Christina A. Brust
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View article: Comparison of Agonist Activity between CB1 and CB2 Receptors with Orthosteric Site Mutations
Comparison of Agonist Activity between CB1 and CB2 Receptors with Orthosteric Site Mutations Open
Human endocannabinoid signaling is primarily mediated by the cannabinoid receptors, CB1 and CB2, which are G protein-coupled receptors (GPCRs). These receptors have been linked to a variety of physiological processes and are being pursued …
View article: Structural and functional insights into the G protein-coupled receptors: CB1 and CB2
Structural and functional insights into the G protein-coupled receptors: CB1 and CB2 Open
The cannabinoid receptors CB1 and CB2 mediate a variety of physiological processes and continue to be explored as desirable drug targets. Both receptors are activated by the endogenous endocannabinoids and the psychoactive components of ma…
View article: Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists
Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists Open
We report the development of novel cannabinergic probes that can stabilize the cannabinoid receptors (CBRs) through tight binding interactions. Ligand design involves the introduction of select groups at a judiciously chosen position withi…
View article: Dietary Chitin Particles Called Mimetic Fungi Ameliorate Colitis in Toll-Like Receptor 2/CD14- and Sex-Dependent Manners
Dietary Chitin Particles Called Mimetic Fungi Ameliorate Colitis in Toll-Like Receptor 2/CD14- and Sex-Dependent Manners Open
Chitin is a natural N -acetylglucosamine polymer and a major structural component of fungal cell walls. Dietary chitin is mucoadhesive; anti-inflammatory effects of chitin microparticles (CMPs; 1- to 10-μm diameters) have been demonstrated…