Christina M. Moloney
YOU?
Author Swipe
View article: Association between antemortem plasma and structural MRI biomarkers and postmortem tau pathology in the Mayo Clinic Study of Aging
Association between antemortem plasma and structural MRI biomarkers and postmortem tau pathology in the Mayo Clinic Study of Aging Open
Our study demonstrates the greater sensitivity of regional MRI to tau pathology in comparison to plasma biomarkers. Future studies should explore newer MRI methods and additional plasma biomarkers more specific to tau pathology such as mic…
View article: Impact of cardiovascular risk factors on plasma biomarkers in prediction of Alzheimer's and cerebrovascular neuropathology
Impact of cardiovascular risk factors on plasma biomarkers in prediction of Alzheimer's and cerebrovascular neuropathology Open
Understanding how cardiovascular risk factors can modulate plasma biomarkers is important for their interpretation with respect to underlying pathology and their clinical application in screening, diagnosis, and prognosis of neurodegenerat…
View article: The Neurofibrillary Tangle Maturity Scale: A Novel Framework for Tangle Pathology Evaluation in Alzheimer’s Disease
The Neurofibrillary Tangle Maturity Scale: A Novel Framework for Tangle Pathology Evaluation in Alzheimer’s Disease Open
Neurofibrillary tangles are dynamic neuropathologic hallmarks of Alzheimer’s disease with a hypothesized lifespan morphologically-defined by three maturity levels: pretangles, mature tangles, and ghost tangles. To better understand the pro…
View article: High resolution autoradiography of [18F]MK-6240 and [18F]Flortaucipir shows similar neurofibrillary tangle binding patterns preferentially recognizing middling neurofibrillary tangle maturity
High resolution autoradiography of [18F]MK-6240 and [18F]Flortaucipir shows similar neurofibrillary tangle binding patterns preferentially recognizing middling neurofibrillary tangle maturity Open
View article: Plasma and MRI biomarkers predict post‐mortem tau pathology
Plasma and MRI biomarkers predict post‐mortem tau pathology Open
Background Imaging and plasma markers are used as key indicators of disease for Alzheimer’s disease (AD) but their usefulness in predicting regional tau pathology is relatively understudied. Our objective was to construct predictive models…
View article: Older predicted age using AI EKG‐based age prediction is associated with higher Alzheimer’s disease neuropathologic change
Older predicted age using AI EKG‐based age prediction is associated with higher Alzheimer’s disease neuropathologic change Open
Background There is increasing need for noninvasive biomarkers of Alzheimer’s Disease (AD) neuropathologic change for early detection and intervention through risk‐factor modification and disease‐modifying therapies. One such biomarker is …
View article: Plasma and MRI biomarkers predict post‐mortem tau pathology
Plasma and MRI biomarkers predict post‐mortem tau pathology Open
Background Imaging and plasma markers are used as key indicators of disease for Alzheimer’s disease (AD) but their usefulness in predicting regional tau pathology is relatively understudied. Our objective was to construct predictive models…
View article: Neurofibrillary tangle characterization in the olfactory bulb among clinicopathologic subtypes of Alzheimer’s disease
Neurofibrillary tangle characterization in the olfactory bulb among clinicopathologic subtypes of Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is neuropathologically heterogeneous and can be objectively classified along a spectrum of corticolimbic tangle distribution as hippocampal sparing (HpSp) AD, typical AD, and limbic predominant AD. The o…
View article: Clinicopathologic Heterogeneity and Glial Activation Patterns in Alzheimer Disease
Clinicopathologic Heterogeneity and Glial Activation Patterns in Alzheimer Disease Open
Importance Factors associated with clinical heterogeneity in Alzheimer disease (AD) lay along a continuum hypothesized to associate with tangle distribution and are relevant for understanding glial activation considerations in therapeutic …
View article: Tangle and neuritic burden from neurofibrillary tangle maturity markers in the hippocampus are differentially correlated to tau‐PET, MRI, and cognitive measures
Tangle and neuritic burden from neurofibrillary tangle maturity markers in the hippocampus are differentially correlated to tau‐PET, MRI, and cognitive measures Open
Background There is a gap in knowledge concerning which tangle maturity levels (Moloney, Alzheimers Dement, 2021) are associated with antemortem measures (tau‐PET, MRI, cognitive testing). We hypothesized antemortem measures would be more …
View article: The SERPINA5 coding variant E228Q does not contribute to clinicopathologic characteristics in Alzheimer’s disease: A cross-sectional study
The SERPINA5 coding variant E228Q does not contribute to clinicopathologic characteristics in Alzheimer’s disease: A cross-sectional study Open
We previously demonstrated that increased expression of the SERPINA5 gene is associated with hippocampal vulnerability in Alzheimer’s disease (AD) brains. SERPINA5 was further demonstrated to be a novel tau-binding partner that colocalizes…
View article: Clinicoradiologic Correlates of Corticolimbic Index (CLix) and Glial Activation Differences Among Neuropathologic Subtypes of Alzheimer's Disease: A Retrospective Study
Clinicoradiologic Correlates of Corticolimbic Index (CLix) and Glial Activation Differences Among Neuropathologic Subtypes of Alzheimer's Disease: A Retrospective Study Open
View article: Global neuropathologic severity of Alzheimer’s disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels
Global neuropathologic severity of Alzheimer’s disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels Open
Background Advances in ultrasensitive detection of phosphorylated tau (p-tau) in plasma has enabled the use of blood tests to measure Alzheimer’s disease (AD) biomarker changes. Examination of postmortem brains of participants with antemor…
View article: Global neuropathologic severity of Alzheimer’s disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels
Global neuropathologic severity of Alzheimer’s disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels Open
Advances in ultrasensitive detection of phosphorylated tau (p-tau) in plasma has enabled the use of blood tests to measure Alzheimer’s disease (AD) biomarker changes. Examination of postmortem brains of participants with antemortem plasma …
View article: Phosphorylated tau sites that are elevated in Alzheimer's disease fluid biomarkers are visualized in early neurofibrillary tangle maturity levels in the <i>post mortem</i> brain
Phosphorylated tau sites that are elevated in Alzheimer's disease fluid biomarkers are visualized in early neurofibrillary tangle maturity levels in the <i>post mortem</i> brain Open
Introduction Alzheimer's disease (AD) biomarkers are increasingly more reliable in predicting neuropathology. To facilitate interpretation of phosphorylated tau sites as an early fluid biomarker, we sought to characterize which neurofibril…
View article: Association of plasma biomarkers of amyloid and neurodegeneration with cerebrovascular disease and Alzheimer's disease
Association of plasma biomarkers of amyloid and neurodegeneration with cerebrovascular disease and Alzheimer's disease Open
View article: Phosphorylated tau fluid biomarker sites recognize earlier neurofibrillary tangle maturity levels in the postmortem Alzheimer’s disease brain
Phosphorylated tau fluid biomarker sites recognize earlier neurofibrillary tangle maturity levels in the postmortem Alzheimer’s disease brain Open
Alzheimer’s disease (AD) biomarkers have become increasingly more reliable in predicting AD pathology. While phosphorylated tau fluid biomarkers have been studied for over 20 years, there is a lack of deep characterization of these sites i…
View article: Transcriptomic analysis to identify genes associated with selective hippocampal vulnerability in Alzheimer’s disease
Transcriptomic analysis to identify genes associated with selective hippocampal vulnerability in Alzheimer’s disease Open
Selective vulnerability of different brain regions is seen in many neurodegenerative disorders. The hippocampus and cortex are selectively vulnerable in Alzheimer’s disease (AD), however the degree of involvement of the different brain reg…
View article: Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research
Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research Open
Neurofibrillary tangles, one of the neuropathologic hallmarks of Alzheimer's disease, have a dynamic lifespan of maturity that associates with progressive neuronal dysfunction and cognitive deficits. As neurofibrillary tangles mature, the …
View article: Leveraging selective hippocampal vulnerability among Alzheimer’s disease subtypes reveals a novel tau binding partner SERPINA5
Leveraging selective hippocampal vulnerability among Alzheimer’s disease subtypes reveals a novel tau binding partner SERPINA5 Open
Summary Selective vulnerability is a central concept to the myriad of devastating neurodegenerative disorders. Although hippocampus and cortex are selectively vulnerable in Alzheimer’s disease (AD), the degree of involvement lies along a s…
View article: Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3
Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3 Open
Mutations in MATR3 have been associated with amyotrophic lateral sclerosis (ALS) as well as a form of distal myopathy termed vocal cord pharyngeal distal myopathy (VCPDM). To begin to understand how mutations in MATR3 may cause disease, he…
View article: Additional file 1: of Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3
Additional file 1: of Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3 Open
Table S1. Animals used in the study. *Indicates genotype has been confirmed by sequencing. § indicates genotype has been confirmed by restriction digest. Bold indicates when data from animal is pictured within figure. Geno., genotype; Gen.…
View article: Additional file 3: of Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3
Additional file 3: of Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3 Open
Table S2. Average body weights for lead MATR3WT and MATR3F115C lines. MATR3WT mice (lead line 1563) were not significantly different when compared to age-matched NT males (~ 2 mo.: two-way ANOVA, p > 0.05; ~ 10 mo.: t-test, p > 0.05) and f…
View article: Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype
Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype Open
The authors are retracting this article. The article describes mice expressing wild-type human MATR3. However, since publication the authors have become aware that all of the lines of mice described express human MATR3 containing the F115C…
View article: RETRACTED ARTICLE: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype
RETRACTED ARTICLE: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype Open
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder of upper and lower motor neurons. Mutations in the gene encoding the nuclear matrix protein Matrin 3 have been found in familial cases of ALS, as well as autos…
View article: Heterogeneity of Matrin 3 in the developing and aging murine central nervous system
Heterogeneity of Matrin 3 in the developing and aging murine central nervous system Open
Mutations in the MATR3 gene encoding the nucleotide binding protein Matrin 3 have recently been identified as causing a subset of familial amyotrophic lateral sclerosis (fALS) and more rarely causing distal myopathy. Translating the identi…