Christin Zasada
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View article: Proteome-Wide Monitoring of Drug Action in Living Cells Using a Novel Label-Free Solvent-Based Shift Assay
Proteome-Wide Monitoring of Drug Action in Living Cells Using a Novel Label-Free Solvent-Based Shift Assay Open
Biophysical proteomics assays allow for proteome-wide, label-free monitoring of ligand-induced changes in protein structure and stability, offering insights into protein-ligand interactions and modulation of biophysical properties of cellu…
View article: Salt Transiently Inhibits Mitochondrial Energetics in Mononuclear Phagocytes
Salt Transiently Inhibits Mitochondrial Energetics in Mononuclear Phagocytes Open
Background: Dietary high salt (HS) is a leading risk factor for mortality and morbidity. Serum sodium transiently increases postprandially but can also accumulate at sites of inflammation affecting differentiation and function of innate an…
View article: Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against<scp><i>MYCN</i></scp>‐amplified neuroblastoma
Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against<span><i>MYCN</i></span>‐amplified neuroblastoma Open
Here we sought metabolic alterations specifically associated with MYCN amplification as nodes to indirectly target the MYCN oncogene. Liquid chromatography‐mass spectrometry‐based proteomics identified seven proteins consistently correlate…
View article: Non-canonical HIF-1 stabilization is essential for intestinal tumorigenesis
Non-canonical HIF-1 stabilization is essential for intestinal tumorigenesis Open
The hypoxia-inducible transcription factor HIF-1 is appreciated as a promising target for cancer therapy. However, conditional deletion of HIF-1 and HIF-1 target genes in cells of the tumor microenvironment can result in accelerated tumor …
View article: Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat
Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat Open
Safe anaerobic metabolism Naked mole-rats live in large colonies deep underground in hypoxic conditions. Park et al. found that these animals fuel anaerobic glycolysis with fructose by a rewired pathway that avoids tissue damage (see the P…