Christina Lang
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View article: Early brain-wide disruption of sleep microarchitecture in Amyotrophic Lateral Sclerosis
Early brain-wide disruption of sleep microarchitecture in Amyotrophic Lateral Sclerosis Open
This work was funded by Agence Nationale de la Recherche (ANR-24-CE37-4064, ANR-10-IDEX-0002, ANR-20-SFRI-0012), Fondation Thierry Latran, Association Francaise de Recherche sur la sclérose latérale amyotrophique, Association Française con…
View article: Sleep alterations in amyotrophic lateral sclerosis
Sleep alterations in amyotrophic lateral sclerosis Open
Purpose of review This review summarizes recent evidence on sleep disturbances in amyotrophic lateral sclerosis (ALS), emphasizing their role as intrinsic features of the disease process rather than consequence of motor decline. Recent fin…
View article: Rapid Enzymatic Detection of Shiga-Toxin-Producing <i>E. coli</i> Using Fluorescence-Labeled Oligonucleotide Substrates
Rapid Enzymatic Detection of Shiga-Toxin-Producing <i>E. coli</i> Using Fluorescence-Labeled Oligonucleotide Substrates Open
Shiga-toxin-producing Escherichia coli (STEC) are important human pathogens causing diarrhea, hemorrhagic colitis, and severe hemolytic uremic syndrome. Timely detection of the multifaceted STEC is of high importance but is challeng…
View article: Changes in Secondary Structure Upon Pr to Pfr Transition in Cyanobacterial Phytochrome Cph1 Detected by DNP NMR
Changes in Secondary Structure Upon Pr to Pfr Transition in Cyanobacterial Phytochrome Cph1 Detected by DNP NMR Open
Phytochromes perceive subtle changes in the light environment and convert them into biological signals by photoconversion between the red‐light absorbing (Pr) and the far‐red‐absorbing (Pfr) states. In the primitive bacteriophytochromes th…
View article: Lateral hypothalamus drives early-onset sleep alterations in amyotrophic lateral sclerosis
Lateral hypothalamus drives early-onset sleep alterations in amyotrophic lateral sclerosis Open
Lateral hypothalamic neurons producing melanin-concentrating hormone (MCH) and orexin/hypocretin are involved in sleep regulation. Both MCH and orexin neurons are altered in amyotrophic lateral sclerosis (ALS), the most common adult-onset …
View article: Enteroaggregative Escherichia coli: Frequent, yet underdiagnosed pathotype among E. coli O111 strains isolated from children with gastrointestinal disorders in the Czech Republic
Enteroaggregative Escherichia coli: Frequent, yet underdiagnosed pathotype among E. coli O111 strains isolated from children with gastrointestinal disorders in the Czech Republic Open
Enteroaggregative Escherichia coli (EAEC) strains including those of serogroup O111 are important causes of diarrhea in children. In the Czech Republic, no information is available on the etiological role of EAEC in pediatric diarrhea due …
View article: Genomic surveillance of STEC/EHEC infections in Germany 2020 to 2022 permits insight into virulence gene profiles and novel O-antigen gene clusters
Genomic surveillance of STEC/EHEC infections in Germany 2020 to 2022 permits insight into virulence gene profiles and novel O-antigen gene clusters Open
Shiga toxin-producing E. coli (STEC), including the subgroup of enterohemorrhagic E. coli (EHEC), are important bacterial pathogens which cause diarrhea and the severe clinical manifestation hemolytic uremic syndrome (HUS). Genomic surveil…
View article: Structure–function relationships underpin disulfide loop cleavage‐dependent activation of <i>Legionella pneumophila</i> lysophospholipase A <scp>PlaA</scp>
Structure–function relationships underpin disulfide loop cleavage‐dependent activation of <i>Legionella pneumophila</i> lysophospholipase A <span>PlaA</span> Open
Legionella pneumophila , the causative agent of a life‐threatening pneumonia, intracellularly replicates in a specialized compartment in lung macrophages, the Legionella ‐containing vacuole (LCV). Secreted proteins of the pathogen govern i…
View article: Rapid enzymatic detection of Shigatoxin-producing<i>E. coli</i>using fluorescence-labeled oligonucleotide substrates
Rapid enzymatic detection of Shigatoxin-producing<i>E. coli</i>using fluorescence-labeled oligonucleotide substrates Open
Shigatoxin-producing E. coli (STEC) are important human pathogens causing disease ranging from diarrhea to severe hemolytic uremic syndrome. As STEC are transmitted via animals, food, and water, and may produce large outbreaks, their timel…
View article: Pitolisant-supported bridging during drug holidays to deal with tolerance to modafinil in patients with narcolepsy
Pitolisant-supported bridging during drug holidays to deal with tolerance to modafinil in patients with narcolepsy Open
Clinical Trials.gov Identifier NCT05321355.
View article: The Industrialisation of Sustainable Construction: A Transdisciplinary Approach to the Large-Scale Introduction of Compacted Mineral Mixtures (CMMs) into Building Construction
The Industrialisation of Sustainable Construction: A Transdisciplinary Approach to the Large-Scale Introduction of Compacted Mineral Mixtures (CMMs) into Building Construction Open
Increasing demand for sustainable, resilient, and low-carbon construction materials has highlighted the potential of Compacted Mineral Mixtures (CMMs), which are formulated from various soil types (sand, silt, clay) and recycled mineral wa…
View article: O-Antigen Diversification Masks Identification of Highly Pathogenic Shiga Toxin-Producing Escherichia coli O104:H4-Like Strains
O-Antigen Diversification Masks Identification of Highly Pathogenic Shiga Toxin-Producing Escherichia coli O104:H4-Like Strains Open
Our data suggest that the high-virulence ensemble of the STEC O104:H4 outbreak strain remains a global threat because genomically similar strains cause disease worldwide but that the horizontal acquisition of O-antigen gene clusters has di…
View article: ALS is imprinted in the chromatin accessibility of blood cells
ALS is imprinted in the chromatin accessibility of blood cells Open
View article: Recyclable and Efficient Construction using Mineral Landfill Materials and Demolition Wastes
Recyclable and Efficient Construction using Mineral Landfill Materials and Demolition Wastes Open
An inter- and transdisciplinary concept has been developed, focusing on the scaling of industrial circular construction using innovative compacted mineral mixtures (CMM) derived from various soil types (sand, silt, clay) and recycled miner…
View article: Structure-function relationships underpin disulfide loop cleavage-dependent activation of<i>Legionella pneumophila</i>lysophosholipase A PlaA
Structure-function relationships underpin disulfide loop cleavage-dependent activation of<i>Legionella pneumophila</i>lysophosholipase A PlaA Open
Legionella pneumophila, the causative agent of a life-threatening pneumonia, intracellularly replicates in a specialized compartment in lung macrophages, the Legionella -containing vacuole (LCV). Secreted proteins of the pathogen govern im…
View article: Ultrafast protein response in the Pfr state of Cph1 phytochrome
Ultrafast protein response in the Pfr state of Cph1 phytochrome Open
View article: What Can SMEs Learn from Universities?: Transferring Entrepreneurship Education Knowledge from the University to the Corporate World
What Can SMEs Learn from Universities?: Transferring Entrepreneurship Education Knowledge from the University to the Corporate World Open
View article: Bestandsaufnahme der verfügbaren und aktuell eingesetzten Typisierungsmethoden von zoonotischen Erregern am Beispiel von Shiga Toxin-bildenden bzw. enterohämorrhagischen Escherichia coli (STEC/EHEC)
Bestandsaufnahme der verfügbaren und aktuell eingesetzten Typisierungsmethoden von zoonotischen Erregern am Beispiel von Shiga Toxin-bildenden bzw. enterohämorrhagischen Escherichia coli (STEC/EHEC) Open
Zusammenfassung Einleitung Für eine Verbesserung der Patientenversorgung und die Erhöhung der Lebensmittelsicherheit im Sinne von One Health wurden im Rahmen des Projekts „Integrierte Genomische Surveillance von Zoonoseerregern (IGS-Zoo)“ …
View article: O-antigen diversification masks identification of highly pathogenic STEC O104:H4-like strains
O-antigen diversification masks identification of highly pathogenic STEC O104:H4-like strains Open
Shiga toxin-producing E. coli (STEC) can give rise to a range of clinical outcomes from diarrhea to the life-threatening systemic condition, hemolytic uremic syndrome (HUS). Although STEC O157:H7 is the serotype most frequently associated …
View article: Sporadic Occurrence of Enteroaggregative Shiga Toxin–Producing <i>Escherichia coli</i> O104:H4 Similar to 2011 Outbreak Strain
Sporadic Occurrence of Enteroaggregative Shiga Toxin–Producing <i>Escherichia coli</i> O104:H4 Similar to 2011 Outbreak Strain Open
We describe the recent detection of 3 Shiga toxin-producing enteroaggregative Escherichia coli O104:H4 isolates from patients and 1 from pork in the Netherlands that were genetically highly similar to isolates from the 2011 large-scale out…
View article: Uncovering goals for corporate entrepreneurship: A classification based on literature review
Uncovering goals for corporate entrepreneurship: A classification based on literature review Open
Corporate Entrepreneurship (CE) has now evolved into an imperative innovation practice of established companies. Despite organizational design models for CE activities and companies' frequent initiation of new activities, effectively manag…
View article: NAD(H)-mediated tetramerization controls the activity of <i>Legionella pneumophila</i> phospholipase PlaB
NAD(H)-mediated tetramerization controls the activity of <i>Legionella pneumophila</i> phospholipase PlaB Open
Significance Secreted bacterial phospholipases, which hydrolyze host membranes, may also harm the pathogen itself. Sophisticated activation mechanisms are therefore required to prevent self-damage before protein export but warrant activity…
View article: Genetic diversity and pathogenic potential of Shiga toxin-producing Escherichia coli (STEC) derived from German flour
Genetic diversity and pathogenic potential of Shiga toxin-producing Escherichia coli (STEC) derived from German flour Open
Shiga toxin-producing Escherichia coli (STEC) can cause severe human illness, which are frequently linked to the consumption of contaminated beef or dairy products. However, recent outbreaks associated with contaminated flour and undercook…
View article: Eye movement alterations in presymptomatic C9orf72 expansion gene carriers
Eye movement alterations in presymptomatic C9orf72 expansion gene carriers Open
View article: NAD(H)-mediated tetramerization controls the activity of<i>Legionella pneumophila</i>phospholipase PlaB
NAD(H)-mediated tetramerization controls the activity of<i>Legionella pneumophila</i>phospholipase PlaB Open
The virulence factor and phospholipase PlaB promotes lung colonization, tissue destruction, and intracellular replication of Legionella pneumophila , the causative agent of Legionnaires’ disease. It is exposed at the bacterial surface and …
View article: Food Authentication: Identification and Quantitation of Different Tuber Species via Capillary Gel Electrophoresis and Real-Time PCR
Food Authentication: Identification and Quantitation of Different Tuber Species via Capillary Gel Electrophoresis and Real-Time PCR Open
Truffles are hypogeous fungi mainly found in Europe and Asia. Due to their special aroma and taste, some truffle species are sold on the international market at an extremely high price. Among the economically relevant species, the white Al…
View article: MAS NMR on a Red/Far-Red Photochromic Cyanobacteriochrome All2699 from Nostoc
MAS NMR on a Red/Far-Red Photochromic Cyanobacteriochrome All2699 from Nostoc Open
Unlike canonical phytochromes, the GAF domain of cyanobacteriochromes (CBCRs) can bind bilins autonomously and is sufficient for functional photocycles. Despite the astonishing spectral diversity of CBCRs, the GAF1 domain of the three-GAF-…
View article: Novel type of pilus associated with a Shiga-toxigenic <i>E. coli</i> hybrid pathovar conveys aggregative adherence and bacterial virulence
Novel type of pilus associated with a Shiga-toxigenic <i>E. coli</i> hybrid pathovar conveys aggregative adherence and bacterial virulence Open
A large German outbreak in 2011 was caused by a locus of enterocyte effacement (LEE)-negative enterohemorrhagic E. coli (EHEC) strain of the serotype O104:H4. This strain harbors markers that are characteristic of both EHEC and ente…
View article: Novel type of pilus associated with a Shiga-toxigenic <i>E. coli</i> hybrid pathovar conveys aggregative adherence and bacterial virulence
Novel type of pilus associated with a Shiga-toxigenic <i>E. coli</i> hybrid pathovar conveys aggregative adherence and bacterial virulence Open
A large German outbreak in 2011 was caused by a locus of enterocyte effacement (LEE)-negative enterohemorrhagic E. coli (EHEC) strain of the serotype O104:H4. This strain harbors markers that are characteristic of both EHEC and enteroaggre…
View article: Initiating intramuscular depot medroxyprogesterone acetate 24–48 hours after mifepristone administration does not affect success of early medical abortion
Initiating intramuscular depot medroxyprogesterone acetate 24–48 hours after mifepristone administration does not affect success of early medical abortion Open
Objectives The primary objective of this study was to determine whether intramuscular depot medroxyprogesterone acetate (IM DMPA) given at the time of misoprostol administration, 24–48 hours after mifepristone, affects the rate of continui…