Christina Ohland
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View article: Role of Acid‐Sensing Ion Channels 1a in the Regulation of Obesity and the Gut Microbiota
Role of Acid‐Sensing Ion Channels 1a in the Regulation of Obesity and the Gut Microbiota Open
Objective Acid‐sensing ion channels are proton‐activated ion channels predominantly found in the nervous system. They are well known to affect metabolic and neurological health, yet their role in obesity and gut physiology remains unclear.…
View article: Bifidobacteria-derived exopolysaccharide promotes anti-tumor immunity
Bifidobacteria-derived exopolysaccharide promotes anti-tumor immunity Open
While several phylogenetically distinct bacterial taxa can predict responses to or improve cancer immunotherapies, the underlying mechanisms remain poorly understood. The use of microbes for microbial therapeutics is currently under intens…
View article: T cells regulate intestinal motility and shape enteric neuronal responses to intestinal microbiota
T cells regulate intestinal motility and shape enteric neuronal responses to intestinal microbiota Open
How the gut microbiota and immune system maintain intestinal homeostasis in concert with the enteric nervous system (ENS) remains incompletely understood. To address this gap, we assessed small intestinal transit, enteric neuronal density,…
View article: Sex-specific post-inflammatory dysbiosis mediates chronic visceral pain in colitis
Sex-specific post-inflammatory dysbiosis mediates chronic visceral pain in colitis Open
Female sex, hormonal status as well as the gut microbiota play a role in pain modulation. Our data highlight the importance of considering biological sex in the evaluation of visceral pain.
View article: T cells regulate intestinal motility and shape enteric neuronal responses to intestinal microbiota
T cells regulate intestinal motility and shape enteric neuronal responses to intestinal microbiota Open
The gut microbiota and immune system maintain intestinal homeostasis and regulate gut physiology in concert with the enteric nervous system (ENS). However, the underlying mechanisms remain incompletely understood. Using wildtype and T-cell…
View article: A47 A PRELIMINARY ANALYSIS OF THE CROHN'S DISEASE THERAPEUTIC INTERVENTION TRIAL (CD-TDI) IN MILD-TO-MODERATE CROHN'S DISEASE
A47 A PRELIMINARY ANALYSIS OF THE CROHN'S DISEASE THERAPEUTIC INTERVENTION TRIAL (CD-TDI) IN MILD-TO-MODERATE CROHN'S DISEASE Open
Background Studies show a diet-CD remission link, yet a lack of clinical trials exists. The CD Therapeutic Dietary Intervention (CD-TDI) is an evidence-based dietary regimen based on the principles of the Mediterranean diet and incorporate…
View article: A182 EXPLORING THE LINK BETWEEN SPECIFIC MICROBIAL STRAINS AND ANXIETY AND DEPRESSION IN PATIENTS WITH ULCERATIVE COLITIS
A182 EXPLORING THE LINK BETWEEN SPECIFIC MICROBIAL STRAINS AND ANXIETY AND DEPRESSION IN PATIENTS WITH ULCERATIVE COLITIS Open
Background Anxiety and/or depression (A/D) have been identified as significant co-morbidities of ulcerative colitis (UC), and even considered as extraintestinal manifestations, with emerging evidence to support the role for gut microbial d…
View article: Weighted Gene Co-Expression Network Analysis Identifies a Functional Guild and Metabolite Cluster Mediating the Relationship between Mucosal Inflammation and Adherence to the Mediterranean Diet in Ulcerative Colitis
Weighted Gene Co-Expression Network Analysis Identifies a Functional Guild and Metabolite Cluster Mediating the Relationship between Mucosal Inflammation and Adherence to the Mediterranean Diet in Ulcerative Colitis Open
Diet influences the pathogenesis and clinical course of inflammatory bowel disease (IBD). The Mediterranean diet (MD) is linked to reductions in inflammatory biomarkers and alterations in microbial taxa and metabolites associated with heal…
View article: Exercise and Prebiotic Fiber Provide Gut Microbiota-Driven Benefit in a Survivor to Germ-Free Mouse Translational Model of Breast Cancer
Exercise and Prebiotic Fiber Provide Gut Microbiota-Driven Benefit in a Survivor to Germ-Free Mouse Translational Model of Breast Cancer Open
The gut microbiota plays a role in shaping overall host health and response to several cancer treatments. Factors, such as diet, exercise, and chemotherapy, can alter the gut microbiota. In the present study, the Alberta Cancer Exercise (A…
View article: Gut Microbiota as a Novel Tool to Dissect the Complex Structures of Black Tea Polymers
Gut Microbiota as a Novel Tool to Dissect the Complex Structures of Black Tea Polymers Open
Thearubigins, polymers of tea catechins, account for more than 20% of the black tea polyphenols and have been reported to be the active components in black tea. However, the chemical structures and underlying mechanisms regarding how the t…
View article: A230 THE ROLE OF THE MICROBIOTA IN NOCICEPTOR DEVELOPMENT AND PAIN SENSITIVITY
A230 THE ROLE OF THE MICROBIOTA IN NOCICEPTOR DEVELOPMENT AND PAIN SENSITIVITY Open
Background Pain is the most common cause of disability in IBD. What causes inter-individual variability in chronic pain after successful treatment of inflammation remains elusive. We have shown that activation of TRPV1+ colonic nociceptors…
View article: Degradation of black tea theaflavin through C-ring cleavage by gut microbiota
Degradation of black tea theaflavin through C-ring cleavage by gut microbiota Open
Increasing evidence has shown that gut microbiota plays important roles in metabolizing large molecular polyphenols to bioavailable and bioactive microbial metabolites. Theaflavin (TF) is one of the major color compounds in black tea and h…
View article: Cooperation between host immunity and the gut bacteria is essential for helminth-evoked suppression of colitis
Cooperation between host immunity and the gut bacteria is essential for helminth-evoked suppression of colitis Open
View article: Black Tea Theaflavin Detoxifies Metabolic Toxins in the Intestinal Tract of Mice
Black Tea Theaflavin Detoxifies Metabolic Toxins in the Intestinal Tract of Mice Open
Scope This study is to determine the in vivo efficacy of black tea theaflavin (TF) to detoxify two metabolic toxins, ammonia and methylglyoxal (MGO), in mice Methods and results Under in vitro conditions, TF is able to react with ammonia, …
View article: Examining the Relationship between Epistemic Beliefs (Justification of Knowing) and the Belief in Conspiracy Theories
Examining the Relationship between Epistemic Beliefs (Justification of Knowing) and the Belief in Conspiracy Theories Open
In times of fake news and alternative facts, a differentiated approach to (scientific) knowledge becomes increasingly important. In light of current events, namely the covid19-pandemic, understanding epistemic beliefs and their effect on d…
View article: Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice
Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice Open
View article: P354 Objectively measured time spent sitting, standing upright, and stepping is associated with disease severity and faecal calprotectin in patients with ulcerative colitis
P354 Objectively measured time spent sitting, standing upright, and stepping is associated with disease severity and faecal calprotectin in patients with ulcerative colitis Open
Background Sitting, lying down, standing upright, and stepping is predominant behaviours occurring throughout the 24-day, yet have not been explored in ulcerative colitis (UC). The purpose of this study was to explore whether objectively m…
View article: P692 Exploring relationships between microbiome, faecal calprotectin and healthy eating index in patients with ulcerative colitis: Interim analyses of a randomised controlled trial
P692 Exploring relationships between microbiome, faecal calprotectin and healthy eating index in patients with ulcerative colitis: Interim analyses of a randomised controlled trial Open
Background This study explored relationships between gut microbiome, faecal calprotectin (FCP) and an adapted Canadian healthy eating index (CHEI) in ulcerative colitis (UC) patients enrolled in a randomised controlled dietary intervention…
View article: Microbiota Facilitates the Formation of the Aminated Metabolite of Tea Polyphenols Which Trap Deleterious Reactive Endogenous Metabolites (P06-022-19)
Microbiota Facilitates the Formation of the Aminated Metabolite of Tea Polyphenols Which Trap Deleterious Reactive Endogenous Metabolites (P06-022-19) Open
OBJECTIVES: The in vivo mechanism of tea polyphenol-mediated prevention of many chronic diseases is still largely unknown. Studies have shown that accumulation of toxic reactive cellular metabolites, such as ammonia and reactive carbonyl s…
View article: Microbiota facilitates the formation of the aminated metabolite of green tea polyphenol (-)-epigallocatechin-3-gallate which trap deleterious reactive endogenous metabolites
Microbiota facilitates the formation of the aminated metabolite of green tea polyphenol (-)-epigallocatechin-3-gallate which trap deleterious reactive endogenous metabolites Open
View article: Microbial dysbiosis associated with impaired intestinal Na+/H+ exchange accelerates and exacerbates colitis in ex-germ free mice
Microbial dysbiosis associated with impaired intestinal Na+/H+ exchange accelerates and exacerbates colitis in ex-germ free mice Open
View article: Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models
Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models Open
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the United States yet data are scant regarding host factors influencing pancreatic carcinogenesis. Increasing evidence support the role of the host micro…
View article: Optimized multiplex immunofluorescence single-cell analysis reveals tuft cell heterogeneity
Optimized multiplex immunofluorescence single-cell analysis reveals tuft cell heterogeneity Open
Intestinal tuft cells are a rare, poorly understood cell type recently shown to be a critical mediator of type 2 immune response to helminth infection. Here, we present advances in segmentation algorithms and analytical tools for multiplex…
View article: Contents
Contents Open
This review discusses recent data on immune signaling pathways involved in the pathogenesis of colitis-associated cancer.These include molecular mechanisms activating the innate and adaptive immune system and thereby contributing to cancer…