Christiane Gasperi
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View article: Genetic Risk Variants for Multiple Sclerosis and Other Loci Linked to Intrathecal Immunoglobulin G Synthesis
Genetic Risk Variants for Multiple Sclerosis and Other Loci Linked to Intrathecal Immunoglobulin G Synthesis Open
Our study revealed a previously unknown association between an intronic variant in SAMD5 with intrathecal IgG synthesis and identified a potential causal variant within the IGHC locus. It further provides evidence for possible effec…
View article: Correction: Pharmacogenomics of clinical response to Natalizumab in multiple sclerosis: a genome-wide multi-centric association study
Correction: Pharmacogenomics of clinical response to Natalizumab in multiple sclerosis: a genome-wide multi-centric association study Open
View article: Insights Into Disability and Disability Progression in People With Multiple Sclerosis Using Large‐Scale Healthcare Data
Insights Into Disability and Disability Progression in People With Multiple Sclerosis Using Large‐Scale Healthcare Data Open
Background Identifying predictors for disability progression is crucial for managing multiple sclerosis (MS). This study aims to explore levels of disability and informative factors for disability progression in people with MS (PwMS) using…
View article: Replication of the 2023 radiologically isolated syndrome criteria in a multi-centre cohort
Replication of the 2023 radiologically isolated syndrome criteria in a multi-centre cohort Open
Radiologically isolated syndrome (RIS) represents a pivotal stage for identifying individuals at high risk of transitioning into multiple sclerosis (MS). Early therapy initiation reduces the risk of conversion. The 2023-RIS criteria were p…
View article: Early comorbidities and diagnostic challenges in people with multiple sclerosis with possible impact on disease management
Early comorbidities and diagnostic challenges in people with multiple sclerosis with possible impact on disease management Open
Background Comorbidities in people with multiple sclerosis (PwMS) can affect disease course and quality of life. Objectives To investigate comorbidities in the five years after diagnosis, timing of comorbidity occurrence, age and sex effec…
View article: Single-cell analysis of cerebrospinal fluid reveals common features of neuroinflammation
Single-cell analysis of cerebrospinal fluid reveals common features of neuroinflammation Open
Neuroinflammation is often characterized by immune cell infiltrates in the cerebrospinal fluid (CSF). Here, we apply single-cell RNA sequencing to explore the functional characteristics of these cells in patients with various inflammatory,…
View article: Serum neurofilament light chain predicts disease severity in axonal variants of acute immune neuropathies: A retrospective monocentric cohort study
Serum neurofilament light chain predicts disease severity in axonal variants of acute immune neuropathies: A retrospective monocentric cohort study Open
Background and purpose The purpose was to explore the prognostic utility of neurofilament light chain (NfL) in patients with immune‐mediated polyradiculoneuropathies (IMPs). Methods This retrospective monocentric study analysed serum and c…
View article: Vaccination as a risk factor for pediatric multiple sclerosis: Insights from a retrospective case–control study
Vaccination as a risk factor for pediatric multiple sclerosis: Insights from a retrospective case–control study Open
This study evaluated the association between pediatric multiple sclerosis and vaccinations within 5 years before diagnosis using German ambulatory claims data. Children with multiple sclerosis ( n = 346) aged 9–17 were analyzed with logist…
View article: Proteomics Reveals Age as Major Modifier of Inflammatory CSF Signatures in Multiple Sclerosis
Proteomics Reveals Age as Major Modifier of Inflammatory CSF Signatures in Multiple Sclerosis Open
This study unveils a unique CSF proteomic signature in MS, providing new pathophysiologic insights and identifying novel biomarker candidates and potential therapeutic targets. Our findings highlight similar immunologic mechanisms in relap…
View article: Pharmacogenomics of clinical response to Natalizumab in multiple sclerosis: a genome-wide multi-centric association study
Pharmacogenomics of clinical response to Natalizumab in multiple sclerosis: a genome-wide multi-centric association study Open
View article: Genetic mapping across autoimmune diseases reveals shared associations and mechanisms
Genetic mapping across autoimmune diseases reveals shared associations and mechanisms Open
View article: Issue Information
Issue Information Open
Wiley is a founding member of the UN-backed HINARI, AGORA, and OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries.
View article: Vaccination frequency in people newly diagnosed with multiple sclerosis
Vaccination frequency in people newly diagnosed with multiple sclerosis Open
Background: Infections are discussed as risk factor for multiple sclerosis (MS) development and relapses. This may lead to decreased vaccination frequency in newly diagnosed patients. Objective: The aim of this study was to evaluate the re…
View article: A Genetic Risk Variant for Multiple Sclerosis Severity is Associated with Brain Atrophy
A Genetic Risk Variant for Multiple Sclerosis Severity is Associated with Brain Atrophy Open
The minor allele of the genetic variant rs10191329 in the DYSF‐ZNF638 locus is associated with unfavorable long‐term clinical outcomes in multiple sclerosis patients. We investigated if rs10191329 is associated with brain atrophy measured …
View article: Locus for severity implicates CNS resilience in progression of multiple sclerosis
Locus for severity implicates CNS resilience in progression of multiple sclerosis Open
View article: A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases
A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases Open
View article: Retrospective cohort study to devise a treatment decision score predicting adverse 24-month radiological activity in early multiple sclerosis
Retrospective cohort study to devise a treatment decision score predicting adverse 24-month radiological activity in early multiple sclerosis Open
Background: Multiple sclerosis (MS) is a chronic neuroinflammatory disease affecting about 2.8 million people worldwide. Disease course after the most common diagnoses of relapsing-remitting multiple sclerosis (RRMS) and clinically isolate…
View article: Lesion location across diagnostic regions in multiple sclerosis
Lesion location across diagnostic regions in multiple sclerosis Open
View article: Single Cell Analysis of Cerebrospinal Fluid Reveals Common Features of Neuroinflammation
Single Cell Analysis of Cerebrospinal Fluid Reveals Common Features of Neuroinflammation Open
View article: Association of the retinal vasculature, intrathecal immunity, and disability in multiple sclerosis
Association of the retinal vasculature, intrathecal immunity, and disability in multiple sclerosis Open
Background Optical coherence tomography angiography (OCT-A) is a novel technique allowing non-invasive assessment of the retinal vasculature. During relapsing remitting multiple sclerosis (RRMS), retinal vessel loss occurs in eyes sufferin…
View article: Association of pregnancies with risk of multiple sclerosis
Association of pregnancies with risk of multiple sclerosis Open
Background: Pregnancies have an impact on the disease course of multiple sclerosis (MS), but their relationship with MS risk is yet unclear. Objective: To determine the relationships of pregnancies and gynecological diagnoses with MS risk.…
View article: Ultrasound-detected inflammation is more common in clinically manifest hand osteoarthritis than in painless bony enlarged finger joints: subanalysis of the population-based Bruneck study
Ultrasound-detected inflammation is more common in clinically manifest hand osteoarthritis than in painless bony enlarged finger joints: subanalysis of the population-based Bruneck study Open
Purpose: The aim of this article is to examine the extent of structural and inflammatory lesions by ultrasound in elderly subjects with hand osteoarthritis (HOA) fulfilling the ACR classification criteria (Group A), in subjects with painle…
View article: Gray matter atrophy in relapsing-remitting multiple sclerosis is associated with white matter lesions in connecting fibers
Gray matter atrophy in relapsing-remitting multiple sclerosis is associated with white matter lesions in connecting fibers Open
Background: Lesions of brain white matter (WM) and atrophy of brain gray matter (GM) are well-established surrogate parameters in multiple sclerosis (MS), but it is unclear how closely these parameters relate to each other. Objective: To a…
View article: Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity Open
View article: Joint analysis reveals shared autoimmune disease associations and identifies common mechanisms
Joint analysis reveals shared autoimmune disease associations and identifies common mechanisms Open
Autoimmune and inflammatory diseases are polygenic disorders of the immune system. Many genomic loci harbor risk alleles for several diseases, but the limited resolution of genetic mapping prevents determining if the same allele is respons…
View article: Shared associations identify causal relationships between gene expression and immune cell phenotypes
Shared associations identify causal relationships between gene expression and immune cell phenotypes Open
View article: Treatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-beta: a GWAS
Treatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-beta: a GWAS Open
View article: Shared associations identify causal relationships between gene expression and immune cell phenotypes
Shared associations identify causal relationships between gene expression and immune cell phenotypes Open
Genetic mapping studies have identified thousands of associations between common variants and hundreds of human traits. Translating these associations into mechanisms is complicated by two factors: they fall into gene regulatory regions; a…
View article: Genetic determinants of the humoral immune response in MS
Genetic determinants of the humoral immune response in MS Open
Although some HLA alleles seem to primarily drive the extent of humoral immune responses in the CNS by increasing CSF B cells and plasmablasts, genetic variants at the immunoglobulin heavy chain constant locus might regulate intrathecal im…
View article: Treatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-beta
Treatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-beta Open
Background: Upon treatment with biopharmaceuticals, the immune system may produce anti-drug antibodies (ADA) that inhibit the therapy. Up to 40% of multiple sclerosis patients treated with interferon β (IFNβ) develop ADA, for which a genet…