Christina S. Thornton
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View article: Remodelling of cystic fibrosis respiratory microbiota in response to extended Elexacaftor–Tezacaftor–Ivacaftor therapy
Remodelling of cystic fibrosis respiratory microbiota in response to extended Elexacaftor–Tezacaftor–Ivacaftor therapy Open
Background Cystic fibrosis (CF) has profoundly changed since the introduction of CF Transmembrane Conductance Regulator modulator therapies (CFTRmt), a class of medications that improve function of the CFTR protein encoded by certain CF-ca…
View article: Effect of transient <i>versus</i> persistent <b> <i>Aspergillus</i> </b> colonization on clinical outcomes in bronchiectasis
Effect of transient <i>versus</i> persistent <b> <i>Aspergillus</i> </b> colonization on clinical outcomes in bronchiectasis Open
View article: Economic impact of elexacaftor/tezacaftor/ivacaftor on healthcare expenditure in Canada
Economic impact of elexacaftor/tezacaftor/ivacaftor on healthcare expenditure in Canada Open
View article: Unveiling hidden culprits: new perspectives on bronchiectasis pathogens in Taiwan
Unveiling hidden culprits: new perspectives on bronchiectasis pathogens in Taiwan Open
Bronchiectasis pathogens in Taiwan have implications on clinical outcomes https://bit.ly/4iCDeK6.
View article: Trends in Medicare versus Medicaid spending on CFTR modulator therapy – an economic evaluation
Trends in Medicare versus Medicaid spending on CFTR modulator therapy – an economic evaluation Open
View article: Impact of Digital Health on Patient-Provider Relationships in Respiratory Secondary Care Based on Qualitative and Quantitative Evidence: Systematic Review
Impact of Digital Health on Patient-Provider Relationships in Respiratory Secondary Care Based on Qualitative and Quantitative Evidence: Systematic Review Open
Background Digital health technology adoption has accelerated in respiratory care, particularly since the COVID-19 pandemic, supporting various applications from self-management to telerehabilitation. While these technologies have transfor…
View article: Viewpoint: a white paper for a greener design, conduct and reporting of clinical trials in respiratory medicine
Viewpoint: a white paper for a greener design, conduct and reporting of clinical trials in respiratory medicine Open
Researchers and the ERJ editor-in-chief advocate for more sustainable clinical trials. Environmental considerations should be integrated from trial funding to dissemination. Stakeholders, including researchers, are urged to take action on …
View article: Clinical epidemiology and impact of Haemophilus influenzae airway infections in adults with cystic fibrosis
Clinical epidemiology and impact of Haemophilus influenzae airway infections in adults with cystic fibrosis Open
Isolation of H. influenzae was common amongst adult pwCF but often transient. H. influenzae infection was not associated with acute PEx or chronic lung function decline.
View article: The Canadian Bronchiectasis and Nontuberculous Mycobacteria Registry: a study protocol
The Canadian Bronchiectasis and Nontuberculous Mycobacteria Registry: a study protocol Open
Background Bronchiectasis is a complex, chronic disease with geographic and ethnic diversity. While the most substantial cohort studies have been conducted in Europe and the USA, Canada also faces considerable challenges. The comprehensive…
View article: Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response
Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response Open
Pseudomonas aeruginosa is a highly adaptable opportunistic pathogen capable of exploiting barriers and immune defects to cause chronic lung infections in conditions such as cystic fibrosis. In these contexts, host immune responses are inef…
View article: Guideline-Concordant Therapy for Community-Acquired Pneumonia in the Hospitalized Population: A Systematic Review and Meta-analysis
Guideline-Concordant Therapy for Community-Acquired Pneumonia in the Hospitalized Population: A Systematic Review and Meta-analysis Open
Background A commonly used guideline for community-acquired pneumonia (CAP) is the joint American Thoracic Society and Infectious Diseases Society of America practice guideline. We aimed to investigate the effect of guideline-concordant th…
View article: Pulmonary pseudallescherioma in a 48-year-old woman with bronchiectasis
Pulmonary pseudallescherioma in a 48-year-old woman with bronchiectasis Open
KEY POINTS A 48-year-old woman from Southeast Asia was referred to our tertiary hospital after an incidental chest radiograph showed bibasilar bronchiectasis ([Figure 1][1]) and 1 of 3 sputum cultures tested positive for Mycobacterium absc…
View article: STOP Using Corticosteroids in Cystic Fibrosis Pulmonary Exacerbations
STOP Using Corticosteroids in Cystic Fibrosis Pulmonary Exacerbations Open
View article: The airway microbiome of persons with cystic fibrosis correlates with acquisition and microbiological outcomes of incident Stenotrophomonas maltophilia infection
The airway microbiome of persons with cystic fibrosis correlates with acquisition and microbiological outcomes of incident Stenotrophomonas maltophilia infection Open
Rationale Chronic infection with Stenotrophomonas maltophilia in persons with cystic fibrosis (pwCF) has been linked to an increased risk of pulmonary exacerbations and lung function decline. We sought to establish whether baseline sputum …
View article: Porcine-derived pancreatic enzyme replacement therapy may be linked to chronic hepatitis E virus infection in cystic fibrosis lung transplant recipients
Porcine-derived pancreatic enzyme replacement therapy may be linked to chronic hepatitis E virus infection in cystic fibrosis lung transplant recipients Open
Objectives In high-income countries hepatitis E virus (HEV) is an uncommonly diagnosed porcine-derived zoonoses. After identifying disproportionate chronic HEV infections in persons with cystic fibrosis (pwCF) postlung transplant, we sough…
View article: Clinical Epidemiology and Impact of Haemophilus influenzae Airways Infections in Adults with Cystic Fibrosis
Clinical Epidemiology and Impact of Haemophilus influenzae Airways Infections in Adults with Cystic Fibrosis Open
Background Haemophilus influenzae is prevalent within the airways of persons with cystic fibrosis (pwCF). H. influenzae is often associated with pulmonary exacerbations (PEx) in pediatric cohorts, but in adults, studies have yielded confli…
View article: Bronchiectasis and COVID-19: For Better or for Worse?
Bronchiectasis and COVID-19: For Better or for Worse? Open
View article: Evaluating Sinus Microbiology by Transplant Status in Persons With Cystic Fibrosis: A Matched Cohort Study
Evaluating Sinus Microbiology by Transplant Status in Persons With Cystic Fibrosis: A Matched Cohort Study Open
Objective Sinus disease is prevalent in persons with cystic fibrosis (PwCF) and may be a reservoir of airway infection in postlung transplant (pTx) patients. The microbial composition of cystic fibrosis sinuses and its associations with ch…
View article: Combined medical-interventional approaches for the management of complex fungal balls: a case series as a viable alternative in non-surgical patients
Combined medical-interventional approaches for the management of complex fungal balls: a case series as a viable alternative in non-surgical patients Open
Intracavitary pulmonary aspergilloma is a persistent and life-threatening infection that carries a mortality rate of up to 15%. It occurs when Aspergillus species gain entry to an existing lung cavity. In the absence of definitive treatmen…
View article: A CASE OF PULMONARY PSEUDALLESCHERIASIS PRESENTING AS A FUNGAL BALL IN A BRONCHIECTASIS PATIENT
A CASE OF PULMONARY PSEUDALLESCHERIASIS PRESENTING AS A FUNGAL BALL IN A BRONCHIECTASIS PATIENT Open
View article: A 17-Year-Old Male With Hypoxemia After Long-Bone Fracture
A 17-Year-Old Male With Hypoxemia After Long-Bone Fracture Open
View article: Stenotrophomonas maltophilia natural history and evolution in the airways of adults with cystic fibrosis
Stenotrophomonas maltophilia natural history and evolution in the airways of adults with cystic fibrosis Open
Introduction Stenotrophomonas maltophilia is an opportunistic pathogen infecting persons with cystic fibrosis (pwCF) and portends a worse prognosis. Studies of S. maltophilia infection dynamics have been limited by cohort size and follow-u…
View article: Quantifying variation in home spirometry in people with cystic fibrosis during baseline health, and associations with clinical outcomes
Quantifying variation in home spirometry in people with cystic fibrosis during baseline health, and associations with clinical outcomes Open
View article: <i>Stenotrophomonas maltophilia</i>natural history and evolution in the airways of adults with cystic fibrosis
<i>Stenotrophomonas maltophilia</i>natural history and evolution in the airways of adults with cystic fibrosis Open
Stenotrophomonas maltophilia is an opportunistic pathogen infecting person with cystic fibrosis (pwCF) and portends a worse prognosis. Studies of S. maltophilia infection dynamics have been limited by cohort size and follow-up. We investig…
View article: Microbial Epidemiology of the Cystic Fibrosis Airways: Past, Present, and Future
Microbial Epidemiology of the Cystic Fibrosis Airways: Past, Present, and Future Open
Progressive obstructive lung disease secondary to chronic airway infection, coupled with impaired host immunity, is the leading cause of morbidity and mortality in cystic fibrosis (CF). Classical pathogens found in the airways of persons w…
View article: Assessment of factors and interventions towards therapeutic adherence among persons with non-cystic fibrosis bronchiectasis
Assessment of factors and interventions towards therapeutic adherence among persons with non-cystic fibrosis bronchiectasis Open
Non-cystic fibrosis bronchiectasis (NCFB) is a highly prevalent chronic respiratory disease with substantial burden to both patients and healthcare systems. Persons with NCFB (pwNCFB) are often given complex acute and chronic treatment reg…
View article: Exploring the Cystic Fibrosis Lung Microbiome: Making the Most of a Sticky Situation
Exploring the Cystic Fibrosis Lung Microbiome: Making the Most of a Sticky Situation Open
Chronic lower respiratory tract infections are a leading contributor to morbidity and mortality in persons with cystic fibrosis (pwCF). Traditional respiratory tract surveillance culturing has focused on a limited range of classic pathogen…
View article: Impact of wait times for treatment on clinical outcomes in patients with obstructive sleep apnoea: protocol for a randomised controlled trial
Impact of wait times for treatment on clinical outcomes in patients with obstructive sleep apnoea: protocol for a randomised controlled trial Open
Background Obstructive sleep apnoea (OSA) is a common chronic condition that is associated with significant morbidity and economic cost. Prolonged wait times are increasingly being recognised as a barrier to diagnosis and treatment of many…
View article: Body Mass Index and Clinical Outcomes in Persons Living With Cystic Fibrosis—Is Bigger Always Better?
Body Mass Index and Clinical Outcomes in Persons Living With Cystic Fibrosis—Is Bigger Always Better? Open
Rita Nagy, MD; Noémi Gede, PhD; Klementina Ocskay, MD; Bernadett-Miriam Dobai, MD; Alan Abada, MD; Zsófia Vereczkei; Piroska Pázmány, MD; Dorottya Kató; Péter Hegyi, MD, PhD, DSc; Andrea Párniczky, MD, PhD
View article: Prolonged SARS-CoV-2 infection following rituximab treatment: clinical course and response to therapeutic interventions correlated with quantitative viral cultures and cycle threshold values
Prolonged SARS-CoV-2 infection following rituximab treatment: clinical course and response to therapeutic interventions correlated with quantitative viral cultures and cycle threshold values Open
Background Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA is completed through reverse transcriptase-PCR (RT-PCR) from either oropharyngeal or nasopharyngeal swabs, critically important for diagnostics but al…