Christiane J. Bruns
YOU?
Author Swipe
View article: Impact of intraoperative fluid therapy on postoperative complications following robotic-assisted minimally invasive esophagectomy (RAMIE)
Impact of intraoperative fluid therapy on postoperative complications following robotic-assisted minimally invasive esophagectomy (RAMIE) Open
Background Robotic-assisted minimally invasive esophagectomy (RAMIE) has become an increasingly adopted approach for the treatment of esophageal cancer. However, the impact of intraoperative fluid therapy on postoperative outcomes remains …
View article: First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia
First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia Open
Background Idiopathic achalasia (IA) is characterised by the degeneration of neurons in the myenteric plexus leading to an irreversible impaired oesophageal function. Although immune-mediated mechanisms have been proposed, the underlying a…
View article: ASO Author Reflections: The Treatment Challenge of cT2cN0 Staged Adenocarcinoma of the Esophagus and the Gastroesophageal Junction
ASO Author Reflections: The Treatment Challenge of cT2cN0 Staged Adenocarcinoma of the Esophagus and the Gastroesophageal Junction Open
View article: Comparison of Pretreatment Strategies for cT2cN0 Staged Adenocarcinoma of the Esophagus and the Gastroesophageal Junction: A European High-Volume Center Cohort Analysis
Comparison of Pretreatment Strategies for cT2cN0 Staged Adenocarcinoma of the Esophagus and the Gastroesophageal Junction: A European High-Volume Center Cohort Analysis Open
View article: Long-term outcomes after open total pericystectomy for cystic echinococcosis
Long-term outcomes after open total pericystectomy for cystic echinococcosis Open
BACKGROUND Liver hydatid cysts (LHC) liver requires effective surgical treatment. Open closed total pericystectomy removes the entire echinococcus cyst while preserving healthy liver tissue. AIM To evaluate the outcomes of pericystectomy a…
View article: Attention to the Editor: “Impact of preoperative diastolic dysfunction on short-term outcomes following robotic-assisted minimally invasive esophagectomy (RAMIE)”
Attention to the Editor: “Impact of preoperative diastolic dysfunction on short-term outcomes following robotic-assisted minimally invasive esophagectomy (RAMIE)” Open
View article: Single-cell analysis of Barrett’s esophagus and carcinoma reveals cell types conferring risk via genetic predisposition
Single-cell analysis of Barrett’s esophagus and carcinoma reveals cell types conferring risk via genetic predisposition Open
Inherited genetic variants contribute to Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC), but it is unknown which cell types are involved in this process. We performed single-cell RNA sequencing of BE, EAC, and paired normal t…
View article: Evaluation of posture in four different robotic surgical systems
Evaluation of posture in four different robotic surgical systems Open
Background While many ergonomic challenges traditionally faced in open and laparoscopic surgery have been overcome by robotic surgery, new challenges have been created. This study aims to identify and compare the ergonomic characteristics …
View article: From Bedside to Bot-Side: Artificial Intelligence in Emergency Appendicitis Management
From Bedside to Bot-Side: Artificial Intelligence in Emergency Appendicitis Management Open
Introduction: Acute appendicitis (AA) is a common cause of abdominal pain that can lead to complications like perforation and intra-abdominal abscesses, increasing morbidity and mortality, often requiring emergency surgery. Nevertheless, a…
View article: Glycocalyx-Shedding and Inflammatory Reactions Occur Yet Do Not Predict Complications Resulting from an Esophagectomy in an Accelerated Recovery After Surgery Program
Glycocalyx-Shedding and Inflammatory Reactions Occur Yet Do Not Predict Complications Resulting from an Esophagectomy in an Accelerated Recovery After Surgery Program Open
Background/Objectives: “Accelerated Recovery after Surgery” (ARAS) programs for esophagectomy aim to shorten the perioperative course without increases in morbidity or mortality. In such programs, the prediction and early detection of peri…
View article: The expression of the tight junction protein and therapeutical target Claudin 18.2 is heterogeneously distributed within esophageal and gastric adenocarcinoma
The expression of the tight junction protein and therapeutical target Claudin 18.2 is heterogeneously distributed within esophageal and gastric adenocarcinoma Open
Claudin 18.2 (CLDN18.2) is a therapeutically relevant biomarker in esophageal (EAC) -and gastric adenocarcinoma (GAC). Little is known about its heterogeneity within the primary tumor and corresponding metastases and how many biopsies are …
View article: Impact of preoperative diastolic dysfunction on short-term outcomes following robotic-assisted minimally invasive esophagectomy (RAMIE)
Impact of preoperative diastolic dysfunction on short-term outcomes following robotic-assisted minimally invasive esophagectomy (RAMIE) Open
View article: The AP-1 factor JUNB correlates with poor survival of patients with esophageal adenocarcinoma
The AP-1 factor JUNB correlates with poor survival of patients with esophageal adenocarcinoma Open
View article: Adjuvant <scp>FLOT</scp> provides survival benefit for oesophagogastric junction and gastric adenocarcinoma patients with low tumour regression after neoadjuvant chemotherapy
Adjuvant <span>FLOT</span> provides survival benefit for oesophagogastric junction and gastric adenocarcinoma patients with low tumour regression after neoadjuvant chemotherapy Open
Oesophagogastric junction and gastric adenocarcinoma (OGA) are associated with high mortality rates, with 5‐year survival rates below 50% in the curative setting. This study evaluates the efficacy of adjuvant chemotherapy (a chemotherapy r…
View article: Impact of Nintedanib on tumor angiogenesis and vascular normalization in a mouse model of colorectal cancer
Impact of Nintedanib on tumor angiogenesis and vascular normalization in a mouse model of colorectal cancer Open
Background For many solid types of cancer including colorectal cancer treatment with the VEGF antibody bevacizumab as anti-angiogenic treatment has become standard of care. Nevertheless, long-term treatment with anti-angiogenic drugs in co…
View article: Anastomotic leakage following robot-assisted minimally invasive esophagectomy (RAMIE): which anastomosis should be preferred?
Anastomotic leakage following robot-assisted minimally invasive esophagectomy (RAMIE): which anastomosis should be preferred? Open
Background The optimal technique for intrathoracic esophagogastric anastomosis in esophagectomy remains undetermined. This study evaluates different anastomotic techniques in robot-assisted minimally invasive esophagectomy (RAMIE) and thei…
View article: Basal-like subtype of esophageal adenocarcinoma and it’s morphological, molecular and clinical characteristics
Basal-like subtype of esophageal adenocarcinoma and it’s morphological, molecular and clinical characteristics Open
Esophageal adenocarcinoma (EAC) and squamous cell carcinoma are the two main tumor types of the esophagus, each with distinct morphological and molecular features. While mixed adeno-squamous carcinomas are recognized, it remains unclear wh…
View article: AKR1C3 enhances radioresistance in esophageal adenocarcinoma via inhibiting ferroptosis through suppressing TRIM21-mediated ubiquitination of HSPA5
AKR1C3 enhances radioresistance in esophageal adenocarcinoma via inhibiting ferroptosis through suppressing TRIM21-mediated ubiquitination of HSPA5 Open
View article: The impact of postoperative atrial fibrillation on complications and mortality following Ivor Lewis esophagectomy for esophageal cancer
The impact of postoperative atrial fibrillation on complications and mortality following Ivor Lewis esophagectomy for esophageal cancer Open
View article: Oligometastasierung
Oligometastasierung Open
View article: An international online survey to improve training in geriatric oncology for undergraduates: Trainees´ interests and preferred teaching strategies
An international online survey to improve training in geriatric oncology for undergraduates: Trainees´ interests and preferred teaching strategies Open
Background Age is a critical driver of the worldwide increasing cancer incidence rates, and with the growing number of older adults diagnosed with cancer, there is a rising need for specialized care. However, geriatric oncology (GO) educat…
View article: Onkologische Operationsberichte: Minimalanforderungen, rechtliche Aspekte und zukünftige Entwicklungen
Onkologische Operationsberichte: Minimalanforderungen, rechtliche Aspekte und zukünftige Entwicklungen Open
Zusammenfassung Die Etablierung onkologischer Zentren zur interdisziplinären Versorgung krebskranker Patienten beruht auf definierten Kriterien, die sich einer regelmäßigen externen Prüfung unterziehen müssen. Dadurch soll ein einheitliche…
View article: Ist der Einsatz digitaler Technologien der Gamechanger für die chirurgische Weiterbildung der Zukunft? Eine deutschlandweite Analyse
Ist der Einsatz digitaler Technologien der Gamechanger für die chirurgische Weiterbildung der Zukunft? Eine deutschlandweite Analyse Open
Zusammenfassung Hintergrund Der Einsatz digitaler Technologien gewinnt in der Medizin zunehmend an Bedeutung und beeinflusst maßgeblich die Entwicklungen in der Chirurgie. In der chirurgischen Aus- und Weiterbildung besteht jedoch ein groß…
View article: Vascularity of the gastric conduit predicts complications after Ivor-Lewis esophagectomy
Vascularity of the gastric conduit predicts complications after Ivor-Lewis esophagectomy Open
Background Anastomotic leakage (AL) contributes to postoperative morbidity and mortality after Ivor-Lewis esophagectomy. Vascular high-risk patients show a significantly increased risk of AL. We previously showed that laparoscopic ischemic…
View article: ACO/ARO/AIO-22 – External beam radiotherapy combined with endorectal high-dose-rate brachytherapy in elderly and frail patients with rectal cancer: A prospective multicentre trial of the German Rectal Cancer Study Group
ACO/ARO/AIO-22 – External beam radiotherapy combined with endorectal high-dose-rate brachytherapy in elderly and frail patients with rectal cancer: A prospective multicentre trial of the German Rectal Cancer Study Group Open
View article: Proteomic characterization of MET-amplified esophageal adenocarcinomas reveals enrichment of alternative splicing- and androgen signaling-related proteins
Proteomic characterization of MET-amplified esophageal adenocarcinomas reveals enrichment of alternative splicing- and androgen signaling-related proteins Open
View article: Supplementary Table S5 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Table S5 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
Table S5
View article: Supplementary Figure S1 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Figure S1 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
CD38 and FoxP3 cells surround B-cell clusters in TLS.
View article: Supplementary Figure S5 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Figure S5 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
TLS in PDAC patients are active germinal centers.
View article: Supplementary Figure S7 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation
Supplementary Figure S7 from Tertiary Lymphoid Structures in Pancreatic Cancer are Structurally Homologous, Share Gene Expression Patterns and B-cell Clones with Secondary Lymphoid Organs, but Show Increased T-cell Activation Open
Germinal center markers are expressed in lymphoid follicles.