Christianne J. Buskens
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View article: Functional validation of the TOpClass classification system for perianal fistulising Crohn’s disease using real-world multicentre data: a 10-year retrospective observational study
Functional validation of the TOpClass classification system for perianal fistulising Crohn’s disease using real-world multicentre data: a 10-year retrospective observational study Open
Background and aims Perianal fistulising Crohn’s disease (pfCD) is an aggressive, disabling condition with significant treatment challenges. The novel TOpClass classification system aims to better capture pfCD’s disease trajectory, improvi…
View article: Long-term comparative outcomes after ileocecal resection for inflammatory versus complicated Crohn’s disease. A multicenter, retrospective study (Crohn's-Urg)
Long-term comparative outcomes after ileocecal resection for inflammatory versus complicated Crohn’s disease. A multicenter, retrospective study (Crohn's-Urg) Open
Long-term outcomes of ICR are similar in inflammatory and complicated CD when appropriate surgical and medical management is applied. Optimizing perioperative care and mitigating modifiable risk factors may improve outcomes, supporting the…
View article: Preoperative Body Composition Parameters Are Associated With Postoperative Outcomes in Patients With Crohn’s Disease
Preoperative Body Composition Parameters Are Associated With Postoperative Outcomes in Patients With Crohn’s Disease Open
View article: Intestinal Ultrasound and Its Advanced Modalities in Characterizing Strictures in Crohn's Disease
Intestinal Ultrasound and Its Advanced Modalities in Characterizing Strictures in Crohn's Disease Open
A combination of IUS and CEUS is accurate to differentiate between inflammatory and chronic strictures in CD. The Stricture Score Amsterdam needs external validation and confirmation in its potential as a diagnostic decision aid when choos…
View article: Quantified motility in Crohn’s disease to evaluate stricture composition using cine-MRI
Quantified motility in Crohn’s disease to evaluate stricture composition using cine-MRI Open
Objectives The histopathological composition of a stricture impacts clinical treatment choice. Therefore, imaging biomarkers that can distinguish a predominantly inflammatory from a chronic (i.e., non-inflammatory) stricture are highly rel…
View article: Combined Clinical and Histopathological Risk Stratification for Prediction of (severe) Endoscopic Postoperative Recurrence in Patients with Crohn’s Disease after Ileocolic Resection
Combined Clinical and Histopathological Risk Stratification for Prediction of (severe) Endoscopic Postoperative Recurrence in Patients with Crohn’s Disease after Ileocolic Resection Open
Objective: This study assessed the association of histopathological features in the resection specimen of CD patients with (severe) endoscopic postoperative recurrence (ePOR) in a large prospective, multicenter cohort study. Summary Backgr…
View article: Early diagnosis of Crohn’s disease in patients presenting with a perianal fistula: systematic review and development of a perianal red flags index
Early diagnosis of Crohn’s disease in patients presenting with a perianal fistula: systematic review and development of a perianal red flags index Open
View article: The impact of advanced medical therapies on time to resection and colorectal cancer outcomes in ulcerative colitis patients undergoing colectomy
The impact of advanced medical therapies on time to resection and colorectal cancer outcomes in ulcerative colitis patients undergoing colectomy Open
Background We aimed to evaluate the impact of advanced medical therapies (biologicals and small molecules) on time to colectomy and oncological outcomes in ulcerative colitis (UC). Methods This cohort study included UC patients who underwe…
View article: Diagnosing Crohn’s disease in presumed cryptoglandular perianal fistulas: an expert Delphi consensus on early identification of patients at risk of Crohn’s disease in perianal fistulas (PREFAB)
Diagnosing Crohn’s disease in presumed cryptoglandular perianal fistulas: an expert Delphi consensus on early identification of patients at risk of Crohn’s disease in perianal fistulas (PREFAB) Open
Background The aim of this Delphi study was to reach consensus on a new clinical decision tool to help identify or exclude Crohn’s disease (CD) in patients with perianal fistula(s) (PAF). Methods A panel of international experts in the fie…
View article: Improving Enhanced Recovery after Surgery (ERAS): The Effect of a Patient-Centred Mobile Application and an Activity Tracker on Patient Engagement in Colorectal Surgery
Improving Enhanced Recovery after Surgery (ERAS): The Effect of a Patient-Centred Mobile Application and an Activity Tracker on Patient Engagement in Colorectal Surgery Open
Background The Enhanced Recovery After Surgery (ERAS) protocol improved perioperative colorectal care. Although the protocol is firmly implemented across hospital settings, there are benefits to gain by actively involving patients in their…
View article: Tuft cells act as regenerative stem cells in the human intestine
Tuft cells act as regenerative stem cells in the human intestine Open
View article: Prolonged Time to Diagnosis of Crohn’s Disease in Patients With Perianal Fistulas Negatively Affects Long-Term Outcomes
Prolonged Time to Diagnosis of Crohn’s Disease in Patients With Perianal Fistulas Negatively Affects Long-Term Outcomes Open
Background and Aim This study aims to evaluate the effect of time to Crohn’s disease (CD) diagnosis on perianal fistula (PAF) outcomes in patients with a fistula as the first manifesting sign. Methods In this multicenter, retrospective stu…
View article: External validation of the MAGNIFI-CD index in patients with complex perianal fistulising Crohn’s disease
External validation of the MAGNIFI-CD index in patients with complex perianal fistulising Crohn’s disease Open
Background There is an increasing need for objective treatment monitoring in perianal fistulising Crohn’s disease (pfCD). Therefore, the magnetic resonance novel index for fistula imaging in CD (MAGNIFI-CD) index has been designed and inte…
View article: Fistulizing Perianal Disease as a First Manifestation of Crohn’s Disease: A Systematic Review and Meta-Analysis
Fistulizing Perianal Disease as a First Manifestation of Crohn’s Disease: A Systematic Review and Meta-Analysis Open
Background: Incidences of perianal fistulas (PAFs) as a first manifestation of Crohn’s disease (CD) vary widely in the literature. Aim: To analyse the percentage of patients with a PAF preceding CD diagnosis and assess the time to diagnosi…
View article: ECCO Guidelines on Therapeutics in Crohn’s Disease: Medical Treatment
ECCO Guidelines on Therapeutics in Crohn’s Disease: Medical Treatment Open
View article: ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment
ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment Open
This article is the second in a series of two publications on the European Crohn’s and Colitis Organisation [ECCO] evidence-based consensus on the management of Crohn’s disease. The first article covers medical management; the present arti…
View article: Short‐term outcomes of surgical treatment for primary ileocaecal Crohn's disease: Results of the Crohn's(urg) study, a multicentre, retrospective, comparative analysis between inflammatory and complicated phenotypes
Short‐term outcomes of surgical treatment for primary ileocaecal Crohn's disease: Results of the Crohn's(urg) study, a multicentre, retrospective, comparative analysis between inflammatory and complicated phenotypes Open
Aim Recent evidence challenges the current standard of offering surgery to patients with ileocaecal Crohn's disease (CD) only when they present complications of the disease. The aim of this study was to compare short‐term results of patien…
View article: Mesenchymal stem cell therapy for therapy refractory complex Crohn’s perianal fistulas: a case series
Mesenchymal stem cell therapy for therapy refractory complex Crohn’s perianal fistulas: a case series Open
View article: Clinical statistical analysis plan for the ACCURE trial: the effect of appendectomy on the clinical course of ulcerative colitis, a randomised international multicentre trial
Clinical statistical analysis plan for the ACCURE trial: the effect of appendectomy on the clinical course of ulcerative colitis, a randomised international multicentre trial Open
Background The primary treatment of ulcerative colitis (UC) is medical therapy using a standard step-up approach. An appendectomy might modulate the clinical course of UC, decreasing the incidence of relapses and reducing need for medicati…
View article: Tuft cells act as regenerative stem cells in the human intestine
Tuft cells act as regenerative stem cells in the human intestine Open
In mice, intestinal tuft cells have been described as a long-lived, post-mitotic cell type of which two distinct subsets have been identified, named tuft-1 and tuft-2 1 . By combining analysis of primary human intestinal resection material…
View article: How Reliable Is Endoscopic Scoring of Postoperative Recurrence in Crohn Disease?: A Systematic Review and Meta-Analysis
How Reliable Is Endoscopic Scoring of Postoperative Recurrence in Crohn Disease?: A Systematic Review and Meta-Analysis Open
Objective: Guidelines advise to perform endoscopic surveillance following ileocolic resection (ICR) in Crohn disease (CD) for timely diagnosis of recurrence. This study aims to assess the variation in endoscopic recurrence (ER) rates in pa…
View article: Optimising surgical anastomosis in ileocolic resection for Crohn’s disease with respect to recurrence and functionality: two international parallel randomized controlled trials comparing handsewn (END-to-end or Kono-S) to stapled anastomosis (HAND2END and the End2End STUDIES)
Optimising surgical anastomosis in ileocolic resection for Crohn’s disease with respect to recurrence and functionality: two international parallel randomized controlled trials comparing handsewn (END-to-end or Kono-S) to stapled anastomosis (HAND2END and the End2End STUDIES) Open
View article: Better stoma care using the Stoma App: does it help? A first randomized double-blind clinical trial on the effect of mobile healthcare on quality of life in stoma patients
Better stoma care using the Stoma App: does it help? A first randomized double-blind clinical trial on the effect of mobile healthcare on quality of life in stoma patients Open
Background Receiving a stoma significantly impacts patients’ quality of life. Coping with this new situation can be difficult, which may result in a variety of physical and psychosocial problems. It is essential to provide adequate guidanc…
View article: P955 The effect of appendicectomy on the clinical course of Ulcerative Colitis: Preliminary results
P955 The effect of appendicectomy on the clinical course of Ulcerative Colitis: Preliminary results Open
Background Emerging evidence indicates an immunomodulatory role of the appendix in ulcerative colitis (UC). Previous studies have suggested a beneficial effect of appendicectomy in inducing and maintaining remission. Therefore, appendicect…
View article: P934 A delphi consensus on the optimisation of medical and surgical therapy in perianal fistulising Crohn’s disease, targeted at individual TOpCLASS classification groups
P934 A delphi consensus on the optimisation of medical and surgical therapy in perianal fistulising Crohn’s disease, targeted at individual TOpCLASS classification groups Open
Background Perianal fistulising Crohn’s Disease (PFCD) is a challenging phenotype of IBD associated with poor outcomes. Classically, fistulae have been classified anatomically and guidelines have been generalised, with a lack of appreciati…
View article: P1171 The impact of biological and small molecule therapy on time to colonic resection and cancer rates in patients with Ulcerative Colitis
P1171 The impact of biological and small molecule therapy on time to colonic resection and cancer rates in patients with Ulcerative Colitis Open
Background The expanding medical armamentarium in ulcerative colitis (UC) has contributed to increased control of inflammation. However, simultaneously, postponed colonic resection with an accumulative inflammatory burden might lead to an …
View article: P243 Multi-modality intestinal ultrasound is accurate and reproducible to distinguish inflammatory from chronic fibrotic strictures in Crohn’s disease – results from the STRICTURE study
P243 Multi-modality intestinal ultrasound is accurate and reproducible to distinguish inflammatory from chronic fibrotic strictures in Crohn’s disease – results from the STRICTURE study Open
Background In 30%-50% of patients with Crohn’s disease (CD) stenotic complications occur1. There is currently no imaging modality to identify stricture composition, which would allow early targeted (anti-inflammatory vs surgical) treatment…
View article: P298 Adherence to diagnostic and treatment recommendations for the management of acute severe ulcerative colitis: a prospective and multinational study
P298 Adherence to diagnostic and treatment recommendations for the management of acute severe ulcerative colitis: a prospective and multinational study Open
Background Acute severe ulcerative colitis (ASUC) is a serious, potentially life-threatening condition. Hospital admission and prompt medical therapy with intravenous steroids is crucial, but rescue medical therapy is frequently needed, an…
View article: P300 An Expert Delphi Consensus: Early Identification of Patients at Risk of Crohn's Disease in Perianal Fistulas and Abscesses (PREFAB) and Identification and Management of Isolated Perianal Crohn's Disease (ipCD) - Part A, PREFAB
P300 An Expert Delphi Consensus: Early Identification of Patients at Risk of Crohn's Disease in Perianal Fistulas and Abscesses (PREFAB) and Identification and Management of Isolated Perianal Crohn's Disease (ipCD) - Part A, PREFAB Open
Background In ± 10% of all Crohn’s disease (CD) patients a perianal abscess (PAA) or fistula (PAF) is the manifesting symptom. The delay in diagnosis of CD, from fistula or abscess onset, is very long and associated with worse outcomes. Th…
View article: DOP77 Mesenchymal stem cell therapy for refractory Crohn’s perianal fistulas: a case series
DOP77 Mesenchymal stem cell therapy for refractory Crohn’s perianal fistulas: a case series Open
Background Nearly one-third of patients with Crohn’s disease will develop one or multiple perianal fistulas within the first two decades after diagnosis, with the majority being complex. Treatment options are limited with high recurrence r…