Christina A. Rostad
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View article: Future Goals and Long-term Vision of the Infectious Diseases Clinical Research Consortium/Vaccine and Treatment Evaluation Unit Network
Future Goals and Long-term Vision of the Infectious Diseases Clinical Research Consortium/Vaccine and Treatment Evaluation Unit Network Open
The Infectious Diseases Clinical Research Consortium and Vaccine Treatment Evaluation Units (VTEUs) are a network of clinicians and scientists who work together with the National Institutes of Allergy and Infectious Diseases to advance vac…
View article: The XBB.1.5 COVID-19 vaccine elicits a durable antibody response to ancestral and XBB.1.5 SARS-CoV-2 spike proteins
The XBB.1.5 COVID-19 vaccine elicits a durable antibody response to ancestral and XBB.1.5 SARS-CoV-2 spike proteins Open
The rapid emergence of divergent SARS-CoV-2 variants led to a 2023–2024 update of the COVID-19 mRNA vaccine to a monovalent version containing the XBB.1.5 SARS-CoV-2 spike antigen. To determine the durability and breadth of the antibody re…
View article: All-Cause and Pneumococcal Community-Acquired Pneumonia Hospitalizations Among Adults in Tennessee and Georgia
All-Cause and Pneumococcal Community-Acquired Pneumonia Hospitalizations Among Adults in Tennessee and Georgia Open
IMPORTANCE Although the use of pneumococcal conjugate vaccines (PCV) has reduced the overall burden of pneumococcal disease, recent measurements of pneumococcal pneumonia incidence are lacking. OBJECTIVE To prospectively quantify the burde…
View article: Viral Etiologies of Acute Respiratory Illness in Older Adults and of Congestive Heart Failure and Chronic Obstructive Pulmonary Disease Exacerbations Requiring Hospitalization During 2 Prepandemic Respiratory Seasons
Viral Etiologies of Acute Respiratory Illness in Older Adults and of Congestive Heart Failure and Chronic Obstructive Pulmonary Disease Exacerbations Requiring Hospitalization During 2 Prepandemic Respiratory Seasons Open
Background In adults, the infectious etiologies of acute respiratory illnesses (ARIs) and of exacerbations of cardiopulmonary diseases requiring hospitalization are incompletely understood. Methods We conducted a prospective surveillance s…
View article: Fc-effector functional antibody assays for SARS-CoV-2 variants of concern
Fc-effector functional antibody assays for SARS-CoV-2 variants of concern Open
Background The Fc regions of antibodies mediate important effector cell functions such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), antibody-dependent neutrophil phagocytosis (ADNP), …
View article: Evaluation of Cellular Immune Responses After mRNA-1273 Vaccination in Children 6 Months to 11 Years of Age
Evaluation of Cellular Immune Responses After mRNA-1273 Vaccination in Children 6 Months to 11 Years of Age Open
Background Cell-mediated immunity (CMI) may help protect against emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that are less susceptible to neutralizing antibodies. We present CMI data after the mRNA-1273 p…
View article: Serologic Responses to COVID-19 Vaccination in Pediatric Kidney Transplant Recipients
Serologic Responses to COVID-19 Vaccination in Pediatric Kidney Transplant Recipients Open
Background. There are limited data describing the immune responses to COVID-19 vaccination in pediatric kidney transplant recipients, and expanding upon this information could help inform vaccination strategies in this unique population. M…
View article: Differential Severity of Sars-Cov-2 Variant Infections in Children and Adults with Covid-19
Differential Severity of Sars-Cov-2 Variant Infections in Children and Adults with Covid-19 Open
View article: A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose
A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose Open
Filoviruses, including Ebola, Marburg, Sudan, and Taï Forest viruses, are zoonotic pathogens that can cause severe viral hemorrhagic fever and death. Developing vaccines that provide durable, broad immunity against multiple filoviruses is …
View article: Altered Spike Immunoglobulin G Fc N-Linked Glycans Are Associated With Hyperinflammatory State in Adult Coronavirus Disease 2019 and Multisystem Inflammatory Syndrome in Children
Altered Spike Immunoglobulin G Fc N-Linked Glycans Are Associated With Hyperinflammatory State in Adult Coronavirus Disease 2019 and Multisystem Inflammatory Syndrome in Children Open
Background Severe coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome (MIS-C) are characterized by excessive inflammatory cytokines/chemokines. In adults, disease severity is associated with severe acute respiratory s…
View article: Plasma cell-free RNA signatures of inflammatory syndromes in children
Plasma cell-free RNA signatures of inflammatory syndromes in children Open
Inflammatory syndromes, including those caused by infection, are a major cause of hospital admissions among children and are often misdiagnosed because of a lack of advanced molecular diagnostic tools. In this study, we explored the utilit…
View article: Safety and Immunogenicity of an mRNA-1273 Booster in Children
Safety and Immunogenicity of an mRNA-1273 Booster in Children Open
Background A 2-dose mRNA-1273 primary series in children aged 6 months–5 years (25 µg) and 6–11 years (50 µg) had an acceptable safety profile and was immunogenic in the phase 2/3 KidCOVE study. We present data from KidCOVE participants wh…
View article: Clinical Features and Outcomes of Pediatric and Adult Patients Hospitalized for Coronavirus Disease 2019: A Comparison Across Age Strata
Clinical Features and Outcomes of Pediatric and Adult Patients Hospitalized for Coronavirus Disease 2019: A Comparison Across Age Strata Open
Background Coronavirus disease 2019 (COVID-19) continues to cause hospitalizations and severe disease in children and adults. Methods This study compared the risk factors, symptoms, and outcomes of children and adults hospitalized for COVI…
View article: Prevalence, Clinical Severity, and Serotype Distribution of Pneumococcal Pneumonia Among Adults Hospitalized With Community-Acquired Pneumonia in Tennessee and Georgia, 2018–2022
Prevalence, Clinical Severity, and Serotype Distribution of Pneumococcal Pneumonia Among Adults Hospitalized With Community-Acquired Pneumonia in Tennessee and Georgia, 2018–2022 Open
Introduction Understanding the pneumococcal serotypes causing community-acquired pneumonia (CAP) is essential for evaluating the impact of pneumococcal vaccines. Methods We conducted a prospective surveillance study of adults aged ≥18 year…
View article: Altered spike IgG Fc N-linked glycans are associated with hyperinflammatory state in adult COVID and Multisystem Inflammatory Syndrome in Children
Altered spike IgG Fc N-linked glycans are associated with hyperinflammatory state in adult COVID and Multisystem Inflammatory Syndrome in Children Open
Background Severe COVID and multisystem inflammatory syndrome (MIS-C) are characterized by excessive inflammatory cytokines/chemokines. In adults, disease severity is associated with SARS-CoV-2-specific IgG Fc afucosylation, which induces …
View article: Relative Contribution of Diagnostic Testing to the Diagnosis of Respiratory Syncytial Virus in Hospitalized Adults in the United States
Relative Contribution of Diagnostic Testing to the Diagnosis of Respiratory Syncytial Virus in Hospitalized Adults in the United States Open
Background Respiratory syncytial virus (RSV) is a leading cause of acute respiratory illness (ARI) in older adults. Optimizing diagnosis could improve understanding of RSV burden. Methods We enrolled adults ≥50 years of age hospitalized wi…
View article: Effectiveness of BNT162b2 Vaccine for Preventing COVID-19-Related Hospitalizations: A Test-Negative Case–Control Study
Effectiveness of BNT162b2 Vaccine for Preventing COVID-19-Related Hospitalizations: A Test-Negative Case–Control Study Open
It is important to understand real-world BNT162b2 COVID-19 vaccine effectiveness (VE), especially among racial and ethnic minority groups. We performed a test-negative case-control study to measure BNT162b2 COVID-19 VE in the prevention of…
View article: Experimental trials of predicted CD4+ and CD8+ T-cell epitopes of respiratory syncytial virus
Experimental trials of predicted CD4+ and CD8+ T-cell epitopes of respiratory syncytial virus Open
Background Respiratory syncytial virus (RSV) is the most common cause of viral lower respiratory tract infections (LRTIs) in young children around the world and an important cause of LRTI in the elderly. The available treatments and FDA-ap…
View article: A Phase 1, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Safety and Immunogenicity of HEV-239 (Hecolin) Vaccine in Healthy US Adults
A Phase 1, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Safety and Immunogenicity of HEV-239 (Hecolin) Vaccine in Healthy US Adults Open
Background Establishing the safety and immunogenicity of a hepatitis E virus vaccine in multiple populations could facilitate broader access and prevent maternal and infant mortality. Methods We conducted a phase 1, randomized, double-blin…
View article: Plasma Cell-free RNA Signatures of Inflammatory Syndromes in Children
Plasma Cell-free RNA Signatures of Inflammatory Syndromes in Children Open
Inflammatory syndromes, including those caused by infection, are a major cause of hospital admissions among children and are often misdiagnosed because of a lack of advanced molecular diagnostic tools. In this study, we explored the utilit…
View article: XBB.1.5 monovalent booster improves antibody binding and neutralization against emerging SARS-CoV-2 Omicron variants
XBB.1.5 monovalent booster improves antibody binding and neutralization against emerging SARS-CoV-2 Omicron variants Open
The rapid emergence of divergent SARS-CoV-2 variants has led to an update of the COVID-19 booster vaccine to a monovalent version containing the XBB.1.5 spike. To determine the neutralization breadth following booster immunization, we coll…
View article: Clinical features and outcomes of children vs. adults hospitalized with coronavirus disease 2019 (COVID-19)
Clinical features and outcomes of children vs. adults hospitalized with coronavirus disease 2019 (COVID-19) Open
View article: Descriptive analysis of clinical characteristics of children hospitalized with COVID-19: a comparison across age groups
Descriptive analysis of clinical characteristics of children hospitalized with COVID-19: a comparison across age groups Open
View article: Development and comparison of immunologic assays to detect primary RSV infections in infants
Development and comparison of immunologic assays to detect primary RSV infections in infants Open
Effective respiratory syncytial virus (RSV) vaccines have been developed and licensed for elderly adults and pregnant women but not yet for infants and young children. The RSV immune state of the young child, i.e., previously RSV infected …
View article: Pre-Existing Memory B Cell Phenotypes Determine the Quality of B Cell Response to Vaccine Boosters
Pre-Existing Memory B Cell Phenotypes Determine the Quality of B Cell Response to Vaccine Boosters Open
View article: Immunogenicity and safety of varying dosages of a fifth-wave influenza A/H7N9 inactivated vaccine given with and without AS03 adjuvant in healthy adults
Immunogenicity and safety of varying dosages of a fifth-wave influenza A/H7N9 inactivated vaccine given with and without AS03 adjuvant in healthy adults Open
View article: 430. Clinical Features and Outcomes of COVID-19 Hospitalized Adults by Variant
430. Clinical Features and Outcomes of COVID-19 Hospitalized Adults by Variant Open
Background SARS-CoV-2 has changed and mutated over time. It is important to evaluate changes in clinical presentation and outcomes based on the emerging variants. In this study, we aimed to compare differences in symptoms and outcomes amon…
View article: 260. Durability of Antibody Responses to RSV in Older Adults Following Hospitalization for Acute Respiratory Infection
260. Durability of Antibody Responses to RSV in Older Adults Following Hospitalization for Acute Respiratory Infection Open
Background Respiratory syncytial virus (RSV) is a common viral pathogen identified in older adults with acute respiratory infections (ARIs). Data describing the durability of immune responses to RSV are limited but suggest responses may be…
View article: 2621. Social Risk Factors for RSV-related Hospitalizations in Adults ≥ 50 years of age
2621. Social Risk Factors for RSV-related Hospitalizations in Adults ≥ 50 years of age Open
Background Although respiratory syncytial virus (RSV) is a common pathogen in older adults, little is known about the social risk factors for RSV hospitalization in this population. In this study, we sought to evaluate the social determina…
View article: 2364. Predictive Ability of mRNA COVID-19 Vaccines Against COVID-19 Disease Severity
2364. Predictive Ability of mRNA COVID-19 Vaccines Against COVID-19 Disease Severity Open
Background Prior studies demonstrated the vaccine effectiveness and safety of mRNA COVID-19 vaccines, but additional data is needed regarding the effects of timing and number of doses on disease severity. This study determined predicted pr…