN1) with miR-155 in serum of patients with dilated cardiomyopathy
Correlation of the novel biomarker cellular communication network factor 1 (CCN1) with miR-155 in serum of patients with dilated cardiomyopathy Open
Background We recently reported an independent prognostic ability of serum CCN1 to predict all-cause mortality in DCM, irrespective of its aetiology (inflammatory DCM (DCMi) or conventional DCM). Interestingly, CCN1 levels were lower in pa…
View article: Anterior mitral leaflet modification with endoscopic scissors during Tendyne implantation
Anterior mitral leaflet modification with endoscopic scissors during Tendyne implantation Open
View article: Ventricular arrhythmia without acute coronary syndrome as an indication for invasive coronary angiography
Ventricular arrhythmia without acute coronary syndrome as an indication for invasive coronary angiography Open
Background In the clinical setting of acute coronary syndrome, ventricular arrhythmia is a validated indication for urgent invasive coronary angiography (ICA). However, the indication for ICA in patients with ventricular arrhythmia but no …
View article: Long term follow-up of patent foramen closure due to embolic infarction in elderly patients
Long term follow-up of patent foramen closure due to embolic infarction in elderly patients Open
Background In patients < 60 years (yrs) with crytogenic embolism associated with a patent foramen ovale (PFO) guidelines recommend interventional closure based on several randomized studies. There is no recommendation for elderly patien…
View article: Inhibition of farnesylation of Ras-GTPases ameliorates inflammation-induced loss of endothelial barrier integrity and leukocyte transmigration
Inhibition of farnesylation of Ras-GTPases ameliorates inflammation-induced loss of endothelial barrier integrity and leukocyte transmigration Open
Background and Aims The family of small GTPases (Rho- and Ras-GTPases) is known to regulate endothelial cytoskeleton dynamics and hence barrier integrity. The role of Rho GTPases (RhoA and Rac1) in endothelial barrier integrity is well cha…
View article: Cardiac decompensation of patients before transcatheter aortic valve implantation—clinical presentation, responsiveness to associated medication, and prognosis
Cardiac decompensation of patients before transcatheter aortic valve implantation—clinical presentation, responsiveness to associated medication, and prognosis Open
Aims Cardiac decompensation (CD) in patients with aortic stenosis is a “red flag” for future adverse events. We classified patients undergoing transcatheter aortic valve implantation (TAVI) into those with acute, prior, or no prior CD at t…
View article: Transcatheter aortic valve implantation versus surgical aortic valve replacement in patients at low to intermediate surgical risk: rationale and design of the randomised DEDICATE Trial
Transcatheter aortic valve implantation versus surgical aortic valve replacement in patients at low to intermediate surgical risk: rationale and design of the randomised DEDICATE Trial Open
Transcatheter aortic valve implantation (TAVI) has become the preferred treatment option for patients with severe aortic stenosis at increased risk for surgical aortic valve replacement (SAVR) and for older patients irrespective of risk. H…
View article: Coronary intravascular lithotripsy and rotational atherectomy for severely calcified stenosis: Results from the ROTA.shock trial
Coronary intravascular lithotripsy and rotational atherectomy for severely calcified stenosis: Results from the ROTA.shock trial Open
Background Severely calcified coronary lesions present a particular challenge for percutaneous coronary intervention. Aims The aim of this randomized study was to determine whether coronary intravascular lithotripsy (IVL) is non‐inferior t…