Christiane E. Whetstone
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View article: Benralizumab Depletes IL‐5Rα‐Bearing Cells in Skin Lesions of Patients With Atopic Dermatitis
Benralizumab Depletes IL‐5Rα‐Bearing Cells in Skin Lesions of Patients With Atopic Dermatitis Open
Background Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by tissue eosinophilia and itch. We evaluated the effect of eosinophil depletion with benralizumab on markers of inflammation in the skin of patients wi…
View article: Evidence of Eczematous Skin Characteristics in Mild Allergic Asthma
Evidence of Eczematous Skin Characteristics in Mild Allergic Asthma Open
View article: Predicting airway hyperresponsiveness to methacholine in patients with atopic dermatitis
Predicting airway hyperresponsiveness to methacholine in patients with atopic dermatitis Open
In this small group study, our data show that patients with AD without asthma but with AHR have higher EASI scores, elevated eosinophil counts, and circulating IgE levels, along with lower values of FEV1/FVC (% predicted).
View article: Pathobiology and Regulation of Eosinophils, Mast Cells, and Basophils in Allergic Asthma
Pathobiology and Regulation of Eosinophils, Mast Cells, and Basophils in Allergic Asthma Open
Eosinophilia is a hallmark of allergic disorders, including asthma, allergic rhinitis, and atopic dermatitis. The onset and maintenance of allergic inflammation in atopic adults involves the activation of selective hemopoietic processes an…
View article: Regulation of Airway Epithelial-Derived Alarmins in Asthma: Perspectives for Therapeutic Targets
Regulation of Airway Epithelial-Derived Alarmins in Asthma: Perspectives for Therapeutic Targets Open
Asthma is a chronic respiratory condition predominantly driven by a type 2 immune response. Epithelial-derived alarmins such as thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, and IL-25 orchestrate the activation of downstream Th…
View article: Benralizumab for allergic asthma: a randomised, double-blind, placebo-controlled trial
Benralizumab for allergic asthma: a randomised, double-blind, placebo-controlled trial Open
Background Benralizumab induces rapid and near-complete depletion of eosinophils from blood and lung tissue. We investigated whether benralizumab could attenuate the allergen-induced late asthmatic response (LAR) in participants with aller…
View article: Effect of benralizumab on inflammation in skin after intradermal allergen challenge in patients with moderate-to-severe atopic dermatitis
Effect of benralizumab on inflammation in skin after intradermal allergen challenge in patients with moderate-to-severe atopic dermatitis Open
Background: Atopic dermatitis (AD) is a skin barrier dysfunction characterized by tissue eosinophilia. Objective: In patients with AD, we evaluated the effect of eosinophil depletion with benralizumab on markers of inflammation in skin aft…
View article: Immune Response Dynamics and Biomarkers in COVID-19 Patients
Immune Response Dynamics and Biomarkers in COVID-19 Patients Open
Background: The immune response dynamics in COVID-19 patients remain a subject of intense investigation due to their implications for disease severity and treatment outcomes. We examined changes in leukocyte levels, eosinophil activity, an…
View article: Comparison of upper and lower airway expression of SARS‐CoV‐2 receptors in allergic asthma
Comparison of upper and lower airway expression of SARS‐CoV‐2 receptors in allergic asthma Open
Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) which is responsible for Coronavirus disease-19 (COVID-19), infects host cells through the cell surface receptor angiotensin-converting enzyme 2 (ACE2) in conjunction with the ce…
View article: Multifactorial Causes and Consequences of TLSP Production, Function, and Release in the Asthmatic Airway
Multifactorial Causes and Consequences of TLSP Production, Function, and Release in the Asthmatic Airway Open
Disruption of the airway epithelium triggers a defensive immune response that begins with the production and release of alarmin cytokines. These epithelial-derived alarmin cytokines, including thymic stromal lymphopoietin (TSLP), are produ…
View article: Machine learning enabled detection of COVID-19 pneumonia using exhaled breath analysis: a proof-of-concept study
Machine learning enabled detection of COVID-19 pneumonia using exhaled breath analysis: a proof-of-concept study Open
Detection of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) relies on real-time-reverse-transcriptase polymerase chain reaction (RT-PCR) on nasopharyngeal swabs. The false-negative rate of RT-PCR can be high when viral bu…
View article: Gene Polymorphisms of Epithelial Cell-Derived Alarmins and Their Effects on Protein Levels and Disease Severity in Patients with COVID-19
Gene Polymorphisms of Epithelial Cell-Derived Alarmins and Their Effects on Protein Levels and Disease Severity in Patients with COVID-19 Open
Background: The immune response in COVID-19 is characterized by the release of alarmin cytokines, which play crucial roles in immune activation and inflammation. The interplay between these cytokines and genetic variations may influence di…
View article: Protein expression of <scp>SARS‐CoV</scp>‐2 receptors <scp>ACE2</scp> and <scp>TMPRSS2</scp> in allergic airways after allergen challenge
Protein expression of <span>SARS‐CoV</span>‐2 receptors <span>ACE2</span> and <span>TMPRSS2</span> in allergic airways after allergen challenge Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes the angiotensin-converting enzyme 2 (ACE2) receptor in conjunction with the cell surface transmembrane protease serine 2 (TMPRSS2) to enter host cells.1 The type 2 (T2) …
View article: The Genetic Factors of the Airway Epithelium Associated with the Pathology of Asthma
The Genetic Factors of the Airway Epithelium Associated with the Pathology of Asthma Open
Asthma is a chronic disease of the airways characterized by inflammation, tightened muscles, and thickened airway walls leading to symptoms such as shortness of breath, chest tightness, and cough in patients. The increased risk of asthma i…
View article: The Role of Airway Epithelial Cell Alarmins in Asthma
The Role of Airway Epithelial Cell Alarmins in Asthma Open
The airway epithelium is the first line of defense for the lungs, detecting inhaled environmental threats through pattern recognition receptors expressed transmembrane or intracellularly. Activation of pattern recognition receptors trigger…
View article: Regulation of Eosinophilia in Asthma—New Therapeutic Approaches for Asthma Treatment
Regulation of Eosinophilia in Asthma—New Therapeutic Approaches for Asthma Treatment Open
Asthma is a complex and chronic inflammatory disease of the airways, characterized by variable and recurring symptoms, reversible airflow obstruction, bronchospasm, and airway eosinophilia. As the pathophysiology of asthma is becoming clea…
View article: The Effect Of Prednisolone Treatment On Histopathological Outcomes In Skin Of Patients With Atopic Dermatitis
The Effect Of Prednisolone Treatment On Histopathological Outcomes In Skin Of Patients With Atopic Dermatitis Open
View article: Prednisolone Treatment Reduces Type 2 Inflammation In Skin Lesions Of Patients With Atopic Dermatitis
Prednisolone Treatment Reduces Type 2 Inflammation In Skin Lesions Of Patients With Atopic Dermatitis Open