Explanipedia

Rewilding catalyzes maturation of the humoral immune system Open

Ying-Han Chen, Kimberly Zaldaña, Frank Yeung, Ivan Vujkovic-Cvijin, Alexander E. Downie , et al. · 2025

Inbred mice used for biomedical research display an underdeveloped immune system compared with adult humans, which is attributed in part to the artificial laboratory environment. Despite representing a central component of adaptive immunit…

Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use Open

Kayla Barekat, Emanuela Ricciotti, Soumita Ghosh, Christin Herrmann, Karl Keat , et al. · 2024

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used medications for the management of chronic pain; however, they are associated with numerous gastrointestinal (GI) adverse events. Although many mechanisms have been sugg…

Stress from environmental change drives clearance of a persistent enteric virus Open

Christin Herrmann, Kimberly Zaldaña, Eva L. Agostino, Sergei B. Koralov, Ken Cadwell · 2024

Persistent viral infections are associated with long-term health issues and prolonged transmission. How external perturbations after initial exposure affect the duration of infection is unclear. We discovered that murine astrovirus, an ent…

SARS-CoV-2 infection predisposes patients to coinfection with <i>Staphylococcus aureus</i> Open

Ashira Lubkin, Lucie Bernard, Ashley Dumont, Ana Mayela Valero Jimenez, Gregory Putzel , et al. · 2024

Severe COVID-19 has been associated with coinfections with bacterial and fungal pathogens. Notably, patients with COVID-19 who develop Staphylococcus aureus bacteremia exhibit higher rates of mortality than those infected with either patho…

Genetic and environmental interactions contribute to immune variation in rewilded mice Open

Oyebola O. Oyesola, Alexander E. Downie, Nina Howard, Ramya S. Barre, Kasalina N. Kiwanuka , et al. · 2024

The relative and synergistic contributions of genetics and environment to interindividual immune response variation remain unclear, despite implications in evolutionary biology and medicine. Here we quantify interactive effects of genotype…

Genetic and Environmental interactions contribute to immune variation in rewilded mice Open

Oyebola O. Oyesola, Alexander E. Downie, Nina Howard, Ramya S. Barre, Kasalina N. Kiwanuka , et al. · 2023

The relative and synergistic contributions of genetics and environment to inter-individual immune response variation remain unclear, despite its implications for understanding both evolutionary biology and medicine. Here, we quantify inter…

Playing dirty with virus transmission Open

Christin Herrmann, Ken Cadwell · 2021

In this issue of JEM, Fay et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211220) cohouse dirty pet store mice and rats with clean laboratory mice to gain insights into infection dynamics, discover new viruses, and identify relatio…

Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNA Open

Alexander M. Price, Robert T. Steinbock, Chao Di, Katharina E. Hayer, Yize Li , et al. · 2021

Eukaryotic cells recognize intracellular pathogens through pattern recognition receptors, including sensors of aberrant nucleic acid structures. Sensors of double-stranded RNA (dsRNA) are known to detect replication intermediates of RNA vi…

Fallvignetten aus der neurologischen Rehabilitation bei Patienten mit Post-COVID-Syndrom Open

Christian Dettmers, C. Weich, Christin Herrmann, Rachid Saı̈le, Malte Preuß , et al. · 2021

Case vignettes from neurological rehabilitation in patients with post-COVID syndrome – Suggested discussion for performance diagnosticsC. Dettmers, C. Weich, C. Herrmann, R. Saile, M. Preuss, S. H. Chanyalew, L. Schleicher, D. Klaasen van …

Enteric viruses evoke broad host immune responses resembling those elicited by the bacterial microbiome Open

Simone Dallari, T. G. Heaney, Adriana Rosas-Villegas, Jessica A. Neil, Serre-Yu Wong , et al. · 2021

Adenovirus-mediated ubiquitination alters protein–RNA binding and aids viral RNA processing Open

Christin Herrmann, Joseph M. Dybas, Jennifer Liddle, Alexander M. Price, Katharina E. Hayer , et al. · 2020

Viral-mediated ubiquitination impacts interactions of host proteins with viral RNA and promotes viral RNA processing Open

Christin Herrmann, Joseph M. Dybas, Jennifer Liddle, Alexander M. Price, Katharina E. Hayer , et al. · 2020

Viruses promote infection by hijacking host ubiquitin machinery to counteract or redirect cellular processes. Adenovirus encodes two early proteins, E1B55K and E4orf6, that together co-opt a cellular ubiquitin ligase complex to overcome ho…

Viral and cellular interactions during adenovirus DNA replication Open

Matthew Charman, Christin Herrmann, Matthew D. Weitzman · 2019

Adenoviruses represent ubiquitous and clinically significant human pathogens, gene‐delivery vectors, and oncolytic agents. The study of adenovirus‐infected cells has long been used as an excellent model to investigate fundamental aspects o…

Adenovirus Strategies for Altering the Cellular Environment in Favor of Infection Open

Christin Herrmann · 2019

Viruses, as obligate intracellular pathogens, rely on their host cell for successful replication. Viruses have evolved different strategies to hijack and redirect cellular processes to benefit infection and overcome host immune responses. …

Ubiquitination at the interface of tumor viruses and DNA damage responses Open

Joseph M. Dybas, Christin Herrmann, Matthew D. Weitzman · 2018

Adenovirus Core Protein VII Downregulates the DNA Damage Response on the Host Genome Open

Daphne C. Avgousti, Ashley N. Della Fera, Clayton J. Otter, Christin Herrmann, Neha J. Pancholi , et al. · 2017

Viral manipulation of cellular proteins allows viruses to suppress host defenses and generate infectious progeny. Due to the linear double-stranded DNA nature of the adenovirus genome, the cellular DNA damage response (DDR) is considered a…

Time-resolved Global and Chromatin Proteomics during Herpes Simplex Virus Type 1 (HSV-1) Infection Open

Katarzyna Kulej, Daphne C. Avgousti, Simone Sidoli, Christin Herrmann, Ashley N. Della Fera , et al. · 2017

Proceedings of the Frontiers of Retrovirology Conference 2016 Open

Irena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, Juliane Reh , et al. · 2016

A core viral protein binds host nucleosomes to sequester immune danger signals Open

Daphne C. Avgousti, Christin Herrmann, Katarzyna Kulej, Neha J. Pancholi, Nikolina Sekulić , et al. · 2016

Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection Open

Xaver Sewald, Mark S. Ladinsky, Pradeep D. Uchil, Jagadish Beloor, Ruoxi Pi , et al. · 2015

A close up view of retrovirus spreading Viral infections typically begin with a small number of viral particles gaining access to the host at a specific tissue site. But how do viruses that cause systemic infections, such as HIV, spread mo…

Virus-induced translational arrest through 4EBP1/2-dependent decay of 5′-TOP mRNAs restricts viral infection Open

Kaycie C. Hopkins, Michael A. Tartell, Christin Herrmann, Brent A. Hackett, Frances Taschuk , et al. · 2015

Significance Rift Valley fever virus (RVFV), a mosquito-transmitted bunyavirus, blocks the two common methods of antiviral translational shutdown, PKR and type I interferon. However, it has previously been shown that RVFV infection halts p…

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