Christina A. Muzny
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View article: <i>Gardnerella</i> species exhibit synergy in their ability to displace <i>Lactobacillus crispatus</i> adhered to HeLa cells
<i>Gardnerella</i> species exhibit synergy in their ability to displace <i>Lactobacillus crispatus</i> adhered to HeLa cells Open
Background Bacterial vaginosis (BV) is the most common vaginal infection in reproductive-age women. It is associated with adverse pregnancy complications, such as preterm birth and low birth weight, in addition to an increased risk of acqu…
View article: From trauma to trust: the initial psychometric evaluation of a survey instrument measuring trauma among transgender women in the US deep south
From trauma to trust: the initial psychometric evaluation of a survey instrument measuring trauma among transgender women in the US deep south Open
Background Transgender women (TGW) experience unique life traumas that may perpetuate negative sexual health outcomes, such as high rates of HIV and sexually transmitted infections. This is especially true in the US Deep South, where struc…
View article: Investigating Bacterial Vaginosis Pathogenesis Using Peptide Nucleic Acid-Fluorescence <i>In Situ</i> Hybridization With a Focus on the Roles of <i>Gardnerella</i> Species, <i>Prevotella bivia</i>, and <i>Fannyhessea vaginae</i>
Investigating Bacterial Vaginosis Pathogenesis Using Peptide Nucleic Acid-Fluorescence <i>In Situ</i> Hybridization With a Focus on the Roles of <i>Gardnerella</i> Species, <i>Prevotella bivia</i>, and <i>Fannyhessea vaginae</i> Open
Background Bacterial vaginosis (BV) is a vaginal dysbiosis characterized by polymicrobial communities of BV-associated bacteria (BVAB) adhered to the vaginal epithelium. Despite decades of research, its etiology remains unknown. We aimed t…
View article: Trichomonas vaginalis Virus: Current Insights and Emerging Perspectives
Trichomonas vaginalis Virus: Current Insights and Emerging Perspectives Open
Trichomonas vaginalis, a prevalent sexually transmitted protozoan parasite, is associated with adverse birth outcomes, increased risk of HIV and other sexually transmitted infections, infertility, and cervical cancer. Despite its widesprea…
View article: Nitazoxanide and tizoxanide demonstrate high levels of <i>in vitro</i> activity against metronidazole-susceptible and metronidazole-resistant <i>Trichomonas vaginalis</i> clinical isolates
Nitazoxanide and tizoxanide demonstrate high levels of <i>in vitro</i> activity against metronidazole-susceptible and metronidazole-resistant <i>Trichomonas vaginalis</i> clinical isolates Open
Trichomonas vaginalis is the most common non-viral sexually transmitted infection worldwide. We compared the in vitro activity of the thiazolide nitazoxanide (NTZ) and its metabolite, tizoxanide (TIZ), with the activity of the Food and Dru…
View article: Predicting Bacterial Vaginosis Development using Artificial Neural Networks
Predicting Bacterial Vaginosis Development using Artificial Neural Networks Open
Bacterial vaginosis (BV) is a dysbiosis of the vaginal microbiome, characterized by the depletion of protective Lactobacillus spp. and overgrowth of anaerobes. Artificial neural network (ANN) modeling of vaginal microbial communities offer…
View article: Trichomoniasis and Other Sexually Transmitted Parasitic Diseases in Women
Trichomoniasis and Other Sexually Transmitted Parasitic Diseases in Women Open
Parasitic sexually transmitted infections are spread through sexual contact (vaginal, oral, and/or anal sex). The majority of parasitic STIs involve protozoan pathogens (ie, Trichomonas vaginalis, Entamoeba histolytica, and Giardia duodena…
View article: Does a waiting room increase same-day treatment for sexually transmitted infections among pregnant women? A quality improvement study at South African primary healthcare facilities
Does a waiting room increase same-day treatment for sexually transmitted infections among pregnant women? A quality improvement study at South African primary healthcare facilities Open
Background Same-day testing and treatment of curable sexually transmitted infections (STI) is a strategy to reduce infection duration and onward transmission. South African primary healthcare facilities often lack sufficient waiting spaces…
View article: Adaptation of key bacterial vaginosis-associated bacteria to a medium simulating genital tract secretions: a transcriptomic analysis
Adaptation of key bacterial vaginosis-associated bacteria to a medium simulating genital tract secretions: a transcriptomic analysis Open
View article: The American Federation for Medical Research maintains commitment to decades of support of vaccine and vaccination research to improve public health
The American Federation for Medical Research maintains commitment to decades of support of vaccine and vaccination research to improve public health Open
View article: From pregnancy to beyond: renewed emphasis on comprehensive HIV prevention in South Africa
From pregnancy to beyond: renewed emphasis on comprehensive HIV prevention in South Africa Open
South Africa continues to document high HIV prevalence, particularly among pregnant women, highlighting significant prevention gaps. This viewpoint triangulates findings from the Sixth South African HIV Prevalence Survey, the 2022 Antenata…
View article: Does a waiting room increase same-day treatment for sexually transmitted infections among pregnant women? A quality improvement study at South African primary healthcare facilities
Does a waiting room increase same-day treatment for sexually transmitted infections among pregnant women? A quality improvement study at South African primary healthcare facilities Open
Background Same-day testing and treatment of curable sexually transmitted infections (STI) is a strategy to reduce infection duration and onward transmission. South African primary healthcare facilities often lack sufficient waiting spaces…
View article: P-1388. Repeat <i>Trichomonas vaginalis</i> Infections Among Pregnant Women in South Africa
P-1388. Repeat <i>Trichomonas vaginalis</i> Infections Among Pregnant Women in South Africa Open
Background Trichomonas vaginalis (TV) is the most common non-viral sexually transmitted infection (STI) worldwide. It has been associated with multiple adverse outcomes in pregnancy. The prevalence of repeat TV infections among pregnant wo…
View article: Key bacterial vaginosis-associated bacteria influence each other's growth in biofilms in rich media and media simulating vaginal tract secretions
Key bacterial vaginosis-associated bacteria influence each other's growth in biofilms in rich media and media simulating vaginal tract secretions Open
Bacterial vaginosis (BV) is a very common gynaecologic condition affecting women of reproductive age worldwide. BV is characterized by a depletion of lactic acid-producing Lactobacillus species and an increase in strict and facultat…
View article: Longitudinal Analysis of Select Bacterial Species Composition Among Women With Incident Bacterial Vaginosis Illuminated Through PNA-FISH
Longitudinal Analysis of Select Bacterial Species Composition Among Women With Incident Bacterial Vaginosis Illuminated Through PNA-FISH Open
View article: Gardnerella vaginalis, Fannyhessea vaginae, and Prevotella bivia Strongly Influence Each Other's Transcriptome in Triple-Species Biofilms
Gardnerella vaginalis, Fannyhessea vaginae, and Prevotella bivia Strongly Influence Each Other's Transcriptome in Triple-Species Biofilms Open
Bacterial vaginosis (BV), the most common vaginal infection worldwide, is characterized by the development of a polymicrobial biofilm on the vaginal epithelium. While Gardnerella spp. have been shown to have a prominent role in BV, little …
View article: Recruiting transgender men in the Southeastern United States for genital microbiome research: Lessons learned
Recruiting transgender men in the Southeastern United States for genital microbiome research: Lessons learned Open
Background Transgender men (TGM) are underrepresented in genital microbiome research. Our prospective study in Birmingham, AL investigated genital microbiota changes over time in TGM initiating testosterone, including the development of in…
View article: In Vitro Testing of Trichomonas vaginalis Drug Susceptibility: Evaluation of Minimal Lethal Concentration for Secnidazole That Correlates With Treatment Success
In Vitro Testing of Trichomonas vaginalis Drug Susceptibility: Evaluation of Minimal Lethal Concentration for Secnidazole That Correlates With Treatment Success Open
We determined the in vitro minimum lethal concentration of secnidazole and assessed the correlation with clinical susceptibility among Trichomonas vaginalis isolates obtained from 71 women, of whom 66 were successfully treated with this me…
View article: The Role of Prevotella Species in Female Genital Tract Infections
The Role of Prevotella Species in Female Genital Tract Infections Open
Female genital tract infections (FGTIs) include vaginal infections (e.g., bacterial vaginosis [BV]), endometritis, pelvic inflammatory disease [PID], and chorioamnionitis [amniotic fluid infection]. They commonly occur in women of reproduc…
View article: Performing<i>Trichomonas vaginalis</i>culture in research studies in low-resource settings
Performing<i>Trichomonas vaginalis</i>culture in research studies in low-resource settings Open
View article: Optimized bacterial absolute quantification method by qPCR using an exogenous bacterial culture as a normalization strategy in triple-species BV-like biofilms
Optimized bacterial absolute quantification method by qPCR using an exogenous bacterial culture as a normalization strategy in triple-species BV-like biofilms Open
View article: Microbial interactions among<i>Gardnerella</i>,<i>Prevotella</i>and<i>Fannyhessea</i>prior to incident bacterial vaginosis: protocol for a prospective, observational study
Microbial interactions among<i>Gardnerella</i>,<i>Prevotella</i>and<i>Fannyhessea</i>prior to incident bacterial vaginosis: protocol for a prospective, observational study Open
Introduction The aetiology of bacterial vaginosis (BV), a biofilm-associated vaginal infection, remains unknown. Epidemiologic data suggest that it is sexually transmitted. BV is characterised by loss of lactic acid-producing lactobacilli …
View article: Incident Bacterial Vaginosis in a Community-Based Cohort of Women
Incident Bacterial Vaginosis in a Community-Based Cohort of Women Open
View article: An Indirect Fluorescence Microscopy Method to Assess Vaginal Lactobacillus Concentrations
An Indirect Fluorescence Microscopy Method to Assess Vaginal Lactobacillus Concentrations Open
Lactobacillus species are the main colonizers of the vaginal microbiota in healthy women. Their absolute quantification by culture-based methods is limited due to their fastidious growth. Flow cytometry can quantify the bacterial concentra…
View article: Genital tract infections, the vaginal microbiome and gestational age at birth among pregnant women in South Africa: a cohort study protocol
Genital tract infections, the vaginal microbiome and gestational age at birth among pregnant women in South Africa: a cohort study protocol Open
Introduction Preterm birth complications are the most common cause of death in children under 5 years. The presence of multiple microorganisms and genital tract inflammation could be the common mechanism driving early onset of labour. Sout…
View article: 263. A preliminary analysis of vaginal microbial changes prior to incident bacterial vaginosis as determined by qPCR and inferred absolute abundance
263. A preliminary analysis of vaginal microbial changes prior to incident bacterial vaginosis as determined by qPCR and inferred absolute abundance Open
Background Bacterial vaginosis (BV) is the most common vaginal infection among reproductive-aged women worldwide. It is associated with multiple adverse obstetric and gynecologic outcomes, yet its etiology remains unknown. BV is characteri…
View article: Efficacy of single-dose oral secnidazole for the treatment of trichomoniasis in women co-infected with trichomoniasis and bacterial vaginosis: a post hoc subgroup analysis of phase 3 clinical trial data
Efficacy of single-dose oral secnidazole for the treatment of trichomoniasis in women co-infected with trichomoniasis and bacterial vaginosis: a post hoc subgroup analysis of phase 3 clinical trial data Open
Objectives Bacterial vaginosis (BV) and trichomoniasis are the most common causes of vaginitis. Both infections are associated with increased risk of acquisition and transmission of HIV and other sexually transmitted infections as well as …
View article: Understanding and Preventing Recurring Bacterial Vaginosis: Important Considerations for Clinicians
Understanding and Preventing Recurring Bacterial Vaginosis: Important Considerations for Clinicians Open
Bacterial vaginosis (BV) is the most common vaginal infection worldwide. It is associated with an increased risk of acquisition of HIV and other sexually transmitted infections (STIs) as well as pelvic inflammatory disease and adverse birt…
View article: Development of a Prevotella bivia PNA probe and a multiplex approach to detect three relevant species in bacterial vaginosis-associated biofilms
Development of a Prevotella bivia PNA probe and a multiplex approach to detect three relevant species in bacterial vaginosis-associated biofilms Open
View article: A novel Gardnerella, Prevotella, and Lactobacillus standard that improves accuracy in quantifying bacterial burden in vaginal microbial communities
A novel Gardnerella, Prevotella, and Lactobacillus standard that improves accuracy in quantifying bacterial burden in vaginal microbial communities Open
Bacterial vaginosis (BV) is the most common vaginal dysbiosis. In this condition, a polymicrobial biofilm develops on vaginal epithelial cells. Accurately quantifying the bacterial burden of the BV biofilm is necessary to further our under…