Christine Knaevelsrud
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View article: The Common Structure of Dimensional Personality Disorder and Attention Deficit Hyperactivity Disorder
The Common Structure of Dimensional Personality Disorder and Attention Deficit Hyperactivity Disorder Open
Background: Common and distinct features of personality disorders (PDs) and attention deficit hyperactivity disorder (ADHD) have long been the focus of research. However, most studies relied on categorical rather than dimensional models, w…
View article: Psychosocial support for Arabic-speaking refugees residing in Switzerland (Sui app): a mixed-methods randomised controlled trial
Psychosocial support for Arabic-speaking refugees residing in Switzerland (Sui app): a mixed-methods randomised controlled trial Open
View article: Optimizing Expectations in an Internet- and mobile-based Intervention for Depression: Study Protocol for a Randomized Factorial Trial
Optimizing Expectations in an Internet- and mobile-based Intervention for Depression: Study Protocol for a Randomized Factorial Trial Open
Background: Expectations are considered an important mechanism of change in psychotherapeutic interventions, including Internet- and mobile-based interventions (IMI). This study aims to investigate whether two expectation-focused micro-int…
View article: Geschlechterunterschiede bei der posttraumatischen Belastungsstörung: aktuelle Evidenz zu Entstehung, Verlauf und Behandlung
Geschlechterunterschiede bei der posttraumatischen Belastungsstörung: aktuelle Evidenz zu Entstehung, Verlauf und Behandlung Open
Zusammenfassung Hintergrund Geschlechterunterschiede bei psychischen Störungen sind weit verbreitet. Die posttraumatische Belastungsstörung (PTBS) zählt hierbei zu den Störungen mit den größten Prävalenzunterschieden zwischen Männern und F…
View article: Mechanisms of change in naturalistic mental health care settings: study protocol for a longitudinal multimethod study
Mechanisms of change in naturalistic mental health care settings: study protocol for a longitudinal multimethod study Open
Introduction Mental disorders are among the leading causes of the global burden of disease and are often associated with severe functional impairment and high societal costs. Psychotherapeutic, psychopharmacological and internet-based ment…
View article: Effectiveness, Effectiveness, Empowerment and Real World Usage: A Randomized Controlled Trial of a Mobile Prescription App for Depression within the German Healthcare System (Preprint)
Effectiveness, Effectiveness, Empowerment and Real World Usage: A Randomized Controlled Trial of a Mobile Prescription App for Depression within the German Healthcare System (Preprint) Open
BACKGROUND Depression is a common mental health issue, while treatment access and utilization are limited. Digital interventions, including prescribable Digital Health Applications (DiGAs), offer scalable solutions for various health cond…
View article: Determining essential dimensions for the clinical approximation of personality disorder severity: multi-method study
Determining essential dimensions for the clinical approximation of personality disorder severity: multi-method study Open
Background Decades of research on the dimensional nature of personality disorder have led to the replacement of categorical personality disorder diagnoses by a dimensional assessment of personality disorder severity (PDS) in ICD-11, which …
View article: Perceived discrimination and mental health in Germany: increasing attention, but persistent gaps
Perceived discrimination and mental health in Germany: increasing attention, but persistent gaps Open
Discrimination is a risk factor for adverse mental health. Regional examinations are necessary to account for the sociocultural context that shapes lived experiences of marginalized groups. This meta-analytic review examined how multiple f…
View article: Using the ICH estimand framework to improve the interpretation of treatment effects in internet interventions
Using the ICH estimand framework to improve the interpretation of treatment effects in internet interventions Open
The ICH E9(R1) Addendum on Estimands and Sensitivity Analysis provides a framework for defining the treatment effect a trial intends to estimate—the estimand. The addendum is widely adopted in pharmaceutical research. However, it remains u…
View article: Moving beyond gender: a systematic review of diversity data gaps in prospective trauma research
Moving beyond gender: a systematic review of diversity data gaps in prospective trauma research Open
Background: To better understand heterogeneity in PTSD development and to ensure that knowledge of risk and intervention mechanisms is available for a diverse group of trauma exposed individuals, psychotraumatology needs to consider…
View article: How to report personalized Internet- and mobile- based intervention components: Introducing the ADAPT-I checklist
How to report personalized Internet- and mobile- based intervention components: Introducing the ADAPT-I checklist Open
Personalization of various Internet- and mobile-based intervention (IMI) components is common, but inconsistent terminology and selective reporting hinder research and practice. This paper introduces the Adjustable Content & Order, Dir…
View article: Sleep quality and the biological stress system during an internet-based intervention for major depressive disorder
Sleep quality and the biological stress system during an internet-based intervention for major depressive disorder Open
Prior to psychotherapeutic treatment MDD patients with poor sleep quality showed a blunted CAR, pointing to hypocortisolemia in these individuals. Furthermore, intervention-induced changes in sleep quality may lead to a normalization of th…
View article: Social support profiles and their association with sociodemographic and mental health characteristics among treatment-seeking adults in Arabic-speaking countries
Social support profiles and their association with sociodemographic and mental health characteristics among treatment-seeking adults in Arabic-speaking countries Open
High prevalences of mental disorders have been found among people from Arabic-speaking countries. Perceived social support has often been identified as a significant factor in the development of mental disorders, and the social environment…
View article: Therapeutic Alliance, Self-efficacy, and Agency as Mechanisms of Change in Blended Care and Routine Psychotherapy
Therapeutic Alliance, Self-efficacy, and Agency as Mechanisms of Change in Blended Care and Routine Psychotherapy Open
Blended Care (BC) has emerged as a promising approach to address the growing demand for accessible mental health treatment. While BC is effective for various mental disorders, little is known about the mechanisms through which BC leads to …
View article: Prävalenz ungewollter Schwangerschaften und Schwangerschaftsausgang bei Frauen mit psychischen Erkrankungen. Ergebnisse aus der ELSA Studie
Prävalenz ungewollter Schwangerschaften und Schwangerschaftsausgang bei Frauen mit psychischen Erkrankungen. Ergebnisse aus der ELSA Studie Open
Zusammenfassung Internationale Studien deuten auf ungünstige Wechselwirkungen zwischen ungewollten Schwangerschaften und psychischer Gesundheit. Die Studie untersucht Prävalenz, Ausgang und soziale Faktoren ungewollter Schwangerschaften be…
View article: The predictive role of childhood maltreatment for long-term HPA axis regulation, chronic stress and postpartum depression
The predictive role of childhood maltreatment for long-term HPA axis regulation, chronic stress and postpartum depression Open
Individuals with a history of childhood maltreatment are highly vulnerable to adverse mental health outcomes in the postpartum period. Perceived chronic stress may be an important underlying pathway, while neuroendocrinological mechanisms …
View article: Effects of an unguided self-help intervention for distressing auditory verbal hallucinations in a heterogenous sample of voice hearers: A randomized controlled trial and explorative cluster analysis
Effects of an unguided self-help intervention for distressing auditory verbal hallucinations in a heterogenous sample of voice hearers: A randomized controlled trial and explorative cluster analysis Open
Even though we found no effect of the MCTVoice on the main outcome, results showed promising outcomes on general hallucinatory experiences in PP data. The identification of AVH clusters could contribute to implement individualiz…
View article: PREACT-digital: study protocol for a longitudinal, observational multicentre study on digital phenotypes of non-response to cognitive behavioural therapy for internalising disorders
PREACT-digital: study protocol for a longitudinal, observational multicentre study on digital phenotypes of non-response to cognitive behavioural therapy for internalising disorders Open
Introduction Cognitive behavioural therapy (CBT) serves as a first-line treatment for internalising disorders (ID), encompassing depressive, anxiety or obsessive-compulsive disorders. Nonetheless, a substantial proportion of patients do no…
View article: Beyond one-cutoff-fits-all: determining cutoff values for the PTSD checklist for DSM-5 (PCL-5)
Beyond one-cutoff-fits-all: determining cutoff values for the PTSD checklist for DSM-5 (PCL-5) Open
Background: There is no universally optimal cutoff score for identifying probable PTSD, which makes reliable PTSD diagnosis challenging not only across different populations but also in different settings. Reliable outcomes require …
View article: A Digital Psychosocial Service (Sui App) for Arabic-Speaking Refugees in Switzerland: Development and Cultural-Contextual Adaptation Using a User-Centered and Participatory Approach
A Digital Psychosocial Service (Sui App) for Arabic-Speaking Refugees in Switzerland: Development and Cultural-Contextual Adaptation Using a User-Centered and Participatory Approach Open
Background Upon arriving in host countries, forcibly displaced people face psychological, cultural, as well as sociostructural challenges. Access to mental health and psychosocial support (MHPSS) remains limited, affecting both refugees an…
View article: “Who blends in and why (not)?” A qualitative study on psychotherapists' patient inclusion in blended care
“Who blends in and why (not)?” A qualitative study on psychotherapists' patient inclusion in blended care Open
View article: A systematic review on personalization of treatment components in IBIs for mental disorders
A systematic review on personalization of treatment components in IBIs for mental disorders Open
View article: The Interplay of Personality Functioning and Affect-Event Dynamics in Predicting Future Impairment and Depression – A Large Mobile Mental Health Ambulatory Assessment Study
The Interplay of Personality Functioning and Affect-Event Dynamics in Predicting Future Impairment and Depression – A Large Mobile Mental Health Ambulatory Assessment Study Open
Since the introduction of the dimensional assessment of personality functioning (PF) in DSM-5 and ICD-11, impairments in PF have consistently been related to transdiagnostic risk-factors for mental health. However, ecological momentary ass…
View article: Childhood maltreatment as a risk factor for depressive symptoms after an unintended pregnancy: The role of emotion regulation difficulties
Childhood maltreatment as a risk factor for depressive symptoms after an unintended pregnancy: The role of emotion regulation difficulties Open
Background: Individuals who experience an unintended pregnancy are at risk of developing depressive symptoms, regardless of whether the pregnancy is terminated or carried to term. Knowledge about particularly vulnerable individuals after a…
View article: Towards Just-In-Time Adaptive Interventions - Moment-to-moment Prediction of Negative Affect in Internalizing Disorders using Digital Phenotyping
Towards Just-In-Time Adaptive Interventions - Moment-to-moment Prediction of Negative Affect in Internalizing Disorders using Digital Phenotyping Open
Negative affect (NA)—encompassing heightened states of sadness, anxiety, and guilt—is a key symptom across a spectrum of internalizing disorders. Recent advancements in digital phenotyping (DP) and machine learning (ML) have raised hopes o…
View article: Give Your Treatment Effect a Meaning: Applying the ICH E9 (R1) Estimand Framework to Internet-based Interventions
Give Your Treatment Effect a Meaning: Applying the ICH E9 (R1) Estimand Framework to Internet-based Interventions Open
The ICH E9(R1) Addendum on Estimands and Sensitivity Analysis provides a rigorous framework for clearly defining the treatment effect a clinical trial aims to estimate—the so-called estimand. Although the addendum has been widely adopted i…
View article: The role of self-efficacy in internet-based interventions for mental health: A systematic review and meta-analysis
The role of self-efficacy in internet-based interventions for mental health: A systematic review and meta-analysis Open
Self-efficacy appears influential in IBI efficacy and may itself be a valuable treatment target. However, mixed results and methodological limitations in mediator studies highlight the need for further research, particularly on long-term e…
View article: Understanding the Unwanted: A Mixed-Methods Study on Negative Effects in an Internet-based Intervention for Depression
Understanding the Unwanted: A Mixed-Methods Study on Negative Effects in an Internet-based Intervention for Depression Open
Internet-based interventions (IBIs) are effective for treating depression, but they can also lead to negative effects in some participants. There is no consensus on which specific characteristics of negative effects clinicians and research…
View article: Determining essential dimensions for the clinical approximation of personality disorder severity - a multimethod study
Determining essential dimensions for the clinical approximation of personality disorder severity - a multimethod study Open
Background: Decades of research on the dimensional nature of personality disorder (PD) have led to the replacement of categorical PD diagnoses by a dimensional assessment of PD severity (PDS) in ICD-11, which essentially corresponds to per…
View article: The Predictive Role of Childhood Maltreatment for Long-Term HPA Axis Regulation, Chronic Stress and Postpartum Depression
The Predictive Role of Childhood Maltreatment for Long-Term HPA Axis Regulation, Chronic Stress and Postpartum Depression Open
Background: Childhood maltreatment increases the risk for mental disorders, including postpartum depression (PPD). Outside the peripartum period, attenuated long-term hypothalamus-pituitary-adrenal (HPA) axis regulation and perceived chron…