Christiane Gasse
YOU?
Author Swipe
View article: Antipsychotic polypharmacy in patients with schizophrenia between 1999 and 2024 in Denmark: Prevalence, time trends, and combinations
Antipsychotic polypharmacy in patients with schizophrenia between 1999 and 2024 in Denmark: Prevalence, time trends, and combinations Open
Antipsychotic polypharmacy (APP) remains common in the treatment of schizophrenia despite increased risk of adverse events and limited evidence of additional efficacy compared to antipsychotic monotherapy (APM). We conducted a nationwide, …
View article: Vocational Rehabilitation in Young Adults With Incident Schizophrenia—A Danish Retrospective Cohort Study
Vocational Rehabilitation in Young Adults With Incident Schizophrenia—A Danish Retrospective Cohort Study Open
Introduction The aim of this study was to compare the multidisciplinary vocational intervention, Morpheus, with standard vocational rehabilitation for young adults with incident schizophrenia undergoing the OPUS specialised early intervent…
View article: Treatment Resistant Depression (TRD) and treatment response of repetitive Transcranial Magnetic Stimulation (rTMS)
Treatment Resistant Depression (TRD) and treatment response of repetitive Transcranial Magnetic Stimulation (rTMS) Open
Introduction Treatment-Resistant Depression (TRD) is commonly defined as an inadequate response to two or more antidepressant trials. The severity of TRD can be evaluated by means of the Maudsley Staging Method (MSM). The MSM consists of f…
View article: Dementia and influenza vaccination: Time trends and predictors of vaccine uptake among older adults
Dementia and influenza vaccination: Time trends and predictors of vaccine uptake among older adults Open
Between 2002/03 and 2018/19 vaccine coverage among older adults in Denmark was <60 %, regardless of dementia status, not reaching the WHO target of 75 %. Home-living older adults with dementia were 24 % less likely to receive an influenza …
View article: Bladder drugs and risk of dementia: Danish nationwide active comparator study
Bladder drugs and risk of dementia: Danish nationwide active comparator study Open
Objective To assess the association between cumulative use of anticholinergic bladder drugs and risk of all cause dementia compared with non-use and use of the β3 agonist bladder drug, mirabegron. Design Danish nationwide active comparator…
View article: Pharmacogenomic markers associated with drug-induced QT prolongation: a systematic review
Pharmacogenomic markers associated with drug-induced QT prolongation: a systematic review Open
Data sets generated by this review are available at figshare: DOI: 10.6084/m9.figshare.27959616.
View article: Opioids and Dementia in the Danish Population
Opioids and Dementia in the Danish Population Open
Importance Opioids have been studied as a potential risk factor for dementia, but evidence concerning long-term noncancer opioid use and exclusive use of weak opioids and associated dementia risk is sparse. Objective To assess the associat…
View article: Depression Treatment Trajectories and Associated Social Determinants: A Three‐Year Follow‐Up Study in 66,540 Older Adults Undergoing First‐Time Depression Treatment in Denmark
Depression Treatment Trajectories and Associated Social Determinants: A Three‐Year Follow‐Up Study in 66,540 Older Adults Undergoing First‐Time Depression Treatment in Denmark Open
Objective This study aimed to describe depression treatment patterns, identify unique trajectory groups using a group‐based trajectory approach, and explore associated social determinants in older adults undergoing first‐time depression tr…
View article: Sociodemographics and clinical factors associated with depression treatment outcomes in 65,741 first-time users of selective serotonin reuptake inhibitors: A Danish cohort study in older adults
Sociodemographics and clinical factors associated with depression treatment outcomes in 65,741 first-time users of selective serotonin reuptake inhibitors: A Danish cohort study in older adults Open
Our findings emphasize considering patient characteristics in clinical decisions, as they can influence the clinical course of those undergoing depression treatment.
View article: Comparative effectiveness of selective serotonin reuptake inhibitors (SSRIs) for depression in 43,061 older adults with chronic somatic diseases: A Danish target trial emulation study
Comparative effectiveness of selective serotonin reuptake inhibitors (SSRIs) for depression in 43,061 older adults with chronic somatic diseases: A Danish target trial emulation study Open
View article: Response to “Comment on ‘Proton pump inhibitors and dementia: A nationwide population‐based study’”
Response to “Comment on ‘Proton pump inhibitors and dementia: A nationwide population‐based study’” Open
We appreciate the interest from Lu et al. suggesting a possible influence on dementia risk owing to the use of aluminum-containing drugs for acid-related disorders among users of proton pump inhibitors (PPIs).1, 2 The association between e…
View article: Excessive mortality risk associated with new opioid use in older people with dementia
Excessive mortality risk associated with new opioid use in older people with dementia Open
Background Opioids have been associated with an increased excess mortality‐risk in the general population. Older people with dementia have been prescribed opioids more frequent and the use of strong opioids has increased considerably over …
View article: Proton pump inhibitors and dementia: A nationwide population‐based study
Proton pump inhibitors and dementia: A nationwide population‐based study Open
INTRODUCTION Proton pump inhibitors (PPIs) may increase dementia risk. However, it is currently unknown whether timing of exposure or age at dementia diagnosis influence the risk. METHODS We assessed associations between cumulative PPI use…
View article: Dementia and influenza vaccination ‐ Time trends and predictors of vaccine uptake among older adults
Dementia and influenza vaccination ‐ Time trends and predictors of vaccine uptake among older adults Open
Background Older adults with dementia are at an increased risk of hospitalizations with respiratory infections and death. This emphasizes the need for increased focus on preventive measures, such as influenza vaccination, in this vulnerabl…
View article: Do sociodemographic and clinical factors affect the selection of initial antidepressant treatment for depression in older adults? Results from a nationwide descriptive study in Denmark
Do sociodemographic and clinical factors affect the selection of initial antidepressant treatment for depression in older adults? Results from a nationwide descriptive study in Denmark Open
View article: Maternal antipsychotic use during pregnancy and congenital malformations
Maternal antipsychotic use during pregnancy and congenital malformations Open
View article: Concurrent use of polypharmacy and potentially inappropriate medications with antidepressants in older adults: A nationwide descriptive study in Denmark during 2015–2019
Concurrent use of polypharmacy and potentially inappropriate medications with antidepressants in older adults: A nationwide descriptive study in Denmark during 2015–2019 Open
High polypharmacy and PIM use with antidepressants underline the importance of regularly reviewing pharmacological treatments in older adults with depression.
View article: Antidepressant treatment initiation and public sick-leave compensation in the following year: a register-based prospective cohort study in Denmark
Antidepressant treatment initiation and public sick-leave compensation in the following year: a register-based prospective cohort study in Denmark Open
Antidepressant treatment initiation was associated with PLSC. The highest risk of PLSC was seen for antidepressants with sedative side effects. Some types of antidepressants were associated with a lower risk of PLSC in the year following t…
View article: Treatment indications and potential off‐label use of antidepressants among older adults: A population‐based descriptive study in Denmark
Treatment indications and potential off‐label use of antidepressants among older adults: A population‐based descriptive study in Denmark Open
Objectives Off‐label prescriptions of antidepressants may be of special concern in older‐adults. We aimed to study the potential off‐label use of antidepressants among adults ≥65 years by describing the patterns, trends, and factors associ…
View article: Association between cholesterol and response to escitalopram and nortriptyline in patients with major depression: Study combining clinical and register-based information
Association between cholesterol and response to escitalopram and nortriptyline in patients with major depression: Study combining clinical and register-based information Open
View article: Psychopharmacological treatment patterns prior to a schizophrenia diagnosis: A Danish nationwide study
Psychopharmacological treatment patterns prior to a schizophrenia diagnosis: A Danish nationwide study Open
Pre-diagnostic psychotropic drug use in schizophrenia was frequent but stable between 1999 and 2019 despite an earlier identification of schizophrenia patients. Our findings emphasize the continued importance of thorough diagnostic intervi…
View article: Free‐of‐charge dispensing of antipsychotics for schizophrenia in Denmark: Impact on the nationwide prescription registry and redemption of somatic medications
Free‐of‐charge dispensing of antipsychotics for schizophrenia in Denmark: Impact on the nationwide prescription registry and redemption of somatic medications Open
Objective Free‐of‐charge dispensing of antipsychotics for schizophrenia was introduced in Denmark around 2008. However, free‐of‐charge dispensing is not recorded in the Danish National Prescription Register (DNPR), potentially introducing …
View article: Clinical Impact of Functional CYP2C19 and CYP2D6 Gene Variants on Treatment with Antidepressants in Young People with Depression: A Danish Cohort Study
Clinical Impact of Functional CYP2C19 and CYP2D6 Gene Variants on Treatment with Antidepressants in Young People with Depression: A Danish Cohort Study Open
Background: The clinical impact of the functional CYP2C19 and CYP2D6 gene variants on antidepressant treatment in people with depression is not well studied. Here, we evaluate the utility of pharmacogenetic (PGx) testing in psychiatry by i…
View article: Clinical impact of functional CYP2C19 and CYP2D6 gene variants on treatment outcomes in patients with depression: a Danish cohort study
Clinical impact of functional CYP2C19 and CYP2D6 gene variants on treatment outcomes in patients with depression: a Danish cohort study Open
Introduction Pharmacogenetic (PGx) targets to optimize drug therapy, but its implementation is rare. Objectives We evaluate the clinical utility of PGx testing in psychiatry by investigating the one-year risks of clinical outcomes in patie…
View article: Pharmacogenetic CYP2D6 variability, phenoconversion and treatment outcomes: A Danish population-based cohort study in 6,798 individuals initiating atomoxetine treatment
Pharmacogenetic CYP2D6 variability, phenoconversion and treatment outcomes: A Danish population-based cohort study in 6,798 individuals initiating atomoxetine treatment Open
Introduction Atomoxetine, a first-line treatment option for ADHD, is affected by pharmacogenetic (PGx) variation of the drug-metabolizing enzyme CYP2D6. Despite the recommendation of CYP2D6 testing, the use of PGx-guided dosing remains low…
View article: Life-time Actionable Pharmacogenetic Drug Use: A Population-based Cohort Study in 86 040 Young People With and Without Mental Disorders in Denmark
Life-time Actionable Pharmacogenetic Drug Use: A Population-based Cohort Study in 86 040 Young People With and Without Mental Disorders in Denmark Open
Objective To describe life-time use of current actionable pharmacogenetic (PGx) somatic and psychotropic drugs according to international PGx consortia in people with and without hospital-diagnosed mental disorders in the Danish population…
View article: Adherence to Direct Oral Anticoagulants in Patients With Non-Valvular Atrial Fibrillation: A Cross-National Comparison in Six European Countries (2008–2015)
Adherence to Direct Oral Anticoagulants in Patients With Non-Valvular Atrial Fibrillation: A Cross-National Comparison in Six European Countries (2008–2015) Open
Aims: To describe and compare the adherence to different direct oral anticoagulants (DOACs) in eight European databases representing six countries. Methods: Longitudinal drug utilization study of new users (≥18 years) of DOACs (dabigatran,…
View article: Cerebrospinal fluid test results and associations with subsequent mental disorders, neurological diseases, and CNS infections: A population-based cohort study
Cerebrospinal fluid test results and associations with subsequent mental disorders, neurological diseases, and CNS infections: A population-based cohort study Open
View article: Risk of hospitalization and hip fracture associated with psychotropic polypharmacy in patients with dementia: A nationwide register‐based study
Risk of hospitalization and hip fracture associated with psychotropic polypharmacy in patients with dementia: A nationwide register‐based study Open
Objective To investigate the association of benzodiazepines and antidepressants on the risk of hospitalization and hip fracture in patients with dementia initiating antipsychotic drug treatment. Methods A register‐based retrospective cohor…
View article: Pharmacogenetic genotype and phenotype frequencies in a large Danish population-based case-cohort sample
Pharmacogenetic genotype and phenotype frequencies in a large Danish population-based case-cohort sample Open
Pharmacogenetics aims to improve clinical care by studying the relationship between genetic variation and variable drug response. Large population-based datasets could improve our current understanding of pharmacogenetics from selected stu…