Christina M. Lockwood
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View article: Dynamic Monitoring of Recurrent Ovarian Cancer Using Serial ctDNA: A Real-World Case Series
Dynamic Monitoring of Recurrent Ovarian Cancer Using Serial ctDNA: A Real-World Case Series Open
Recurrent ovarian cancer (OC) is challenging to detect early using current methods like CA-125 and imaging. Circulating tumor DNA (ctDNA) may improve disease monitoring. Here, we assess the real-world clinical utility of serial ctDNA analy…
View article: Correlates of risk of respiratory syncytial virus disease: a prospective cohort study
Correlates of risk of respiratory syncytial virus disease: a prospective cohort study Open
Few population-based studies have evaluated the importance of pre-existing respiratory syncytial virus (RSV) antibody on RSV susceptibility among children and adults. We conducted a prospective, community-based cohort study among individua…
View article: Recommended Clinical Context and Patient Context Data Elements for Liquid Biopsy Data Submitted to Data Repositories and Data Commons
Recommended Clinical Context and Patient Context Data Elements for Liquid Biopsy Data Submitted to Data Repositories and Data Commons Open
In 2020, BLOODPAC recommended 11 pre‐analytical minimal technical data elements for collection and submission of liquid biopsy data to public databases. This article expands on that work by recommending 22 clinical context and 10 patient c…
View article: 424. SARS-CoV-2 Positivity and Genetic Relationships among Cases within Households in the Cascadia Prospective Cohort Study, July 2022 to May 2023
424. SARS-CoV-2 Positivity and Genetic Relationships among Cases within Households in the Cascadia Prospective Cohort Study, July 2022 to May 2023 Open
Background Household transmission is a major driver of SARS-CoV-2 spread. Viral genomic sequencing is a powerful tool for evaluation of putative within-household transmission. Characteristics of participants from multi-participant househol…
View article: P-1951. Incidence of SARS-CoV-2 Infection among those 6 Months to 49 Years of Age in the Cascadia Prospective Cohort Study, Oregon and Washington, United States, July 1, 2022 – March 31, 2024
P-1951. Incidence of SARS-CoV-2 Infection among those 6 Months to 49 Years of Age in the Cascadia Prospective Cohort Study, Oregon and Washington, United States, July 1, 2022 – March 31, 2024 Open
Background With the ending of the public health emergency and changes in the testing landscape, less is known about SARS-CoV-2 incidence in the community than earlier in the pandemic. Our goal was to describe SARS-CoV-2 incidence among ind…
View article: Effectiveness of mRNA COVID-19 Vaccines and Hybrid Immunity in Preventing SARS-CoV-2 Infection and Symptomatic COVID-19 Among Adults in the United States
Effectiveness of mRNA COVID-19 Vaccines and Hybrid Immunity in Preventing SARS-CoV-2 Infection and Symptomatic COVID-19 Among Adults in the United States Open
Background Understanding protection against SARS-CoV-2 infection by vaccine and hybrid immunity is important for informing public health strategies as new variants emerge. Methods We analyzed data from 3 cohort studies spanning 1 September…
View article: Targeted detection of sequence variants in cell-free DNA from cerebrospinal fluid in pediatric central nervous system tumors
Targeted detection of sequence variants in cell-free DNA from cerebrospinal fluid in pediatric central nervous system tumors Open
The emergence of liquid biopsy technologies holds great promise in the cancer setting, including in pediatric central nervous system (CNS) tumors. In contrast to broad lower-depth sequencing, commonly referred to as low pass whole genome s…
View article: P709: Comparison of prenatal cell-free DNA screen positive for monosomy X with diagnostic maternal and fetal cytogenetic studies: A single-center study
P709: Comparison of prenatal cell-free DNA screen positive for monosomy X with diagnostic maternal and fetal cytogenetic studies: A single-center study Open
View article: P772: A tale of two sides: A rare pediatric neuro-oncology case
P772: A tale of two sides: A rare pediatric neuro-oncology case Open
View article: Effectiveness of mRNA COVID-19 vaccines and hybrid immunity in preventing SARS-CoV-2 infection and symptomatic COVID-19 among adults in the United States
Effectiveness of mRNA COVID-19 vaccines and hybrid immunity in preventing SARS-CoV-2 infection and symptomatic COVID-19 among adults in the United States Open
Background Understanding protection against SARS-CoV-2 infection by vaccine and hybrid immunity is important for informing public health strategies as new variants emerge. Methods We analyzed data from three cohort studies spanning Septemb…
View article: Towards Preanalytical Best Practices for Liquid Biopsy Studies: A BLOODPAC Landscape Analysis
Towards Preanalytical Best Practices for Liquid Biopsy Studies: A BLOODPAC Landscape Analysis Open
BLOODPAC is a public‐private consortium that develops best practices, coordinates clinical and translational research, and manages the BLOODPAC Data Commons to broadly support the liquid biopsy community and accelerate regulatory review to…
View article: METB-05. CSF LIQUID BIOPSY: PAVING THE WAY FOR MINIMALLY INVASIVE BRAIN TUMOR SURVEILLANCE USING LOW-PASS WHOLE GENOME SEQUENCING
METB-05. CSF LIQUID BIOPSY: PAVING THE WAY FOR MINIMALLY INVASIVE BRAIN TUMOR SURVEILLANCE USING LOW-PASS WHOLE GENOME SEQUENCING Open
OBJECTIVE We describe a clinical liquid biopsy platform for disease detection and surveillance in pediatric patients with primary central nervous system (CNS) tumors using low-pass whole genome sequencing (LP-WGS) on cell-free DNA (cfDNA) …
View article: A child possessing a concurrent germline NF1 variant and a mosaic TP53 variant: A rare case discussion
A child possessing a concurrent germline NF1 variant and a mosaic TP53 variant: A rare case discussion Open
A child possessing a concurrent germline NF1 variant and a mosaic TP53 variant: A rare case discussionMaya Ball-Burack1,2, Francisco A Perez2,3, Natalie Waligorski2, Shannon M Stasi7, Bonnie L Cole6,7, Rebecca Ronsley1, 2, 4, Vera Paulson5…
View article: Clarification of Information in “Navigating Next-Generation Sequencing Laboratory Developed Tests: A Critical Look at Proficiency Testing, US Food and Drug Administration Regulations, and Clinical Laboratory Performance Tests”
Clarification of Information in “Navigating Next-Generation Sequencing Laboratory Developed Tests: A Critical Look at Proficiency Testing, US Food and Drug Administration Regulations, and Clinical Laboratory Performance Tests” Open
To the Editor.—In the recently published editorial "Navigating Next-Generation Sequencing Laboratory Developed Tests: A Critical Look at Proficiency Testing, US Food and Drug Administration Regulations, and Clinical Laboratory Performance,…
View article: Looking beyond year 1 in the molecular era of pediatric brain tumor diagnosis: confirmatory testing of germline variants found on tumor sequencing
Looking beyond year 1 in the molecular era of pediatric brain tumor diagnosis: confirmatory testing of germline variants found on tumor sequencing Open
Purpose Somatic molecular profiling of pediatric brain tumors aids with the diagnosis and treatment of patients with a variety of high- and low-grade central nervous system neoplasms. Here, we report follow-up targeted germline evaluation …
View article: SARS-CoV-2 diversity and transmission on a university campus across two academic years during the pandemic
SARS-CoV-2 diversity and transmission on a university campus across two academic years during the pandemic Open
Institutions of higher education (IHEs) have been a focus of SARS-CoV-2 transmission studies but there is limited information on how viral diversity and transmission at IHEs changed as the pandemic progressed. Here we analyze 3606 viral ge…
View article: Genomic data in the All of Us Research Program
Genomic data in the All of Us Research Program Open
View article: Cerebrospinal fluid liquid biopsy by low-pass whole genome sequencing for clinical disease monitoring in pediatric embryonal tumors
Cerebrospinal fluid liquid biopsy by low-pass whole genome sequencing for clinical disease monitoring in pediatric embryonal tumors Open
Background Liquid biopsy assays that detect cell-free DNA (cfDNA) in cerebrospinal fluid (CSF) are a promising tool for disease monitoring in pediatric patients with primary central nervous system (CNS) tumors. As a compliment to tissue-de…
View article: Tiny swabs: nasal swabs integrated into tube caps facilitate large-scale self-collected SARS-CoV-2 testing
Tiny swabs: nasal swabs integrated into tube caps facilitate large-scale self-collected SARS-CoV-2 testing Open
The COVID-19 pandemic spurred the development of innovative solutions for specimen collection and molecular detection for large-scale community testing. Among these developments is the RHINOstic nasal swab, a plastic anterior nares …
View article: Table of Contents
Table of Contents Open
View article: SPOT/Dx Pilot Reanalysis and College of American Pathologists Proficiency Testing for <i>KRAS</i> and <i>NRAS</i> Demonstrate Excellent Laboratory Performance
SPOT/Dx Pilot Reanalysis and College of American Pathologists Proficiency Testing for <i>KRAS</i> and <i>NRAS</i> Demonstrate Excellent Laboratory Performance Open
Context.— The Sustainable Predictive Oncology Therapeutics and Diagnostics quality assurance pilot study (SPOT/Dx pilot) on molecular oncology next-generation sequencing (NGS) reportedly demonstrated performance limitations of NGS laborato…
View article: Robust Response of the Clinical Laboratory to the COVID-19 Pandemic despite Significant Challenges
Robust Response of the Clinical Laboratory to the COVID-19 Pandemic despite Significant Challenges Open
Background Clinical laboratories immediately provided rapid, reliable, and high-throughout diagnostic testing for COVID-19, which was an essential component in combating the pandemic. As the pandemic evolved, the clinical laboratory was fa…
View article: <i>BLM</i> overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor–resistant <i>BRCA</i> -mutant ovarian cancer
<i>BLM</i> overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor–resistant <i>BRCA</i> -mutant ovarian cancer Open
Poly(ADP-ribose) polymerase inhibitors (PARPis) have changed the treatment paradigm in breast cancer gene ( BRCA )–mutant high-grade serous ovarian carcinoma (HGSC). However, most patients eventually develop resistance to PARPis, highlight…
View article: METB-12. CLINICAL MONITORING OF MEASURABLE RESIDUAL DISEASE BY CELL-FREE DNA IN PEDIATRIC BRAIN TUMORS
METB-12. CLINICAL MONITORING OF MEASURABLE RESIDUAL DISEASE BY CELL-FREE DNA IN PEDIATRIC BRAIN TUMORS Open
Conventional response monitoring relies on imperfect tools like MRI and cerebrospinal fluid (CSF) cytology to detect measurable residual disease (MRD) in children with brain tumors. “Liquid biopsy” techniques provide a minimally-invasive m…
View article: Diagnosis of Ovarian Carcinoma Homologous Recombination DNA Repair Deficiency From Targeted Gene Capture Oncology Assays
Diagnosis of Ovarian Carcinoma Homologous Recombination DNA Repair Deficiency From Targeted Gene Capture Oncology Assays Open
PURPOSE Homologous recombination DNA repair deficiency (HRD) is a therapeutic biomarker for sensitivity to platinum and poly(ADP-ribose) polymerase inhibitor therapies in breast and ovarian cancers. Several molecular phenotypes and diagnos…
View article: Table S1 from Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations
Table S1 from Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations Open
SCH Clinical and Sequencing Data
View article: Data from Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations
Data from Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations Open
Desmoplastic infantile ganglioglioma (DIG) and desmoplastic infantile astrocytoma (DIA) are extremely rare tumors that typically arise in infancy; however, these entities have not been well characterized in terms of genetic alterations or …
View article: Table S1 from Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations
Table S1 from Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations Open
SCH Clinical and Sequencing Data
View article: Data from Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations
Data from Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations Open
Desmoplastic infantile ganglioglioma (DIG) and desmoplastic infantile astrocytoma (DIA) are extremely rare tumors that typically arise in infancy; however, these entities have not been well characterized in terms of genetic alterations or …
View article: Infantile ZFTA Fusion–Positive Tumor of the Posterior Fossa: Molecular Tumor Board
Infantile ZFTA Fusion–Positive Tumor of the Posterior Fossa: Molecular Tumor Board Open