Christian Waeber
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View article: General Practitioners’ Views on Mental Health Following Stroke: Findings from a Cross-Sectional Study
General Practitioners’ Views on Mental Health Following Stroke: Findings from a Cross-Sectional Study Open
Background Post-stroke mood changes currently affect a significant proportion of stroke survivors and are seldom recognised or treated in clinical practice. As general practitioners (GPs) typically know their patients well and see them reg…
View article: Behavioral assessment of neuropsychiatric outcomes in rodent stroke models
Behavioral assessment of neuropsychiatric outcomes in rodent stroke models Open
Stroke-associated mood disorders are less recognised than sensorimotor impairment, despite their high prevalence. Similarly, few experimental stroke studies assess non-sensorimotor functions. This study examined the prevalence and implemen…
View article: Discovery of Sphingosine Kinase Inhibition by Modified Quinoline-5,8-Diones
Discovery of Sphingosine Kinase Inhibition by Modified Quinoline-5,8-Diones Open
Background: Sphingosine kinase (SphK) overexpression is observed in many cancers, including breast, renal and leukaemia, which leads to increased cellular proliferation, survival and growth. SphK inhibition has been an attractive target fo…
View article: In Vivo Ocular Pharmacokinetics and Toxicity of Siponimod in Albino Rabbits
In Vivo Ocular Pharmacokinetics and Toxicity of Siponimod in Albino Rabbits Open
Siponimod is a promising agent for the inhibition of ocular neovascularization in diabetic retinopathy and age-related macular degeneration. Siponimod's development for ophthalmological application is hindered by the limited information av…
View article: The impact of fingolimod on Treg function in brain ischaemia
The impact of fingolimod on Treg function in brain ischaemia Open
Fingolimod has generally shown neuroprotective effects in stroke models. Here, we tested the hypothesis that fingolimod modulates T‐cell cytokine production towards a regulatory phenotype. Second, we investigated how fingolimod altered the…
View article: Estrogen modulation of cortical spreading depression
Estrogen modulation of cortical spreading depression Open
Background and aims Cortical spreading depression (CSD), a transient neuronal and glial depolarization that propagates slowly across the cerebral cortex, is the putative electrophysiological event underlying migraine aura and a headache tr…
View article: Siponimod As a Novel Inhibitor of Retinal Angiogenesis: In Vitro and In Vivo Evidence of Therapeutic Efficacy
Siponimod As a Novel Inhibitor of Retinal Angiogenesis: In Vitro and In Vivo Evidence of Therapeutic Efficacy Open
View article: Siponimod as a novel inhibitor of retinal angiogenesis: in vitro and in vivo evidence of therapeutic efficacy
Siponimod as a novel inhibitor of retinal angiogenesis: in vitro and in vivo evidence of therapeutic efficacy Open
Background and Purpose: S1P receptors control endothelial cell proliferation, migration, and survival. Evidence of the ability of S1P receptor modulators to influence multiple endothelial cell functions suggests their potential use for ant…
View article: Recombinant pregnancy-specific glycoprotein-1-Fc reduces functional deficit in a mouse model of permanent brain ischaemia
Recombinant pregnancy-specific glycoprotein-1-Fc reduces functional deficit in a mouse model of permanent brain ischaemia Open
The administration of rPSG1-Fc improved functional recovery in post-ischaemic mice without impacting infarct size. Improved outcome was associated with a modulation of the cytokine-secreting phenotype of CD4+ and CD8+…
View article: Preclinical Evaluation of Fingolimod in Rodent Models of Stroke With Age or Atherosclerosis as Comorbidities
Preclinical Evaluation of Fingolimod in Rodent Models of Stroke With Age or Atherosclerosis as Comorbidities Open
Preclinical data indicate that fingolimod improves outcome post-ischaemia. This study used a rigorous study design in normal male C57BL/6JOlaHsd mice and in mice with common stroke comorbidities to further evaluate the translational potent…
View article: Polymer based sustained drug delivery to the ocular posterior segment: barriers and future opportunities for the treatment of neovascular pathologies
Polymer based sustained drug delivery to the ocular posterior segment: barriers and future opportunities for the treatment of neovascular pathologies Open
There is an increasing momentum in research and pharmaceutical industry communities to design sustained, non-invasive delivery systems to treat chronic neovascular ocular diseases that affect the posterior segment of the eye including age-…
View article: Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE−/− mice in the presence and absence of immunomodulation with fingolimod
Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE−/− mice in the presence and absence of immunomodulation with fingolimod Open
In this work, the sphingosine-1-phosphate receptor modulator fingolimod was assessed as a preclinical candidate for the treatment of acute ischaemic stroke according to the Stroke Therapy Academic Industry Roundtable (STAIR) preclinical re…
View article: Sphingosine 1-phosphate, a potential target in neovascular retinal disease
Sphingosine 1-phosphate, a potential target in neovascular retinal disease Open
Neovascular ocular diseases (such as age-related macular degeneration, diabetic retinopathy and retinal vein occlusion) are characterised by common pathological processes that contribute to disease progression. These include angiogenesis, …
View article: The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia
The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia Open
View article: Acute Treatment With Fingolimod Does Not Confer Long-Term Benefit in a Mouse Model of Intracerebral Haemorrhage
Acute Treatment With Fingolimod Does Not Confer Long-Term Benefit in a Mouse Model of Intracerebral Haemorrhage Open
Intracerebral haemorrhage (ICH) has no specific treatment, but accounts for up to 15% of all strokes and has the highest mortality. Fingolimod (FTY720) is an immunomodulator approved for the management of multiple sclerosis, with abundant …
View article: Development of electrospun polymer scaffolds for the localized and controlled delivery of siponimod for the management of critical bone defects
Development of electrospun polymer scaffolds for the localized and controlled delivery of siponimod for the management of critical bone defects Open
Sphingosine 1-phosphate (S1P) receptor modulators can influence bone regeneration owing to their positive impact on osteoblast differentiation and neovascularisation. While previous studies have utilised non-specific S1P and fingolimod, th…
View article: A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy
A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy Open
View article: Bone regenerative potential of the selective sphingosine 1-phosphate receptor modulator siponimod: In vitro characterisation using osteoblast and endothelial cells
Bone regenerative potential of the selective sphingosine 1-phosphate receptor modulator siponimod: In vitro characterisation using osteoblast and endothelial cells Open
The repair of critical bone defects remains a significant therapeutic challenge. While the implantation of drug-eluting scaffolds is an option, a drug with the optimal pharmacological properties has not yet been identified. Agents acting a…
View article: Immunomodulatory Therapeutic Strategies in Stroke
Immunomodulatory Therapeutic Strategies in Stroke Open
The role of immunity in all stages of stroke is increasingly being recognized, from the pathogenesis of risk factors to tissue repair, leading to the investigation of a range of immunomodulatory therapies. In the acute phase of stroke, pro…
View article: The immune system and stroke: from current targets to future therapy
The immune system and stroke: from current targets to future therapy Open
Stroke is a major cause of morbidity and mortality worldwide. Despite the intensive search for new therapies, hundreds of agents targeting various pathophysiological mechanisms have failed clinical trials, and the thrombolytic agent tissue…
View article: The role and mechanisms of sphingosine kinase 2 in cerebral preconditioning-induced autophagy activation
The role and mechanisms of sphingosine kinase 2 in cerebral preconditioning-induced autophagy activation Open
Our previous findings suggest that sphingosine kinase 2(SPK2) mediates ischemic tolerance and autophagy in cerebral preconditioning. The aim of this study was to determine by which mechanism SPK2 activates autophagy in neural cells. In bot…
View article: Sphingosine 1-phosphate (S1P) signalling: Role in bone biology and potential therapeutic target for bone repair
Sphingosine 1-phosphate (S1P) signalling: Role in bone biology and potential therapeutic target for bone repair Open
View article: Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain
Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain Open
Our previous findings suggest that sphingosine kinase 2 (SPK2) mediates ischemic tolerance and autophagy in cerebral preconditioning. The aim of this study was to determine by which mechanism SPK2 activates autophagy in neural cells. In bo…
View article: Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke
Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke Open
Background and Purpose— The debate over the fact that experimental drugs proposed for the treatment of stroke fail in the translation to the clinical situation has attracted considerable attention in the literature. In this context, we pre…
View article: CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation
CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation Open
There are numerous barriers to white matter repair after central nervous system injury and the underlying mechanisms remain to be fully understood. In this study, we propose the hypothesis that inflammatory macrophages in damaged white mat…