Christina Reinauer
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View article: Patients with Allan‐Herndon‐Dudley Syndrome (<scp>MCT8</scp> Deficiency) Display Symptoms of Parkinsonism in Childhood and Respond to Levodopa/Carbidopa Treatment
Patients with Allan‐Herndon‐Dudley Syndrome (<span>MCT8</span> Deficiency) Display Symptoms of Parkinsonism in Childhood and Respond to Levodopa/Carbidopa Treatment Open
Background Patients with mutations in the monocarboxylate transporter 8 (MCT8, SLC16A2 ) suffer from X‐linked recessive Allan‐Herndon‐Dudley syndrome (AHDS), which is characterized by developmental delay and a severe movement disorder. Cur…
View article: Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration
Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration Open
View article: Patients with Allan-Herndon-Dudley Syndrome (MCT8 Deficiency) Display Symptoms of Parkinsonism in Childhood and Respond to Levodopa/Carbidopa Treatment
Patients with Allan-Herndon-Dudley Syndrome (MCT8 Deficiency) Display Symptoms of Parkinsonism in Childhood and Respond to Levodopa/Carbidopa Treatment Open
Background: Patients with mutations in the monocarboxylate transporter 8 (MCT8) suffer from Allan-Herndon-Dudley syndrome (AHDS), characterized by developmental delay and a highly disabling movement disorder. Despite the potential of thyro…
View article: Trends in the incidence of type 1 diabetes and type 2 diabetes in children and adolescents in North Rhine-Westphalia, Germany, from 2002 to 2022
Trends in the incidence of type 1 diabetes and type 2 diabetes in children and adolescents in North Rhine-Westphalia, Germany, from 2002 to 2022 Open
The incidence rates of T1DM and T2DM have increased over the past 20 years, with a wave-like pattern during the Covid-19 pandemic.
View article: Mental disorders in children and adolescents with type 1 diabetes before and during the COVID-19 pandemic: results from the DPV registry
Mental disorders in children and adolescents with type 1 diabetes before and during the COVID-19 pandemic: results from the DPV registry Open
Objectives The COVID-19 pandemic affected the mental health of children and adolescents in the general population, yet its impact on those with chronic conditions is relatively unknown. This study aimed to compare the incidences of comorbi…
View article: Diabetes care and outcomes of pediatric refugees and migrants from Ukraine and Syria/Afghanistan with type 1 diabetes in German-speaking countries
Diabetes care and outcomes of pediatric refugees and migrants from Ukraine and Syria/Afghanistan with type 1 diabetes in German-speaking countries Open
Introduction Currently, over two million war refugees live in Germany. Exposure to war and flight is associated with a high burden of diseases, not limited to mental disorders and infections. We aimed to analyze diabetes treatment and outc…
View article: Motivational interviewing from the paediatricians’ perspective: assessments after a 2-day training for physicians caring for adolescents with chronic medical conditions (CMCs)
Motivational interviewing from the paediatricians’ perspective: assessments after a 2-day training for physicians caring for adolescents with chronic medical conditions (CMCs) Open
View article: Resilience strengthening in youth with a chronic medical condition: a randomized controlled feasibility trial of a combined app and coaching program
Resilience strengthening in youth with a chronic medical condition: a randomized controlled feasibility trial of a combined app and coaching program Open
Youth with a chronic medical condition (CMC) are often affected by comorbid mental disorders. Resilience-strengthening interventions can protect youth’s mental health, yet evidence-based programs remain scarce. To address this lack, this s…
View article: Testing a model of benefit-finding and growth in youths with chronic health conditions
Testing a model of benefit-finding and growth in youths with chronic health conditions Open
Background The experience of benefit-finding and growth (BFG), defined as perceiving positive life changes resulting from adversity, is increasingly studied among youths with chronic health conditions (CCs). However, empirical evidence is …
View article: Outpatient screening for anxiety and depression symptoms in adolescents with type 1 diabetes - a cross-sectional survey
Outpatient screening for anxiety and depression symptoms in adolescents with type 1 diabetes - a cross-sectional survey Open
View article: Abstracts der JA-PED 2023
Abstracts der JA-PED 2023 Open
View article: Resilience strengthening in youth with a chronic medical condition- a randomized controlled feasibility trial of a combined app and coaching program
Resilience strengthening in youth with a chronic medical condition- a randomized controlled feasibility trial of a combined app and coaching program Open
Objective: Youth with a chronic medical condition (CMC) are often affected by comorbid mental disorders. Resilience-strengthening interventions can protect youth’s mental health, yet evidence-based programs remain scarce. To address this l…
View article: Motivational interviewing from the pediatricians' perspective: assessments after a 2-day training for physicians caring for adolescents with chronic medical conditions (CMCs)
Motivational interviewing from the pediatricians' perspective: assessments after a 2-day training for physicians caring for adolescents with chronic medical conditions (CMCs) Open
Background: Counseling adolescents with chronic medical conditions (CMCs) can be challenging regarding suitable interviewing skills and clinicians' attitudes toward the patient. Successful communication can be a key element of treatment. M…
View article: Altered DNA methylation at age-associated CpG sites in children with growth disorders: impact on age estimation?
Altered DNA methylation at age-associated CpG sites in children with growth disorders: impact on age estimation? Open
Age estimation based on DNA methylation (DNAm) can be applied to children, adolescents and adults, but many CG dinucleotides (CpGs) exhibit different kinetics of age-associated DNAm across these age ranges. Furthermore, it is still unclear…
View article: Anxiety, depression, and quality of life in parents of children with congenital hyperinsulinism
Anxiety, depression, and quality of life in parents of children with congenital hyperinsulinism Open
View article: Anxiety, Depression and Quality of Life in Parents of Children with Congenital Hyperinsulinism
Anxiety, Depression and Quality of Life in Parents of Children with Congenital Hyperinsulinism Open
This study aimed to assess the mental health, family burden, and quality of life in parents of children with persisting congenital hyperinsulinism (CHI). Forty-eight individual parents (75% female) of children with CHI completed self-repor…
View article: Next Generation Sequencing Identifies the HLA-DQA1*03:03 Allele in the Type 1 Diabetes Risk-Associated HLA-DQ8 Serotype
Next Generation Sequencing Identifies the HLA-DQA1*03:03 Allele in the Type 1 Diabetes Risk-Associated HLA-DQ8 Serotype Open
The highest genetic type 1 diabetes risk is conferred by HLA class II haplotypes defined by alleles at the HLA-DR and -DQ loci. The combination of HLA-DQA1*03:01 and DQB1*03:02 alleles (summarized as ‘HLA-DQ8′) is reported to be among the …
View article: Long-Term Efficacy of T3 Analogue Triac in Children and Adults With MCT8 Deficiency: A Real-Life Retrospective Cohort Study
Long-Term Efficacy of T3 Analogue Triac in Children and Adults With MCT8 Deficiency: A Real-Life Retrospective Cohort Study Open
Context Patients with mutations in thyroid hormone transporter MCT8 have developmental delay and chronic thyrotoxicosis associated with being underweight and having cardiovascular dysfunction. Objective Our previous trial showed improvemen…
View article: Interleukin‐7‐dependent nonclassical monocytes and CD40 expression are affected in children with type 1 diabetes
Interleukin‐7‐dependent nonclassical monocytes and CD40 expression are affected in children with type 1 diabetes Open
The important role of IL‐7 in the generation of self‐reactive T‐cells in autoimmune diseases is well established. Recent studies on autoimmunity‐associated genetic polymorphisms indicated that differential IL‐7 receptor (IL‐7R) expression …
View article: Efficacy of Motivational Interviewing to Improve Utilization of Mental Health Services Among Youths With Chronic Medical Conditions
Efficacy of Motivational Interviewing to Improve Utilization of Mental Health Services Among Youths With Chronic Medical Conditions Open
German Trials Registry: DRKS00014043.
View article: A prospective investigation of developmental trajectories of psychosocial adjustment in adolescents facing a chronic condition - study protocol of an observational, multi-center study
A prospective investigation of developmental trajectories of psychosocial adjustment in adolescents facing a chronic condition - study protocol of an observational, multi-center study Open
View article: Author response for "Interleukin‐7 dependent non‐classical monocytes and CD40 expression are affected in children with type 1 diabetes"
Author response for "Interleukin‐7 dependent non‐classical monocytes and CD40 expression are affected in children with type 1 diabetes" Open
View article: CD5‐expressing CD8<sup>+</sup> T‐cell subsets differ between children with type 1 diabetes and controls
CD5‐expressing CD8<sup>+</sup> T‐cell subsets differ between children with type 1 diabetes and controls Open
Different lymphocyte subsets are involved in autoimmune pathogenesis of type 1 diabetes (T1D). Previous studies suggested a role of CD5‐expressing T and B cells including rare unconventional lymphocytes with combined T‐ and B‐cell features…
View article: CD5 expressing CD8+ T cell subsets differ between children with Type 1 Diabetes and controls
CD5 expressing CD8+ T cell subsets differ between children with Type 1 Diabetes and controls Open
Different lymphocyte subsets are involved in autoimmune pathogenesis of Type 1 Diabetes (T1D). Previous studies suggested a role of CD5 expressing T and B cells including rare unconventional lymphocytes with combined T- and B-cell features…
View article: Worse glycemic control, higher rates of diabetic ketoacidosis, and more hospitalizations in children, adolescents, and young adults with type 1 diabetes and anxiety disorders
Worse glycemic control, higher rates of diabetic ketoacidosis, and more hospitalizations in children, adolescents, and young adults with type 1 diabetes and anxiety disorders Open
The aim of the study was to explore the metabolic characteristics and outcome parameters in youth with type 1 diabetes and anxiety disorders. HbA1c levels, rates of severe hypoglycemia, diabetic ketoacidosis (DKA), and hospital admission i…
View article: Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study
Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study Open
View article: CD4+ T-Cells With High Common γ Chain Expression and Disturbed Cytokine Production Are Enriched in Children With Type-1 Diabetes
CD4+ T-Cells With High Common γ Chain Expression and Disturbed Cytokine Production Are Enriched in Children With Type-1 Diabetes Open
The common gamma chain (γc) contributes to the formation of different cytokine receptors [e.g., IL-2 receptor (IL-2R), IL-7R, and IL-15R], which are important for generation of self-reactive T-cells in autoimmune diseases, like …
View article: Motivational Interviewing as a tool to enhance access to mental health treatment in adolescents with chronic medical conditions and need for psychological support (COACH-MI): study protocol for a clusterrandomised controlled trial
Motivational Interviewing as a tool to enhance access to mental health treatment in adolescents with chronic medical conditions and need for psychological support (COACH-MI): study protocol for a clusterrandomised controlled trial Open
View article: Correction: Reinauer et al., The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype. Genes 2017, 8, 146
Correction: Reinauer et al., The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype. Genes 2017, 8, 146 Open
The article entitled “The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes is Independent of the HLA DR-DQ Genotype” contained a calculation error in Table 2 and the statistical methods used were not completely d…
View article: Polycystic Ovary Syndrome (PCOS) in Juvenile and Adult Type 1 Diabetes in a German/Austrian Cohort
Polycystic Ovary Syndrome (PCOS) in Juvenile and Adult Type 1 Diabetes in a German/Austrian Cohort Open
Context While an association between PCOS and type 2 diabetes is well established, to date there have been few data on clinical care of type 1 diabetes (T1D) patients with PCOS. Objective The aim of our study was to characterize T1D patien…