Christina Deligianni
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View article: Correction: The role of community pharmacists in managing common headache disorders, and their integration within structured headache services: position statement on behalf of the European Headache Federation (EHF) and Lifting The Burden (LTB: the Global Campaign against Headache), with the formal endorsement of the International Pharmaceutical federation
Correction: The role of community pharmacists in managing common headache disorders, and their integration within structured headache services: position statement on behalf of the European Headache Federation (EHF) and Lifting The Burden (LTB: the Global Campaign against Headache), with the formal endorsement of the International Pharmaceutical federation Open
View article: The role of community pharmacists in managing common headache disorders, and their integration within structured headache services: position statement on behalf of the European Headache Federation (EHF) and Lifting The Burden (LTB: the Global Campaign against Headache), with the formal endorsement of the International Pharmaceutical Federation
The role of community pharmacists in managing common headache disorders, and their integration within structured headache services: position statement on behalf of the European Headache Federation (EHF) and Lifting The Burden (LTB: the Global Campaign against Headache), with the formal endorsement of the International Pharmaceutical Federation Open
In the sustainable development goals (SDG) context of seeking universal health coverage, the expanding gap between the supply of specialized and primary health-care providers of headache-related health care and the care needs of the very l…
View article: Comparative effects of drug interventions for the acute management of migraine episodes in adults: systematic review and network meta-analysis
Comparative effects of drug interventions for the acute management of migraine episodes in adults: systematic review and network meta-analysis Open
Objective To compare all licensed drug interventions as oral monotherapy for the acute treatment of migraine episodes in adults. Design Systematic review and network meta-analysis. Data sources Cochrane Central Register of Controlled Trial…
View article: European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention - part 4: propranolol
European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention - part 4: propranolol Open
Objective The aim of this paper is to critically re-appraise the published trials assessing propranolol for migraine prophylaxis. Methods We report methods and results following the Preferred Reporting Items for Systematic Reviews (PRISMA)…
View article: Onabotulinumtoxina in the Prevention of Migraine in Pediatric Population: A Systematic Review
Onabotulinumtoxina in the Prevention of Migraine in Pediatric Population: A Systematic Review Open
Migraine is a leading cause of disability worldwide, yet it remains underrecognized and undertreated, especially in the pediatric and adolescent population. Chronic migraine occurs approximately in 1% of children and adolescents requiring …
View article: Galcanezumab Add-on in Refractory Cluster Headache
Galcanezumab Add-on in Refractory Cluster Headache Open
Background: Cluster headache (CH), currently one of the most painful conditions, lacks a well-established, disease specific, and mechanism-based prophylactic treatment. Galganezumab, a monoclonal antibody targeting the calcitonin gene-rela…
View article: <scp>Reply to the letter: Headaches during</scp>/<scp>after SARS‐CoV</scp>‐2 <scp>infection</scp>/<scp>vaccination can be primary and secondary as well as acute and chronic,</scp> by Finsterer J and Mehri S
<span>Reply to the letter: Headaches during</span>/<span>after SARS‐CoV</span>‐2 <span>infection</span>/<span>vaccination can be primary and secondary as well as acute and chronic,</span> by Finsterer J and Mehri S Open
Paroxysmal Cerebral Disorders
View article: Depression and Anxiety Symptoms in Headache Disorders: An Observational, Cross-Sectional Study
Depression and Anxiety Symptoms in Headache Disorders: An Observational, Cross-Sectional Study Open
Background: Headache disorders have been associated with anxiety and depressive disorders. The aim of this study was to assess symptoms of anxiety and depression in a large sample of individuals with different headache disorders (HDs) in o…
View article: Placebo responses vary by route of administration in migraine prevention trials. What does this mean?
Placebo responses vary by route of administration in migraine prevention trials. What does this mean? Open
View article: Headaches and facial pain attributed to SARS‐CoV‐2 infection and vaccination: a systematic review
Headaches and facial pain attributed to SARS‐CoV‐2 infection and vaccination: a systematic review Open
Background and purpose The aim was to provide insights to the characteristics of headache in the context of COVID‐19 on behalf of the Headache Scientific Panel and the Neuro‐COVID‐19 Task Force of the European Academy of Neurology (EAN) an…
View article: European Headache Federation (EHF) critical reappraisal and meta-analysis of oral drugs in migraine prevention – part 3: topiramate
European Headache Federation (EHF) critical reappraisal and meta-analysis of oral drugs in migraine prevention – part 3: topiramate Open
Objective Topiramate is a repurposed first-line treatment for migraine prophylaxis. The aim of this systematic review and meta-analysis is to critically re-appraise the existing evidence supporting the efficacy and tolerability of topirama…
View article: European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention—part 2: flunarizine
European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention—part 2: flunarizine Open
View article: Second messenger signalling bypasses CGRP receptor blockade to provoke migraine attacks in humans
Second messenger signalling bypasses CGRP receptor blockade to provoke migraine attacks in humans Open
There are several endogenous molecules that can trigger migraine attacks when administered to humans. Notably, calcitonin gene-related peptide (CGRP) has been identified as a key player in a signalling cascade involved in migraine attacks,…
View article: Correction: The effect of Lu AG09222 on PACAP38- and VIP-induced vasodilation, heart rate increase, and headache in healthy subjects: an interventional, randomized, double-blind, parallel-group, placebo-controlled study
Correction: The effect of Lu AG09222 on PACAP38- and VIP-induced vasodilation, heart rate increase, and headache in healthy subjects: an interventional, randomized, double-blind, parallel-group, placebo-controlled study Open
View article: Are indirect comparisons for treatments in migraine necessitas? Many inevitable challenges to overcome
Are indirect comparisons for treatments in migraine necessitas? Many inevitable challenges to overcome Open
View article: The effect of Lu AG09222 on PACAP38- and VIP-induced vasodilation, heart rate increase, and headache in healthy subjects: an interventional, randomized, double-blind, parallel-group, placebo-controlled study
The effect of Lu AG09222 on PACAP38- and VIP-induced vasodilation, heart rate increase, and headache in healthy subjects: an interventional, randomized, double-blind, parallel-group, placebo-controlled study Open
Background Pituitary adenylate cyclase-activating polypeptide (PACAP), structurally related to vasoactive intestinal peptide (VIP), is one of the important mediators in the pathogenesis of migraine and is known to dilate cranial arteries a…
View article: The comparative effectiveness of migraine preventive drugs: a systematic review and network meta-analysis
The comparative effectiveness of migraine preventive drugs: a systematic review and network meta-analysis Open
View article: Plasma levels of VIP are not elevated during PACAP- and VIP-induced cluster headache attacks: an exploratory study
Plasma levels of VIP are not elevated during PACAP- and VIP-induced cluster headache attacks: an exploratory study Open
Background Pituitary adenylate cyclase-activating peptide (PACAP) and vasoactive intestinal peptide (VIP) provoked cluster headache attacks in individuals with episodic cluster headache during their active phase and individuals with chroni…
View article: The comparative effectiveness of migraine preventive drugs: a systematic review and network meta-analysis
The comparative effectiveness of migraine preventive drugs: a systematic review and network meta-analysis Open
Objective : While there are several trials that support the efficacy of various drugs for migraine prophylaxis against placebo, there is limited evidence addressing the comparative safety and efficacy of these drugs. We conducted a systema…
View article: European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention—part 1: amitriptyline
European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention—part 1: amitriptyline Open
View article: Hellenic Headache Society Recommendations for the Use of Monoclonal Antibodies Targeting the Calcitonin Gene-Related Peptide Pathway for the Prevention of Migraine and Cluster Headache—2023 Update
Hellenic Headache Society Recommendations for the Use of Monoclonal Antibodies Targeting the Calcitonin Gene-Related Peptide Pathway for the Prevention of Migraine and Cluster Headache—2023 Update Open
The confirmed involvement of the neuropeptide calcitonin gene-related peptide (CGRP) in the pathophysiology of migraine has led to the development of treatments, which for the first time are specific to migraine and mechanism based, in con…
View article: European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention - Part 1 Amitriptyline
European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention - Part 1 Amitriptyline Open
Objective The aim of this paper is to critically re-appraise the published trials assessing amitriptyline for migraine prophylaxis. Methods We report our methods and results following the Preferred Reporting Items for Systematic Reviews (P…
View article: European Headache Federation (EHF) consensus on the definition of effective treatment of a migraine attack and of triptan failure
European Headache Federation (EHF) consensus on the definition of effective treatment of a migraine attack and of triptan failure Open
View article: European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention – 2022 update
European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention – 2022 update Open
View article: Nocebo-Prone Behavior Associated with SARS-CoV-2 Vaccine Hesitancy in Healthcare Workers
Nocebo-Prone Behavior Associated with SARS-CoV-2 Vaccine Hesitancy in Healthcare Workers Open
Among healthcare workers (HCWs), SARS-CoV-2 vaccine hesitancy may be linked to a higher susceptibility to nocebo effects, i.e., adverse events (AEs) experienced after medical treatments due to negative expectations. To investigate this hyp…
View article: Monoclonal Antibodies Targeting CGRP: From Clinical Studies to Real-World Evidence—What Do We Know So Far?
Monoclonal Antibodies Targeting CGRP: From Clinical Studies to Real-World Evidence—What Do We Know So Far? Open
Now more than ever is the time of monoclonal antibody use in neurology. In headaches, disease-specific and mechanism-based treatments existed only for symptomatic management of migraines (i.e., triptans), while the standard prophylactic an…
View article: Nocebo-Prone Behavior Contributes to SARS-CoV-2 Vaccine Hesitancy in Healthcare Workers
Nocebo-Prone Behavior Contributes to SARS-CoV-2 Vaccine Hesitancy in Healthcare Workers Open
View article: Therapeutic Management: When and What
Therapeutic Management: When and What Open
Migraine is a widespread brain disease that is classified as the second most disabling condition and has the third highest prevalence of all medical conditions. Despite its non-emergent or life-threatening nature, migraine can progress to …
View article: Patients’ preferences for headache acute and preventive treatment
Patients’ preferences for headache acute and preventive treatment Open
View article: Refractory burning mouth syndrome: clinical and paraclinical evaluation, comorbidities, treatment and outcome
Refractory burning mouth syndrome: clinical and paraclinical evaluation, comorbidities, treatment and outcome Open
BMS deserves bottomless psychiatric evaluation and management when current available treatments fail. Treatment with venlafaxine combined with topical and systemic clonazepam may be effective in refractory BMS cases but further investigati…