Christiane Gruner
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View article: Myocardial Fibrosis Quantification Methods by Cardiovascular Magnetic Resonance Imaging in Patients with Fabry Disease
Myocardial Fibrosis Quantification Methods by Cardiovascular Magnetic Resonance Imaging in Patients with Fabry Disease Open
Background/Objectives: The presence of late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) in patients with Fabry disease (FD) is a predictor of adverse cardiac events. The aim of this study was to establish the most reli…
View article: Fabry disease: development and progression of left ventricular hypertrophy despite long-term enzyme replacement therapy
Fabry disease: development and progression of left ventricular hypertrophy despite long-term enzyme replacement therapy Open
Background Enzyme replacement therapy (ERT) may halt or attenuate disease progression in patients with Anderson-Fabry disease (AFD). However, whether left ventricular hypertrophy (LVH) can be prevented by early therapy or may still progres…
View article: Assessment of treatment response in cardiac sarcoidosis based on myocardial 18F-FDG uptake
Assessment of treatment response in cardiac sarcoidosis based on myocardial 18F-FDG uptake Open
Objective Immunosuppressive therapy for cardiac sarcoidosis (CS) still largely consists of corticosteroid monotherapy. However, high relapse rates after tapering and insufficient efficacy are significant problems. The objective of this stu…
View article: Right ventricular global longitudinal strain is associated with cardiovascular outcome in left ventricular non-compaction phenotype
Right ventricular global longitudinal strain is associated with cardiovascular outcome in left ventricular non-compaction phenotype Open
Introduction Speckle-tracking echocardiography is an increasingly important tool for assessing left ventricular non-compaction (LVNC) phenotype. This study aims to analyse right (RV) and left (LV) ventricular global longitudinal strain (GL…
View article: Left ventricular early diastolic strain rate and cardiovascular outcome in patients with left ventricular non-compaction phenotype
Left ventricular early diastolic strain rate and cardiovascular outcome in patients with left ventricular non-compaction phenotype Open
Introduction Speckle-tracking echocardiography is an increasingly important tool for assessing left ventricular non-compaction phenotype (LVNC). This study aims to analyse left ventricular early diastolic strain rate (eSR) in LVNC and expl…
View article: Clinical and CMR characteristics associated with cardiac events in patients with Fabry disease
Clinical and CMR characteristics associated with cardiac events in patients with Fabry disease Open
LVH and LGE detected by CMR were associated with adverse cardiac events in FD. In particular maximal wall thickness can be useful in cardiac risk stratification of FD patients.
View article: Five years’ experience of the endocarditis team in a tertiary referral centre
Five years’ experience of the endocarditis team in a tertiary referral centre Open
INTRODUCTION: Current European guidelines recommend a multidisciplinary team approach in infective endocarditis in order to ensure adequate treatment and follow-up. The aim of this contribution is to describe the organisation of the Endoca…
View article: Sarcoidosis – a multisystem disease
Sarcoidosis – a multisystem disease Open
Sarcoidosis is a systemic inflammatory disease, characterised by granuloma formation upon an unknown trigger in genetically predisposed individuals. The inflammation is characterised by an activation of both the innate immune system, with …
View article: Myocardial fibrosis quantification methods by cardiovascular magnetic resonance imaging with contrast-enhancement in patients with Fabry disease
Myocardial fibrosis quantification methods by cardiovascular magnetic resonance imaging with contrast-enhancement in patients with Fabry disease Open
Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): National Agency for Academic Exchange (NAWA). Background. Presence and extent of late gadolinium enhancement (LGE) in patients with Fab…
View article: Left ventricular mechanics and cardiovascular outcomes in non-compaction phenotype
Left ventricular mechanics and cardiovascular outcomes in non-compaction phenotype Open
GLS, GCS, regional strain, and twist were impaired in LVNC. APCS, APSR, and twist exhibited strong association with CV events independent of and incremental to LVEF and NC:C ratio, and in case of twist even GLS. Thus, STE-derived parameter…
View article: Dataset related to the article "Differentiating Hereditary Arrhythmogenic Right Ventricular Cardiomyopathy from Cardiac Sarcoidosis Fulfilling 2010 ARVC Task Force Criteria."
Dataset related to the article "Differentiating Hereditary Arrhythmogenic Right Ventricular Cardiomyopathy from Cardiac Sarcoidosis Fulfilling 2010 ARVC Task Force Criteria." Open
This record contains raw data related to the article "Differentiating Hereditary Arrhythmogenic Right Ventricular Cardiomyopathy from Cardiac Sarcoidosis Fulfilling 2010 ARVC Task Force Criteria." Abstract Background: The clinical presenta…
View article: Dataset related to the article "Differentiating Hereditary Arrhythmogenic Right Ventricular Cardiomyopathy from Cardiac Sarcoidosis Fulfilling 2010 ARVC Task Force Criteria."
Dataset related to the article "Differentiating Hereditary Arrhythmogenic Right Ventricular Cardiomyopathy from Cardiac Sarcoidosis Fulfilling 2010 ARVC Task Force Criteria." Open
This record contains raw data related to the article "Differentiating Hereditary Arrhythmogenic Right Ventricular Cardiomyopathy from Cardiac Sarcoidosis Fulfilling 2010 ARVC Task Force Criteria." Abstract Background: The clinical presenta…
View article: Right ventricular involvement in left ventricular non-compaction cardiomyopathy
Right ventricular involvement in left ventricular non-compaction cardiomyopathy Open
Right ventricle size and function in LVNC can be measured by CMR and TTE, while RV trabeculation can only be quantified by CMR. RV myocardium displays more trabeculations in LVNC; however, overlap with normal individuals is extensive, not …
View article: Diagnostic criteria for left ventricular non-compaction in cardiac computed tomography
Diagnostic criteria for left ventricular non-compaction in cardiac computed tomography Open
LVNC can be diagnosed with ECG-triggered low-dose CCT and discriminated from normal individuals using a NC:C ratio of ≥1.8 in diastole. There is a very good correlation of NC:C ratio in TTE and CCT.
View article: Cardiovascular magnetic resonance T2* mapping for the assessment of cardiovascular events in hypertrophic cardiomyopathy
Cardiovascular magnetic resonance T2* mapping for the assessment of cardiovascular events in hypertrophic cardiomyopathy Open
Background Hypertrophic cardiomyopathy (HCM) is associated with an increased risk of adverse cardiac events. Beyond classic risk factors, relative myocardial ischaemia and succeeding myocardial alterations, which can be detected using eith…
View article: Hypertrophic obstructive cardiomyopathy: what, when, why, for whom?
Hypertrophic obstructive cardiomyopathy: what, when, why, for whom? Open
Hypertrophic cardiomyopathy is the most common genetic cardiovascular disorder and is associated with symptoms of heart failure and increased risk of sudden cardiac death. The most common condition is obstruction of the left ventricular ou…
View article: Percutaneous mitral valve repair with the MitraClip™ system
Percutaneous mitral valve repair with the MitraClip™ system Open
OBJECTIVES: We performed extended follow-up for longer than 1 year in consecutive patients undergoing percutaneous mitral valve repair (PMVR) with the MitraClip™ system.
View article: Impact of growing cohorts of adults with congenital heart disease on clinical workload: a 20-year experience at a tertiary care centre
Impact of growing cohorts of adults with congenital heart disease on clinical workload: a 20-year experience at a tertiary care centre Open
BACKGROUND Population based studies show a steady increase in adult patients with congenital heart defects. The aim of this study was to assess the evolution of such a patient cohort and its burden on clinical care at a dedicated tertiary …
View article: Lack of Phenotypic Differences by Cardiovascular Magnetic Resonance Imaging in MYH7 (β-Myosin Heavy Chain)- Versus MYBPC3 (Myosin-Binding Protein C)-Related Hypertrophic Cardiomyopathy
Lack of Phenotypic Differences by Cardiovascular Magnetic Resonance Imaging in MYH7 (β-Myosin Heavy Chain)- Versus MYBPC3 (Myosin-Binding Protein C)-Related Hypertrophic Cardiomyopathy Open
Background— The 2 most commonly affected genes in hypertrophic cardiomyopathy (HCM) are MYH7 (β-myosin heavy chain) and MYBPC3 (β-myosin-binding protein C). Phenotypic differences between patients with mutations in these 2 genes have been …
View article: High prevalence of baffle leaks in adults after atrial switch operations for transposition of the great arteries
High prevalence of baffle leaks in adults after atrial switch operations for transposition of the great arteries Open
Because of the high prevalence of baffle leaks in adults after atrial switch operations, we propose routine screening with agitated saline contrast, particularly prior to implantation of transvenous pacemaker or defibrillator leads.
View article: Prevention of sudden death in hypertrophic cardiomyopathy: bridging the gaps in knowledge
Prevention of sudden death in hypertrophic cardiomyopathy: bridging the gaps in knowledge Open
Sudden cardiac death (SCD) is the most devastating complication of hypertrophic cardiomyopathy (HCM). Although the annual rate of SCD in the general HCM population is <1% per year according to contemporary series, there is still a small su…
View article: Changes in serum biomarker profiles after percutaneous mitral valve repair with the MitraClip system
Changes in serum biomarker profiles after percutaneous mitral valve repair with the MitraClip system Open
Despite successful PMVR, NT-proBNP remain fairly unchanged on follow-up and changes in NT-proBNP levels are poor predictors of functional improvement or clinical outcome after MitraClip treatment.
View article: The value of ECG parameters as markers of treatment response in Fabry cardiomyopathy
The value of ECG parameters as markers of treatment response in Fabry cardiomyopathy Open
Objective Best treatment outcomes in Fabry disease (FD) associated cardiomyopathy can be obtained when treatment is started as early as possible. The rationale of this study was to assess the role of ECG changes for identification of cardi…
View article: Elevated high-sensitivity troponin T levels are associated with adverse cardiac remodelling and myocardial fibrosis in hypertrophic cardiomyopathy
Elevated high-sensitivity troponin T levels are associated with adverse cardiac remodelling and myocardial fibrosis in hypertrophic cardiomyopathy Open
Elevated hs-cTnT levels in HCM patients are associated with disease severity and, potentially, with more adverse cardiac events. Future studies should test whether integration of hs-cTnT in clinical decision algorithms will improve risk st…