Christine Goffinet
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View article: Synergistic latency reversal by the SMAC mimetic AZD5582 and iBET JQ1, combined with Nef ablation, facilitates immune-mediated elimination of latently HIV-1-infected T-cells
Synergistic latency reversal by the SMAC mimetic AZD5582 and iBET JQ1, combined with Nef ablation, facilitates immune-mediated elimination of latently HIV-1-infected T-cells Open
Recent breakdowns in the supply chains of antiretroviral therapy (ART) to lower income countries, where they are needed most, underpin the pressing need for an accessible and scalable HIV cure that would allow ART-free control of the virus…
View article: A Multiplex qPCR to Differentiate Monkeypox Virus Clades
A Multiplex qPCR to Differentiate Monkeypox Virus Clades Open
We designed a multiplex qPCR to differentiate monkeypox virus clades. In evaluations using clinical samples collected in the UK and Nigeria, the assay had an overall sensitivity of 78% (95% CI: 67.67% to 86.14%) and specificity of 94% (95%…
View article: Neural network-assisted humanisation of COVID-19 hamster transcriptomic data reveals matching severity states in human disease
Neural network-assisted humanisation of COVID-19 hamster transcriptomic data reveals matching severity states in human disease Open
View article: Single-cell-resolved interspecies comparison shows a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19
Single-cell-resolved interspecies comparison shows a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19 Open
A key issue for research on COVID-19 pathogenesis is the lack of biopsies from patients and of samples at the onset of infection. To overcome these hurdles, hamsters were shown to be useful models for studying this disease. Here, we furthe…
View article: TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution
TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution Open
The accessory protease transmembrane protease serine 2 (TMPRSS2) enhances severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uptake into ACE2-expressing cells, although how increased entry impacts downstream viral and host proces…
View article: Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens
Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens Open
View article: A recent gibbon ape leukemia virus germline integration in a rodent from New Guinea
A recent gibbon ape leukemia virus germline integration in a rodent from New Guinea Open
Germline colonization by retroviruses results in the formation of endogenous retroviruses (ERVs). Most colonization’s occurred millions of years ago. However, in the Australo-Papuan region (Australia and New Guinea), several recent germlin…
View article: Neural Network-Assisted Humanization of COVID-19 Hamster scRNAseq Data Reveals Matching Severity States in Human Disease
Neural Network-Assisted Humanization of COVID-19 Hamster scRNAseq Data Reveals Matching Severity States in Human Disease Open
Translating findings from animal models to human disease is essential for dissecting disease mechanisms, developing and testing precise therapeutic strategies. The coronavirus disease 2019 (COVID-19) pandemic has highlighted this need, par…
View article: P023 Patient experience and care needs within a Motor Neurone Disease Multidisciplinary Clinic
P023 Patient experience and care needs within a Motor Neurone Disease Multidisciplinary Clinic Open
Background The Sunshine Coast Hospital and Health Service (SCHHS) Motor Neurone Disease (MND) Multidisciplinary Clinic has been running since early 2020 and is the only one of its kind north of Brisbane. Patients with MND have complex care…
View article: Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection
Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection Open
Inhibitors of bromodomain and extra-terminal proteins (iBETs), including JQ-1, have been suggested as potential prophylactics against SARS-CoV-2 infection. However, molecular mechanisms underlying JQ-1-mediated antiviral activity and its s…
View article: Single-cell-resolved interspecies comparison identifies a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19
Single-cell-resolved interspecies comparison identifies a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19 Open
Key issues for research of COVID-19 pathogenesis are the lack of biopsies from patients and of samples at the onset of infection. To overcome these hurdles, hamsters were shown to be useful models for studying this disease. Here, we furthe…
View article: 90K/LGALS3BP expression is upregulated in COVID-19 but may not restrict SARS-CoV-2 infection
90K/LGALS3BP expression is upregulated in COVID-19 but may not restrict SARS-CoV-2 infection Open
View article: Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters
Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters Open
View article: Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication
Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication Open
View article: HIV-1 infection causes depletion of monocytic cells through a non-canonical cell death pathway
HIV-1 infection causes depletion of monocytic cells through a non-canonical cell death pathway Open
Programmed cell death is a regulatory mechanism to eliminate infected or damaged cells. Several programmed cell death pathways exist, including apoptosis, necroptosis and pyroptosis, which can be distinguished by the cellular molecules inv…
View article: SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression
SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression Open
Epidemiological data demonstrate that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) Alpha and Delta are more transmissible, infectious, and pathogenic than previous variants. Phenotypic properties …
View article: Dysfunctional purinergic signaling correlates with disease severity in COVID-19 patients
Dysfunctional purinergic signaling correlates with disease severity in COVID-19 patients Open
Ectonucleotidases modulate inflammatory responses by balancing extracellular ATP and adenosine (ADO) and might be involved in COVID-19 immunopathogenesis. Here, we explored the contribution of extracellular nucleotide metabolism to COVID-1…
View article: Pharmacological inhibition of bromodomain and extra-terminal proteins induces NRF-2-mediated inhibition of SARS-CoV-2 replication and is subject to viral antagonism
Pharmacological inhibition of bromodomain and extra-terminal proteins induces NRF-2-mediated inhibition of SARS-CoV-2 replication and is subject to viral antagonism Open
Inhibitors of bromodomain and extra-terminal proteins (iBETs), including JQ-1, have been suggested as potential therapeutics against SARS-CoV-2 infection. However, molecular mechanisms underlying JQ-1-induced antiviral activity and its sus…
View article: SARS-CoV-2 entry route impacts a range of downstream viral and cellular processes
SARS-CoV-2 entry route impacts a range of downstream viral and cellular processes Open
SARS-CoV-2 entry is promoted by both cell-surface TMPRSS2 and endolysosomal cathepsins. To investigate the impact of differentially routed virions on host and viral processes, lung epithelial cells expressing distinct combinations of entry…
View article: A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913
A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913 Open
Upon recognition of aberrantly located DNA, the innate immune sensor cyclic GMP-AMP synthase (cGAS) activates stimulator of IFN genes (STING)/IFN regulatory factor (IRF)3–driven antiviral responses. In this study, we characterized the abil…
View article: Nonproductive exposure of <scp>PBMCs</scp> to <scp>SARS‐CoV</scp> ‐2 induces cell‐intrinsic innate immune responses
Nonproductive exposure of <span>PBMCs</span> to <span>SARS‐CoV</span> ‐2 induces cell‐intrinsic innate immune responses Open
View article: Vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after TH2-biased immunization
Vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after TH2-biased immunization Open
Vaccine-associated enhanced respiratory disease (VAERD) is a severe complication for some respiratory infections. To investigate the potential for VAERD induction in coronavirus disease 2019 (COVID-19), we evaluate two vaccine leads utiliz…
View article: 90K/<i>LGALS3BP</i> Expression is Upregulated in COVID-19 but Does Not Restrict SARS-CoV-2 Infection
90K/<i>LGALS3BP</i> Expression is Upregulated in COVID-19 but Does Not Restrict SARS-CoV-2 Infection Open
Glycoprotein 90K, encoded by the interferon-stimulated gene LGALS3BP , displays broad antiviral activity. It reduces HIV-1 infectivity by interfering with Env maturation and virion incorporation, and increases survival of Influenza A virus…
View article: Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilises the angiotensin-converting enzyme 2 (ACE2) transmembrane peptidase as cellular entry receptor. However, whether SARS-CoV-2 in the alveolar compartment is stri…
View article: The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus Replication
The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus Replication Open
In this study, we discover the tetraspanin CD81 as a host factor for the globally emerging chikungunya virus and related alphaviruses. We show that CD81 promotes replication of viral genomes in human and mouse cells, while virus entry into…
View article: A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants
A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants Open
Vaccines are a cornerstone in COVID-19 pandemic management. Here, we compare immune responses to and preclinical efficacy of the mRNA vaccine BNT162b2, an adenovirus-vectored spike vaccine, and the live-attenuated-virus vaccine candidate s…
View article: Early and Rapid Identification of COVID-19 Patients with Neutralizing Type I Interferon Auto-antibodies
Early and Rapid Identification of COVID-19 Patients with Neutralizing Type I Interferon Auto-antibodies Open
View article: Evidence for an ACE2-Independent Entry Pathway That Can Protect from Neutralization by an Antibody Used for COVID-19 Therapy
Evidence for an ACE2-Independent Entry Pathway That Can Protect from Neutralization by an Antibody Used for COVID-19 Therapy Open
The interaction of the SARS-CoV-2 spike protein (S) with the cellular receptor ACE2 is considered essential for infection and constitutes the key target for antibodies induced upon infection and vaccination. Here, using a surrogate system …
View article: Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics
Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics Open
View article: Non-productive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immunity responses
Non-productive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immunity responses Open
Cell-intrinsic responses mounted in vivo in PBMCs during mild and severe COVID-19 differ quantitatively and qualitatively. Whether they are triggered by signals emitted by productively infected cells of the respiratory tract or are, at lea…