Christine J. Kubin
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View article: <i>Acinetobacter baumannii</i> treatment strategies: a review of therapeutic challenges and considerations
<i>Acinetobacter baumannii</i> treatment strategies: a review of therapeutic challenges and considerations Open
Antimicrobial resistance poses a major challenge in the treatment of Acinetobacter baumannii. Acinetobacter spp. are intrinsically resistant to a number of commonly used antibiotics. Over the past 3 years, the European and American Profess…
View article: Population Pharmacokinetic/Toxicodynamic Model for Polymyxin B in Critically Ill Patients to Identify the Risk of Nephrotoxicity
Population Pharmacokinetic/Toxicodynamic Model for Polymyxin B in Critically Ill Patients to Identify the Risk of Nephrotoxicity Open
Polymyxins are used against highly resistant Gram‐negative pathogens, and nephrotoxicity (acute kidney injury, AKI) is the major dose‐limiting adverse effect. We aimed to develop a well‐informed population pharmacokinetic/toxicodynamic (PK…
View article: Association Between Inpatient Medication Treatment for Opioid Use Disorder and Reduced One-Year All-Cause Mortality in Patients With Invasive Bacterial Infections
Association Between Inpatient Medication Treatment for Opioid Use Disorder and Reduced One-Year All-Cause Mortality in Patients With Invasive Bacterial Infections Open
Invasive bacterial infections are frequent causes of hospitalization among people who use opioids. We evaluated the association between inpatient administration of medication for opioid use disorder with one-year all-cause mortality in pat…
View article: P-862. Hospital administered MOUD is associated with decreased one-year mortality among PWUD admitted with bloodstream infections
P-862. Hospital administered MOUD is associated with decreased one-year mortality among PWUD admitted with bloodstream infections Open
Background Bloodstream infections (BSI) including infective endocarditis (IE) are highly morbid complications of substance use that contribute to the syndemic of invasive bacterial infections in persons who use drugs (PWUD). In this retros…
View article: P-1476. Cefiderocol Treatment Outcomes and Risk Factors for Gram-negative Bacterial Infection Treatment Failure
P-1476. Cefiderocol Treatment Outcomes and Risk Factors for Gram-negative Bacterial Infection Treatment Failure Open
Background The IDSA 2023 guidance lacks strong evidence about cefiderocol (FDC) efficacy and real-world data are limited. The aim of this study was to evaluate effectiveness, safety, and risk factors for clinical failure (ClinF) associated…
View article: P-2309. Assessment of Risk Factors Associated with Subtherapeutic Posaconazole Levels
P-2309. Assessment of Risk Factors Associated with Subtherapeutic Posaconazole Levels Open
Background There is significant variability in patient serum posaconazole levels, and it is unclear what characteristics increase the risk for subtherapeutic levels. Higher levels have been associated with improved outcomes. The purpose of…
View article: Initial micafungin treatment does not improve outcomes compared to fluconazole treatment in immunocompromised and critically ill patients with candidaemia
Initial micafungin treatment does not improve outcomes compared to fluconazole treatment in immunocompromised and critically ill patients with candidaemia Open
Background Candidaemia is associated with poor outcomes including high mortality rates. Controversy remains regarding whether fluconazole or an echinocandin is the optimal choice for initial candidaemia treatment, particularly among high-r…
View article: 680. Comparison of Extended Duration Vancomycin Regimens for <i>Clostridioides difficile</i> Infection in Patients on Prolonged Antibiotic Courses
680. Comparison of Extended Duration Vancomycin Regimens for <i>Clostridioides difficile</i> Infection in Patients on Prolonged Antibiotic Courses Open
Background Antibiotic exposure is a primary risk factor for Clostridioides difficile infection (CDI) and recurrence. We compared CDI recurrence in patients who received extended oral vancomycin (poV) after diagnosis of CDI, at a dose of q1…
View article: 2815. Outcomes of Novel Antimicrobials Compared to Polymyxin B for treatment of infections due Carbapenem-Resistant Enterobacterales Infections
2815. Outcomes of Novel Antimicrobials Compared to Polymyxin B for treatment of infections due Carbapenem-Resistant Enterobacterales Infections Open
Background Carbapenem-resistant Gram-negative infections remain a serious threat due to their increasing incidence and high mortality rates. Since 2015, various antimicrobials with in vitro activity against carbapenem-resistant Enterobacte…
View article: Race and Remdesivir: Examination of Clinical Outcomes in a Racially and Ethnically Diverse Cohort in New York City
Race and Remdesivir: Examination of Clinical Outcomes in a Racially and Ethnically Diverse Cohort in New York City Open
Objective To compare clinical characteristics and examine in-hospital length of stay (LOS) differences for COVID-19 patients who received remdesivir, by race or ethnicity. Design Retrospective descriptive analysis comparing cumulative LOS …
View article: 892. Clinical Impact of Early Antifungal De-escalation (≤ 2 days) based on Rapid Species Identification in Patients with Azole-susceptible Candidemia
892. Clinical Impact of Early Antifungal De-escalation (≤ 2 days) based on Rapid Species Identification in Patients with Azole-susceptible Candidemia Open
Background Echinocandins are first-line therapy of candidemia with an option to de-escalate (DE) to oral azoles based on clinical response and susceptibilities. There are no universally accepted DE criteria but rapid diagnostic testing (RD…
View article: Assessing the predictive performance of population pharmacokinetic models for intravenous polymyxin B in critically ill patients
Assessing the predictive performance of population pharmacokinetic models for intravenous polymyxin B in critically ill patients Open
Polymyxin B (PMB) has reemerged as a last‐line therapy for infections caused by multidrug‐resistant gram‐negative pathogens, but dosing is challenging because of its narrow therapeutic window and pharmacokinetic (PK) variability. Populatio…
View article: <i>In Vitro</i> Cytotoxicity and Clinical Correlates of MRSA Bacteremia
<i>In Vitro</i> Cytotoxicity and Clinical Correlates of MRSA Bacteremia Open
Methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections are associated with significant morbidity and mortality. MRSA secretes a number of virulence factors and pore-forming toxins that enable tissue invasion.
View article: Characterization of Bacterial and Fungal Infections in Hospitalized Patients With Coronavirus Disease 2019 and Factors Associated With Health Care-Associated Infections
Characterization of Bacterial and Fungal Infections in Hospitalized Patients With Coronavirus Disease 2019 and Factors Associated With Health Care-Associated Infections Open
Background Patients hospitalized with coronavirus disease 2019 (COVID-19) are at increased risk of health care–associated infections (HAIs), especially with prolonged hospital stays. We sought to identify incidence, antimicrobial susceptib…
View article: Cardiac Corrected QT Interval Changes Among Patients Treated for COVID-19 Infection During the Early Phase of the Pandemic
Cardiac Corrected QT Interval Changes Among Patients Treated for COVID-19 Infection During the Early Phase of the Pandemic Open
In this cohort study, COVID-19 infection was independently associated with significant mean QTc prolongation at days 5 and 2 of hospitalization compared with day 0. More patients with COVID-19 had QTc of 500 milliseconds or greater compare…
View article: Antimicrobial stewardship perspectives from a New York City hospital during the COVID-19 pandemic: Challenges and opportunities
Antimicrobial stewardship perspectives from a New York City hospital during the COVID-19 pandemic: Challenges and opportunities Open
Purpose To share challenges and opportunities for antimicrobial stewardship programs based on one center’s experience during the early weeks of the coronavirus disease 2019 (COVID-19) pandemic. Summary In the spring of 2020, New York City …
View article: Limited Utility of Procalcitonin in Identifying Community-Associated Bacterial Infections in Patients Presenting with Coronavirus Disease 2019
Limited Utility of Procalcitonin in Identifying Community-Associated Bacterial Infections in Patients Presenting with Coronavirus Disease 2019 Open
The role of procalcitonin in identifying community-associated bacterial infections among patients with coronavirus disease 2019 is not yet established. In 2,443 patients with 148 bacterial coinfections, mean procalcitonin levels were signi…
View article: 1579. <i>Burkholderia</i> Returns: Are Two Drugs Better or Back to Bactrim?
1579. <i>Burkholderia</i> Returns: Are Two Drugs Better or Back to Bactrim? Open
Background Trimethoprim-sulfamethoxazole (T/S) and levofloxacin are considered first line agents for the treatment of Burkholderia cepacia complex (Bcc). Combination therapy (CT) is frequently utilized despite limited clinical evidence sup…
View article: Clinical Outcomes Associated With Methylprednisolone in Mechanically Ventilated Patients With COVID-19
Clinical Outcomes Associated With Methylprednisolone in Mechanically Ventilated Patients With COVID-19 Open
Background The efficacy and safety of methylprednisolone in mechanically ventilated patients with acute respiratory distress syndrome resulting from coronavirus disease 2019 (COVID-19) are unclear. In this study, we evaluated the associati…
View article: Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19
Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 Open
In this observational study involving patients with Covid-19 who had been admitted to the hospital, hydroxychloroquine administration was not associated with either a greatly lowered or an increased risk of the composite end point of intub…
View article: MP83-16 PREOPERATIVE GENTAMICIN UNDERDOSING IN THE UROLOGY PATIENT
MP83-16 PREOPERATIVE GENTAMICIN UNDERDOSING IN THE UROLOGY PATIENT Open
You have accessJournal of UrologyGeneral & Epidemiological Trends & Socioeconomics: Quality Improvement & Patient Safety IV (MP83)1 Apr 2020MP83-16 PREOPERATIVE GENTAMICIN UNDERDOSING IN THE UROLOGY PATIENT Jane Kurtzman*, Ezra Margolin, G…
View article: 2439. Outcomes of Minocycline Use on Gram-Negative Infections and Implications of MIC
2439. Outcomes of Minocycline Use on Gram-Negative Infections and Implications of MIC Open
BACKGROUND: Minocycline (MINO) is a treatment option for Acinetobacter baumannii and Stenotrophomonas maltophilia infections due to high in vitro susceptibility. Literature suggests it may also be an option for carbapenamase-producing ente…
View article: ICE volume 39 issue 3 Cover and Front matter
ICE volume 39 issue 3 Cover and Front matter Open
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View article: Population Pharmacokinetics of Intravenous Polymyxin B from Clinical Samples
Population Pharmacokinetics of Intravenous Polymyxin B from Clinical Samples Open
A retrospective study was conducted in hospitalized patients receiving intravenous polymyxin B who underwent therapeutic drug monitoring during treatment. The aim of this study was to assess the population pharmacokinetics (PK) of intraven…
View article: Population Pharmacokinetics of Polymyxin B in Acutely Ill Adult Patients
Population Pharmacokinetics of Polymyxin B in Acutely Ill Adult Patients Open
Polymyxin B (PB) has reemerged as a common treatment against multidrug-resistant Gram-negative pathogens. However, nephrotoxicity remains a significant dose-limiting side effect, and contemporary pharmacokinetic (PK) data are limited. This…
View article: Association of Bacteriuria by Time and Organism Following Kidney Transplantation with Allograft Survival and Rejection
Association of Bacteriuria by Time and Organism Following Kidney Transplantation with Allograft Survival and Rejection Open
Bacteriuria is a common complication after kidney transplantation (KT) and has been linked to poor allograft outcomes. While conflicting data exists regarding the association between bacteriuria and graft survival, little is known about th…
View article: Influence of Polymyxin B Dose on Development and Recovery of Acute Kidney Injury
Influence of Polymyxin B Dose on Development and Recovery of Acute Kidney Injury Open
Background Nephrotoxicity is a common adverse effect of polymyxin B (PMB) with reported acute kidney injury (AKI) rates of 20% to >60%. Data on PMB dosing to optimize efficacy while minimizing toxicity are limited. Previous studies sugg…