Christina Schäffer
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Vitamin D3 Modulates Inflammatory and Antimicrobial Responses in Oral Epithelial Cells Exposed to Periodontitis-Associated Bacteria Open
The oral epithelium is essential for maintaining oral health and plays a key role in the onset and progression of periodontitis. It serves as both a mechanical and immunological barrier and possesses antimicrobial activity. Vitamin D3, a h…
View article: Effect of Low-Level Laser Therapy on Periodontal Host Cells and a Seven-Species Periodontitis Model Biofilm
Effect of Low-Level Laser Therapy on Periodontal Host Cells and a Seven-Species Periodontitis Model Biofilm Open
Low-level laser therapy (LLLT) is gaining attention as an effective adjunct to non-surgical periodontal treatment. This study evaluates the potential of LLLT to reduce bacterial load in a clinically relevant in vitro subgingival biofilm mo…
View article: Synthesis, Microbiology, and Biophysical Characterization of Mutanofactins from the Human Oral Microbiome
Synthesis, Microbiology, and Biophysical Characterization of Mutanofactins from the Human Oral Microbiome Open
Mutanofactins are a family of natural products produced by Streptococcus mutans from the human oral microbiome. We report a unified approach to all mutanofactins by developing a total synthesis amenable to diversification. The key to succe…
View article: Decoding gene expression dynamics in planktonic and biofilm cells of Streptococcus mutans: regulation and role of mutanofactin genes in biofilm formation
Decoding gene expression dynamics in planktonic and biofilm cells of Streptococcus mutans: regulation and role of mutanofactin genes in biofilm formation Open
Introduction Dental caries is the most prevalent chronic infectious disease globally, with Streptococcus mutans recognized as a primary causative agent due to its acidogenicity and robust biofilm-forming ability. In S. mutans biofilm forma…
Insights into structure and activity of a UDP-GlcNAc 2-epimerase involved in secondary cell wall polymer biosynthesis in Paenibacillus alvei Open
Introduction S-layer anchoring in Paenibacillus alvei is enabled by a non-covalent interaction between an S-layer homology domain trimer and a secondary cell wall polymer (SCWP), ensuring the structural integrity of the bacterial cell wall…
View article: Deciphering fucosylated protein-linked <i>O</i>-glycans in oral <i>Tannerella serpentiformis</i>: Insights from NMR spectroscopy and glycoproteomics
Deciphering fucosylated protein-linked <i>O</i>-glycans in oral <i>Tannerella serpentiformis</i>: Insights from NMR spectroscopy and glycoproteomics Open
Tannerella serpentiformis is a health-associated Gram-negative oral anaerobe, while its closest phylogenetic relative is the periodontal pathogen Tannerella forsythia. The pathogen employs glycan mimicry through protein O-glycosylation, di…
Investigating the role of a Tannerella forsythia HtrA protease in host protein degradation and inflammatory response Open
Introduction Degradation of host proteins by bacterial proteases leads to the subversion of the host response and disruption of oral epithelial integrity, which is considered an essential factor in the progression of periodontitis. High-te…
The intriguing strategies of Tannerella forsythia's host interaction Open
Tannerella forsythia , a member of the “red complex” bacteria implicated in severe periodontitis, employs various survival strategies and virulence factors to interact with the host. It thrives as a late colonizer in the oral biofilm, rely…
Red-complex bacteria exhibit distinctly different interactions with human periodontal ligament stromal cells compared to Fusobacterium nucleatum Open
Oral bacteria of different pathogenicity status interact differently with hPDL-MSCs. The data support P. gingivalis' capability to manipulate the inflammatory host response. Further research is necessary to obtain a comprehensive picture o…
Glycolanguage of the oral microbiota Open
The oral cavity harbors a diverse and dynamic bacterial biofilm community which is pivotal to oral health maintenance and, if turning dysbiotic, can contribute to various diseases. Glycans as unsurpassed carriers of biological information …
Oral streptococci: modulators of health and disease Open
Streptococci are primary colonizers of the oral cavity where they are ubiquitously present and an integral part of the commensal oral biofilm microflora. The role oral streptococci play in the interaction with the host is ambivalent. On th…
View article: Motivation and perception of farmers on the benefits and challenges of agroforestry in Sweden (Northern Europe)
Motivation and perception of farmers on the benefits and challenges of agroforestry in Sweden (Northern Europe) Open
Agroforestry systems provide multiple benefits for human wellbeing and biodiversity; however, their diversity and spatial distribution sharply decline across Europe. This study focuses on agroforestry farms in Sweden. The aim of the study …
Multispecies biofilm behavior and host interaction support the association of <i>Tannerella serpentiformis</i> with periodontal health Open
The recently identified bacterium Tannerella serpentiformis is the closest phylogenetic relative of Tannerella forsythia , whose presence in oral biofilms is associated with periodontitis. Conversely, T. serpentiformis is considered health…
Shut-Down of Type IX Protein Secretion Alters the Host Immune Response to Tannerella forsythia and Porphyromonas gingivalis Open
Tannerella forsythia and Porphyromonas gingivalis target distinct virulence factors bearing a structurally conserved C-terminal domain (CTD) to the type IX protein secretion system (T9SS). The T9SS comprises an outer membrane translocation…
View article: A Combination of Structural, Genetic, Phenotypic and Enzymatic Analyses Reveals the Importance of a Predicted Fucosyltransferase to Protein O-Glycosylation in the Bacteroidetes
A Combination of Structural, Genetic, Phenotypic and Enzymatic Analyses Reveals the Importance of a Predicted Fucosyltransferase to Protein O-Glycosylation in the Bacteroidetes Open
Diverse members of the Bacteroidetes phylum have general protein O-glycosylation systems that are essential for processes such as host colonization and pathogenesis. Here, we analyzed the function of a putative fucosyltransferase (FucT) fa…
View article: Assaying Paenibacillus alvei CsaB-Catalysed Ketalpyruvyltransfer to Saccharides by Measurement of Phosphate Release
Assaying Paenibacillus alvei CsaB-Catalysed Ketalpyruvyltransfer to Saccharides by Measurement of Phosphate Release Open
Ketalpyruvyltransferases belong to a widespread but little investigated class of enzymes, which utilise phosphoenolpyruvate (PEP) for the pyruvylation of saccharides. Pyruvylated saccharides play pivotal biological roles, ranging from prot…
LytR-CpsA-Psr Glycopolymer Transferases: Essential Bricks in Gram-Positive Bacterial Cell Wall Assembly Open
The cell walls of Gram-positive bacteria contain a variety of glycopolymers (CWGPs), a significant proportion of which are covalently linked to the peptidoglycan (PGN) scaffolding structure. Prominent CWGPs include wall teichoic acids of S…
View article: Peptidoglycan Salvage Enables the Periodontal Pathogen <b><i>Tannerella forsythia</i></b> to Survive within the Oral Microbial Community
Peptidoglycan Salvage Enables the Periodontal Pathogen <b><i>Tannerella forsythia</i></b> to Survive within the Oral Microbial Community Open
Tannerella forsythia is an anaerobic, fusiform Gram-negative oral pathogen strongly associated with periodontitis, a multibacterial inflammatory disease that leads to the destruction of the teeth-supporting tissue, ultimately causing tooth…
Utilization of different MurNAc sources by the oral pathogen Tannerella forsythia and role of the inner membrane transporter AmpG Open
Background The Gram-negative oral pathogen Tannerella forsythia strictly depends on the external supply of the essential bacterial cell wall sugar N -acetylmuramic acid (MurNAc) for survival because of the lack of the common MurNAc biosynt…
View article: Synthesis of a pyruvylated N-acetyl-β-D-mannosamine containing disaccharide repeating unit of a cell wall glycopolymer from Paenibacillus alvei
Synthesis of a pyruvylated N-acetyl-β-D-mannosamine containing disaccharide repeating unit of a cell wall glycopolymer from Paenibacillus alvei Open
A disaccharide implicated in anchoring of bacterial Surface-layer proteins to secondary cell wall glycopolymers has been prepared by glycosylation of a protected N-acetyl glucosamine acceptor with a glucopyranosyl donor to generate the β-(…
The Intriguing Interaction of Escherichia coli with the Host Environment and Innovative Strategies To Interfere with Colonization: a Summary of the 2019 E. coli and the Mucosal Immune System Meeting Open
The third E. coli and the Mucosal Immune System (ECMIS) meeting was held at Ghent University in Belgium from 2 to 5 June 2019. It brought together an international group of scientists interested in mechanisms of colonization, host response…
View article: Response of Human Mesenchymal Stromal Cells from Periodontal Tissue to LPS Depends on the Purity but Not on the LPS Source
Response of Human Mesenchymal Stromal Cells from Periodontal Tissue to LPS Depends on the Purity but Not on the LPS Source Open
Human periodontal ligament stromal cells (hPDLSCs) and gingival mesenchymal stromal cells (hGMSCs) are resident mesenchymal stromal cells (MSCs) of the periodontal tissue. The lipopolysaccharide (LPS) from Porphyromonas gingivalis is struc…
The Högdalen urban farm: a real case assessment of sustainability attributes Open
While urban indoor farming is a fairly new phenomenon, there is a growing interest from producers, authorities and consumers alike. However, many assumptions are made, and expectations held, about urban indoor farming from a sustainability…
Additional file 3 of Comparative genome characterization of the periodontal pathogen Tannerella forsythia Open
Additional file 3: Table S3. List of promising therapeutic targets based on presence-absence analyses.