Christina Morse
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View article: LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease
LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease Open
Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monito…
View article: Corrigendum to High IFN-γ and low SLPI mark severe asthma in mice and humans
Corrigendum to High IFN-γ and low SLPI mark severe asthma in mice and humans Open
View article: Molecular Changes Implicate Angiogenesis and Arterial Remodeling in Systemic Sclerosis–Associated and Idiopathic Pulmonary Hypertension
Molecular Changes Implicate Angiogenesis and Arterial Remodeling in Systemic Sclerosis–Associated and Idiopathic Pulmonary Hypertension Open
BACKGROUND: Pulmonary hypertension (PH) is a common complication of systemic sclerosis (SSc) and a leading cause of mortality among patients with this disease. PH can also occur as an idiopathic condition (idiopathic pulmonary arterial hyp…
View article: Fibronectin-EDA accumulates via reduced ubiquitination downstream of Toll-like receptor 9 activation in SSc-ILD fibroblasts
Fibronectin-EDA accumulates via reduced ubiquitination downstream of Toll-like receptor 9 activation in SSc-ILD fibroblasts Open
Accumulation of excessive extracellular matrix (ECM) components from lung fibroblasts is a feature of systemic sclerosis-associated interstitial lung disease (SSc-ILD), and there is increasing evidence that innate immune signaling pathways…
View article: Epigenetic Regulation of Profibrotic Macrophages in Systemic Sclerosis–Associated Interstitial Lung Disease
Epigenetic Regulation of Profibrotic Macrophages in Systemic Sclerosis–Associated Interstitial Lung Disease Open
Objective Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is the leading cause of death in patients with SSc with unclear pathogenesis and limited treatment options. Evidence strongly supports an important role for profib…
View article: A pilot study of dimethyl fumarate in pulmonary arterial hypertension associated with systemic sclerosis
A pilot study of dimethyl fumarate in pulmonary arterial hypertension associated with systemic sclerosis Open
Introduction: Given the poor treatment options for pulmonary arterial hypertension–associated systemic sclerosis patients, we sought to determine clinical safety and efficacy of dimethyl fumarate, an Nrf2 agonist, and the effects on biomar…
View article: Expansion of Fcγ Receptor <scp>IIIa</scp>–Positive Macrophages, Ficolin 1–Positive <scp>Monocyte‐Derived</scp> Dendritic Cells, and Plasmacytoid Dendritic Cells Associated With Severe Skin Disease in Systemic Sclerosis
Expansion of Fcγ Receptor <span>IIIa</span>–Positive Macrophages, Ficolin 1–Positive <span>Monocyte‐Derived</span> Dendritic Cells, and Plasmacytoid Dendritic Cells Associated With Severe Skin Disease in Systemic Sclerosis Open
Objective In this study, we sought a comprehensive understanding of myeloid cell types driving fibrosis in diffuse cutaneous systemic sclerosis (dcSSc) skin. Methods We analyzed the transcriptomes of 2,465 myeloid cells from skin biopsy sp…
View article: THU0329 SAFETY, TARGET ENGAGEMENT, AND INITIAL EFFICACY OF AVID200, A FIRST-IN-CLASS POTENT AND ISOFORM-SELECTIVE INHIBITOR OF TGF-BETA 1 AND 3, IN PATIENTS WITH DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS (DCSSC): A PHASE 1 DOSE ESCALATION STUDY
THU0329 SAFETY, TARGET ENGAGEMENT, AND INITIAL EFFICACY OF AVID200, A FIRST-IN-CLASS POTENT AND ISOFORM-SELECTIVE INHIBITOR OF TGF-BETA 1 AND 3, IN PATIENTS WITH DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS (DCSSC): A PHASE 1 DOSE ESCALATION STUDY Open
View article: Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis
Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis Open
View article: Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease
Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease Open
View article: Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis
Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis Open
A comprehensive understanding of the changes in gene expression in cell types involved in idiopathic pulmonary fibrosis (IPF) will shed light on the mechanisms underlying the loss of alveolar epithelial cells and development of honeycomb c…
View article: Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin
Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin Open
Objective: The mechanisms that lead to endothelial cell (EC) injury and propagate the vasculopathy in Systemic Sclerosis (SSc) are not well understood. Using single cell RNA sequencing (scRNA-seq), our goal was to identify EC marker…
View article: SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin
SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin Open
View article: IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice
IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice Open
Severe asthma (SA) is a significant problem both clinically and economically, given its poor response to corticosteroids (CS). We recently reported a complex type 1-dominated (IFN-γ-dominated) immune response in more than 50% of severe ast…
View article: The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia
The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia Open
View article: Mitochondrial H2O2 in Lung Antigen-Presenting Cells Blocks NF-κB Activation to Prevent Unwarranted Immune Activation
Mitochondrial H2O2 in Lung Antigen-Presenting Cells Blocks NF-κB Activation to Prevent Unwarranted Immune Activation Open
View article: High IFN-γ and low SLPI mark severe asthma in mice and humans
High IFN-γ and low SLPI mark severe asthma in mice and humans Open
Severe asthma (SA) is a challenge to control, as patients are not responsive to high doses of systemic corticosteroids (CS). In contrast, mild-moderate asthma (MMA) is responsive to low doses of inhaled CS, indicating that Th2 cells, which…